Fig. 4. Relative contribution of Stim1, Orai1, Orai2, Orai3 and TrpC1 to astrocytic SOCE. (a) Comparison of Ca2+ imaging traces from 1000s to 1500s normalized by amplitude of ER Ca2+ release. (b) Comparison of mean “Ratio” values in each condition. (c) Relative SOCE portion of each gene. 35.7% for Orai1, 20.3% for Orai2, 26.8% for Orai3, and 12.2% for TrpC1, 67.6% for Orai1/2/3 and 79.2% for Stim1. (d) Schematic diagram and summary of relative contributions. ns: not significant, *p<0.05, ****p<0.0001, student's t-test.
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