Fig. 6. Akt inhibitor IV reduced the activity of the NF-κB promoter in postconditioning. NF-κB activity was detected by a reporter gene assay in bEnd.3 cells at 1 and 4 h reperfusion. In the OGD group, NF-κB promoter activity was increased compared to the normoxia group, and activity was higher in the postconditioning group than the OGD group. When Akt inhibitor IV was applied, the activity of the NF-κB promoter was reduced in the OGD group and was even lower in the postconditioning group. Data are mean±SE. n=4. Data were analyzed by ANOVA (#p<0.05 and ###p<0.001 compared with normoxia group; ***p<0.001 compared with the vehicle group at the same time point).
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