Differences in variables in affected and unaffected individuals
| Biomarkers | Group | Paired t-test | ||||
|---|---|---|---|---|---|---|
| Mean | SD | t | df | p value | ||
| Lactate | Affected group | 19.79 | 11.29 | -3.71 | 73.2 | 0.0003 |
| Unaffected group | 13.84 | 6.12 | ||||
| Pyruvate | Affected group | 1.10 | 0.45 | -1.45 | 193 | 0.1495 |
| Unaffected group | 1.01 | 0.37 | ||||
| Lactate-to-pyruvate ratio | Affected group | 21.47 | 18.43 | -2.55 | 71.35 | 0.0131 |
| Unaffected group | 15.03 | 9.37 | ||||
| mtDNA CNV | Affected group | 163.66 | 42.46 | 1.46 | 193 | 0.1466 |
| Unaffected group | 179.34 | 77.66 | ||||
| PGC-1α | Affected group | 0.17 | 0.17 | -0.55 | 178 | 0.5867 |
| Unaffected group | 0.16 | 0.09 | ||||
*p<0.05, **p<0.01.
mtDNA CNV, mitochondrial DNA copy number variation; PGC-1α, peroxisome proliferator-activated receptor gamma coactivator 1-alpha methylation ratio.