Fig. 4. CUS-induced anhedonic behaviors were alleviated by Htr1a knockdown in the mPFC. (A) Experimental schedule. (B) Representative images of AAV injection site in the mPFC. Scale bar=1,000 μm (C) Efficiency of Htr1a knockdown (KD) by AAV expression in the mPFC. Mann-Whitney U test; Scramble (n=6), Htr1a KD (n=6). (D) Sucrose preference after CUS±Htr1a KD. Tukey’s test; No CUS+AAV-scramble (n=8), CUS+AAV-scramble (n=8), CUS+AAV-shHtr1a (n=8). (E) Body weight after CUS±Htr1a KD. Tukey’s test; No CUS+AAV-scramble (n=8), CUS+AAV-scramble (n=8), CUS+AAV-shHtr1a (n=8). *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001, ns (not significant).
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