Differences in [123I]FP-CIT BPND

Drug Dose (mg/kg) Striatum Midbrain


BPND % Difference p BPND % Difference p
VEH - 1.64±0.13 - - 1.69±0.32 - -
BUP 20 1.37±0.22 −16.50±13.41 0.3954 1.16±0.16 −31.57±9.26 0.2165
100 0.72±0.08 −56.29±4.59 0.0006 0.79±0.12 −53.08±7.21 0.0376
HAL 1 1.22±0.09 −25.29±5.60 0.0749 0.70±0.12 −58.74±7.38 0.0041
7 1.60±0.06 −2.27±3.65 0.9797 0.85±0.05 −49.64±3.13 0.0215
CLZ 10 1.95±0.20 18.85±12.00 0.2257 1.04±0.11 −38.60±6.53 0.0668
54 2.27±0.13 38.64±7.87 0.0061 1.01±0.05 −40.38±2.76 0.0676

Values are the mean±SEM. VEH, vehicle; BUP, bupropion; HAL, haloperidol; CLZ, clozapine.

Experimental Neurobiology 2019;28:602~611 https://doi.org/10.5607/en.2019.28.5.602
© Exp Neurobiol