Impaired autophagy in age-related diseases

DiseaseMajor causes and defectsReferences
Alzheimer’s diseaseClearance of misfolded plaque as autophagy substrate[1, 111113, 117120]
Lysosomal. acidification[112, 113, 116]
Inflammatory cytokine & Reactive microglia[8, 121125, 127]
Oxidative stress[128130]
Mitochondrial oxidative damage[131, 133]
Huntington’s diseaseAccumulation of mutant htt & Cell death[134, 136139]
Oxidative stress & DNA repair system[9, 135, 137, 140, 141]
Parkinson’s diseaseGenetic mutations in autosomal dominant genes[12, 142, 144, 145, 148, 149]
Genetic mutations in autosomal recessive genes[12, 146, 147]
Oxidative stress & DNA repair system[10, 150152]
Amyotrophic lateral sclerosisMutation of SOD1 gene[153155, 157, 158]
Mutation of p62[153, 156]
Abnormal cytoplasmic accumulation of TDP-43[153, 159, 160]
Deletion of C9ORF72[161]
Inflammatory responses & Reactive microglia[11, 162165]
Experimental Neurobiology 2019;28:643~657 https://doi.org/10.5607/en.2019.28.6.643
© Exp Neurobiol