Significant change in white matter tracts between MDD patients and HC also controlling for depression severity
| Tract of interest | MDD (n = 101) | HC (n = 99) | MDD vs. HC | |||||
|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | F | p-value | |||
| AD | ||||||||
| Left SLFP | 1.14×10-3 | 6.71×10-5 | 1.12×10-3 | 5.48×10-5 | 15.574 | 1.11×10-4 | ||
| Left SLFT | 1.18×10-3 | 6.07×10-5 | 1.17×10-3 | 5.09×10-5 | 15.155 | 1.36×10-4 | ||
| Left UNC | 1.20×10-3 | 5.70×10-5 | 1.12×10-3 | 5.44×10-5 | 12.127 | 6.14×10-4 | ||
| Right SLFP | 1.11×10-3 | 7.11×10-5 | 1.10×10-3 | 6.59×10-5 | 12.536 | 5.00×10-4 | ||
| RD | ||||||||
| Left CST | 4.91×10-4 | 4.69×10-5 | 4.83×10-4 | 4.30×10-5 | 15.258 | 1.29×10-4 | ||
| Left ILF | 5.77×10-4 | 4.06×10-5 | 5.64×10-4 | 3.56×10-5 | 13.971 | 2.44×10-4 | ||
| Left SLFP | 5.75×10-4 | 4.12×10-5 | 5.67×10-4 | 3.73×10-5 | 14.059 | 2.34×10-4 | ||
| Left SLFT | 5.60×10-4 | 4.02×10-5 | 5.50×10-4 | 3.63×10-5 | 16.130 | 8.45×10-5 | ||
| Left UNC | 5.99×10-4 | 4.72×10-5 | 5.91×10-4 | 3.75×10-5 | 12.661 | 4.69×10-4 | ||
| Right CAB | 5.91×10-4 | 8.10×10-5 | 5.74×10-4 | 7.82×10-5 | 12.458 | 5.20×10-4 | ||
| Right SLFP | 5.49×10-4 | 5.12×10-5 | 5.38×10-4 | 4.68×10-5 | 13.126 | 3.72×10-4 | ||
| Right SLFT | 5.43×10-4 | 4.50×10-5 | 5.34×10-4 | 4.01×10-5 | 12.310 | 5.60×10-4 | ||
| MD | ||||||||
| Left CST | 7.34×10-4 | 5.08×10-5 | 7.30×10-4 | 4.42×10-5 | 15.815 | 9.85×10-5 | ||
| Left ILF | 8.04×10-4 | 4.56×10-5 | 7.95×10-4 | 3.97×10-5 | 12.588 | 4.87×10-4 | ||
| Left SLFP | 7.62×10-4 | 4.69×10-5 | 7.51×10-4 | 3.99×10-5 | 16.613 | 6.68×10-5 | ||
| Left SLFT | 7.65×10-4 | 4.51×10-5 | 7.56×10-4 | 3.75×10-5 | 17.775 | 3.81×10-5 | ||
| Left UNC | 7.99×10-4 | 4.63×10-5 | 7.88×10-4 | 3.76×10-5 | 15.503 | 1.15×10-4 | ||
| Right ATR | 7.44×10-4 | 4.29×10-5 | 7.35×10-4 | 3.87×10-5 | 12.526 | 5.02×10-4 | ||
| Right SLFP | 7.37×10-4 | 5.53×10-5 | 7.24×10-4 | 5.08×10-5 | 14.032 | 2.37×10-4 | ||
| Right SLFT | 7.42×10-4 | 5.30×10-5 | 7.33×10-4 | 4.75×10-5 | 11.967 | 6.66×10-4 | ||
The F and p values were obtained using one-way analysis of covariance (ANCOVA) with the adjustment for age, sex, depression severity and education level as covariates.
MDD, patients with major depressive disorder; HC, healthy control participants; SD, standard deviation; ATR, anterior thalamic radiations; CAB, cingulum - angular bundle; CST, corticospinal tract; ILF, inferior longitudinal fasciculus; SLFP, superior longitudinal fasciculus - parietal endings; SLFT, superior longitudinal fasciculus - temporal endings; UNC, uncinate fasciculus
Bonferroni correction was applied: p<0.05/72=0.00069