Highlights
  • Review Article | December 31, 2019

    Causative factors in aging, such as oxidative stress, DNA damage, telomere shortening, and SASP, are closely related to autophagy and modulation of autophagy may be a potential clinical intervention for age-related diseases.

    Show more full text
    Causative factors in aging, such as oxidative stress, DNA damage, telomere shortening, and SASP, are closely related to autophagy and modulation of autophagy may be a potential clinical intervention for age-related diseases.
    So Yeong Cheon, Hyunjeong Kim, David C. Rubinsztein and Jong Eun Lee
  • Original Article | December 31, 2019

    The EF-hand like region in ANO1 which is highly homologous to the EF hand in calmodulin coordinates with Ca2+ and modulate the activation by Ca2+ and voltage.

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    The EF-hand like region in ANO1 which is highly homologous to the EF hand in calmodulin coordinates with Ca2+ and modulate the activation by Ca2+ and voltage.
    Min Ho Tak, Yongwoo Jang, Woo Sung Son et al.
  • Original Article | December 31, 2019

    GDNF-hNSPCs implanted into the injured spinal cord induce extensive neuroprotection, neurite outgrowth and axonal extension, myelination, and functional recovery post-SCI.

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    GDNF-hNSPCs implanted into the injured spinal cord induce extensive neuroprotection, neurite outgrowth and axonal extension, myelination, and functional recovery post-SCI.
    Kyujin Hwang, Kwangsoo Jung, Il-Sun Kim et al.
  • Original Article | December 31, 2019

    We developed a 3-dimensional volumetric protocol for determining volume-based changes and performing RNAscope analysis for RNA profiling of known regional markers such as Tac1, ChAT, and Tacr1 in habenula (Hb) in lipopolysaccharide (LPS)-mediated depressed mice. In these mice, a significant reduction in Hb volume was detected in medial Hb, but not in lateral Hb. Similar reductions were also observed in mRNA expression of Tac1, ChAT, and Tacr1. As the dimensions of such a small brain structure can recognized and measured with this protocol, this method can also be used for a wide variety of applications requiring precise volume measurements.

    Show more full text
    We developed a 3-dimensional volumetric protocol for determining volume-based changes and performing RNAscope analysis for RNA profiling of known regional markers such as Tac1, ChAT, and Tacr1 in habenula (Hb) in lipopolysaccharide (LPS)-mediated depressed mice. In these mice, a significant reduction in Hb volume was detected in medial Hb, but not in lateral Hb. Similar reductions were also observed in mRNA expression of Tac1, ChAT, and Tacr1. As the dimensions of such a small brain structure can recognized and measured with this protocol, this method can also be used for a wide variety of applications requiring precise volume measurements.
    Esther Yang, Jin Yong Kim, Soo Hyun Yang et al.
Vol.28 No.6 | December 31, 2019
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2017 Impact Factor 3.810. 2018 Impact Factor 2.360 en Experimental Neurobiology in SCIe As of August 2017 Covered from 2015

Highly Cited Papers

  • Review Article | July 1, 2015
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  • Original Article | August 31, 2018

    We explored the potential roles of purinergic receptor 7 (P2X7R)/extracellular signal-regulated kinase (ERK) signaling in the anti-nociceptive effect of dexmedetomidine in a rat model of neuropathic pain. We found that intrathecal administration of dexmedetomidine not only attenuated neuropathic pain but also inhibited chronic constriction injury-induced P2X7R upregulation and ERK phosphorylation, indicating the potential therapeutic implications of dexmedetomidine administration for the treatment of neuropathic pain.

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    We explored the potential roles of purinergic receptor 7 (P2X7R)/extracellular signal-regulated kinase (ERK) signaling in the anti-nociceptive effect of dexmedetomidine in a rat model of neuropathic pain. We found that intrathecal administration of dexmedetomidine not only attenuated neuropathic pain but also inhibited chronic constriction injury-induced P2X7R upregulation and ERK phosphorylation, indicating the potential therapeutic implications of dexmedetomidine administration for the treatment of neuropathic pain.
    Jia-Piao Lin, Chao-Qin Chen, Ling-Er Huang et al.
  • Review Article | December 31, 2018

    In this report, we review the application of current multi-channel neural probes (i.e., the tetrode, Utah array, and Michigan probe) to brain–machine interface (BMI) systems, as well as developments regarding next-generation neural probes. Furthermore, we discuss recent advancements in neural probe research, as well as the properties required for real-world applications of these probes to BMI systems.

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    In this report, we review the application of current multi-channel neural probes (i.e., the tetrode, Utah array, and Michigan probe) to brain–machine interface (BMI) systems, as well as developments regarding next-generation neural probes. Furthermore, we discuss recent advancements in neural probe research, as well as the properties required for real-world applications of these probes to BMI systems.
    Jong-ryul Choi, Seong-Min Kim, Rae-Hyung Ryu et al.

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olume 28, Number 6, December 2019

Review Article

643 Autophagy, Cellular Aging and Age-related Human Diseases

So Yeong Cheon, Hyunjeong Kim, David C. Rubinsztein and Jong Eun Lee

Causative factors in aging, such as oxidative stress, DNA damage, telomere shortening, and SASP, are closely related to autophagy and modulation of autophagy may be a potential clinical intervention for age-related diseases.

Original Articles

658 EF-hand like Region in the N-terminus of Anoctamin 1 Modulates Channel Activity by Ca2+ and Voltage

Min Ho Tak, Yongwoo Jang, Woo Sung Son, Young Duk Yang and Uhtaek Oh

The EF-hand like region in ANO1 which is highly homologous to the EF hand in calmodulin coordinates with Ca2+ and modulate the activation by Ca2+ and voltage.

670 The Molecular Signatures of Acute-immobilization-induced Antinociception and Chronic-immobilization-induced Antinociceptive Tolerance

Jing-Hui Feng, Hee-Jung Lee and Hong-Won Suh

The acute restraint stress-induced antinociception was attenuated by chronic restraint stress. The molecules, COX-2, JNK, AMPKα1, mTOR, and p-P38, were involved in this tolerance.

679 Glial Cell Line-derived Neurotrophic Factor-overexpressing Human Neural Stem/Progenitor Cells Enhance Therapeutic Efficiency in Rat with Traumatic Spinal Cord Injury

Kyujin Hwang, Kwangsoo Jung, Il-Sun Kim, Miri Kim, Jungho Han, Joohee Lim, Jeong Eun Shin, Jae-Hyung Jang and Kook In Park

GDNF-hNSPCs implanted into the injured spinal cord induce extensive neuroprotection, neurite outgrowth and axonal extension, myelination, and functional recovery post-SCI.

697 Darine Froy N. Mabunga, Donghyun Park, Onjeon Ryu, Schley T. Valencia, Keremkleroo Jym L. Adil, Seonmin Kim, Kyoung Ja Kwon, Chan Young Shin and Se Jin Jeon

Junsung Woo, Hyejin Yang, Minseok Yoon, Changdev G. Gadhe, Ae Nim Pae, Suengmok Cho and C. Justin Lee

MK-801 in CD-1 mice can effectively model various symptoms of different neuropsychiatric disorders in a dose-dependent manner. The observed sensitivity against spatial-memory impairment and impulsive behaviors at a low concentration of MK-801 compared to other behaviors such as locomotive activity and social interaction suggest that MK-801 may modulate cognitive function and impulsivity in even lower concentration before it can modulate other behavioral domains.

709 Esther Yang, Jin Yong Kim, Soo Hyun Yang, Eunsoo Lee, Woong Sun, Hyun Woo Lee and Hyun Kim

So Hyeon Park, Yoo Sung Song, Byung Seok Moon, Byung Chul Lee, Hyun Soo Park and Sang Eun Kim

We developed a 3-dimensional volumetric protocol for determining volume-based changes and performing RNAscope analysis for RNA profiling of known regional markers such as Tac1, ChAT, and Tacr1 in habenula (Hb) in lipopolysaccharide (LPS)-mediated depressed mice. In these mice, a significant reduction in Hb volume was detected in medial Hb, but not in lateral Hb. Similar reductions were also observed in mRNA expression of Tac1, ChAT, and Tacr1. As the dimensions of such a small brain structure can recognized and measured with this protocol, this method can also be used for a wide variety of applications requiring precise volume measurements.

720 B Cell Immunophenotyping and Transcriptional Profiles of Memory B Cells in Patients with Myasthenia Gravis

Young Gi Min, Canaria Park, Young-Nam Kwon, Je-Young Shin, Jung-Joon Sung and Yoon-Ho Hong

Peripheral blood B-cell immunophenotyping and transcript profiling of memory B cells may provide potential immunological biomarkers of disease activity in myasthenia gravis.