Fig. 4. Inhibition of SK channel by Zn in single channel recording. (A) Inside-out patch single-channel records from a SNc dopaminergic neuron, showing inward SK currents under symmetric potassium conditions. Holding potential was −60 mV, and the calcium concentration at the intracellular patch face was increased to 0.1 mM free calcium as shown by the single channel openings at the top. Middle and bottom panel show SK single-channel current traces in the absence and the presence of 100 μM Zn. The zero current trace is marked by the dashed line (C, closed; O, open). (B) The open probability histogram of an SK channel being open (Popen ) during 10 s in the absence and the presence of Zn.
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