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Fig. 4AEffects of MK-801 administration on social behaviors of mice in the three-chamber social assay. Subject mice were administered with either MK-801 (0.1, 0.12, 0.15, 0.2 and 0.3 mg kg−1) or 0.9% NaCl thirty minutes prior to performing three-chamber social assay. shows the effects of MK-801 on the stay duration of mice in the stranger, center, and empty sides. The chamber preference index for the social interaction phase was then calculated as described in the Materials and Methods section and is shown in Fig. 4B. Figs. 4C and demonstrate the effects of MK-801 on the social preference phase. All data are expressed as the mean±S.E.M (n=15~20 mice per group). *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001 vs. vehicle group as revealed by post hoc Tukey's multiple comparisons test.
Experimental Neurobiology 2019;28:697~708
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