Fig. 4. Ethosuximide normalizes enhanced 3-Hz thalamic oscillations, enhanced cortical theta EEG rhythms, and hyperactivity in Git1-/- mice. (A and B) Ethosuximide (etho) but not saline (sal) normalizes enhanced 3-Hz thalamic rhythms in Git1-/- mice. n=4 (KO sal), 4 (KO etho). *p < 0.05; Student's t-test. (C and D) Ethosuximide reduces cortical theta EEG rhythms in Git1-/- mice. (E~G) Ethosuximide normalizes hyperactivity in Git1-/- mice in an open field arena, without affecting the time spent in the center region. n=8 (WT sal), 8 (KO sal), 10 (KO etho). *p < 0.05, **p < 0.01, n.s., not significant; one-way ANOVA. (H and I) Ethosuximide does not rescue impaired recognition memory in Git1-/- mice. Saline-treated Git1-/- mice (KO sal) and ethosuximide-treated Git1-/- mice (KO etho) spent comparable amounts of time exploring two identical objects in the sample phase of the object recognition test (I). n=9 (KO sal), 6 (KO etho). n.s., not significant; Student's t-test.
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