The list of PTPs inhibitors used in this study
Chemical name of inhibitorsTarget PTPsSubtype (synonyms)References
Non-receptor PTP
 (S)-4-(((S)-1-(l2-azanyl)-3-(4-(difluoro(phosphono) methyl)phenyl)-1-oxopropan-2-yl)amino)-3-((S)-3-(4-(difluoro(phosphono)methyl)phenyl)-2-pentadecanamidopropanamido)-4-oxobutanoic acidProtein tyrosine phosphatase type 1B (PTP1B)NT1 (PTP-1, PTPN1)[9]
 ((4-((S)-3-(((S)-1-amino-6-(4-ethylbenzamido)-1-oxohexan-2-yl)amino)-2-((S)-2-(2-(((1R,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)acetamido)-3-phenylpropanamido)-3-oxopropyl)phenyl)difluoromethyl)phosphonic acidT-cell phosphatase (TC-PTP)NT2 (PTP-2, PTPN2)[16]
 ((4-((S)-3-(((S)-1-(((S)-1-amino-3-(2-(4-hydroxy-3-methoxyphenyl)acetamido)-1-oxopropan-2-yl)amino)-5-(3-iodobenzamido)-1-oxopentan-2-yl)amino)-6-hydroxy-3-iodo-1-methyl-2-(3-(2-oxo-2-((4-(thiophen-3-yl)phenyl) amino)acetamido)phenyl)-1H-indole-5-carboxylic acidSrc homology domain2-containing PTP2 (SHP2)NT3 (SH-PTP2, PTPN11)[33]
 ((4-((S)-3-(((S)-1-(((S)-1-amino-3-(2-(4-hydroxy-3-methoxyphenyl)acetamido)-1-oxopropan-2-yl)amino)-5-(3-iodobenzamido)-1-oxopentan-2-yl)amino)-2-(3-bromo-4-methylbenzamido)-3-oxopropyl)phenyl)difluoromethyl) phosphonic acidMegakaryocyte-PTP2 (MEG2)NT3 (PTPN9)[15]
 3-((3-Chlorophenyl)ethynyl)-2-(4-(2-(cyclopropylamino)-2-oxoethoxy)phenyl)-6-hydroxybenzofuran-5-carboxylic AcidLymphoid specific-tyrosine phosphatase (LYP)NT4 (LYP)[14]
Receptor PTP
 2-(3-(2-(3-bromo-5-iodobenzamido)acetamido)phenyl)-6-hydroxy-3-iodo-1-methyl-1H-indole-5-carboxylic acidReceptor-type tyrosine protein phosphatase beta (RPTPβ)(PTPRZ1 VE-PTP)[13]
Exp Neurobiol 2016;25:252~261 https://doi.org/10.5607/en.2016.25.5.252
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