en Experimental Neurobiology

Cited by CrossRef (56)

  1. Jung-Hoon Koo, Yong-Chul Jang, Dong-Ju Hwang, Hyun-Seob Um, Nam-Hee Lee, Jae-Hoon Jung, Joon-Yong Cho. Treadmill exercise produces neuroprotective effects in a murine model of Parkinson’s disease by regulating the TLR2/MyD88/NF-κB signaling pathway. Neuroscience 2017;356:102
    https://doi.org/10.1016/j.neuroscience.2017.05.016
  2. Ana Agustí, Maria P. García-Pardo, Inmaculada López-Almela, Isabel Campillo, Michael Maes, Marina Romaní-Pérez, Yolanda Sanz. Interplay Between the Gut-Brain Axis, Obesity and Cognitive Function. Front. Neurosci. 2018;12
    https://doi.org/10.3389/fnins.2018.00155
  3. Juan García-Revilla, Antonio Boza-Serrano, Ana M. Espinosa-Oliva, Manuel Sarmiento Soto, Tomas Deierborg, Rocío Ruiz, Rocío M. de Pablos, Miguel Angel Burguillos, Jose L. Venero. Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration. Cell Death Dis 2022;13
    https://doi.org/10.1038/s41419-022-05058-3
  4. Rezan Ashayeri Ahmadabad, Zahra Mirzaasgari, Ali Gorji, Maryam Khaleghi Ghadiri. Toll-Like Receptor Signaling Pathways: Novel Therapeutic Targets for Cerebrovascular Disorders. IJMS 2021;22:6153
    https://doi.org/10.3390/ijms22116153
  5. Taewoo Kim, Seohoe Song, Yeongwon Park, Sinil Kang, Hyemyung Seo. HDAC Inhibition by Valproic Acid Induces Neuroprotection and Improvement of PD-like Behaviors in LRRK2 R1441G Transgenic Mice. Exp Neurobiol 2019;28:504
    https://doi.org/10.5607/en.2019.28.4.504
  6. Anil Gupta. Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases. 2019.
    https://doi.org/10.1016/B978-0-12-820122-0.00001-7
  7. Sarah R. Ocañas, Kevin D. Pham, Jillian E. J. Cox, Alex W. Keck, Sunghwan Ko, Felix A. Ampadu, Hunter L. Porter, Victor A. Ansere, Adam Kulpa, Collyn M. Kellogg, Adeline H. Machalinski, Manu A. Thomas, Zsabre Wright, Ana J. Chucair-Elliott, Willard M. Freeman. Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer’s disease. J Neuroinflammation 2023;20
    https://doi.org/10.1186/s12974-023-02870-2
  8. C.-F. Huang, J.-X. Du, W. Deng, X.-C. Cheng, S.-Y. Zhang, S.-J. Zhao, M.-J. Tao, G.-Z. Chen, X.-Q. Hao. Effect of prenatal exposure to LPS combined with pre- and post-natal high-fat diet on hippocampus in rat offspring. Neuroscience 2015;286:364
    https://doi.org/10.1016/j.neuroscience.2014.12.002
  9. Diogo Lobo‐Silva, Guilhermina M. Carriche, A. Gil Castro, Susana Roque, Margarida Saraiva. Interferon‐β regulates the production of IL‐10 by toll‐like receptor‐activated microglia. Glia 2017;65:1439
    https://doi.org/10.1002/glia.23172
  10. Mélanie Kremer, Ipek Yalcin, Yannick Goumon, Xavier Wurtz, Laurent Nexon, Dorothée Daniel, Salim Megat, Rhian A. Ceredig, Carl Ernst, Gustavo Turecki, Virginie Chavant, Jean-François Théroux, Adrien Lacaud, Lauriane-Elisabeth Joganah, Vincent Lelievre, Dominique Massotte, Pierre-Eric Lutz, Ralf Gilsbach, Eric Salvat, Michel Barrot. A Dual Noradrenergic Mechanism for the Relief of Neuropathic Allodynia by the Antidepressant Drugs Duloxetine and Amitriptyline. J. Neurosci. 2018;38:9934
    https://doi.org/10.1523/JNEUROSCI.1004-18.2018
  11. Rezan Ashayeri Ahmadabad, Maryam Khaleghi Ghadiri, Ali Gorji. The role of Toll-like receptor signaling pathways in cerebrovascular disorders: the impact of spreading depolarization. J Neuroinflammation 2020;17
    https://doi.org/10.1186/s12974-020-01785-6
  12. Hao-Ling Li, Yan Huang, Ya-Lan Zhou, Run-Hua Teng, Shu-Zhuan Zhou, Jia-Piao Lin, Yan Yang, Sheng-Mei Zhu, Hua Xu, Yong-Xing Yao. C-X-C Motif Chemokine 10 Contributes to the Development of Neuropathic Pain by Increasing the Permeability of the Blood–Spinal Cord Barrier. Front. Immunol. 2020;11
    https://doi.org/10.3389/fimmu.2020.00477
  13. Xiaoyuan Li, Li Xue, Jinfang Sun, Yanping Sun, Anmu Xie. Single nucleotide polymorphisms in the toll-like receptor 2 (TLR2) gene are associated with sporadic Parkinson’s disease in the North-eastern Han Chinese population. Neuroscience Letters 2017;656:72
    https://doi.org/10.1016/j.neulet.2017.07.014
  14. Andres M. Salazar, Jordan Grafman. Traumatic Brain Injury, Part II. 2017.
    https://doi.org/10.1016/B978-0-444-63521-1.00033-9
  15. Rachel E. Miller, Shingo Ishihara, Phuong B. Tran, Suzanne B. Golub, Karena Last, Richard J. Miller, Amanda J. Fosang, Anne-Marie Malfait. An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2. 2018;3
    https://doi.org/10.1172/jci.insight.95704
  16. Carolina R. Cawthon, Rebecca A. Kirkland, Shreya Pandya, Nigel A. Brinson, Claire B. de La Serre. Non-neuronal crosstalk promotes an inflammatory response in nodose ganglia cultures after exposure to byproducts from gram positive, high-fat-diet-associated gut bacteria. Physiology & Behavior 2020;226:113124
    https://doi.org/10.1016/j.physbeh.2020.113124
  17. Ghanshyam N. Pandey, Hooriyah S. Rizavi, Runa Bhaumik, Xinguo Ren. Innate immunity in the postmortem brain of depressed and suicide subjects: Role of Toll-like receptors. Brain, Behavior, and Immunity 2019;75:101
    https://doi.org/10.1016/j.bbi.2018.09.024
  18. Ahmad Reza aminian, Fatemeh Forouzanfar. Interplay between Heat Shock Proteins, Inflammation and Pain: A Promising Therapeutic Approach. CMP 2021;15:170
    https://doi.org/10.2174/1874467214666210719143150
  19. Wenjun Deng, Emiri Mandeville, Yasukazu Terasaki, Wenlu Li, Julie Holder, Aaron TT Chuang, Mingming Ning, Ken Arai, Eng H Lo, Changhong Xing. Transcriptomic characterization of microglia activation in a rat model of ischemic stroke. J Cereb Blood Flow Metab 2020;40:S34
    https://doi.org/10.1177/0271678X20932870
  20. Yongqiu Xie, Yi-Ju Li, Beilei Lei, Dawn Kernagis, Wen-Wei Liu, Ellen R. Bennett, Talagnair Venkatraman, Christopher D. Lascola, Daniel T. Laskowitz, David S. Warner, Michael L. James. Sex Differences in Gene and Protein Expression After Intracerebral Hemorrhage in Mice. Transl. Stroke Res. 2019;10:231
    https://doi.org/10.1007/s12975-018-0633-z
  21. Imola Wilhelm, Ádám Nyúl-Tóth, Mihály Kozma, Attila E. Farkas, István A. Krizbai. Role of pattern recognition receptors of the neurovascular unit in inflamm-aging. American Journal of Physiology-Heart and Circulatory Physiology 2017;313:H1000
    https://doi.org/10.1152/ajpheart.00106.2017
  22. Stefano Federico, Luca Pozzetti, Alessandro Papa, Gabriele Carullo, Sandra Gemma, Stefania Butini, Giuseppe Campiani, Nicola Relitti. Modulation of the Innate Immune Response by Targeting Toll-like Receptors: A Perspective on Their Agonists and Antagonists. J. Med. Chem. 2020;63:13466
    https://doi.org/10.1021/acs.jmedchem.0c01049
  23. Lidia Fernández-Paredes, Rebeca Pérez de Diego, Clara de Andrés, Silvia Sánchez-Ramón. Close Encounters of the First Kind: Innate Sensors and Multiple Sclerosis. Mol Neurobiol 2017;54:101
    https://doi.org/10.1007/s12035-015-9665-5
  24. Masataka Ifuku, Alice Buonfiglioli, Philipp Jordan, Seija Lehnardt, Helmut Kettenmann. TLR2 controls random motility, while TLR7 regulates chemotaxis of microglial cells via distinct pathways. Brain, Behavior, and Immunity 2016;58:338
    https://doi.org/10.1016/j.bbi.2016.08.003
  25. Ana Agusti, A. Moya-Pérez, I. Campillo, S. Montserrat-de la Paz, V. Cerrudo, A. Perez-Villalba, Yolanda Sanz. Bifidobacterium pseudocatenulatum CECT 7765 Ameliorates Neuroendocrine Alterations Associated with an Exaggerated Stress Response and Anhedonia in Obese Mice. Mol Neurobiol 2018;55:5337
    https://doi.org/10.1007/s12035-017-0768-z
  26. Isabelle Guisle, Geoffrey Canet, Séréna Pétry, Parissa Fereydouni-Forouzandeh, Françoise Morin, Rémi Kérauden, Robert A. Whittington, Frédéric Calon, Sébastien S. Hébert, Emmanuel Planel. Sauna-like conditions or menthol treatment reduce tau phosphorylation through mild hyperthermia. Neurobiology of Aging 2022;113:118
    https://doi.org/10.1016/j.neurobiolaging.2022.02.011
  27. Rentang Bi, Zhi Fang, Mingfeng You, Quanwei He, Bo Hu. Microglia Phenotype and Intracerebral Hemorrhage: A Balance of Yin and Yang. Front. Cell. Neurosci. 2021;15
    https://doi.org/10.3389/fncel.2021.765205
  28. Anne-Marie Howe, Sinéad Burke, Marcella E. O’Reilly, Fiona C. McGillicuddy, Derek A. Costello. Palmitic Acid and Oleic Acid Differently Modulate TLR2-Mediated Inflammatory Responses in Microglia and Macrophages. Mol Neurobiol 2022;59:2348
    https://doi.org/10.1007/s12035-022-02756-z
  29. Rong Fan, Yinan Hua, Jingyi Shen, Rong Xiao, Weiwei Ma. Dietary fatty acids affect learning and memory ability via regulating inflammatory factors in obese mice. The Journal of Nutritional Biochemistry 2022;103:108959
    https://doi.org/10.1016/j.jnutbio.2022.108959
  30. Yuye Wang, Shuang Lv, Xiao Zhou, Xiaoqian Niu, Leian Chen, Ziyuan Yang, Dantao Peng. Identification of TLR2 as a Key Target in Neuroinflammation in Vascular Dementia. Front. Genet. 2022;13
    https://doi.org/10.3389/fgene.2022.860122
  31. Ping Kei Yip, Alejandro Carrillo-Jimenez, Paul King, Anna Vilalta, Koji Nomura, Chi Cheng Chau, Alexander Michael Scott Egerton, Zhuo-Hao Liu, Ashray Jayaram Shetty, Jordi L. Tremoleda, Meirion Davies, Tomas Deierborg, John V. Priestley, Guy Charles Brown, Adina Teodora Michael-Titus, Jose Luis Venero, Miguel Angel Burguillos. Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration. Sci Rep 2017;7
    https://doi.org/10.1038/srep41689
  32. Zheng Lin, Haoran Lin, Wenlu Li, Yuwen Huang, Haibin Dai. Complement Component C3 Promotes Cerebral Ischemia/Reperfusion Injury Mediated by TLR2/NFκB Activation in Diabetic Mice. Neurochem Res 2018;43:1599
    https://doi.org/10.1007/s11064-018-2574-z
  33. Sabita Neupane, Sunil Srivastav, Sunil Bhurtel, Nikita Katila, Sina Shadfar, Pil-Hoon Park, Jin Tae Hong, Dong-Young Choi. Enhanced neuroinflammatory responses after systemic LPS injection in IL-32β transgenic mice. Journal of Chemical Neuroanatomy 2018;94:173
    https://doi.org/10.1016/j.jchemneu.2018.07.002
  34. Baozhu Fan, Riffat Jabeen, Bing Bo, Chunlei Guo, Mengjie Han, Hui Zhang, Juan Cen, Xinying Ji, Jianshe Wei. What and How Can Physical Activity Prevention Function on Parkinson’s Disease?. Oxidative Medicine and Cellular Longevity 2020;2020:1
    https://doi.org/10.1155/2020/4293071
  35. P. Josić Dominović, M. Dobrivojević Radmilović, S. Srakočić, I. Mišerić, S. Škokić, S. Gajović. Validation and application of caged Z-DEVD-aminoluciferin bioluminescence for assessment of apoptosis of wild type and TLR2-deficient mice after ischemic stroke. Journal of Photochemistry and Photobiology B: Biology 2024;253:112871
    https://doi.org/10.1016/j.jphotobiol.2024.112871
  36. Yuting Hu, Xiaoyu Sun, Shang Wang, Chao Zhou, Li Lin, Xiaohui Ding, Jingjing Han, Yan Zhou, Guoliang Jin, Yuqiao Wang, Wei Zhang, Hongjuan Shi, Zuohui Zhang, Xinxin Yang, Fang Hua. Toll-like receptor-2 gene knockout results in neurobehavioral dysfunctions and multiple brain structural and functional abnormalities in mice. Brain, Behavior, and Immunity 2021;91:257
    https://doi.org/10.1016/j.bbi.2020.10.004
  37. Nibaldo C. Inestrosa, Juvenal A. Ríos, Pedro Cisternas, Cheril Tapia‐Rojas, Daniela S. Rivera, Nady Braidy, Juan M. Zolezzi, Juan A. Godoy, Francisco J. Carvajal, Alvaro O. Ardiles, Francisco Bozinovic, Adrián G. Palacios, Perminder S. Sachdev. Age Progression of Neuropathological Markers in the Brain of the Chilean Rodent Octodon degus, a Natural Model of Alzheimer's Disease. Brain Pathology 2015;25:679
    https://doi.org/10.1111/bpa.12226
  38. Roman Fischer, Olaf Maier. Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF. Oxidative Medicine and Cellular Longevity 2015;2015:1
    https://doi.org/10.1155/2015/610813
  39. B. García Bueno, J.R. Caso, J.L.M. Madrigal, J.C. Leza. Innate immune receptor Toll-like receptor 4 signalling in neuropsychiatric diseases. Neuroscience & Biobehavioral Reviews 2016;64:134
    https://doi.org/10.1016/j.neubiorev.2016.02.013
  40. Xin Fan, Yun Zhong, Lingling Zhang, Jiaqi Li, Fei Xie, Zhiyuan Zhang, Jing Zhong. Abdominal Obesity: An Independent Influencing Factor of Visuospatial and Executive/Language Ability and the Serum Levels of Aβ40/Aβ42/Tau Protein. Disease Markers 2022;2022:1
    https://doi.org/10.1155/2022/3622149
  41. Andrea Wieck, Rodrigo Grassi-Oliveira, Carine Hartmann do Prado, Thiago Wendt Viola, Laura Esteves Petersen, Bárbara Porto, Antônio Lúcio Teixeira, Moisés Evandro Bauer. Toll-like receptor expression and function in type I bipolar disorder. Brain, Behavior, and Immunity 2016;54:110
    https://doi.org/10.1016/j.bbi.2016.01.011
  42. Szabolcs Kéri, Csilla Szabó, Oguz Kelemen. Antipsychotics influence Toll-like receptor (TLR) expression and its relationship with cognitive functions in schizophrenia. Brain, Behavior, and Immunity 2017;62:256
    https://doi.org/10.1016/j.bbi.2016.12.011
  43. Jesse Peterson, Kinga Balogh Sivars, Ambra Bianco, Katja Röper. Toll-like receptor signalling via IRAK4 affects epithelial integrity and tightness through regulation of junctional tension. 2023;150
    https://doi.org/10.1242/dev.201893
  44. Yongchul Jang, Jung-Hoon Koo, Insu Kwon, Eun-Bum Kang, Hyun-Seob Um, Hideaki Soya, Youngil Lee, Joon-Yong Cho. Neuroprotective effects of endurance exercise against neuroinflammation in MPTP-induced Parkinson's disease mice. Brain Research 2017;1655:186
    https://doi.org/10.1016/j.brainres.2016.10.029
  45. Bryan E. McGill, Ruteja A. Barve, Susan E. Maloney, Amy Strickland, Nicholas Rensing, Peter L. Wang, Michael Wong, Richard Head, David F. Wozniak, Jeffrey Milbrandt. Abnormal Microglia and Enhanced Inflammation-Related Gene Transcription in Mice with Conditional Deletion ofCtcfinCamk2a-Cre-Expressing Neurons. J. Neurosci. 2018;38:200
    https://doi.org/10.1523/JNEUROSCI.0936-17.2017
  46. Carla Marinelli, Rosa Di Liddo, Laura Facci, Thomas Bertalot, Maria Teresa Conconi, Morena Zusso, Stephen D. Skaper, Pietro Giusti. Ligand engagement of Toll-like receptors regulates their expression in cortical microglia and astrocytes. J Neuroinflammation 2015;12
    https://doi.org/10.1186/s12974-015-0458-6
  47. Delson José da Silva, Arissa Felipe Borges, Priscila Oliveira Souza, Patrícia Reis de Souza, Cristina Ribeiro de Barros Cardoso, Miriam Leandro Dorta, Milton Adriano Pelli de Oliveira, Antônio Lúcio Teixeira, Fátima Ribeiro-Dias. Decreased Toll-Like Receptor 2 and Toll-Like Receptor 7/8-Induced Cytokines in Parkinson's Disease Patients. Neuroimmunomodulation 2016;23:58
    https://doi.org/10.1159/000443238
  48. Hye Won Kim, Na Kyung Kim, Jesse Thompson, Mackenzie de Jesus, Josh Rehberger, Thomas Rehberger, Alexandra Helena Smith, Roderick Ian Mackie. Effects of dosing non-toxigenic Clostridia on the bacterial populations and immunological responses in the intestinal tract of lactating dairy cows. Front. Microbiol. 2023;14
    https://doi.org/10.3389/fmicb.2023.1107964
  49. Heera Yoon, Yong Ho Jang, Sang Jeong Kim, Sung Joong Lee, Sun Kwang Kim. Toll-like Receptor 2 is Dispensable for an Immediate-early Microglial Reaction to Two-photon Laser-induced Cortical InjuryIn vivo. Korean J Physiol Pharmacol 2015;19:461
    https://doi.org/10.4196/kjpp.2015.19.5.461
  50. Agnieszka M. Jurga, Ewelina Rojewska, Anna Piotrowska, Wioletta Makuch, Dominika Pilat, Barbara Przewlocka, Joanna Mika. Blockade of Toll-Like Receptors (TLR2, TLR4) Attenuates Pain and Potentiates Buprenorphine Analgesia in a Rat Neuropathic Pain Model. Neural Plasticity 2016;2016:1
    https://doi.org/10.1155/2016/5238730
  51. Yan Deng, Kui Liu, Yueying Pan, Jie Ren, Jin Shang, Lei chen, Huiguo Liu. TLR2 antagonism attenuates the hippocampal neuronal damage in a murine model of sleep apnea via inhibiting neuroinflammation and oxidative stress. Sleep Breath 2020;24:1613
    https://doi.org/10.1007/s11325-020-02030-3
  52. Krishan K. Thakur, Jyoti Saini, Kanika Mahajan, Dhyanendra Singh, Dinkar P. Jayswal, Srishti Mishra, Anupam Bishayee, Gautam Sethi, Ajaikumar B. Kunnumakkara. Therapeutic implications of toll-like receptors in peripheral neuropathic pain. Pharmacological Research 2017;115:224
    https://doi.org/10.1016/j.phrs.2016.11.019
  53. Ling Zhu, Xiaoyu Liu, Daniel P. Nemeth, Damon J. DiSabato, Kristina G. Witcher, Daniel B. Mckim, Braedan Oliver, Xi Le, Gowthami Gorantla, Olimpia Berdysz, Jiaoni Li, Aishwarya D. Ramani, Zhibiao Chen, Dongcheng Wu, Jonathan P. Godbout, Ning Quan. Interleukin-1 causes CNS inflammatory cytokine expression via endothelia-microglia bi-cellular signaling. Brain, Behavior, and Immunity 2019;81:292
    https://doi.org/10.1016/j.bbi.2019.06.026
  54. Elizabeth C. Delery, Scott Edwards. Neuropeptide and cytokine regulation of pain in the context of substance use disorders. Neuropharmacology 2020;174:108153
    https://doi.org/10.1016/j.neuropharm.2020.108153
  55. Eun-Jung Lee, Jin-Sun Park, Yu-Young Lee, Do-Yeon Kim, Jihee Lee Kang, Hee-Sun Kim. Anti-inflammatory and anti-oxidant mechanisms of an MMP-8 inhibitor in lipoteichoic acid-stimulated rat primary astrocytes: involvement of NF-κB, Nrf2, and PPAR-γ signaling pathways. J Neuroinflammation 2018;15
    https://doi.org/10.1186/s12974-018-1363-6
  56. Khutso M. Mothapo, J. ten Oever, P. Koopmans, F. F. Stelma, S. Burm, J. Bajramovic, M. M. Verbeek, M. G. Olde Rikkert, M. G. Netea, G. Koopman, A. J. van der Ven. Soluble TLR2 and 4 concentrations in cerebrospinal fluid in HIV/SIV-related neuropathological conditions. J. Neurovirol. 2017;23:250
    https://doi.org/10.1007/s13365-016-0495-7