Fig. 1. Validation of MAOB-KO and GFAP-MAOB transgenic mice. (A) Schematic diagram of MAOB-KO and GFAP-MAOB transgenic mice. (B) Schematic diagram of MAOB enzyme activity assay. (C) Quantification of MAOB enzyme activity in MAOB-KO mice and WT littermates. Pargyline is used as a selective MAOB inhibitor (N=4, 2, 4, and 2 mice for each group). (D) Quantification of MAOB enzyme activity in doxycycline-treated or non-treated GFAP-MAOB mice (N=4 mice for each group).
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