Immunohistochemistry analysis of MCT-1, MCT-2, MCT-4, and GLT-1 in the cortex of the ipsilesional hemisphere of the UCCAO mouse brains (A) MCT-1 expression was observed to increase in the asymmetric group. (B) Intensity of MCT-1 significantly differed between groups (n=6 per each group, p<0.05). (C) MCT-1 appeared to colocalize with neurons in the ischemic hemisphere of the asymmetric group. (D) MCT-2 expression tended to increase in the asymmetric group. (E) The difference did not reach statistical significance (n=6 per each group). (F) MCT-2 appeared to colocalize with neurons in the ischemic hemisphere of the asymmetric group. (G) MCT-4 expression was found along the vessels. (H) The expression did not differ between groups (n=6). (I) GLT-1 (red) expression was observed to increase in the asymmetric group. (J) The intensity of GLT-1 significantly differed between groups (n=4 per each group, p<0.05). No specific findings were observed in the contralateral hemisphere in the asymmetric brains. Data are expressed as the mean±standard error of the mean. GLT, glutamate transporter; MCT, monocarboxylate transporter; UCCAO, unilateral common carotid artery occlusion. *p<0.05;
