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Original Article | August 31, 2020
In the majority of PD patients, chronic use of L-DOPA causes uncontrollable, involuntary movements known as L-DOPA-induced dyskinesia (LID). In this study, we successfully developed a LID animal model by using a well established α-Syn (A53T) Drosophila larva in order to further examine dyskinetic behaviors. Our LID model developed in a Drosophila genetic model of PD can be a useful experimental platform to study pathophysiological mechanisms underlying LID and also provide a new avenue for developing potential treatments of LID.
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In the majority of PD patients, chronic use of L-DOPA causes uncontrollable, involuntary movements known as L-DOPA-induced dyskinesia (LID). In this study, we successfully developed a LID animal model by using a well established α-Syn (A53T) Drosophila larva in order to further examine dyskinetic behaviors. Our LID model developed in a Drosophila genetic model of PD can be a useful experimental platform to study pathophysiological mechanisms underlying LID and also provide a new avenue for developing potential treatments of LID.Joshua A. Blosser, Eric Podolsky and Daewoo Lee -
Original Article | August 31, 2020
Monkey RGCs show strongly synchronized bursting compared with mouse RGCs, implying different coding schemes for retinal processing between non-primate and primate retina.
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Monkey RGCs show strongly synchronized bursting compared with mouse RGCs, implying different coding schemes for retinal processing between non-primate and primate retina.Jungryul Ahn, Huu Lam Phan, Seongkwang Cha et al. -
Original Article | August 31, 2020
The present study demonstrates the use of a behavioral assessment tool to provide an objective evaluation of fine motor function based on hand dexterity in NHP stroke model.
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The present study demonstrates the use of a behavioral assessment tool to provide an objective evaluation of fine motor function based on hand dexterity in NHP stroke model.Jinyoung Won, Kyung Sik Yi, Chi-Hoon Choi et al. -
Original Article | August 31, 2020
Research has been ongoing for years to identify biochemical markers related to mitochondrial dysfunction linked to autism spectrum disorder (ASD). This study attempted to identify biomarkers related to mitochondrial dysfunction in ASD patients and their unaffected family members, finding a significantly higher level of lactate, lactate-to-pyruvate ratio, and high frequency of abnormally high range of lactate, pyruvate, and lactate-to-pyruvate.
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Research has been ongoing for years to identify biochemical markers related to mitochondrial dysfunction linked to autism spectrum disorder (ASD). This study attempted to identify biomarkers related to mitochondrial dysfunction in ASD patients and their unaffected family members, finding a significantly higher level of lactate, lactate-to-pyruvate ratio, and high frequency of abnormally high range of lactate, pyruvate, and lactate-to-pyruvate.Miae Oh, Soon Ae Kim and Hee Jeong Yoo
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기초과학연구원 인지및사회성연구단 이창준 단장과 동(同)소속 한영은 박사가 2020년 한국과학기술단체총연합회(KOFST, 이...…
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Korean researchers have developed new technology that can detect COVID-19 virus infections within 4 hours at a laboratory. The team led by Lee Chang-joon,...…
Show more2020-03-12 -
This event combined introductory presentations by the editors from major scientific journals and an open panel discussion. The aim was to have an open exchan...…
Show more2019-12-02
