Fig. 3. L-LTP is unaffected in the Rev-erbα KO mice during the subjective day and night. Example traces from baseline and LTP at times indicated by (a) and (b): WT (black) and KO (red or blue). (A) During the subjective day, Rev-erbα KO mice did not exhibit any impairment in the TBS-induced hippocampal L-LTP, and the potentiation level was maintained at a level comparable with that in the WT mice for 3 h (WT, 7 slices from 6 mice; Rev-erbα KO, 6 slices from 6 mice; average fEPSP slopes for the last 5 min; WT, 139.6%±5.199%; Rev-erbα KO, 128.2%±7.817%; unpaired t test; p=0.2388). (B) During the subjective night, Rev-erbα KO mice did not show any deficits in the TBS-induced hippocampal L-LTP (WT, 6 slices from 6 mice; Rev-erbα KO, 6 slices from 6 mice; average fEPSP slopes for the last 5 min; WT, 132.6%±5.213%; Rev-erbα KO, 143.6%±7.963%; unpaired t test; p=0.2736).
© Exp Neurobiol
