Fig. 2. Morin diminishes GCD and mossy fiber sprouting in the KA-treated DG. (A, B) Morin (20, 40, and 80 mg/kg per day) was orally administered to the mice 1 day before the KA injection, and then administered for 7 more days. (A) The representative sections of the ipsilateral DG following Nissl staining by cresyl violet. CON, contralateral side. Scale bar, 200 µm. (B) The quantification of GCD normalized to the contralateral side for each sample. **p<0.01 vs. CON, #p<0.05 vs. KA alone (one-way ANOVA and Tukey's post-hoc analysis; n=4, each experimental group), $p<0.05 vs. KA alone (t-test analysis; n=4, each experimental group). (C, D) Morin (80 mg/kg per day) was orally administered to the mice 1 day before the KA injection, and then administered for 35 more days. (C) The representative sections of the ipsilateral DG following Timm's staining. (D) The semi-quantification of Timm's staining results. Data was presented by mean Timm scores for each sample. ***p<0.001 vs. CON (one-way ANOVA and Tukey's post-hoc analysis; n=4, each experimental group).
© Exp Neurobiol
