Fig. 5. Pharmacological inhibition of the MCH receptor system conferred anxiolytic effects. (A) Experimental design for treatment with the 2 h×14 d restraint and post-stress treatment with the MCH receptor 1 antagonist (SNAP-94847). SNAP-94847 was intraperitoneally administered at a dose of 30 mg/kg/day on post-stress days 1~3. Behavioral assessments were carried out on post-stress days 4~6. (B) Stress-induced reduced social interaction in the sociability test was reversed by post-stress treatment with SNAP-94847. The U-field with a social target are shown (right panel). (C) Stress-induced reduction in the number of marbles buried in the marble-burying test was partially reversed by SNAP-94847. Data are presented as mean±SEM (n=7~8). *, p<0.05 for the differences between the control and indicated groups (one-way ANOVA and Newman-Keuls post hoc test).
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