Highlights
  • Original Article | August 31, 2020

    In the majority of PD patients, chronic use of L-DOPA causes uncontrollable, involuntary movements known as L-DOPA-induced dyskinesia (LID). In this study, we successfully developed a LID animal model by using a well established α-Syn (A53T) Drosophila larva in order to further examine dyskinetic behaviors. Our LID model developed in a Drosophila genetic model of PD can be a useful experimental platform to study pathophysiological mechanisms underlying LID and also provide a new avenue for developing potential treatments of LID.

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    In the majority of PD patients, chronic use of L-DOPA causes uncontrollable, involuntary movements known as L-DOPA-induced dyskinesia (LID). In this study, we successfully developed a LID animal model by using a well established α-Syn (A53T) Drosophila larva in order to further examine dyskinetic behaviors. Our LID model developed in a Drosophila genetic model of PD can be a useful experimental platform to study pathophysiological mechanisms underlying LID and also provide a new avenue for developing potential treatments of LID.
    Joshua A. Blosser, Eric Podolsky and Daewoo Lee
  • Original Article | August 31, 2020

    Monkey RGCs show strongly synchronized bursting compared with mouse RGCs, implying different coding schemes for retinal processing between non-primate and primate retina.

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    Monkey RGCs show strongly synchronized bursting compared with mouse RGCs, implying different coding schemes for retinal processing between non-primate and primate retina.
    Jungryul Ahn, Huu Lam Phan, Seongkwang Cha et al.
  • Original Article | August 31, 2020

    The present study demonstrates the use of a behavioral assessment tool to provide an objective evaluation of fine motor function based on hand dexterity in NHP stroke model.

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    The present study demonstrates the use of a behavioral assessment tool to provide an objective evaluation of fine motor function based on hand dexterity in NHP stroke model.
    Jinyoung Won, Kyung Sik Yi, Chi-Hoon Choi et al.
  • Original Article | August 31, 2020

    Research has been ongoing for years to identify biochemical markers related to mitochondrial dysfunction linked to autism spectrum disorder (ASD). This study attempted to identify biomarkers related to mitochondrial dysfunction in ASD patients and their unaffected family members, finding a significantly higher level of lactate, lactate-to-pyruvate ratio, and high frequency of abnormally high range of lactate, pyruvate, and lactate-to-pyruvate.

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    Research has been ongoing for years to identify biochemical markers related to mitochondrial dysfunction linked to autism spectrum disorder (ASD). This study attempted to identify biomarkers related to mitochondrial dysfunction in ASD patients and their unaffected family members, finding a significantly higher level of lactate, lactate-to-pyruvate ratio, and high frequency of abnormally high range of lactate, pyruvate, and lactate-to-pyruvate.
    Miae Oh, Soon Ae Kim and Hee Jeong Yoo
Vol.29 No.4 | August 31, 2020

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Distinctive retinal processing through bursting activity across species

This scheme presents the bursting activities of retinal ganglion cells (RGCs) and burst synchrony between RGCs across species. Monkey RGCs showed a larger number of spikes in a burst, while the inter-spike interval, burst duration, and inter-burst interval were smaller compared with mouse RGCs. Monkey RGCs showed a strong burst synchronization between RGCs, whereas mouse RGCs showed no correlated burst firing. This study emphasizes that two species have a different bursting activity of RGCs and different burst synchronization suggesting two species have distinctive retinal processing.