Fig. 3. FITC-conjugated TAP2 preferentially targeted spinal microglia in rats with SNL-induced neuropathic pain. On day 3 after surgery, FITC-conjugated TAP2 (FITC-TAP2) was administered intrathecally to SNL-induced rats. After 4 days, L5 spinal sections were prepared and incubated with an antibody against the microglia marker Iba1. Arrowheads indicate the microglial cells targeted by FITC-conjugated TAP2 in the spinal dorsal horn. Scale bar=500 µm (left), 200 µm (right). The numbers of Iba1/FITC–TAP2-positive cells were quantified in the contralateral (Contra) and ipsilateral (Ipsi) spinal dorsal horn. Data are presented as means±SEM (unpaired Student's t test, ***p<0.001 vs. Contra; n=3 per group).
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