en Experimental Neurobiology

Cited by CrossRef (100)

  1. Zhihao Qi, Zhen Huang, Feng Xie, Linxi Chen. Dynamin‐related protein 1: A critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases. Journal Cellular Physiology 2019;234:10032
    https://doi.org/10.1002/jcp.27866
  2. So Hee Ko, Gee Euhn Choi, Ji Young Oh, Hyun Jik Lee, Jun Sung Kim, Chang Woo Chae, Diana Choi, Ho Jae Han. Succinate promotes stem cell migration through the GPR91-dependent regulation of DRP1-mediated mitochondrial fission. Sci Rep 2017;7
    https://doi.org/10.1038/s41598-017-12692-x
  3. Yang Sui, Huy Bang Nguyen, Truc Quynh Thai, Kazuhiro Ikenaka, Nobuhiko Ohno. Myelin. 2017.
    https://doi.org/10.1007/978-981-32-9636-7_10
  4. Bereketeab Haileselassie, Riddhita Mukherjee, Amit U. Joshi, Brooke A. Napier, Liliana M. Massis, Nicolai Patrick Ostberg, Bruno B. Queliconi, Denise Monack, Daniel Bernstein, Daria Mochly-Rosen. Drp1/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy. Journal of Molecular and Cellular Cardiology 2019;130:160
    https://doi.org/10.1016/j.yjmcc.2019.04.006
  5. Miao Yu, Jinghua Yang, Xiang Gao, Wenchang Sun, Shiyu Liu, Yarao Han, Xiaobo Lu, Cuihong Jin, Shengwen Wu, Yuan Cai. Lanthanum chloride impairs spatial learning and memory by inducing [Ca2+]m overload, mitochondrial fission–fusion disorder and excessive mitophagy in hippocampal nerve cells of rats. 2020;12:592
    https://doi.org/10.1039/c9mt00291j
  6. Seung Hyun Baek, So Jung Park, Jae In Jeong, Sung Hyun Kim, Jihoon Han, Jae Won Kyung, Sang-Ha Baik, Yuri Choi, Bo Youn Choi, Jin Su Park, Gahee Bahn, Ji Hyun Shin, Doo Sin Jo, Joo-Yong Lee, Choon-Gon Jang, Thiruma V. Arumugam, Jongpil Kim, Jeung-Whan Han, Jae-Young Koh, Dong-Hyung Cho, Dong-Gyu Jo. Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model. J. Neurosci. 2017;37:5099
    https://doi.org/10.1523/JNEUROSCI.2385-16.2017
  7. Chun-Qiu Dai, Yu Guo, Xue-Yan Chu. Neuropathic Pain: the Dysfunction of Drp1, Mitochondria, and ROS Homeostasis. Neurotox Res 2020;38:553
    https://doi.org/10.1007/s12640-020-00257-2
  8. Hui-Ching Tseng, Chih-Chung Lin, Li-Der Hsiao, Chuen-Mao Yang. Lysophosphatidylcholine-induced mitochondrial fission contributes to collagen production in human cardiac fibroblasts. Journal of Lipid Research 2019;60:1573
    https://doi.org/10.1194/jlr.RA119000141
  9. Nanshan Song, Hong Zhu, Rong Xu, Jiaqi Liu, Yinquan Fang, Jing Zhang, Jianhua Ding, Gang Hu, Ming Lu. Induced Expression of kir6.2 in A1 Astrocytes Propagates Inflammatory Neurodegeneration via Drp1-dependent Mitochondrial Fission. Front. Pharmacol. 2021;11
    https://doi.org/10.3389/fphar.2020.618992
  10. Joseph Johnson, Elizabeth Mercado-Ayon, Yesica Mercado-Ayon, Yi Na Dong, Sarah Halawani, Lucie Ngaba, David R. Lynch. Mitochondrial dysfunction in the development and progression of neurodegenerative diseases. Archives of Biochemistry and Biophysics 2021;702:108698
    https://doi.org/10.1016/j.abb.2020.108698
  11. Márcio Ribeiro, Tatiana R. Rosenstock, Ana M. Oliveira, Catarina R. Oliveira, A. Cristina Rego. Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington’s disease knock-in striatal cells. Free Radical Biology and Medicine 2014;74:129
    https://doi.org/10.1016/j.freeradbiomed.2014.06.023
  12. Dmitry B. Zorov, Ivan A. Vorobjev, Vasily A. Popkov, Valentina A. Babenko, Ljubava D. Zorova, Irina B. Pevzner, Denis N. Silachev, Savva D. Zorov, Nadezda V. Andrianova, Egor Y. Plotnikov. Lessons from the Discovery of Mitochondrial Fragmentation (Fission): A Review and Update. Cells 2019;8:175
    https://doi.org/10.3390/cells8020175
  13. Milena Jankovic, Ivana Novakovic, Phepy Gamil Anwar Dawod, Ayman Gamil Anwar Dawod, Aleksandra Drinic, Fayda I. Abdel Motaleb, Sinisa Ducic, Dejan Nikolic. Current Concepts on Genetic Aspects of Mitochondrial Dysfunction in Amyotrophic Lateral Sclerosis. IJMS 2021;22:9832
    https://doi.org/10.3390/ijms22189832
  14. S Saez-Atienzar, L Bonet-Ponce, J R Blesa, F J Romero, M P Murphy, J Jordan, M F Galindo. The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling. Cell Death Dis 2014;5:e1368
    https://doi.org/10.1038/cddis.2014.320
  15. Surinder Singh, Saurabh Sharma. Dynamin-related protein-1 as potential therapeutic target in various diseases. Inflammopharmacol 2017;25:383
    https://doi.org/10.1007/s10787-017-0347-y
  16. Dong Gil Lee, Kyung-Min Kim, Hyun-Shik Lee, Yong Chul Bae, Jae-Won Huh, Sang-Rae Lee, Dong-Seok Lee. Peroxiredoxin 5 prevents diethylhexyl phthalate-induced neuronal cell death by inhibiting mitochondrial fission in mouse hippocampal HT-22 cells. NeuroToxicology 2019;74:242
    https://doi.org/10.1016/j.neuro.2019.08.003
  17. Odile Robicsek, Hila M Ene, Rachel Karry, Ofer Ytzhaki, Eyal Asor, Donna McPhie, Bruce M Cohen, Rotem Ben-Yehuda, Ina Weiner, Dorit Ben-Shachar. Isolated Mitochondria Transfer Improves Neuronal Differentiation of Schizophrenia-Derived Induced Pluripotent Stem Cells and Rescues Deficits in a Rat Model of the Disorder. 2018;44:432
    https://doi.org/10.1093/schbul/sbx077
  18. Karthik Suresh, Laura Servinsky, Haiyang Jiang, Zahna Bigham, Joel Zaldumbide, John C. Huetsch, Corrine Kliment, Michelle G. Acoba, Brian J. Kirsch, Steven M. Claypool, Anne Le, Mahendra Damarla, Larissa A. Shimoda. Regulation of mitochondrial fragmentation in microvascular endothelial cells isolated from the SU5416/hypoxia model of pulmonary arterial hypertension. American Journal of Physiology-Lung Cellular and Molecular Physiology 2019;317:L639
    https://doi.org/10.1152/ajplung.00396.2018
  19. Hyun Jung Kim, Mohammed R. Shaker, Bongki Cho, Hyo Min Cho, Hyun Kim, Joo Yeon Kim, Woong Sun. Dynamin-related protein 1 controls the migration and neuronal differentiation of subventricular zone-derived neural progenitor cells. Sci Rep 2015;5
    https://doi.org/10.1038/srep15962
  20. Wenjia Shi, Cheng Tan, Can Liu, Dan Chen. Mitochondrial fission mediated by Drp1-Fis1 pathway and neurodegenerative diseases. 2023;34:275
    https://doi.org/10.1515/revneuro-2022-0056
  21. Sang-Bin Lee, Hyun Ok Yang. Sinapic Acid Ameliorates REV-ERB α Modulated Mitochondrial Fission against MPTP-Induced Parkinson's Disease Model. Biomol Ther (Seoul) 2022;30:409
    https://doi.org/10.4062/biomolther.2022.020
  22. Mi Hye Kim, Ju-Sik Min, Joon Yeop Lee, Unbin Chae, Eun-Ju Yang, Kyung-Sik Song, Hyun-Shik Lee, Hong Jun Lee, Sang-Rae Lee, Dong-Seok Lee. Oleuropein isolated from Fraxinus rhynchophylla inhibits glutamate-induced neuronal cell death by attenuating mitochondrial dysfunction. Nutritional Neuroscience 2018;21:520
    https://doi.org/10.1080/1028415X.2017.1317449
  23. Koen D. W. Hendriks, Eleonora Lupi, Maarten C. Hardenberg, Femke Hoogstra-Berends, Leo E. Deelman, Robert H. Henning. Differences in mitochondrial function and morphology during cooling and rewarming between hibernator and non-hibernator derived kidney epithelial cells. Sci Rep 2017;7
    https://doi.org/10.1038/s41598-017-15606-z
  24. Yingqiong Xu, Yan Wang, Guangyun Wang, Xinyi Ye, Jiangwei Zhang, Guosheng Cao, Yazheng Zhao, Zhen Gao, Yuanyuan Zhang, Boyang Yu, Junping Kou, M. Dolores Martín-de-Saavedra. YiQiFuMai Powder Injection Protects against Ischemic Stroke via Inhibiting Neuronal Apoptosis and PKCδ/Drp1‐Mediated Excessive Mitochondrial Fission. Oxidative Medicine and Cellular Longevity 2017;2017
    https://doi.org/10.1155/2017/1832093
  25. Mina Makvand, Seyed Davood Mirtorabi, Arezoo Campbell, Alireza Zali, Ghasem Ahangari. Exploring neuroadaptive cellular pathways in chronic morphine exposure: An in‐vitro analysis of cabergoline and Mdivi‐1 co‐treatment effects on the autophagy–apoptosis axis. J of Cellular Biochemistry 2024;125
    https://doi.org/10.1002/jcb.30558
  26. Shangcheng Xu, Huifeng Pi, Lei Zhang, Nixian Zhang, YuMing Li, Huiliang Zhang, Ju Tang, Huijuan Li, Min Feng, Ping Deng, Pan Guo, Li Tian, Jia Xie, Mindi He, Yonghui Lu, Min Zhong, Yanwen Zhang, Wang Wang, Russel J. Reiter, Zhengping Yu, Zhou Zhou. Melatonin prevents abnormal mitochondrial dynamics resulting from the neurotoxicity of cadmium by blocking calcium‐dependent translocation of Drp1 to the mitochondria. Journal of Pineal Research 2016;60:291
    https://doi.org/10.1111/jpi.12310
  27. Qiru Wang, Dongxia Duan, Chao Luo, Jinlu Huang, Jinbao Wei, Yang Zhang, Ke Zhang, Tong Zhou, Wei Wang, Shaoxin Yang, Le Ma. Astilbin exerts anti-hypersensitivity by regulating metabolic demand and neuronal activity in rodent model of neuropathic pain. Annals of Medicine 2024;56
    https://doi.org/10.1080/07853890.2024.2396561
  28. Ziming Cao, Meng Zhao, Hao Sun, Liang Hu, Yunfeng Chen, Zhichao Fan. Roles of mitochondria in neutrophils. Front. Immunol. 2022;13
    https://doi.org/10.3389/fimmu.2022.934444
  29. Kuldeep Tripathi, Dorit Ben-Shachar. Mitochondria in the Central Nervous System in Health and Disease: The Puzzle of the Therapeutic Potential of Mitochondrial Transplantation. Cells 2024;13:410
    https://doi.org/10.3390/cells13050410
  30. Antero Salminen, Annakaisa Haapasalo, Anu Kauppinen, Kai Kaarniranta, Hilkka Soininen, Mikko Hiltunen. Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape. Progress in Neurobiology 2015;131:1
    https://doi.org/10.1016/j.pneurobio.2015.05.001
  31. Jia-yu Jin, Xiang-xiang Wei, Xiu-ling Zhi, Xin-hong Wang, Dan Meng. Drp1-dependent mitochondrial fission in cardiovascular disease. Acta Pharmacol Sin 2021;42:655
    https://doi.org/10.1038/s41401-020-00518-y
  32. Tianzheng Yu, Iman Ferdjallah, Falicia Elenberg, Star K. Chen, Patricia Deuster, Yifan Chen. Mitochondrial fission contributes to heat-induced oxidative stress in skeletal muscle but not hyperthermia in mice. Life Sciences 2018;200:6
    https://doi.org/10.1016/j.lfs.2018.02.031
  33. Jae Hyeon Park, Juyeon Ko, Jungwook Hwang, Hyun Chul Koh. Dynamin-related protein 1 mediates mitochondria-dependent apoptosis in chlorpyrifos-treated SH-SY5Y cells. NeuroToxicology 2015;51:145
    https://doi.org/10.1016/j.neuro.2015.10.008
  34. Mengtian Pan, Xiang Li, Guangchen Xu, Xinjuan Tian, Yunman Li, Weirong Fang. Tripartite Motif Protein Family in Central Nervous System Diseases. Cell Mol Neurobiol 2023;43:2567
    https://doi.org/10.1007/s10571-023-01337-5
  35. Voahanginirina Randriamboavonjy, W. Alexander Mann, Amro Elgheznawy, Rüdiger Popp, Paul Rogowski, Imke Dornauf, Stefan Dröse, Ingrid Fleming. Metformin reduces hyper-reactivity of platelets from patients with polycystic ovary syndrome by improving mitochondrial integrity. Thromb Haemost 2015;114:569
    https://doi.org/10.1160/TH14-09-0797
  36. Maria E. Solesio, Lihan Xie, Brendan McIntyre, Mathew Ellenberger, Erna Mitaishvili, Siddharth Bhadra-Lobo, Lisa F. Bettcher, Jason N. Bazil, Daniel Raftery, Ursula Jakob, Evgeny V. Pavlov. Depletion of mitochondrial inorganic polyphosphate (polyP) in mammalian cells causes metabolic shift from oxidative phosphorylation to glycolysis. 2021;478:1631
    https://doi.org/10.1042/BCJ20200975
  37. Xiao-xiao Ni, Jing Nie, Qiu-you Xie, Rong-hao Yu, Lei Su, Zhi-feng Liu. Protective Effects of Hyperbaric Oxygen Therapy on Brain Injury by Regulating the Phosphorylation of Drp1 Through ROS/PKC Pathway in Heatstroke Rats. Cell Mol Neurobiol 2020;40:1253
    https://doi.org/10.1007/s10571-020-00811-8
  38. Mulate Zerihun, Surya Sukumaran, Nir Qvit. The Drp1-Mediated Mitochondrial Fission Protein Interactome as an Emerging Core Player in Mitochondrial Dynamics and Cardiovascular Disease Therapy. IJMS 2023;24:5785
    https://doi.org/10.3390/ijms24065785
  39. Thomas Garton, Richard F Keep, Ya Hua, Guohua Xi. Brain iron overload following intracranial haemorrhage. Stroke Vasc Neurol 2016;1:172
    https://doi.org/10.1136/svn-2016-000042
  40. Zhifeng Qi, Wenjuan Shi, Yongmei Zhao, Xunming Ji, Ke Jian Liu. Zinc accumulation in mitochondria promotes ischemia-induced BBB disruption through Drp1-dependent mitochondria fission. Toxicology and Applied Pharmacology 2019;377:114601
    https://doi.org/10.1016/j.taap.2019.114601
  41. Jinghan Feng, Xingmiao Chen, Binghe Guan, Caiming Li, Jinhua Qiu, Jiangang Shen. Inhibition of Peroxynitrite-Induced Mitophagy Activation Attenuates Cerebral Ischemia-Reperfusion Injury. Mol Neurobiol 2018;55:6369
    https://doi.org/10.1007/s12035-017-0859-x
  42. Joseph Kedra, Shen Lin, Almudena Pacheco, Gianluca Gallo, George M. Smith. Axotomy Induces Drp1-Dependent Fragmentation of Axonal Mitochondria. Front. Mol. Neurosci. 2021;14
    https://doi.org/10.3389/fnmol.2021.668670
  43. Amanda J. Clark, Samir M. Parikh. Targeting energy pathways in kidney disease: the roles of sirtuins, AMPK, and PGC1α. Kidney International 2021;99:828
    https://doi.org/10.1016/j.kint.2020.09.037
  44. Peter W. Halcrow, Miranda L. Lynch, Jonathan D. Geiger, Joyce E. Ohm. Role of endolysosome function in iron metabolism and brain carcinogenesis. Seminars in Cancer Biology 2021;76:74
    https://doi.org/10.1016/j.semcancer.2021.06.013
  45. Ya‐Fan Bai, Wen‐Jing Li, Yu‐Wei Ji, Li‐Xin An, Li Zhang, Jun‐Fa Li. Sevoflurane induces neurotoxic effects on developing neurons through theWNK1/NKCC1/Ca2+/Drp‐1 signalling pathway. Clin Exp Pharma Physio 2023;50:393
    https://doi.org/10.1111/1440-1681.13755
  46. Seokjo Kang, Jayoung Byun, Sung Min Son, Inhee Mook-Jung. Thrombospondin-1 protects against Aβ-induced mitochondrial fragmentation and dysfunction in hippocampal cells. Cell Death Discovery 2018;4
    https://doi.org/10.1038/s41420-017-0023-4
  47. Ji Eun Bae, So Jung Park, Youlim Hong, Doo Sin Jo, Heejin Lee, Na Yeon Park, Joon Bum Kim, Hyun Jun Park, Heeyoun Bunch, Jeong Ho Chang, Eun Kyung Lee, Dong-Hyung Cho. Loss of RNA binding protein, human antigen R enhances mitochondrial elongation by regulating Drp1 expression in SH-SY5Y cells. Biochemical and Biophysical Research Communications 2019;516:713
    https://doi.org/10.1016/j.bbrc.2019.06.091
  48. Mi Hye Kim, Hong Jun Lee, Sang-Rae Lee, Hyun-Shik Lee, Jae-Won Huh, Yong Chul Bae, Dong-Seok Lee. Peroxiredoxin 5 Inhibits Glutamate-Induced Neuronal Cell Death through the Regulation of Calcineurin-Dependent Mitochondrial Dynamics in HT22 Cells. Molecular and Cellular Biology 2019;39
    https://doi.org/10.1128/MCB.00148-19
  49. Kathleen Atkins, Asish Dasgupta, Kuang-Hueih Chen, Jeff Mewburn, Stephen L. Archer. The role of Drp1 adaptor proteins MiD49 and MiD51 in mitochondrial fission: implications for human disease. 2016;130:1861
    https://doi.org/10.1042/CS20160030
  50. Hyo Min Cho, Woong Sun. Control of Mitochondrial Dynamics by Fas-induced Caspase-8 Activation in Hippocampal Neurons. Exp Neurobiol 2015;24:219
    https://doi.org/10.5607/en.2015.24.3.219
  51. Henrik Tonner, Selina Hunn, Nadine Auler, Carsten Schmelter, Norbert Pfeiffer, Franz Grus. Dynamin-like Protein 1 (DNML1) as a Molecular Target for Antibody-Based Immunotherapy to Treat Glaucoma. IJMS 2022;23:13618
    https://doi.org/10.3390/ijms232113618
  52. Cuiping Mao, Jinjin Zhang, Shengcui Lin, Lili Jing, Jing Xiang, Meirong Wang, Bingsi Wang, Pan Xu, Weili Liu, Xiaodong Song, Changjun Lv. MiRNA‐30a inhibits AECs‐II apoptosis by blocking mitochondrial fission dependent on Drp‐1. J Cellular Molecular Medi 2014;18:2404
    https://doi.org/10.1111/jcmm.12420
  53. Hao Chiang, Nobuhiko Ohno, Yu-Lin Hsieh, Don J. Mahad, Shin Kikuchi, Hitoshi Komuro, Sung-Tsang Hsieh, Bruce D. Trapp. Mitochondrial fission augments capsaicin-induced axonal degeneration. Acta Neuropathol 2015;129:81
    https://doi.org/10.1007/s00401-014-1354-3
  54. Xiaohong An, Xiao Ma, Heng Liu, Jing Song, Tiange Wei, Rongzhan Zhang, Xiao Zhan, Hongyang Li, Jia Zhou. Inhibition of PDGFRβ alleviates endothelial cell apoptotic injury caused by DRP-1 overexpression and mitochondria fusion failure after mitophagy. Cell Death Dis 2023;14
    https://doi.org/10.1038/s41419-023-06272-3
  55. Marta Cherubini, Mar Puigdellívol, Jordi Alberch, Silvia Ginés. Cdk5-mediated mitochondrial fission: A key player in dopaminergic toxicity in Huntington's disease. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2015;1852:2145
    https://doi.org/10.1016/j.bbadis.2015.06.025
  56. Barbara Pascucci, Mariarosaria D’Errico, Alessandra Romagnoli, Chiara De Nuccio, Miriam Savino, Donatella Pietraforte, Manuela Lanzafame, Angelo Salvatore Calcagnile, Paola Fortini, Sara Baccarini, Donata Orioli, Paolo Degan, Sergio Visentin, Miria Stefanini, Ciro Isidoro, Gian Maria Fimia, Eugenia Dogliotti. Overexpression of parkin rescues the defective mitochondrial phenotype and the increased apoptosis of Cockayne Syndrome A cells. Oncotarget 2017;8:102852
    https://doi.org/10.18632/oncotarget.9913
  57. Ela Mishra, Mahendra Kumar Thakur. Mdivi-1 Rescues Memory Decline in Scopolamine-Induced Amnesic Male Mice by Ameliorating Mitochondrial Dynamics and Hippocampal Plasticity. Mol Neurobiol 2023;60:5426
    https://doi.org/10.1007/s12035-023-03397-6
  58. Shenglan Zeng, Ze Zhao, Shengnan Zheng, Mengting Wu, Xiaomeng Song, Yiquan Li, Yi Zheng, Bingyu Liu, Lin Chen, Chengjiang Gao, Huiqing Liu. The E3 ubiquitin ligase TRIM31 is involved in cerebral ischemic injury by promoting degradation of TIGAR. Redox Biology 2021;45:102058
    https://doi.org/10.1016/j.redox.2021.102058
  59. Riddhi Banerjee, Agradeep Mukherjee, Shirisha Nagotu. Mitochondrial dynamics and its impact on human health and diseases: inside the DRP1 blackbox. J Mol Med 2022;100:1
    https://doi.org/10.1007/s00109-021-02150-7
  60. Youhwa Jo, Hyo Min Cho, Woong Sun, Jae Ryun Ryu. Localization of dynamin-related protein 1 and its potential role in lamellipodia formation. Histochem Cell Biol 2017;148:13
    https://doi.org/10.1007/s00418-017-1554-8
  61. Wenzhi Tan, Piera Pasinelli, Davide Trotti. Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2014;1842:1295
    https://doi.org/10.1016/j.bbadis.2014.02.009
  62. Yi Qu, Jing Shi, Ying Tang, Fengyan Zhao, Shiping Li, Junjie Meng, Jun Tang, Xuemei Lin, Xiaodong Peng, Dezhi Mu. MLKL inhibition attenuates hypoxia-ischemia induced neuronal damage in developing brain. Experimental Neurology 2016;279:223
    https://doi.org/10.1016/j.expneurol.2016.03.011
  63. Juan A. Godoy, Macarena S. Arrázola, Daniela Ordenes, Carmen Silva-Alvarez, Nady Braidy, Nibaldo C. Inestrosa. Wnt-5a Ligand Modulates Mitochondrial Fission-Fusion in Rat Hippocampal Neurons. Journal of Biological Chemistry 2014;289:36179
    https://doi.org/10.1074/jbc.M114.557009
  64. Kristina Friedland-Leuner, Carola Stockburger, Isabel Denzer, Gunter P. Eckert, Walter E. Müller. The Mitochondrion in Aging and Disease. 2014.
    https://doi.org/10.1016/B978-0-12-394625-6.00007-6
  65. Dah Ihm Kim, Ki Hoon Lee, Amr Ahmed Gabr, Gee Euhn Choi, Jun Sung Kim, So Hee Ko, Ho Jae Han. Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2016;1863:2820
    https://doi.org/10.1016/j.bbamcr.2016.09.003
  66. Nathalie Launay, Montserrat Ruiz, Laura Planas-Serra, Edgard Verdura, Agustí Rodríguez-Palmero, Agatha Schlüter, Leire Goicoechea, Cristina Guilera, Josefina Casas, Felix Campelo, Emmanuelle Jouanguy, Jean-Laurent Casanova, Odile Boespflug-Tanguy, Maria Vazquez Cancela, Luis González Gutiérrez-Solana, Carlos Casasnovas, Estela Area-Gomez, Aurora Pujol. RINT1 deficiency disrupts lipid metabolism and underlies a complex hereditary spastic paraplegia. 2023;133
    https://doi.org/10.1172/JCI162836
  67. Miao Wang, Ranru Wei, Guohui Li, Hai-Lian Bi, Zhaojun Jia, Mengjie Zhang, Mengyao Pang, Xiaona Li, Liming Ma, Ying Tang. SUMOylation of SYNJ2BP-COX16 promotes breast cancer progression through DRP1-mediated mitochondrial fission. Cancer Letters 2022;547:215871
    https://doi.org/10.1016/j.canlet.2022.215871
  68. Ting-Ting Luo, Chun-Qiu Dai, Jia-Qi Wang, Zheng-Mei Wang, Yi Yang, Kun-Long Zhang, Fei-Fei Wu, Yan-Ling Yang, Ya-Yun Wang. Drp1 is widely, yet heterogeneously, distributed in the mouse central nervous system. Mol Brain 2020;13
    https://doi.org/10.1186/s13041-020-00628-y
  69. Bongki Cho, Hyo Min Cho, Hyun Jung Kim, Jaehoon Jeong, Sang Ki Park, Eun Mi Hwang, Jae-Yong Park, Woon Ryoung Kim, Hyun Kim, Woong Sun. CDK5-dependent inhibitory phosphorylation of Drp1 during neuronal maturation. Exp Mol Med 2014;46:e105
    https://doi.org/10.1038/emm.2014.36
  70. Jing Jin, Xin Shen, Yu Tai, Shanliang Li, Mingyu Liu, Changlin Zhen, Xiuchen Xuan, Xiyue Zhang, Nan Hu, Xinzi Zhang, Deli Dong. Arterial relaxation is coupled to inhibition of mitochondrial fission in arterial smooth muscle cells: comparison of vasorelaxant effects of verapamil and phentolamine. Acta Pharmaceutica Sinica B 2017;7:319
    https://doi.org/10.1016/j.apsb.2016.12.009
  71. Arpita Bera, Gantyada Lavanya, Ravada Reshmi, Kapil Dev, Rahul Kumar. Mechanistic and therapeutic role of Drp1 in the pathogenesis of Alzheimer's disease. Eur J of Neuroscience 2022;56:5516
    https://doi.org/10.1111/ejn.15611
  72. Mattéa J. Finelli. Redox Post-translational Modifications of Protein Thiols in Brain Aging and Neurodegenerative Conditions—Focus on S-Nitrosation. Front. Aging Neurosci. 2020;12
    https://doi.org/10.3389/fnagi.2020.00254
  73. Arisa Parameyong, Piyarat Govitrapong, Banthit Chetsawang. Melatonin attenuates the mitochondrial translocation of mitochondrial fission proteins and Bax, cytosolic calcium overload and cell death in methamphetamine-induced toxicity in neuroblastoma SH-SY5Y cells. Mitochondrion 2015;24:1
    https://doi.org/10.1016/j.mito.2015.07.004
  74. Dah Ihm Kim, Ki Hoon Lee, Ji Young Oh, Jun Sung Kim, Ho Jae Han. Relationship Between β-Amyloid and Mitochondrial Dynamics. Cell Mol Neurobiol 2017;37:955
    https://doi.org/10.1007/s10571-016-0434-4
  75. Satinder Kaur, Naina Khullar, Umashanker Navik, Anjana Bali, Gurjit Kaur Bhatti, Jasvinder Singh Bhatti. Multifaceted role of dynamin-related protein 1 in cardiovascular disease: From mitochondrial fission to therapeutic interventions. Mitochondrion 2024;78:101904
    https://doi.org/10.1016/j.mito.2024.101904
  76. Nathalie Launay, Jone Lopez-Erauskin, Patrizia Bianchi, Sanjib Guha, Janani Parameswaran, Andrea Coppa, Lorenzo Torreni, Agatha Schlüter, Stéphane Fourcade, Abraham J Paredes-Fuentes, Rafael Artuch, Carlos Casasnovas, Montserrat Ruiz, Aurora Pujol. Imbalanced mitochondrial dynamics contributes to the pathogenesis of X-linked adrenoleukodystrophy. 2024;147:2069
    https://doi.org/10.1093/brain/awae038
  77. Youngjin Han, Untack Cho, Soochi Kim, In Sil Park, Jae Hyun Cho, Danny N. Dhanasekaran, Yong Sang Song. Tumour microenvironment on mitochondrial dynamics and chemoresistance in cancer. Free Radical Research 2018;52:1271
    https://doi.org/10.1080/10715762.2018.1459594
  78. Shubham Upadhayay, Puneet Kumar. Mitochondrial targeted antioxidants as potential therapy for huntington’s disease. Pharmacol. Rep 2024;76:693
    https://doi.org/10.1007/s43440-024-00619-z
  79. Karthik Suresh, Laura Servinsky, Haiyang Jiang, Zahna Bigham, Xin Yun, Corrine Kliment, John Huetsch, Mahendra Damarla, Larissa A. Shimoda. Reactive oxygen species induced Ca2+influx via TRPV4 and microvascular endothelial dysfunction in the SU5416/hypoxia model of pulmonary arterial hypertension. American Journal of Physiology-Lung Cellular and Molecular Physiology 2018;314:L893
    https://doi.org/10.1152/ajplung.00430.2017
  80. Yu Song, Huan Cao, Chengchao Zuo, Zhongya Gu, Yaqi Huang, Jinfeng Miao, Yufeng Fu, Yu Guo, Yongsheng Jiang, Furong Wang. Mitochondrial dysfunction: A fatal blow in depression. Biomedicine & Pharmacotherapy 2023;167:115652
    https://doi.org/10.1016/j.biopha.2023.115652
  81. Chun Guo, Kevin A. Wilkinson, Ashley J. Evans, Philip P. Rubin, Jeremy M. Henley. SENP3-mediated deSUMOylation of Drp1 facilitates interaction with Mff to promote cell death. Sci Rep 2017;7
    https://doi.org/10.1038/srep43811
  82. Thomas Garton, Jennifer M. Strahle. Cerebrospinal Fluid Disorders. 2017.
    https://doi.org/10.1007/978-3-319-97928-1_2
  83. H. Díez, E. Cortès‐Saladelafont, A. Ormazábal, A. Fernández Marmiese, J. Armstrong, Leslie Matalonga, Miren Bravo, Paz Briones, Sonia Emperador, Julio Montoya, Rafael Artuch, Marisa Giros, Àngels Garcia‐Cazorla. Severe infantile parkinsonism because of a de novo mutation on DLP1 mitochondrial‐peroxisomal protein. Movement Disorders 2017;32:1108
    https://doi.org/10.1002/mds.27021
  84. Rasha Sabouny, Erik Fraunberger, Michèle Geoffrion, Andy Cheuk-Him Ng, Stephen D. Baird, Robert A. Screaton, Ross Milne, Heidi M. McBride, Timothy E. Shutt. The Keap1–Nrf2 Stress Response Pathway Promotes Mitochondrial Hyperfusion Through Degradation of the Mitochondrial Fission Protein Drp1. Antioxidants & Redox Signaling 2017;27:1447
    https://doi.org/10.1089/ars.2016.6855
  85. Ramesh Chandra, Michel Engeln, Christopher Schiefer, Mary H. Patton, Jennifer A. Martin, Craig T. Werner, Lace M. Riggs, T. Chase Francis, Madeleine McGlincy, Brianna Evans, Hyungwoo Nam, Shweta Das, Kasey Girven, Prasad Konkalmatt, Amy M. Gancarz, Sam A. Golden, Sergio D. Iñiguez, Scott J. Russo, Gustavo Turecki, Brian N. Mathur, Meaghan Creed, David M. Dietz, Mary Kay Lobo. Drp1 Mitochondrial Fission in D1 Neurons Mediates Behavioral and Cellular Plasticity during Early Cocaine Abstinence. Neuron 2017;96:1327
    https://doi.org/10.1016/j.neuron.2017.11.037
  86. Garrett M. Fogo, Anthony R. Anzell, Kathleen J. Maheras, Sarita Raghunayakula, Joseph M. Wider, Katlynn J. Emaus, Timothy D. Bryson, Melissa J. Bukowski, Robert W. Neumar, Karin Przyklenk, Thomas H. Sanderson. Machine learning-based classification of mitochondrial morphology in primary neurons and brain. Sci Rep 2021;11
    https://doi.org/10.1038/s41598-021-84528-8
  87. So Yoen Choi, Ju-Hyun Lee, Ah-Young Chung, Youhwa Jo, Joo-ho Shin, Hae-Chul Park, Hyun Kim, Rodrigo Lopez-Gonzalez, Jae Ryun Ryu, Woong Sun. Prevention of mitochondrial impairment by inhibition of protein phosphatase 1 activity in amyotrophic lateral sclerosis. Cell Death Dis 2020;11
    https://doi.org/10.1038/s41419-020-03102-8
  88. Anuradha Sehrawat, Suman K. Samanta, Eun-Ryeong Hahm, Claudette St. Croix, Simon Watkins, Shivendra V. Singh. Withaferin A-mediated apoptosis in breast cancer cells is associated with alterations in mitochondrial dynamics. Mitochondrion 2019;47:282
    https://doi.org/10.1016/j.mito.2019.01.003
  89. Gabriella Casinelli, Jeff LaRosa, Manika Sharma, Edward Cherok, Swati Banerjee, Maria Branca, Lia Edmunds, Yudong Wang, Sunder Sims-Lucas, Luke Churley, Samantha Kelly, Ming Sun, Donna Stolz, J Anthony Graves. N-Myc overexpression increases cisplatin resistance in neuroblastoma via deregulation of mitochondrial dynamics. Cell Death Discovery 2016;2
    https://doi.org/10.1038/cddiscovery.2016.82
  90. Shiv Kumar Saini, Damanpreet Singh. Mitochondrial mechanisms in Cerebral Ischemia-Reperfusion Injury: Unravelling the intricacies. Mitochondrion 2024;77:101883
    https://doi.org/10.1016/j.mito.2024.101883
  91. Kyle H. Flippo, Stefan Strack. Mitochondrial dynamics in neuronal injury, development and plasticity. 2017;130:671
    https://doi.org/10.1242/jcs.171017
  92. Xiao -Dong Yang, Qi Shi, Jing Sun, Yan Lv, Yue Ma, Cao Chen, Kang Xiao, Wei Zhou, Xiao-Ping Dong. Aberrant Alterations of Mitochondrial Factors Drp1 and Opa1 in the Brains of Scrapie Experiment Rodents. J Mol Neurosci 2017;61:368
    https://doi.org/10.1007/s12031-016-0866-9
  93. Yingjie Ji, Han Zhou, Chen Yang, Jingjie Li. Post-Translational Modification of Drp1 is a Promising Target for Treating Cardiovascular Diseases. CVIA 2023;8
    https://doi.org/10.15212/CVIA.2023.0043
  94. Barbara Pascucci, Francesca Spadaro, Donatella Pietraforte, Chiara De Nuccio, Sergio Visentin, Paola Giglio, Eugenia Dogliotti, Mariarosaria D’Errico. DRP1 Inhibition Rescues Mitochondrial Integrity and Excessive Apoptosis in CS-A Disease Cell Models. IJMS 2021;22:7123
    https://doi.org/10.3390/ijms22137123
  95. Xianchong Zheng, Mimi Chen, Xiaojing Meng, Xinwei Chu, Chunqing Cai, Fei Zou. Phosphorylation of dynamin-related protein 1 at Ser616 regulates mitochondrial fission and is involved in mitochondrial calcium uniporter-mediated neutrophil polarization and chemotaxis. Molecular Immunology 2017;87:23
    https://doi.org/10.1016/j.molimm.2017.03.019
  96. Lixuan Zhan, Zhiwei Lu, Xinyong Zhu, Wensheng Xu, Luxi Li, Xinyu Li, Siyuan Chen, Weiwen Sun, En Xu. Hypoxic preconditioning attenuates necroptotic neuronal death induced by global cerebral ischemia via Drp1‐dependent signaling pathway mediated by CaMKIIα inactivation in adult rats. The FASEB Journal 2019;33:1313
    https://doi.org/10.1096/fj.201800111RR
  97. Tatiana Brustovetsky, Rajesh Khanna, Nickolay Brustovetsky. Involvement of CRMP2 in Regulation of Mitochondrial Morphology and Motility in Huntington’s Disease. Cells 2021;10:3172
    https://doi.org/10.3390/cells10113172
  98. Xirui Yan, Yifang Yang, Weiling Huang, Shuping Fu, Bo Cui, Min Chu, Yang Dong, Yinting Peng, Haiyan Song, Jianrong Shi, Qing Liu. Beneficial effects of the herbal medicine zuo gui wan in a mice model of Alzheimer's disease via Drp1-Mediated inhibition of mitochondrial fission and activation of AMPK/PGC-1α-regulated mitochondrial bioenergetics. Journal of Ethnopharmacology 2025;342:119425
    https://doi.org/10.1016/j.jep.2025.119425
  99. Ghulam Md Ashraf, Stylianos Chatzichronis, Athanasios Alexiou, Gazala Firdousi, Mohammad Amjad Kamal, Magdah Ganash. Dietary Alterations in Impaired Mitochondrial Dynamics Due to Neurodegeneration. Front. Aging Neurosci. 2022;14
    https://doi.org/10.3389/fnagi.2022.893018
  100. Lingling Yu, Zuke Xiao, Hongying Tu, Bo Tong, Shengsong Chen. The expression and prognostic significance of Drp1 in lung cancer. 2019;98:e18228
    https://doi.org/10.1097/MD.0000000000018228