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Review Article | December 31, 2019
Causative factors in aging, such as oxidative stress, DNA damage, telomere shortening, and SASP, are closely related to autophagy and modulation of autophagy may be a potential clinical intervention for age-related diseases.
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Causative factors in aging, such as oxidative stress, DNA damage, telomere shortening, and SASP, are closely related to autophagy and modulation of autophagy may be a potential clinical intervention for age-related diseases.So Yeong Cheon, Hyunjeong Kim, David C. Rubinsztein and Jong Eun Lee -
Original Article | December 31, 2019
The EF-hand like region in ANO1 which is highly homologous to the EF hand in calmodulin coordinates with Ca2+ and modulate the activation by Ca2+ and voltage.
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The EF-hand like region in ANO1 which is highly homologous to the EF hand in calmodulin coordinates with Ca2+ and modulate the activation by Ca2+ and voltage.Min Ho Tak, Yongwoo Jang, Woo Sung Son et al. -
Original Article | December 31, 2019
GDNF-hNSPCs implanted into the injured spinal cord induce extensive neuroprotection, neurite outgrowth and axonal extension, myelination, and functional recovery post-SCI.
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GDNF-hNSPCs implanted into the injured spinal cord induce extensive neuroprotection, neurite outgrowth and axonal extension, myelination, and functional recovery post-SCI.Kyujin Hwang, Kwangsoo Jung, Il-Sun Kim et al. -
Original Article | December 31, 2019
We developed a 3-dimensional volumetric protocol for determining volume-based changes and performing RNAscope analysis for RNA profiling of known regional markers such as Tac1, ChAT, and Tacr1 in habenula (Hb) in lipopolysaccharide (LPS)-mediated depressed mice. In these mice, a significant reduction in Hb volume was detected in medial Hb, but not in lateral Hb. Similar reductions were also observed in mRNA expression of Tac1, ChAT, and Tacr1. As the dimensions of such a small brain structure can recognized and measured with this protocol, this method can also be used for a wide variety of applications requiring precise volume measurements.
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We developed a 3-dimensional volumetric protocol for determining volume-based changes and performing RNAscope analysis for RNA profiling of known regional markers such as Tac1, ChAT, and Tacr1 in habenula (Hb) in lipopolysaccharide (LPS)-mediated depressed mice. In these mice, a significant reduction in Hb volume was detected in medial Hb, but not in lateral Hb. Similar reductions were also observed in mRNA expression of Tac1, ChAT, and Tacr1. As the dimensions of such a small brain structure can recognized and measured with this protocol, this method can also be used for a wide variety of applications requiring precise volume measurements.Esther Yang, Jin Yong Kim, Soo Hyun Yang et al.
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Highly Cited Papers
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Review Article | July 1, 2015Joo Hong Woo, Jee Hoon Lee, Hyunmi Kim et al.
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Original Article | August 31, 2018
We explored the potential roles of purinergic receptor 7 (P2X7R)/extracellular signal-regulated kinase (ERK) signaling in the anti-nociceptive effect of dexmedetomidine in a rat model of neuropathic pain. We found that intrathecal administration of dexmedetomidine not only attenuated neuropathic pain but also inhibited chronic constriction injury-induced P2X7R upregulation and ERK phosphorylation, indicating the potential therapeutic implications of dexmedetomidine administration for the treatment of neuropathic pain.
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We explored the potential roles of purinergic receptor 7 (P2X7R)/extracellular signal-regulated kinase (ERK) signaling in the anti-nociceptive effect of dexmedetomidine in a rat model of neuropathic pain. We found that intrathecal administration of dexmedetomidine not only attenuated neuropathic pain but also inhibited chronic constriction injury-induced P2X7R upregulation and ERK phosphorylation, indicating the potential therapeutic implications of dexmedetomidine administration for the treatment of neuropathic pain.Jia-Piao Lin, Chao-Qin Chen, Ling-Er Huang et al. -
Review Article | December 31, 2018
In this report, we review the application of current multi-channel neural probes (i.e., the tetrode, Utah array, and Michigan probe) to brain–machine interface (BMI) systems, as well as developments regarding next-generation neural probes. Furthermore, we discuss recent advancements in neural probe research, as well as the properties required for real-world applications of these probes to BMI systems.
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In this report, we review the application of current multi-channel neural probes (i.e., the tetrode, Utah array, and Michigan probe) to brain–machine interface (BMI) systems, as well as developments regarding next-generation neural probes. Furthermore, we discuss recent advancements in neural probe research, as well as the properties required for real-world applications of these probes to BMI systems.Jong-ryul Choi, Seong-Min Kim, Rae-Hyung Ryu et al.
News
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This event combined introductory presentations by the editors from major scientific journals and an open panel discussion. The aim was to have an open exchan...…
Show more2019-12-02 -
Here are the winners of the 2019 EN Best Article Award held in Daegu, EXCO on September 23rd during IBRO 2019.Congratulations to Prof. Jong Eun Lee for winni...…
Show more2019-12-02 -
아주대학교 의과대학 조은혜 교수가 2019년 한국과학기술단체총연합회(KOFST, 이하 과총) ‘제29회 과학기술우수논문상&...…
Show more2019-09-20
