Fig. 3. Western blot analysis shows that axonal guidance signaling-related proteins are down-regulated in the cortex of postmortem brain in CTE patients. (A) Neuronal beta III tubulin (TUBB3) and cofilin (CFL1) proteins were down-regulated in the cortex of postmortem brain of CTE patients compared to normal subjects. Western blot data represent each of the three cases of normal subjects (Nor) and CTE patients. (B) Oligodendrocyte MAG and TUBB4 proteins are down-regulated in CTE. (C) MEK2/MAP2K2 and RHO G, a Rho GTPase family protein, were down-regulated in CTE. Significantly different from normal (Nor) subject at *p<0.05; **p<0.01. All bar graph data represent the mean±SEM from five cases of normal subjects (n=5) and CTE patients (n=5).
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