Highlights
  • Review Article | October 31, 2020

    Technical developments in proteomic and metabolomic analysis revealed urine as a promising source of neurodegenerative disease biomarker. This review provides a reader comprehensive summary of the field.

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    Technical developments in proteomic and metabolomic analysis revealed urine as a promising source of neurodegenerative disease biomarker. This review provides a reader comprehensive summary of the field.
    Wongi Seol, Hyejung Kim and Ilhong Son
  • Short Communication | October 31, 2020

    The present study demonstrates that deficiency of Arhgef4, a brain-enriched rho guanine nucleotide exchange factor 4, does not alter general motor activity and anxiety-like behavior, but significantly improves long-term spatial and recognition memories, indicating its role as a negative regulator of synaptic PSD-95.

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    The present study demonstrates that deficiency of Arhgef4, a brain-enriched rho guanine nucleotide exchange factor 4, does not alter general motor activity and anxiety-like behavior, but significantly improves long-term spatial and recognition memories, indicating its role as a negative regulator of synaptic PSD-95.
    Ki-Seo Yoo, Kina Lee, Yong-Seok Lee et al.
  • Original Article | October 31, 2020

    Hand dexterity task (HDT) latency significantly increased in MPTP induced monkey models. A significant inverse correlation between HDT and dopamine transporters was identified.

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    Hand dexterity task (HDT) latency significantly increased in MPTP induced monkey models. A significant inverse correlation between HDT and dopamine transporters was identified.
    Jincheol Seo, Jinyoung Won, Keonwoo Kim et al.
  • Original Article | October 31, 2020

    This study revealed the fragrance–EEG index–menopausal symptom severity links. We found that fragrances increased alpha power and decreased β/α ratio depending on the severity of menopausal symptoms in a stressful situation.

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    This study revealed the fragrance–EEG index–menopausal symptom severity links. We found that fragrances increased alpha power and decreased β/α ratio depending on the severity of menopausal symptoms in a stressful situation.
    Sun Ae Moon, Jisub Bae, Kwangsu Kim et al.
Vol.29 No.5 | October 31, 2020

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EEG revealed that fragrances positively affect menopausal symptoms in mid-life women

During mid-life, women experienced not only physical but also neurological transition. Because of this, many women suffer from physiological and/or psychological menopausal symptoms. Although hormone therapy (HT) was broadly used to alleviate menopausal symptoms, HT showed inconsistent effects in case of psychological symptoms. Moreover, mid-life women’s brains have distinct characteristics than in other periods of life, it is needed to study psychological symptoms in shifted brain network of mid-life women. As an alternative, inhalation of fragrances may alleviate psychological menopausal symptoms. To characterize the alleviation mechanism by fragrances, we tested the effect of fragrances on menopausal symptoms using electroencephalographic (EEG) methods. We hypothesized that fragrance could restore mid-life women’s brain response to stressful situations. We tested six fragrance conditions, including no-odor condition (solvent only) in twenty-eight mid-life women (49.75 years±3.49). Our results showed that fragrances increased alpha power and decreased β/α ratio depending on the severity of menopausal symptoms in a stressful situation. Our study would be helpful in psychological menopausal symptom alleviation as well as fragrance screening for well-being in mid-life.