Fig. 3. The mechanism of inhibition of apocynin on NOX-induced superoxide production. In neutrophil, dimerized apocynin by MPO and H2O2 prevents assembly of an intact enzyme complex by preventing the association of cytosolic subunit p47 with the membrane subunit gp91. In vascular cell, apocynin could also be dimerized by MPO secreted from neutroophils. It inhibits vascular NOX, which is composed of NOX2 or its homologues (NOX1, NOX4, or NOX5) as the catalytic subunit. (Apo: Apocynin)
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