Fig. 6. A scheme illustrating that deregulation of neuronal and oligodendrocyte (OGD) proteins are associated with the neurodegenerative pathology of chronic traumatic encephalopathy (CTE). Repetitive closed head injury, so called non-penetrating traumatic brain injury (TBI) or blunt TBI in human, alters axonal guidance signaling-related proteome signatures in both neurons (such as CFL1 and 2, and TUBB3) and oligodendrocytes (such as MAG and TUBB4). Consequently, the dysfunction of axonal guidance signaling pathway leads to impaired myelination and neurodegeneration that are associated with the white matter pathology in CTE patients.
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