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Exp Neurobiol 2016; 25(1): 24-32
Published online February 29, 2016
https://doi.org/10.5607/en.2016.25.1.24
© The Korean Society for Brain and Neural Sciences
Juhyun Song1, Byeori Lee1, Somang Kang1,2, Yumi Oh1,2, Eosu Kim3, Chul-Hoon Kim4, Ho-Taek Song5 and Jong Eun Lee1,2*
1Department of Anatomy, Yonsei University College of Medicine, 2BK21 Plus Project for Medical Sciences, and Brain Research Institute, Yonsei University College of Medicine, 3Department of Psychiatry, Yonsei University College of Medicine, 4Department of Pharmacology, Yonsei University College of Medicine, 5Department of Diagnostic Radiology, Yonsei University College of Medicine, Seoul 03722, Korea
Correspondence to: *To whom correspondence should be addressed.
TEL: 82-2-2228-1646, 1659, FAX: 82-2-365-0700
e-mail: jelee@yuhs.ac
Neuronal senescence caused by diabetic neuropathy is considered a common complication of diabetes mellitus. Neuronal senescence leads to the secretion of pro-inflammatory cytokines, the production of reactive oxygen species, and the alteration of cellular homeostasis. Agmatine, which is biosynthesized by arginine decarboxylation, has been reported in previous
Keywords: Agmatine, High glucose, Hyperglycemia, Cell death, Senescence, Pro-inflammatory cytokines, p53, p21