en Experimental Neurobiology

Cited by CrossRef (995)

  1. Konrad A. Szychowski, Agnieszka Rombel-Bryzek, Agnieszka Dołhańczuk-Śródka, Jan Gmiński. Antiproliferative Effect of Elastin-Derived Peptide VGVAPG on SH-SY5Y Neuroblastoma Cells. Neurotox Res 2019;36:503
    https://doi.org/10.1007/s12640-019-00040-y
  2. Miguel Pinto, Sofia Benfeito, Carlos Fernandes, Fernanda Borges. Oxidative Stress and Dietary Antioxidants in Neurological Diseases. 2019.
    https://doi.org/10.1016/B978-0-12-817780-8.00009-8
  3. Mengjiao Sun, Xiaoling Li, Jing Sun, Hongxia Wang, Qinfang Xie, Manxia Wang. The Top-Cited Original Articles on the Role of Microglia in Neurodegenerative Diseases: A Bibliometric and Visualized Study. Front. Aging Neurosci. 2022;14
    https://doi.org/10.3389/fnagi.2022.869964
  4. Erjie Tian, Gaurav Sharma, Chongshan Dai. Neuroprotective Properties of Berberine: Molecular Mechanisms and Clinical Implications. Antioxidants 2023;12:1883
    https://doi.org/10.3390/antiox12101883
  5. Catherine E. Dominguez, David Cunningham, Dawn S. Chandler. SMN regulation in SMA and in response to stress: new paradigms and therapeutic possibilities. Hum Genet 2017;136:1173
    https://doi.org/10.1007/s00439-017-1835-2
  6. Michiel Van Bulck, Ana Sierra-Magro, Jesus Alarcon-Gil, Ana Perez-Castillo, Jose A. Morales-Garcia. Novel Approaches for the Treatment of Alzheimer’s and Parkinson’s Disease. IJMS 2019;20:719
    https://doi.org/10.3390/ijms20030719
  7. Andrea Bacci, Francesca Corsi, Massimiliano Runfola, Simona Sestito, Ilaria Piano, Clementina Manera, Giuseppe Saccomanni, Claudia Gargini, Simona Rapposelli. Design, Synthesis, and In Vitro Evaluation of Novel 8-Amino-Quinoline Combined with Natural Antioxidant Acids. Pharmaceuticals 2022;15:688
    https://doi.org/10.3390/ph15060688
  8. Malika Bahiani, Souad Babahani, Abdelhafid Nani, Ishak Boukhetache. Dates (Phoenix dactylifera L.) from the Adrar region of Algeria are rich in polyphenols, and ternary solvent extracts’ antioxidant activity correlates with condensed tannins content. Vegetos 2023;37:918
    https://doi.org/10.1007/s42535-023-00622-4
  9. Joanna A Ruszkiewicz, Shaojun Li, Maliya B Rodriguez, Michael Aschner. Is Triclosan a neurotoxic agent?. Journal of Toxicology and Environmental Health, Part B 2017;20:104
    https://doi.org/10.1080/10937404.2017.1281181
  10. Kamila Kopeć, Stanisław Szleszkowski, Dariusz Koziorowski, Stanislaw Szlufik. Glymphatic System and Mitochondrial Dysfunction as Two Crucial Players in Pathophysiology of Neurodegenerative Disorders. IJMS 2023;24:10366
    https://doi.org/10.3390/ijms241210366
  11. Sean Hong Tan, Venkatanaidu Karri, Nicole Wuen Rong Tay, Kuan Hui Chang, Hui Yen Ah, Phui Qi Ng, Hui San Ho, Hsiao Wai Keh, Mayuren Candasamy. Emerging pathways to neurodegeneration: Dissecting the critical molecular mechanisms in Alzheimer’s disease, Parkinson’s disease. Biomedicine & Pharmacotherapy 2019;111:765
    https://doi.org/10.1016/j.biopha.2018.12.101
  12. Yuchen Lei, Yuxiang Huang, Xin Wen, Zhangyuan Yin, Zhihai Zhang, Daniel J. Klionsky. How Cells Deal with the Fluctuating Environment: Autophagy Regulation under Stress in Yeast and Mammalian Systems. Antioxidants 2022;11:304
    https://doi.org/10.3390/antiox11020304
  13. Xiaolie He, Yanjing Zhu, Bei Ma, Xu Xu, Ruiqi Huang, Liming Cheng, Rongrong Zhu. Bioactive 2D nanomaterials for neural repair and regeneration. Advanced Drug Delivery Reviews 2022;187:114379
    https://doi.org/10.1016/j.addr.2022.114379
  14. Mattéa J. Finelli, Peter L. Oliver. TLDc proteins: new players in the oxidative stress response and neurological disease. Mamm Genome 2017;28:395
    https://doi.org/10.1007/s00335-017-9706-7
  15. Qiuyang Zheng, Xiaoyuan Zheng, Lishan Zhang, Hong Luo, Lingzhi Qian, Xing Fu, Yiqian Liu, Yuehong Gao, Mengxi Niu, Jian Meng, Muxian Zhang, Guojun Bu, Huaxi Xu, Yun-wu Zhang. The Neuron-Specific Protein TMEM59L Mediates Oxidative Stress-Induced Cell Death. Mol Neurobiol 2017;54:4189
    https://doi.org/10.1007/s12035-016-9997-9
  16. Barbora Svobodova, Eva Mezeiova, Vendula Hepnarova, Martina Hrabinova, Lubica Muckova, Tereza Kobrlova, Daniel Jun, Ondrej Soukup, María Luisa Jimeno, José Marco-Contelles, Jan Korabecny. Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors. Biomolecules 2019;9:379
    https://doi.org/10.3390/biom9080379
  17. Anna Fracassi, Michela Marcatti, Olga Zolochevska, Natalie Tabor, Randall Woltjer, Sandra Moreno, Giulio Taglialatela. Oxidative Damage and Antioxidant Response in Frontal Cortex of Demented and Nondemented Individuals with Alzheimer's Neuropathology. J. Neurosci. 2021;41:538
    https://doi.org/10.1523/JNEUROSCI.0295-20.2020
  18. Domenico Nuzzo, Pasquale Picone, Costanza Giardina, Miriana Scordino, Giuseppa Mudò, Mario Pagliaro, Antonino Scurria, Francesco Meneguzzo, Laura M. Ilharco, Alexandra Fidalgo, Rosa Alduina, Alessandro Presentato, Rosaria Ciriminna, Valentina Di Liberto. New Neuroprotective Effect of Lemon IntegroPectin on Neuronal Cellular Model. Antioxidants 2021;10:669
    https://doi.org/10.3390/antiox10050669
  19. M. Iftikhar Hussain, Muhammad Farooq, Qamar Abbas Syed. Nutritional and biological characteristics of the date palm fruit (Phoenix dactylifera L.) – A review. Food Bioscience 2020;34:100509
    https://doi.org/10.1016/j.fbio.2019.100509
  20. Wen-Jie Shu, Zhengzhi Cao, Yuxing Yan, Zhuang Cai, Fu Wang. Endogenous molecule-targeted fluorescent probes for ferroptosis visualization: Current progress and future prospects. Coordination Chemistry Reviews 2023;496:215432
    https://doi.org/10.1016/j.ccr.2023.215432
  21. Kumari Neha, Md Rafi Haider, Ankita Pathak, M. Shahar Yar. Medicinal prospects of antioxidants: A review. European Journal of Medicinal Chemistry 2019;178:687
    https://doi.org/10.1016/j.ejmech.2019.06.010
  22. Maciej Spiegel. Unveiling the Antioxidative Potential of Galangin: Complete and Detailed Mechanistic Insights through Density Functional Theory Studies. J. Org. Chem. 2024;89:8676
    https://doi.org/10.1021/acs.joc.4c00611
  23. Wan Muhammad Hilmi Wan Yaacob, Idris Long, Rahimah Zakaria, Zahiruddin Othman. Tualang honey and its methanolic fraction ameliorate lipopolysaccharide-induced oxidative stress, amyloid deposition and neuronal loss of the rat hippocampus. ADV TRADIT MED (ADTM) 2021;21:121
    https://doi.org/10.1007/s13596-020-00449-3
  24. Anna A. Pimenova, Manon Herbinet, Ishaan Gupta, Saima I. Machlovi, Kathryn R. Bowles, Edoardo Marcora, Alison M. Goate. Alzheimer's-associated PU.1 expression levels regulate microglial inflammatory response. Neurobiology of Disease 2021;148:105217
    https://doi.org/10.1016/j.nbd.2020.105217
  25. Mohamed F. Abdel Rahman, Enas Elhawary, Ahmed M. Hafez, Esra Capanoglu, Yajing Fang, Mohamed A. Farag. How does olive seed chemistry, health benefits and action mechanisms compare to its fruit oil? A comprehensive review for valorization purposes and maximizing its health benefits. Food Bioscience 2024;59:104017
    https://doi.org/10.1016/j.fbio.2024.104017
  26. Óscar M. Bautista‐Aguilera, Stefanie Hagenow, Alejandra Palomino‐Antolin, Víctor Farré‐Alins, Lhassane Ismaili, Pierre‐Louis Joffrin, María L. Jimeno, Ondřej Soukup, Jana Janočková, Lena Kalinowsky, Ewgenij Proschak, Isabel Iriepa, Ignacio Moraleda, Johannes S. Schwed, Alejandro Romero Martínez, Francisco López‐Muñoz, Mourad Chioua, Javier Egea, Rona R. Ramsay, José Marco‐Contelles, Holger Stark. Multipotente Liganden mit kombinierter Cholinesterase‐ und Monoaminooxidase‐Inhibition sowie Histamin‐H3R‐Antagonismus bei neurodegenerativen Erkrankungen. Angewandte Chemie 2017;129:12939
    https://doi.org/10.1002/ange.201706072
  27. Kerry C. Ryan, Jocelyn T. Laboy, Kenneth R. Norman. Deregulation of Mitochondrial Calcium Handling Due to Presenilin Loss Disrupts Redox Homeostasis and Promotes Neuronal Dysfunction. Antioxidants 2022;11:1642
    https://doi.org/10.3390/antiox11091642
  28. Lena Hoffmann, Marcel S. Waclawczyk, Stephan Tang, Eva-Maria Hanschmann, Manuela Gellert, Marco B. Rust, Carsten Culmsee. Cofilin1 oxidation links oxidative distress to mitochondrial demise and neuronal cell death. Cell Death Dis 2021;12
    https://doi.org/10.1038/s41419-021-04242-1
  29. Mi Yang, Xiaofei Zhou, Xi Tan, Xincheng Huang, Lu Yuan, Zipeng Zhang, Yan Yang, Min Xu, Ying Wan, Zezhi Li. The Status of Oxidative Stress in Patients with Alcohol Dependence: A Meta-Analysis. Antioxidants 2022;11:1919
    https://doi.org/10.3390/antiox11101919
  30. Divinah Manoharan, Liu‐Chun Wang, Ying‐Chi Chen, Wei‐Peng Li, Chen‐Sheng Yeh. Catalytic Nanoparticles in Biomedical Applications: Exploiting Advanced Nanozymes for Therapeutics and Diagnostics. Adv Healthcare Materials 2024;13
    https://doi.org/10.1002/adhm.202400746
  31. Ochuko L. Erukainure, Omamuyovwi M. Ijomone, Olakunle Sanni, Michael Aschner, Md. Shahidul Islam. Type 2 diabetes induced oxidative brain injury involves altered cerebellar neuronal integrity and elemental distribution, and exacerbated Nrf2 expression: therapeutic potential of raffia palm (Raphia hookeri) wine. Metab Brain Dis 2019;34:1385
    https://doi.org/10.1007/s11011-019-00444-x
  32. Dmitry S. Semenovich, Egor Yu. Plotnikov, Oksana V. Titko, Elena P. Lukiyenko, Nina P. Kanunnikova. Effects of Panthenol and N-Acetylcysteine on Changes in the Redox State of Brain Mitochondria under Oxidative Stress In Vitro. Antioxidants 2021;10:1699
    https://doi.org/10.3390/antiox10111699
  33. Rui Li, Wenzhou Liu, Li Ou, Feng Gao, Min Li, Liping Wang, Peifeng Wei, Feng Miao. Emodin Alleviates Hydrogen Peroxide-Induced Inflammation and Oxidative Stress via Mitochondrial Dysfunction by Inhibiting the PI3K/mTOR/GSK3β Pathway in Neuroblastoma SH-SY5Y Cells. BioMed Research International 2020;2020:1
    https://doi.org/10.1155/2020/1562915
  34. Cristina Angeloni, Marco Malaguti, Cecilia Prata, Michela Freschi, Maria Barbalace, Silvana Hrelia. Mechanisms Underlying Neurodegenerative Disorders and Potential Neuroprotective Activity of Agrifood By-Products. Antioxidants 2022;12:94
    https://doi.org/10.3390/antiox12010094
  35. Yoonjin Park, Mihae Yun, Seunggwan Lee, Boyong Kim. Protective Effects of Allium senescens Extract against 6-Hydroxydopamine in Neurons. Applied Sciences 2024;14:5579
    https://doi.org/10.3390/app14135579
  36. Javad Sharifi-Rad, Simona Rapposelli, Simona Sestito, Jesús Herrera-Bravo, Alejandra Arancibia-Diaz, Luis A. Salazar, Balakyz Yeskaliyeva, Ahmet Beyatli, Gerardo Leyva-Gómez, Carlos González-Contreras, Eda Sönmez Gürer, Miquel Martorell, Daniela Calina. Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation. JPM 2022;12:1515
    https://doi.org/10.3390/jpm12091515
  37. Dimitar Tonev, Albena Momchilova. Oxidative Stress and the Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Pathway in Multiple Sclerosis: Focus on Certain Exogenous and Endogenous Nrf2 Activators and Therapeutic Plasma Exchange Modulation. IJMS 2023;24:17223
    https://doi.org/10.3390/ijms242417223
  38. Tingting Wen, Zhaohui Zhang. Cellular mechanisms of fibrin (ogen): insight from neurodegenerative diseases. Front. Neurosci. 2023;17
    https://doi.org/10.3389/fnins.2023.1197094
  39. Nermin M. Madi, Mervat H. El-Saka. The possible protective effect of lactoferrin on lipopolysaccharide-induced memory impairment in albino rats. Alexandria Journal of Medicine 2018;54:295
    https://doi.org/10.1016/j.ajme.2018.05.003
  40. Jingxing Zhang, Weifang Tong, Hui Sun, Ming Jiang, Yijue Shen, Yigang Liu, Hua Gu, Jia Guo, Jianmin Fang, Lingjing Jin. Nrf2-mediated neuroprotection by MANF against 6-OHDA-induced cell damage via PI3K/AKT/GSK3β pathway. Experimental Gerontology 2017;100:77
    https://doi.org/10.1016/j.exger.2017.10.021
  41. Elif Oguz, Berna Terzioglu Bebitoglu, Gokce Acet, Ajla Hodzic, Nebile Hatiboglu, Saniye Ada. Effect of lycopene on As2O3 induced oxidative stress in SH-SY5Y cells. Mol Biol Rep 2021;48:3205
    https://doi.org/10.1007/s11033-021-06377-y
  42. Vinayak Uppin, Pooja Acharya, Kempaiah Bettadaiah Bheemanakere, Ramaprasad Ravichandra Talahalli. Hyperlipidemia Downregulate Brain Antioxidant Defense Enzymes and Neurotrophins in Rats: Assessment of the Modulatory Potential of EPA+DHA and Zerumbone. Molecular Nutrition Food Res 2020;64
    https://doi.org/10.1002/mnfr.202000381
  43. Mohit Kumar, Palkin Arora, Rajat Sandhir. Hydrogen Sulfide Reverses LPS-Induced Behavioral Deficits by Suppressing Microglial Activation and Promoting M2 Polarization. J Neuroimmune Pharmacol 2021;16:483
    https://doi.org/10.1007/s11481-020-09920-z
  44. Tikam Chand Dakal, Kanika Choudhary, Isha Tiwari, Vikas Yadav, Pawan Kumar Maurya, Narendra Kumar Sharma. Unraveling the Triad: Hypoxia, Oxidative Stress and Inflammation in Neurodegenerative Disorders. Neuroscience 2024;552:126
    https://doi.org/10.1016/j.neuroscience.2024.06.021
  45. Svetlana A. Khmeleva, Sergey P. Radko, Sergey A. Kozin, Yana Y. Kiseleva, Yuri V. Mezentsev, Vladimir A. Mitkevich, Leonid K. Kurbatov, Alexis S. Ivanov, Alexander A. Makarov, Natalia Stefanova. Zinc-Mediated Binding of Nucleic Acids to Amyloid-β Aggregates: Role of Histidine Residues. JAD 2016;54:809
    https://doi.org/10.3233/JAD-160415
  46. Yu-Chiu Kao, Yu-Cing Liao, Pei-Lin Cheng, Chau-Hwang Lee. Neurite regrowth stimulation by a red-light spot focused on the neuronal cell soma following blue light-induced retraction. Sci Rep 2019;9
    https://doi.org/10.1038/s41598-019-54687-w
  47. Narayanaperumal Pravin, Krzysztof Jozwiak. Effects of Linkers and Substitutions on Multitarget Directed Ligands for Alzheimer’s Diseases: Emerging Paradigms and Strategies. IJMS 2022;23:6085
    https://doi.org/10.3390/ijms23116085
  48. Junghyung Park, Jinyoung Won, Eunyeoung Yang, Jincheol Seo, Jiyeon Cho, Jung Bae Seong, Hyeon-Gu Yeo, Keonwoo Kim, Yu Gyeong Kim, Minji Kim, Chang-Yeop Jeon, Kyung Seob Lim, Dong-Seok Lee, Youngjeon Lee. Peroxiredoxin 1 inhibits streptozotocin-induced Alzheimer’s disease-like pathology in hippocampal neuronal cells via the blocking of Ca2+/Calpain/Cdk5-mediated mitochondrial fragmentation. Sci Rep 2024;14
    https://doi.org/10.1038/s41598-024-66256-x
  49. Andrea Bacci, Massimiliano Runfola, Simona Sestito, Simona Rapposelli. Beyond Antioxidant Effects: Nature-Based Templates Unveil New Strategies for Neurodegenerative Diseases. Antioxidants 2021;10:367
    https://doi.org/10.3390/antiox10030367
  50. Nurul ‘Izzah Ibrahim, Nur Balqis Muhammad Ismail Tadj, Md. Moklesur Rahman Sarker, Isa Naina Mohamed. The Potential Mechanisms of the Neuroprotective Actions of Oil Palm Phenolics: Implications for Neurodegenerative Diseases. Molecules 2020;25:5159
    https://doi.org/10.3390/molecules25215159
  51. Negin Nouraei, Lauren Zarger, Justin N. Weilnau, Jimin Han, Daniel M. Mason, Rehana K. Leak. Investigation of the therapeutic potential of N-acetyl cysteine and the tools used to define nigrostriatal degeneration in vivo. Toxicology and Applied Pharmacology 2016;296:19
    https://doi.org/10.1016/j.taap.2016.02.010
  52. Silvia Cellone Trevelin, Ajay M. Shah, Giovanna Lombardi. Beyond bacterial killing: NADPH oxidase 2 is an immunomodulator. Immunology Letters 2020;221:39
    https://doi.org/10.1016/j.imlet.2020.02.009
  53. Lei An, Mengxue Li, Cunen Zou, Ke Wang, Wei Zhang, Xiaolong Huang, Yousheng Wang. Walnut polyphenols and the active metabolite urolithin A improve oxidative damage in SH-SY5Y cells by up-regulating PKA/CREB/BDNF signaling. Food Funct. 2023;14:2698
    https://doi.org/10.1039/D2FO03310K
  54. Jianda Kong, Rao Fan, Yuanqi Zhang, Zixuan Jia, Jing Zhang, Huixin Pan, Qinglu Wang. Oxidative stress in the brain–lung crosstalk: cellular and molecular perspectives. Front. Aging Neurosci. 2024;16
    https://doi.org/10.3389/fnagi.2024.1389454
  55. Slim Azouzi, Hubert Santuz, Sandrine Morandat, Catia Pereira, Francine Côté, Olivier Hermine, Karim El Kirat, Yves Colin, Caroline Le Van Kim, Catherine Etchebest, Pascal Amireault. Antioxidant and Membrane Binding Properties of Serotonin Protect Lipids from Oxidation. Biophysical Journal 2017;112:1863
    https://doi.org/10.1016/j.bpj.2017.03.037
  56. Rungtip Soi-ampornkul, Ei Ei Phyo Myint, Wipawan Thangnipon, Nutnicha Tantarungsee, Chalermchai Mitrpant, Patoomratana Tuchinda, Saksit Nobsathian, Chinnavuth Vatanashevanopakorn. N-trans-feruloyltyramine Protects Human Neuroblastoma SK-N-SH Cell Line Against H2O2-Induced Cytotoxicity. Natural Product Communications 2022;17:1934578X2211173
    https://doi.org/10.1177/1934578X221117312
  57. Clea Bárcena, Pablo Mayoral, Pedro M. Quirós. Mitochondria and Longevity. 2022.
    https://doi.org/10.1016/bs.ircmb.2018.05.002
  58. Ming‐ming Xu, Mao‐tian Zhou, Shu‐wei Li, Xue‐chu Zhen, Shuang Yang. Glycoproteins as diagnostic and prognostic biomarkers for neurodegenerative diseases: A glycoproteomic approach. J of Neuroscience Research 2021;99:1308
    https://doi.org/10.1002/jnr.24805
  59. Priyanka Saxena, Kanagarethinam Selvaraj, Sunil Kumar Khare, Nidhee Chaudhary. Superoxide dismutase as multipotent therapeutic antioxidant enzyme: Role in human diseases. Biotechnol Lett 2022;44:1
    https://doi.org/10.1007/s10529-021-03200-3
  60. Magisetty Obulesu. Alzheimer's Disease Theranostics. 2022.
    https://doi.org/10.1016/B978-0-12-816412-9.00003-3
  61. Seung Baek, Bruce Hammock, In-Koo Hwang, Qing Li, Naima Moustaid-Moussa, Yeonhwa Park, Stephen Safe, Nanjoo Suh, Sun-Shin Yi, Darryl Zeldin, Qixin Zhong, Jennifer Bradbury, Matthew Edin, Joan Graves, Hyo-Young Jung, Young-Hyun Jung, Mi-Bo Kim, Woosuk Kim, Jaehak Lee, Hong Li, Jong-Seok Moon, Ik-Dong Yoo, Yiren Yue, Ji-Young Lee, Ho-Jae Han. Natural Products in the Prevention of Metabolic Diseases: Lessons Learned from the 20th KAST Frontier Scientists Workshop. Nutrients 2021;13:1881
    https://doi.org/10.3390/nu13061881
  62. Esma Yagdi, Claudia Cerella, Mario Dicato, Marc Diederich. Garlic-derived natural polysulfanes as hydrogen sulfide donors: Friend or foe?. Food and Chemical Toxicology 2016;95:219
    https://doi.org/10.1016/j.fct.2016.07.016
  63. Carla I. Nieto, María Pilar Cornago, María Pilar Cabildo, Dionisia Sanz, Rosa M. Claramunt, María Carmen Torralba, María Rosario Torres, Diana Martínez Casanova, Yaiza Rebeca Sánchez-Alegre, Esther Escudero, José Luis Lavandera. Evaluation of the Antioxidant and Neuroprotectant Activities of New Asymmetrical 1,3-Diketones. Molecules 2018;23:1837
    https://doi.org/10.3390/molecules23081837
  64. Federica Rey, Alice Balsari, Toniella Giallongo, Sara Ottolenghi, Anna M. Di Giulio, Michele Samaja, Stephana Carelli. Erythropoietin as a Neuroprotective Molecule: An Overview of Its Therapeutic Potential in Neurodegenerative Diseases. ASN Neuro 2019;11:175909141987142
    https://doi.org/10.1177/1759091419871420
  65. Quan Truong Hoang, DaeYong Lee, Dae Gun Choi, Yeu-Chun Kim, Min Suk Shim. Efficient and selective cancer therapy using pro-oxidant drug-loaded reactive oxygen species (ROS)-responsive polypeptide micelles. Journal of Industrial and Engineering Chemistry 2021;95:101
    https://doi.org/10.1016/j.jiec.2020.12.009
  66. Muneeb U. Rehman, Nouroz Sehar, Nawab John Dar, Andleeb Khan, Azher Arafah, Summya Rashid, Shahzada Mudasir Rashid, Majid Ahmad Ganaie. Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: An update on current advances and impediments. Neuroscience & Biobehavioral Reviews 2023;144:104961
    https://doi.org/10.1016/j.neubiorev.2022.104961
  67. Marcus O.W. Grimm, Daniel M. Michaelson, Tobias Hartmann. Omega-3 fatty acids, lipids, and apoE lipidation in Alzheimer's disease: a rationale for multi-nutrient dementia prevention. Journal of Lipid Research 2017;58:2083
    https://doi.org/10.1194/jlr.R076331
  68. Metka Ravnik-Glavač, Katja Goričar, David Vogrinc, Blaž Koritnik, Jakob Gašper Lavrenčič, Damjan Glavač, Vita Dolžan. Genetic Variability of Inflammation and Oxidative Stress Genes Affects Onset, Progression of the Disease and Survival of Patients with Amyotrophic Lateral Sclerosis. Genes 2022;13:757
    https://doi.org/10.3390/genes13050757
  69. Yan He, Junjie Li, Liling Yi, Xiaohuan Li, Man Luo, Yayan Pang, Maoju Wang, Zhaolun Li, Mingliang Xu, Zhifang Dong, Yehong Du, Ling-Qiang Zhu. Octadecaneuropeptide Ameliorates Cognitive Impairments Through Inhibiting Oxidative Stress in Alzheimer’s Disease Models. JAD 2023;92:1413
    https://doi.org/10.3233/JAD-221115
  70. Tobore Onojighofia Tobore. On alcohol disinhibition and inhibition: The intricate relationship between oxidative stress and behavior. Aggression and Violent Behavior 2020;51:101378
    https://doi.org/10.1016/j.avb.2020.101378
  71. Long Binh Vong, Yukio Nagasaki. Targeted Nanosystems for Therapeutic Applications: New Concepts, Dynamic Properties, Efficiency, and Toxicity. 2020.
    https://doi.org/10.1021/bk-2019-1309.ch012
  72. Hyo Won Lee, Vinayak Juvekar, Dong Joon Lee, Hwan Myung Kim. Recent advances in organelle-specific two-photon small-molecule fluorescent probes for bioanalysis in live tissues. TrAC Trends in Analytical Chemistry 2023;165:117128
    https://doi.org/10.1016/j.trac.2023.117128
  73. Carmen Peña-Bautista, Lourdes Álvarez, Thierry Durand, Claire Vigor, Ana Cuevas, Miguel Baquero, Máximo Vento, David Hervás, Consuelo Cháfer-Pericás. Clinical Utility of Plasma Lipid Peroxidation Biomarkers in Alzheimer’s Disease Differential Diagnosis. Antioxidants 2020;9:649
    https://doi.org/10.3390/antiox9080649
  74. Ashraf Albrakati. The potential neuroprotective of luteolin against acetamiprid-induced neurotoxicity in the rat cerebral cortex. Front. Vet. Sci. 2024;11
    https://doi.org/10.3389/fvets.2024.1361792
  75. B. Haridevamuthu, Tamilvelan Manjunathan, Ajay Guru, Carlton Ranjith Wilson Alphonse, Seenivasan Boopathi, Raghul Murugan, Mansour K. Gatasheh, Ashraf Atef Hatamleh, Annie Juliet, Pushparathinam Gopinath, Jesu Arockiaraj. Amelioration of acrylamide induced neurotoxicity by benzo[b]thiophene analogs via glutathione redox dynamics in zebrafish larvae. Brain Research 2022;1788:147941
    https://doi.org/10.1016/j.brainres.2022.147941
  76. Ava Nasrolahi, Javad Mahmoudi, Ali Noori-Zadeh, Karimeh Haghani, Salar Bakhtiyari, Shahram Darabi. Shared Pathological Mechanisms Between Diabetes Mellitus and Neurodegenerative Diseases. Curr Pharmacol Rep 2019;5:219
    https://doi.org/10.1007/s40495-019-00191-8
  77. Ji Zhang, Wen Chai, Zhengbing Xiang, Xinhua Zhou, Ping Zhang. MZF1 alleviates oxidative stress and apoptosis induced by rotenone in SH-SY5Y cells by promoting RBM3 transcription. J. Toxicol. Sci. 2021;46:477
    https://doi.org/10.2131/jts.46.477
  78. Kirti Wasnik, Prem Shankar Gupta, Gurmeet Singh, Somedutta Maity, Sukanya Patra, Divya Pareek, Sandeep Kumar, Vipin Rai, Ravi Prakash, Arbind Acharya, Pralay Maiti, Sudip Mukherjee, Yitzhak Mastai, Pradip Paik. Neurogenic and angiogenic poly(N-acryloylglycine)-co-(acrylamide)-co-(N-acryloyl-glutamate) hydrogel: preconditioning effect under oxidative stress and use in neuroregeneration. J. Mater. Chem. B 2024;12:6221
    https://doi.org/10.1039/D4TB00243A
  79. Soudeh Ghafouri-Fard, Hamed Shoorei, Mohammad Taheri. Non-coding RNAs are involved in the response to oxidative stress. Biomedicine & Pharmacotherapy 2020;127:110228
    https://doi.org/10.1016/j.biopha.2020.110228
  80. Nora Hanke, Abdelhaq Rami. Cerebral Ischemia Induces Iron Deposit, Ferritin Accumulation, Nuclear Receptor Coactivator 4-depletion, and Ferroptosis. CNR 2022;19:47
    https://doi.org/10.2174/1567202619666220321120954
  81. Beihui Liu, Anja G. Teschemacher, Sergey Kasparov. Astroglia as a cellular target for neuroprotection and treatment of neuro‐psychiatric disorders. Glia 2017;65:1205
    https://doi.org/10.1002/glia.23136
  82. Mariana B. Fiadeiro, João C. Diogo, Ana A. Silva, Yoon-Seong Kim, Ana C. Cristóvão. NADPH Oxidases in Neurodegenerative Disorders: Mechanisms and Therapeutic Opportunities. Antioxidants & Redox Signaling 2024
    https://doi.org/10.1089/ars.2023.0002
  83. Guangtao Yang, Wei Zhou, Minhong Zhang, Xiaohuan Zhong, Haili Qiu, Yingping Xiang, Zhimin Zhang, Peimao Li, Dianpeng Wang. Induced oxidative stress and apoptosis by 1-bromopropane in SH-SY5Y cells correlates with inhibition of Nrf2 function. Drug and Chemical Toxicology 2024;47:756
    https://doi.org/10.1080/01480545.2023.2288795
  84. Ángel Rodríguez-Huamán, Sandra Casimiro-Gonzales, Jorge Antonio Chávez-Pérez, Carla Gonzales-Arimborgo, Richard Cisneros-Fernández, Luis Ángel Aguilar-Mendoza, Gustavo F. Gonzales. Antioxidant and neuroprotector effect of Lepidium meyenii (maca) methanol leaf extract against 6-hydroxy dopamine (6-OHDA)-induced toxicity in PC12 cells. Toxicology Mechanisms and Methods 2017;27:279
    https://doi.org/10.1080/15376516.2016.1275908
  85. John Means, Bryan Gerdes, Peter Koulen. Distinct Mechanisms Underlying Resveratrol-Mediated Protection from Types of Cellular Stress in C6 Glioma Cells. IJMS 2017;18:1521
    https://doi.org/10.3390/ijms18071521
  86. Tobore Onojighofia Tobore. On the potential harmful effects of E‐Cigarettes (EC) on the developing brain: The relationship between vaping‐induced oxidative stress and adolescent/young adults social maladjustment.. Journal of Adolescence 2019;76:202
    https://doi.org/10.1016/j.adolescence.2019.09.004
  87. Diogo Carregosa, Sara Mota, Sofia Ferreira, Beatriz Alves-Dias, Natasa Loncarevic-Vasiljkovic, Carolina Lage Crespo, Regina Menezes, Rita Teodoro, Cláudia Nunes dos Santos. Overview of Beneficial Effects of (Poly)phenol Metabolites in the Context of Neurodegenerative Diseases on Model Organisms. Nutrients 2021;13:2940
    https://doi.org/10.3390/nu13092940
  88. Anam Shabbir, Kanwal Rehman, Moazzama Akbar, Muhammad Sajid Hamid Akash. Neuroprotective Potential of Curcuminoids in Modulating Alzheimer’s Disease via Multiple Signaling Pathways. CMC 2022;29:5560
    https://doi.org/10.2174/0929867329666220607161328
  89. Miguel Reina, Eduardo Gabriel Guzmán‐López, Annia Galano. Computational design of rasagiline derivatives: Searching for enhanced antioxidant capability. Int J of Quantum Chemistry 2023;123
    https://doi.org/10.1002/qua.27011
  90. Sajid Maqsood, Oladipupo Adiamo, Mudasir Ahmad, Priti Mudgil. Bioactive compounds from date fruit and seed as potential nutraceutical and functional food ingredients. Food Chemistry 2020;308:125522
    https://doi.org/10.1016/j.foodchem.2019.125522
  91. Huifang Cao, Lichao Zhang, Zhenzhen Qu, Shuang Tian, Zhiyong Wang, Yuhang Jiang, Qian Hou, Lijing Jia, Weiping Wang. The protective effect of hydroxylated fullerene pretreatment on pilocarpine-induced status epilepticus. Brain Research 2021;1764:147468
    https://doi.org/10.1016/j.brainres.2021.147468
  92. Nathan C. Winn, Katrina M. Volk, Alyssa H. Hasty. Regulation of tissue iron homeostasis: the macrophage “ferrostat”. 2020;5
    https://doi.org/10.1172/jci.insight.132964
  93. Nicholas J. Day, Tong Zhang, Matthew J. Gaffrey, Rui Zhao, Thomas L. Fillmore, Ronald J. Moore, George G. Rodney, Wei-Jun Qian. A deep redox proteome profiling workflow and its application to skeletal muscle of a Duchenne Muscular Dystrophy model. Free Radical Biology and Medicine 2022;193:373
    https://doi.org/10.1016/j.freeradbiomed.2022.10.300
  94. Tao Ma, Ye Zhang, Kai Fu, Zhichun Li, Changchun Yuan, Wenbing Ma. Design, synthesis and properties of hydrogen peroxide fluorescent probe based on benzothiazole. Bioorganic Chemistry 2022;123:105798
    https://doi.org/10.1016/j.bioorg.2022.105798
  95. Josiel M. Mack, Tainara M. Moura, Débora Lanznaster, Franciane Bobinski, Caio M. Massari, Tuane B. Sampaio, Ariana E. Schmitz, Luiz F. Souza, Roger Walz, Carla I. Tasca, Anicleto Poli, Richard L. Doty, Alcir L. Dafre, Rui D. Prediger. Intranasal administration of sodium dimethyldithiocarbamate induces motor deficits and dopaminergic dysfunction in mice. NeuroToxicology 2018;66:107
    https://doi.org/10.1016/j.neuro.2018.03.011
  96. Chanchai Boonla. Reactive Oxygen Species (ROS) in Living Cells. 2018.
    https://doi.org/10.5772/intechopen.75366
  97. Shiori Ando, Michinori Funato, Kazuki Ohuchi, Tsubasa Kameyama, Satoshi Inagaki, Junko Seki, Chizuru Kawase, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideo Kaneko, Hideaki Hara. Edaravone is a candidate agent for spinal muscular atrophy: In vitro analysis using a human induced pluripotent stem cells-derived disease model. European Journal of Pharmacology 2017;814:161
    https://doi.org/10.1016/j.ejphar.2017.08.005
  98. Liang Yang, Bing Xu, Chunxu Yuan, Zhi Dai, Yong Wang, Qiongya Li, Qifan Yang, Nuomin Li, Hong Qing. The Antioxidative Action of ZTP by Increasing Nrf2/ARE Signal Pathway. Evidence-Based Complementary and Alternative Medicine 2019;2019:1
    https://doi.org/10.1155/2019/5421528
  99. Daisuke Matsumaru, Hozumi Motohashi. The KEAP1-NRF2 System in Healthy Aging and Longevity. Antioxidants 2021;10:1929
    https://doi.org/10.3390/antiox10121929
  100. Osama A. Mohammed, Mohammed S. Elballal, Ahmed A. El-Husseiny, Emad Gamil Khidr, Manar Mohammed El Tabaa, Ola Elazazy, Mai A. Abd-Elmawla, Ahmed E. Elesawy, Henwa M. Ibrahim, Ahmed I. Abulsoud, Walaa A. El-Dakroury, Sherif S. Abdel Mageed, Mahmoud A. Elrebehy, Yousra Nomier, Mustafa Ahmed Abdel-Reheim, Hussein M. El-Husseiny, Abdulla M.A. Mahmoud, Sameh Saber, Ahmed S. Doghish. Unraveling the role of miRNAs in the diagnosis, progression, and therapeutic intervention of Parkinson’s disease. Pathology - Research and Practice 2024;253:155023
    https://doi.org/10.1016/j.prp.2023.155023
  101. Yingying Cong, Vincent So, Marina A. J. Tijssen, Dineke S. Verbeek, Fulvio Reggiori, Mario Mauthe. WDR45, one gene associated with multiple neurodevelopmental disorders. Autophagy 2021;17:3908
    https://doi.org/10.1080/15548627.2021.1899669
  102. Justine Demay, Cécile Bernard, Anita Reinhardt, Benjamin Marie. Natural Products from Cyanobacteria: Focus on Beneficial Activities. Marine Drugs 2019;17:320
    https://doi.org/10.3390/md17060320
  103. Mohammad Panahi, Bahareh Rahimi, Golbarg Rahimi, Teck Yew Low, Neda Saraygord‐Afshari, Effat Alizadeh. Cytoprotective effects of antioxidant supplementation on mesenchymal stem cell therapy. Journal Cellular Physiology 2020;235:6462
    https://doi.org/10.1002/jcp.29660
  104. Akira Uruno, Daisuke Matsumaru, Rie Ryoke, Ritsumi Saito, Shiori Kadoguchi, Daisuke Saigusa, Takashi Saito, Takaomi C. Saido, Ryuta Kawashima, Masayuki Yamamoto. Nrf2 Suppresses Oxidative Stress and Inflammation inAppKnock-In Alzheimer’s Disease Model Mice. Molecular and Cellular Biology 2020;40
    https://doi.org/10.1128/MCB.00467-19
  105. Pungbili Islary, Rajesh Kumar Meher, Suparna Biswas, Derhasat Basumatary, Indra Bhusan Basumatary, Debasmita Dubey, Deepak Basumatary, Rebecca Daimari. Evaluation of anticancer, immunomodulatory and anti-inflammatory potential of antioxidant rich Anzia ornatoides, a lichen species from eastern Himalayan region. South African Journal of Botany 2024;164:266
    https://doi.org/10.1016/j.sajb.2023.11.037
  106. Taiwo Olayemi Elufioye, Tomayo Ireti Berida, Solomon Habtemariam, Olumayokun A. Olajide. Plants‐Derived Neuroprotective Agents: Cutting the Cycle of Cell Death through Multiple Mechanisms. Evidence-Based Complementary and Alternative Medicine 2017;2017
    https://doi.org/10.1155/2017/3574012
  107. Elena Sidorova-Darmos, Rosa Sommer, James H. Eubanks. The Role of SIRT3 in the Brain Under Physiological and Pathological Conditions. Front. Cell. Neurosci. 2018;12
    https://doi.org/10.3389/fncel.2018.00196
  108. Panagiotis Theodosis-Nobelos, Eleni A. Rekka. The Antioxidant Potential of Vitamins and Their Implication in Metabolic Abnormalities. Nutrients 2024;16:2740
    https://doi.org/10.3390/nu16162740
  109. Rossana Migheli, Giada Lostia, Grazia Galleri, Gaia Rocchitta, Pier Andrea Serra, Ilaria Campesi, Valentina Bassareo, Elio Acquas, Alessandra T. Peana. New perspective for an old drug: Can naloxone be considered an antioxidant agent?. Biochemistry and Biophysics Reports 2023;34:101441
    https://doi.org/10.1016/j.bbrep.2023.101441
  110. A. G Moiseenok, N. P Kanunnikova. Brain CoA and acetyl CoA system in mechanisms of neurodegeneration. Biohimiâ 2023;88:569
    https://doi.org/10.31857/S0320972523040036
  111. Noemí Echegaray, Mirian Pateiro, Beatriz Gullón, Ryszard Amarowicz, Jane M. Misihairabgwi, José M. Lorenzo. Phoenix dactylifera products in human health – A review. Trends in Food Science & Technology 2020;105:238
    https://doi.org/10.1016/j.tifs.2020.09.017
  112. Yosup Kim, Ho Hee Jang. Role of Cytosolic 2-Cys Prx1 and Prx2 in Redox Signaling. Antioxidants 2019;8:169
    https://doi.org/10.3390/antiox8060169
  113. Despoina Eleftheriadou, Despoina Kesidou, Francisco Moura, Eric Felli, Wenhui Song. Redox‐Responsive Nanobiomaterials‐Based Therapeutics for Neurodegenerative Diseases. Small 2020;16
    https://doi.org/10.1002/smll.201907308
  114. Qiang Li, Wenbin Zhou, Yuyan Wang, Fang Kou, Chunming Lyu, Hai Wei. Metabolic mechanism and anti-inflammation effects of sinomenine and its major metabolites N-demethylsinomenine and sinomenine-N-oxide. Life Sciences 2020;261:118433
    https://doi.org/10.1016/j.lfs.2020.118433
  115. Janaína Niero Mazon, Aline Haas de Mello, Gabriela Kozuchovski Ferreira, Gislaine Tezza Rezin. The impact of obesity on neurodegenerative diseases. Life Sciences 2017;182:22
    https://doi.org/10.1016/j.lfs.2017.06.002
  116. Samar A. Salim, Taher A. Salaheldin, Mohamed M. Elmazar, A. F. Abdel-Aziz, Elbadawy A. Kamoun. Smart biomaterials for enhancing cancer therapy by overcoming tumor hypoxia: a review. RSC Adv. 2022;12:33835
    https://doi.org/10.1039/D2RA06036A
  117. Lin Wang, Bing-Jin Liu, Yun Cao, Wei-Qi Xu, Dong-Sheng Sun, Meng-Zhu Li, Fang-Xiao Shi, Man Li, Qing Tian, Jian-Zhi Wang, Xin-Wen Zhou. Deletion of Type-2 Cannabinoid Receptor Induces Alzheimer’s Disease-Like Tau Pathology and Memory Impairment Through AMPK/GSK3β Pathway. Mol Neurobiol 2018;55:4731
    https://doi.org/10.1007/s12035-017-0676-2
  118. Emma F. Smith, Pamela J. Shaw, Kurt J. De Vos. The role of mitochondria in amyotrophic lateral sclerosis. Neuroscience Letters 2019;710:132933
    https://doi.org/10.1016/j.neulet.2017.06.052
  119. Carlos Fernández-Moriano, Elena González-Burgos, Irene Iglesias, Rafael Lozano, M. Pilar Gómez-Serranillos, Mahesh Narayan. Evaluation of the adaptogenic potential exerted by ginsenosides Rb1 and Rg1 against oxidative stress-mediated neurotoxicity in an in vitro neuronal model. PLoS ONE 2017;12:e0182933
    https://doi.org/10.1371/journal.pone.0182933
  120. Chen-Wen Li, Lan-Lan Li, Sheng Chen, Jian-Xiang Zhang, Wan-Liang Lu. Antioxidant Nanotherapies for the Treatment of Inflammatory Diseases. Front. Bioeng. Biotechnol. 2020;8
    https://doi.org/10.3389/fbioe.2020.00200
  121. Nataliya Salyha, Yuriy Salyha. Protective role of l-glutamic acid and l-cysteine in mitigation the chlorpyrifos-induced oxidative stress in rats. Environmental Toxicology and Pharmacology 2018;64:155
    https://doi.org/10.1016/j.etap.2018.10.010
  122. Michael R. Volkert, David J. Crowley. Preventing Neurodegeneration by Controlling Oxidative Stress: The Role of OXR1. Front. Neurosci. 2020;14
    https://doi.org/10.3389/fnins.2020.611904
  123. Junliang Qian, Huiyin Tu, Dongze Zhang, Aaron N. Barksdale, Kaushik P. Patel, Michael C. Wadman, Yu-Long Li. Therapeutic effects of masitinib on abnormal mechanoreception in a mouse model of tourniquet-induced extremity ischemia-reperfusion. European Journal of Pharmacology 2021;911:174549
    https://doi.org/10.1016/j.ejphar.2021.174549
  124. Wing-Fai Yap, Vangene Tay, Sie-Hui Tan, Yoon-Yen Yow, Jactty Chew. Decoding Antioxidant and Antibacterial Potentials of Malaysian Green Seaweeds: Caulerpa racemosa and Caulerpa lentillifera. Antibiotics 2019;8:152
    https://doi.org/10.3390/antibiotics8030152
  125. Emily Leung, Lili-Naz Hazrati. Breast cancer type 1 and neurodegeneration: consequences of deficient DNA repair. 2021;3
    https://doi.org/10.1093/braincomms/fcab117
  126. Ruoyu Zhang, Xiaotong Chen, Yuanyuan Cheng, Zixuan Chen, Xiaoqiong Li, Yulin Deng. Recent advances of nanomaterials for intervention in Parkinson’s disease in the context of anti-inflammation. Coordination Chemistry Reviews 2024;502:215616
    https://doi.org/10.1016/j.ccr.2023.215616
  127. Jinggong Guo, Shan Shen, Xiao Zhang, Guoying Wang, Yiqing Lu, Xiping Liu, Shuyun Wang, Qin Li, Yue Cong, Bingyang Shi. Chemical compounds with a neuroprotective effect from the seeds of Celosia argentea L.. Food Funct. 2021;12:83
    https://doi.org/10.1039/D0FO02033H
  128. Monika Katarzyna Lesiów, Urszula Katarzyna Komarnicka, Agnieszka Kyzioł, Alina Bieńko, Piotr Pietrzyk. ROS-mediated lipid peroxidation as a result of Cu(ii) interaction with FomA protein fragments of F. nucleatum: relevance to colorectal carcinogenesis. Metallomics 2019;11:2066
    https://doi.org/10.1039/C9MT00179D
  129. Alexandre Vallée, Jean-Noël Vallée, Yves Lecarpentier. Parkinson’s Disease: Potential Actions of Lithium by Targeting the WNT/β-Catenin Pathway, Oxidative Stress, Inflammation and Glutamatergic Pathway. Cells 2021;10:230
    https://doi.org/10.3390/cells10020230
  130. Shiv Kumar Kushawaha, Mahendra Singh Ashawat, Ashish Baldi. Neuroprotective Effect of Aurothioglucose-Loaded PLGA Nanoparticles in an Aluminum Chloride-Induced Rat Model of Alzheimer's Disease. RJPT 2024:756
    https://doi.org/10.52711/0974-360X.2024.00118
  131. Sayali Chandrashekhar Deolankar, Prashant Kumar Modi, Yashwanth Subbannayya, Ravishankar Pervaje, Thottethodi Subrahmanya Keshava Prasad. Molecular Targets from Traditional Medicines for Neuroprotection in Human Neurodegenerative Diseases. OMICS: A Journal of Integrative Biology 2020;24:394
    https://doi.org/10.1089/omi.2020.0033
  132. Adem Ahlatcı, Kenan Yıldızhan, Ahmet Şevki Taşkıran. The protective effect of venlafaxine on hydrogen peroxide-induced cytotoxicity in C6 glioma cells. 2024;8:77
    https://doi.org/10.30565/medalanya.1459206
  133. Li Zhu, Ning Ning, Yu Li, Qiu-Fang Zhang, Yong-Chao Xie, Maida Irshad, Xing Feng, Xiao-Jun Tao, Juntra Karbwang. Biatractylolide Modulates PI3K‐Akt‐GSK3β‐Dependent Pathways to Protect against Glutamate‐Induced Cell Damage in PC12 and SH‐SY5Y Cells. Evidence-Based Complementary and Alternative Medicine 2017;2017
    https://doi.org/10.1155/2017/1291458
  134. J.M. Santos, L.C.A. Pereira, C.S. Branco. . 2017.
    https://doi.org/10.1016/B978-0-443-15756-1.00019-7
  135. Shahnawaz Ali Bhat, Ruby Goel, Shubha Shukla, Rakesh Shukla, Kashif Hanif. Angiotensin Receptor Blockade by Inhibiting Glial Activation Promotes Hippocampal Neurogenesis Via Activation of Wnt/β-Catenin Signaling in Hypertension. Mol Neurobiol 2018;55:5282
    https://doi.org/10.1007/s12035-017-0754-5
  136. Ricardo Dias, Helder Oliveira, Iva Fernandes, Jesus Simal-Gandara, Rosa Perez-Gregorio. Recent advances in extracting phenolic compounds from food and their use in disease prevention and as cosmetics. Critical Reviews in Food Science and Nutrition 2021;61:1130
    https://doi.org/10.1080/10408398.2020.1754162
  137. Siti Fatimah Zaharah Mustafa, Mustafa Mat Deris, Teh Sabariah Binti Abd Manan, Salmia Beddu, Nur Liyana Mohd Kamal, Daud Mohamad, Saba Yavari, Sobia Qazi, Zarimah Hanafiah, Shefaa Omar Abu Nassar, Kai Lun Yeoh, Ishmail Sheriff, Wan Hanna Melini Wan Mohtar, Mohamed Hasnain Isa, Mohd Suffian Yusoff, Hamidi Abdul Aziz. Modelling of similarity characteristics of polycyclic aromatic hydrocarbons (PAHs) in Sungai Perak, Malaysia via rough set theory and principal component analysis (PCA). Chemical Physics Letters 2023;828:140721
    https://doi.org/10.1016/j.cplett.2023.140721
  138. Seung Yun Lee, Sun Jin Hur. Protective effect of a 3 kDa peptide obtained from beef myofibrillar protein using alkaline-AK on neuronal cells. Neurochemistry International 2019;129:104459
    https://doi.org/10.1016/j.neuint.2019.05.003
  139. Iipsha Bhaduri, Anchal Trisal, Abhishek Kumar Singh. Emerging Anti-Aging Strategies. 2019.
    https://doi.org/10.1007/978-981-19-7443-4_3
  140. Xiangwen Tang, Peng Deng, Yizhen Jiang, Lingling Zhang, Yuqing He, Hao Yang. An Overview of Recent Advances in the Neuroprotective Potentials of Fisetin against Diverse Insults in Neurological Diseases and the Underlying Signaling Pathways. Biomedicines 2023;11:2878
    https://doi.org/10.3390/biomedicines11112878
  141. Cyrille Garnier, François Devred, Deborah Byrne, Rémy Puppo, Andrei Yu. Roman, Soazig Malesinski, Andrey V. Golovin, Régine Lebrun, Natalia N. Ninkina, Philipp O. Tsvetkov. Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates. Sci Rep 2017;7
    https://doi.org/10.1038/s41598-017-07215-7
  142. Bianca A. Trombetta, Becky C. Carlyle, Aaron M. Koenig, Leslie M. Shaw, John Q. Trojanowski, David A. Wolk, Joseph J. Locascio, Steven E. Arnold, Stephen D. Ginsberg. The technical reliability and biotemporal stability of cerebrospinal fluid biomarkers for profiling multiple pathophysiologies in Alzheimer’s disease. PLoS ONE 2018;13:e0193707
    https://doi.org/10.1371/journal.pone.0193707
  143. Yuanbo Wu, Meiqiao Chen, Jielong Jiang. Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling. Mitochondrion 2019;49:35
    https://doi.org/10.1016/j.mito.2019.07.003
  144. Airton C. Martins, Miriam B. Virgolini, Daiana Silva Ávila, Pablo Scharf, Jung Li, Alexey A. Tinkov, Anatoly V. Skalny, Aaron B. Bowman, João B. T. Rocha, Michael Aschner. Mitochondria in the Spotlight: C. elegans as a Model Organism to Evaluate Xenobiotic-Induced Dysfunction. Cells 2023;12:2124
    https://doi.org/10.3390/cells12172124
  145. Grace F. Crotty, Alberto Ascherio, Michael A. Schwarzschild. Targeting urate to reduce oxidative stress in Parkinson disease. Experimental Neurology 2017;298:210
    https://doi.org/10.1016/j.expneurol.2017.06.017
  146. Zheng Liu, Wei Cai, Ming Lang, Ruizuo Yan, Zhenshen Li, Gaoxiao Zhang, Pei Yu, Yuqiang Wang, Yewei Sun, Zaijun Zhang. Neuroprotective Effects and Mechanisms of Action of Multifunctional Agents Targeting Free Radicals, Monoamine Oxidase B and Cholinesterase in Parkinson’s Disease Model. J Mol Neurosci 2017;61:498
    https://doi.org/10.1007/s12031-017-0891-3
  147. Anchalee Prasansuklab, Tewin Tencomnao. Acanthus ebracteatus leaf extract provides neuronal cell protection against oxidative stress injury induced by glutamate. BMC Complement Altern Med 2018;18
    https://doi.org/10.1186/s12906-018-2340-4
  148. Peter X. Shaw, Travis Stiles, Christopher Douglas, Daisy Ho, Wei Fan, Hongjun Du, Xu Xiao. Oxidative stress, innate immunity, and age-related macular degeneration. 2016;3:196
    https://doi.org/10.3934/molsci.2016.2.196
  149. Liyi Zou, Shaoru Chen, Li Li, Tie Wu. The protective effect of hyperoside on carbon tetrachloride-induced chronic liver fibrosis in mice via upregulation of Nrf2. Experimental and Toxicologic Pathology 2017;69:451
    https://doi.org/10.1016/j.etp.2017.04.001
  150. Ji Hee Kim, Heui Seung Lee, Jun Hyong Ahn, Jae Keun Oh, In Bok Chang, Joon Ho Song, Jee Hye Wee, Chan Yang Min, Dae Myoung Yoo, Hyo Geun Choi. Association Between Thyroid Diseases and Parkinson’s Disease: A Nested Case-Control Study Using a National Health Screening Cohort. JPD 2021;11:211
    https://doi.org/10.3233/JPD-202265
  151. Cristina Eugenia Gallegos, Mariana Bartos, Fernanda Gumilar, Rita Raisman-Vozari, Alejandra Minetti, Carlos Javier Baier. Intranasal glyphosate-based herbicide administration alters the redox balance and the cholinergic system in the mouse brain. NeuroToxicology 2020;77:205
    https://doi.org/10.1016/j.neuro.2020.01.007
  152. Md. Sahab Uddin, Abdullah Al Mamun, Md. Tanvir Kabir, Jamil Ahmad, Philippe Jeandet, Md. Shahid Sarwar, Ghulam Md Ashraf, Lotfi Aleya. Neuroprotective role of polyphenols against oxidative stress-mediated neurodegeneration. European Journal of Pharmacology 2020;886:173412
    https://doi.org/10.1016/j.ejphar.2020.173412
  153. Yoonsu Kim, Minjung Cho, Chan Jang, Jeong Lee, Jong-Sang Kim, Jisun Oh, Jinkyu Lim. Oral Administration of Euonymus alatus Leaf Extract Ameliorates Alzheimer’s Disease Phenotypes in 5xFAD Transgenic Mice. Foods 2024;13:682
    https://doi.org/10.3390/foods13050682
  154. Esteban Rodríguez-Arce, Marianela Saldías. Antioxidant properties of flavonoid metal complexes and their potential inclusion in the development of novel strategies for the treatment against neurodegenerative diseases. Biomedicine & Pharmacotherapy 2021;143:112236
    https://doi.org/10.1016/j.biopha.2021.112236
  155. Hayate Javed, Mohamed Fizur Nagoor Meeran, Niraj Kumar Jha, Ghulam Md Ashraf, Shreesh Ojha. Sesamol: A Phenolic Compound of Health Benefits and Therapeutic Promise in Neurodegenerative Diseases. CTMC 2024;24:797
    https://doi.org/10.2174/0115680266273944231213070916
  156. Mateusz Maciejczyk, Anna Zalewska, Karolina Gerreth. Salivary Redox Biomarkers in Selected Neurodegenerative Diseases. JCM 2020;9:497
    https://doi.org/10.3390/jcm9020497
  157. René Günther, Arun Pal, Chloe Williams, Vitaly L. Zimyanin, Maria Liehr, Cläre von Neubeck, Mechthild Krause, Mrudula G. Parab, Susanne Petri, Norman Kalmbach, Stefan L. Marklund, Jared Sterneckert, Peter Munch Andersen, Florian Wegner, Jonathan D. Gilthorpe, Andreas Hermann. Alteration of Mitochondrial Integrity as Upstream Event in the Pathophysiology of SOD1-ALS. Cells 2022;11:1246
    https://doi.org/10.3390/cells11071246
  158. Zikang Hao, Kerui Liu, Lu Zhou, Ping Chen. Precious but convenient means of prevention and treatment: physiological molecular mechanisms of interaction between exercise and motor factors and Alzheimer’s disease. Front. Physiol. 2023;14
    https://doi.org/10.3389/fphys.2023.1193031
  159. Wongi Seol, Hyejung Kim, Ilhong Son. Urinary Biomarkers for Neurodegenerative Diseases. Exp Neurobiol 2020;29:325
    https://doi.org/10.5607/en20042
  160. Yunhui Cai, Ran Xiao, Yadan Zhang, Diya Xu, Ni Wang, Mengze Han, Yili Zhang, Lin Zhang, Wenhua Zhou. DHPA Protects SH-SY5Y Cells from Oxidative Stress-Induced Apoptosis via Mitochondria Apoptosis and the Keap1/Nrf2/HO-1 Signaling Pathway. Antioxidants 2022;11:1794
    https://doi.org/10.3390/antiox11091794
  161. Yashumati Ratan, Aishwarya Rajput, Ashutosh Pareek, Aaushi Pareek, Vivek Jain, Sonia Sonia, Zeba Farooqui, Ranjeet Kaur, Gurjit Singh. Advancements in Genetic and Biochemical Insights: Unraveling the Etiopathogenesis of Neurodegeneration in Parkinson’s Disease. Biomolecules 2024;14:73
    https://doi.org/10.3390/biom14010073
  162. Sónia C. Correia, Paula I. Moreira. Mitochondrial Biology and Experimental Therapeutics. 2024.
    https://doi.org/10.1007/978-3-319-73344-9_11
  163. Keiichi Ishihara. Factors Affecting Neurodevelopment. 2024.
    https://doi.org/10.1016/B978-0-12-817986-4.00008-0
  164. Nazrana Payal, Lalit Sharma, Aditi Sharma, Yahya Hosan Hobanii, Mashael Ahmed Hakami, Nemat Ali, Summya Rashid, Monika Sachdeva, Monica Gulati, Shivam Yadav, Sridevi Chigurupati, Abhiav Singh, Haroon Khan, Tapan Behl. Understanding the Therapeutic Approaches for Neuroprotection. CPD 2023;29:3368
    https://doi.org/10.2174/0113816128275761231103102125
  165. Monika Kosztelnik, Anita Kurucz, Diana Papp, Emily Jones, Timea Sigmond, Janos Barna, Maria H. Traka, Tamas Lorincz, Andras Szarka, Gabor Banhegyi, Tibor Vellai, Tamas Korcsmaros, Orsolya Kapuy. Suppression ofAMPK/aak‐2by NRF2/SKN‐1 down‐regulates autophagy during prolonged oxidative stress. FASEB j. 2019;33:2372
    https://doi.org/10.1096/fj.201800565RR
  166. Janos Paloczi, Zoltan V. Varga, George Hasko, Pal Pacher. Neuroprotection in Oxidative Stress-Related Neurodegenerative Diseases: Role of Endocannabinoid System Modulation. Antioxidants & Redox Signaling 2018;29:75
    https://doi.org/10.1089/ars.2017.7144
  167. Jeongmin Lee, Poornima D.E. Weerasinghe-Mudiyanselage, Bohye Kim, Sohi Kang, Joong-Sun Kim, Changjong Moon. Particulate matter exposure and neurodegenerative diseases: A comprehensive update on toxicity and mechanisms. Ecotoxicology and Environmental Safety 2023;266:115565
    https://doi.org/10.1016/j.ecoenv.2023.115565
  168. Paula Sienes Bailo, Elena Llorente Martín, Pilar Calmarza, Silvia Montolio Breva, Adrián Bravo Gómez, Adela Pozo Giráldez, Joan J. Sánchez-Pascuala Callau, Juana M. Vaquer Santamaría, Anita Dayaldasani Khialani, Concepción Cerdá Micó, Jordi Camps Andreu, Guillermo Sáez Tormo, Isabel Fort Gallifa. The role of oxidative stress in neurodegenerative diseases and potential antioxidant therapies. 2022;3:342
    https://doi.org/10.1515/almed-2022-0111
  169. Jungnam Kim, Ji Yu Choi, Jeongyeon Seo, Insung S. Choi. Neuroprotective Effect of Cannabidiol Against Hydrogen Peroxide in Hippocampal Neuron Culture. Cannabis and Cannabinoid Research 2021;6:40
    https://doi.org/10.1089/can.2019.0102
  170. Ana M. Ruiz Lopez, Sarah L. Roche, Alice C. Wyse Jackson, Jennifer N. Moloney, Ashleigh M. Byrne, Thomas G. Cotter, Giovanna Mallucci. Pro‐survival redox signalling in progesterone‐mediated retinal neuroprotection. Eur J of Neuroscience 2017;46:1663
    https://doi.org/10.1111/ejn.13604
  171. Huanliang Liu, Wei Zhang, Yanjun Fang, Honglian Yang, Lei Tian, Kang Li, Wenqing Lai, Liping Bian, Bencheng Lin, Xiaohua Liu, Zhuge Xi. Neurotoxicity of aluminum oxide nanoparticles and their mechanistic role in dopaminergic neuron injury involving p53-related pathways. Journal of Hazardous Materials 2020;392:122312
    https://doi.org/10.1016/j.jhazmat.2020.122312
  172. Ekta Singh, Giles Devasahayam. Neurodegeneration by oxidative stress: a review on prospective use of small molecules for neuroprotection. Mol Biol Rep 2020;47:3133
    https://doi.org/10.1007/s11033-020-05354-1
  173. Shahnawaz Ali Bhat, Zoya Fatima, Anika Sood, Rakesh Shukla, Kashif Hanif. The Protective Effects of AT2R Agonist, CGP42112A, Against Angiotensin II-Induced Oxidative Stress and Inflammatory Response in Astrocytes: Role of AT2R/PP2A/NFκB/ROS Signaling. Neurotox Res 2021;39:1991
    https://doi.org/10.1007/s12640-021-00403-4
  174. Yun-zhi Ling, Xiao-hong Li, Li Yu, Ye Zhang, Qi-sheng Liang, Xiao-di Yang, Hong-tao Wang. Protective effects of parecoxib on rat primary astrocytes from oxidative stress induced by hydrogen peroxide. J. Zhejiang Univ. Sci. B 2016;17:692
    https://doi.org/10.1631/jzus.B1600017
  175. Raziye Ozturk Urek, Aylin Oner. Extraction of phenolic compounds from Acinos rotundifolius pers. And evaluation of bioactivities. Biochemical Systematics and Ecology 2024;116:104876
    https://doi.org/10.1016/j.bse.2024.104876
  176. Jacqueline M. Garrick, Toby B. Cole, Theo K. Bammler, James W. MacDonald, Judit Marsillach, Clement E. Furlong, Lucio G. Costa. Paraoxonase 2 deficiency in mice alters motor behavior and causes region-specific transcript changes in the brain. Neurotoxicology and Teratology 2021;87:107010
    https://doi.org/10.1016/j.ntt.2021.107010
  177. Juanjuan Tian, Qing Xu, Xiaomeng Wang, Xueliang Zhang, Xiaohong Chen, Xin Rui, Qiuqin Zhang, Mingsheng Dong, Wei Li. Protective effects and mechanism of Paecilomyces cicadaeTJJ1213 intracellular polysaccharide against H2O2‐induced PC12 cells damage. Chem Biol Drug Des 2023;102:471
    https://doi.org/10.1111/cbdd.14253
  178. Ping Gong, Fang Deng, Wei Zhang, Jin Ji, Jia Liu, Yinan Sun, Jiayu Hu. Tectorigenin attenuates the MPP+‑induced SH‑SY5Y cell damage, indicating a potential beneficial role in Parkinson's disease by oxidative stress inhibition. Exp Ther Med 2017
    https://doi.org/10.3892/etm.2017.5049
  179. Ján Elečko, Mária Vilková, Richard Frenák, Deepti Routray, Dajana Ručová, Martin Bačkor, Michal Goga. A Comparative Study of Isolated Secondary Metabolites from Lichens and Their Antioxidative Properties. Plants 2022;11:1077
    https://doi.org/10.3390/plants11081077
  180. Alexandre Vallée, Yves Lecarpentier, Rémy Guillevin, Jean-Noël Vallée. Thermodynamics in Neurodegenerative Diseases: Interplay Between Canonical WNT/Beta-Catenin Pathway–PPAR Gamma, Energy Metabolism and Circadian Rhythms. Neuromol Med 2018;20:174
    https://doi.org/10.1007/s12017-018-8486-x
  181. Sajad Fakhri, Ina Yosifova Aneva, Mohammad Hosein Farzaei, Eduardo Sobarzo-Sánchez. The Neuroprotective Effects of Astaxanthin: Therapeutic Targets and Clinical Perspective. Molecules 2019;24:2640
    https://doi.org/10.3390/molecules24142640
  182. T. Squillaro, A. Cimini, G. Peluso, A. Giordano, M.A.B. Melone. Nano-delivery systems for encapsulation of dietary polyphenols: An experimental approach for neurodegenerative diseases and brain tumors. Biochemical Pharmacology 2018;154:303
    https://doi.org/10.1016/j.bcp.2018.05.016
  183. Prakash Kharel, Naveen Kumar Singhal, Thulasi Mahendran, Nicole West, Brintha Croos, Joram Rana, Lindsey Smith, Ernest Freeman, Ansuman Chattopadhyay, Jennifer McDonough, Soumitra Basu. NAT8L mRNA oxidation is linked to neurodegeneration in multiple sclerosis. Cell Chemical Biology 2023;30:308
    https://doi.org/10.1016/j.chembiol.2023.02.007
  184. Dillon J. Rinauro, Fabrizio Chiti, Michele Vendruscolo, Ryan Limbocker. Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases. Mol Neurodegeneration 2024;19
    https://doi.org/10.1186/s13024-023-00651-2
  185. Amita Daverey, Sandeep K. Agrawal. Curcumin alleviates oxidative stress and mitochondrial dysfunction in astrocytes. Neuroscience 2016;333:92
    https://doi.org/10.1016/j.neuroscience.2016.07.012
  186. Jianqiao Liao, Yifan Nai, Li Feng, Yimeng Chen, Mei Li, Huaide Xu. Walnut Oil Prevents Scopolamine-Induced Memory Dysfunction in a Mouse Model. Molecules 2020;25:1630
    https://doi.org/10.3390/molecules25071630
  187. Weiyi Chu, Chia Wei Phan, Seng Joe Lim, Abdul Salam Babji. Insights on the molecular mechanism of neuroprotection exerted by edible bird’s nest and its bioactive constituents. Food Science and Human Wellness 2023;12:1008
    https://doi.org/10.1016/j.fshw.2022.10.021
  188. Qian Tan, Danfang Yu, Lin Song. Atorvastatin disrupts primary human brain microvascular endothelial cell functions via prenylation‐dependent mitochondrial inhibition and oxidative stress. Fundamemntal Clinical Pharma 2021;35:341
    https://doi.org/10.1111/fcp.12615
  189. Maria Hepel, Magdalena Stobiecka. Supramolecular interactions of oxidative stress biomarker glutathione with fluorone black. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2018;192:146
    https://doi.org/10.1016/j.saa.2017.11.017
  190. Nasreena Sajjad, Abubakar Wani, Ankita Sharma, Rohaya Ali, Sumaya Hassan, Rabia Hamid, Huma Habib, Bashir Ahmad Ganai. Artemisia amygdalina Upregulates Nrf2 and Protects Neurons Against Oxidative Stress in Alzheimer Disease. Cell Mol Neurobiol 2019;39:387
    https://doi.org/10.1007/s10571-019-00656-w
  191. Aluru Rammohan, Grigory V. Zyryanov, Yerramathi Babu Bhagath, Kola Manjula. Antioxidants. 2019.
    https://doi.org/10.1016/bs.vh.2022.10.001
  192. Paulo Mecenas Alves Farias-Junior, Francisco Bruno Teixeira, Nathalia Carolina Fernandes Fagundes, Giza Hellen Nonato Miranda, Leonardo Oliveira Bittencourt, Ricardo Sousa de Oliveira Paraense, Márcia Cristina Freitas Silva, Fernanda do Espírito Santo Sagica, Edivaldo Herculano de Oliveira, Maria Elena Crespo-López, Rafael Rodrigues Lima. Chronic intoxication by methylmercury leads to oxidative damage and cell death in salivary glands of rats. Metallomics 2017;9:1778
    https://doi.org/10.1039/C7MT00168A
  193. Shigenori Kumazawa. Baccharis. 2017.
    https://doi.org/10.1007/978-3-030-83511-8_20
  194. Jyoti Suryavanshi, Chandra Prakash, Deepak Sharma. Asiatic acid attenuates aluminium chloride-induced behavioral changes, neuronal loss and astrocyte activation in rats. Metab Brain Dis 2022;37:1773
    https://doi.org/10.1007/s11011-022-00998-3
  195. Aleksandra Zambrowicz, Agnieszka Zabłocka, Dominika Bednarz, Łukasz Bobak. Importance for humans of recently discovered protein compounds – yolkin and yolk glycopeptide 40, present in the plasma of hen egg yolk. Poultry Science 2023;102:102770
    https://doi.org/10.1016/j.psj.2023.102770
  196. Anshula Samarajeewa, Danielle R. Lenz, Lihong Xie, Hao Chiang, Rory Kirchner, Joanna F. Mulvaney, Albert S. B. Edge, Alain Dabdoub. Transcriptional response to Wnt activation regulates the regenerative capacity of the mammalian cochlea. 2018;145
    https://doi.org/10.1242/dev.166579
  197. Mattéa J. Finelli. Redox Post-translational Modifications of Protein Thiols in Brain Aging and Neurodegenerative Conditions—Focus on S-Nitrosation. Front. Aging Neurosci. 2020;12
    https://doi.org/10.3389/fnagi.2020.00254
  198. Wei-Ting Chen, Guan-Bo Lin, Yu-Yi Kuo, Chih-Hsiung Hsieh, Chueh-Hsuan Lu, Yi-Kun Sun, Chih-Yu Chao, Vladimir Trajkovic. Effect of high-frequency low-intensity pulsed electric field on protecting SH-SY5Y cells against hydrogen peroxide and β-amyloid-induced cell injury via ERK pathway. PLoS ONE 2021;16:e0250491
    https://doi.org/10.1371/journal.pone.0250491
  199. Genevieve Duché, John M Sanderson. The Chemical Reactivity of Membrane Lipids. Chem. Rev. 2024;124:3284
    https://doi.org/10.1021/acs.chemrev.3c00608
  200. Bayan Bokhari, Sudha Sharma. Stress Marks on the Genome: Use or Lose?. IJMS 2019;20:364
    https://doi.org/10.3390/ijms20020364
  201. Kazuki Ide, Norihiro Matsuoka, Hiroshi Yamada, Daisuke Furushima, Koji Kawakami. Effects of Tea Catechins on Alzheimer’s Disease: Recent Updates and Perspectives. Molecules 2018;23:2357
    https://doi.org/10.3390/molecules23092357
  202. Ke Du, Ming-Yan Liu, Yan-Zhu Pan, Xin Zhong, Min-Jie Wei. Association of circulating manganese levels with Parkinson’s disease: A meta-analysis. Neuroscience Letters 2018;665:92
    https://doi.org/10.1016/j.neulet.2017.11.054
  203. Neha Singh, Sheekha Vijayanti, Lekha Saha, Alka Bhatia, Dibyajyoti Banerjee, Amitava Chakrabarti. Neuroprotective effect of Nrf2 activator dimethyl fumarate, on the hippocampal neurons in chemical kindling model in rat. Epilepsy Research 2018;143:98
    https://doi.org/10.1016/j.eplepsyres.2018.02.011
  204. Miroslava Georgieva Varadinova, Maria Lozanova Valcheva-Traykova, Nadka Ivanova Boyadjieva. Neuroscience of Alcohol. 2018.
    https://doi.org/10.1016/B978-0-12-813125-1.00052-0
  205. Daniel Mihai Teleanu, Adelina-Gabriela Niculescu, Iulia Ioana Lungu, Crina Ioana Radu, Oana Vladâcenco, Eugenia Roza, Bogdan Costăchescu, Alexandru Mihai Grumezescu, Raluca Ioana Teleanu. An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases. IJMS 2022;23:5938
    https://doi.org/10.3390/ijms23115938
  206. Manal Mohammad Morsy, Marwa M. Ahmad, Nancy Husseiny Hassan. Maternal exposure to low-dose bisphenol A and its potential neurotoxic impact on male pups: A histological, immunohistochemical, and ultrastructural study. Tissue and Cell 2024;90:102503
    https://doi.org/10.1016/j.tice.2024.102503
  207. Kavita Patel, Ashutosh Mani. Food-derived Peptides as Promising Neuroprotective Agents: Mechanism and Therapeutic Potential. CTMC 2024;24:1212
    https://doi.org/10.2174/0115680266289248240322061723
  208. Rengasamy Balakrishnan, Shofiul Azam, Duk-Yeon Cho, In Su-Kim, Dong-Kug Choi, Erica Buoso. Natural Phytochemicals as Novel Therapeutic Strategies to Prevent and Treat Parkinson’s Disease: Current Knowledge and Future Perspectives. Oxidative Medicine and Cellular Longevity 2021;2021
    https://doi.org/10.1155/2021/6680935
  209. María José Ferreiro, Coralia Pérez, Mariana Marchesano, Santiago Ruiz, Angel Caputi, Pedro Aguilera, Rosa Barrio, Rafael Cantera. Drosophila melanogaster White Mutant w1118 Undergo Retinal Degeneration. Front. Neurosci. 2018;11
    https://doi.org/10.3389/fnins.2017.00732
  210. Simona Feno, Gaia Butera, Denis Vecellio Reane, Rosario Rizzuto, Anna Raffaello. Crosstalk between Calcium and ROS in Pathophysiological Conditions. Oxidative Medicine and Cellular Longevity 2019;2019:1
    https://doi.org/10.1155/2019/9324018
  211. Shoujiao Peng, Yanan Hou, Juan Yao, Jianguo Fang. Activation of Nrf2-driven antioxidant enzymes by cardamonin confers neuroprotection of PC12 cells against oxidative damage. Food Funct. 2017;8:997
    https://doi.org/10.1039/C7FO00054E
  212. Brett M. Culbert, Peter D. Dijkstra, Kathleen M. Gilmour, Sigal Balshine. Antioxidant capacity differs across social ranks and with ascension in males of a group-living fish. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 2022;265:111126
    https://doi.org/10.1016/j.cbpa.2021.111126
  213. Bahda Yun, Maria King, Mohamed S. Draz, Terence Kline, Alex Rodriguez-Palacios. Oxidative reactivity across kingdoms in the gut: Host immunity, stressed microbiota and oxidized foods. Free Radical Biology and Medicine 2022;178:97
    https://doi.org/10.1016/j.freeradbiomed.2021.11.009
  214. Yixuan Yang, Lina Qiu. Research Progress on the Pathogenesis, Diagnosis, and Drug Therapy of Alzheimer’s Disease. Brain Sciences 2024;14:590
    https://doi.org/10.3390/brainsci14060590
  215. Saisree Iyer, Ishani Bhat, Mamatha Bangera Sheshappa. Lutein and the Underlying Neuroprotective Promise against Neurodegenerative Diseases. Molecular Nutrition Food Res 2024;68
    https://doi.org/10.1002/mnfr.202300409
  216. Galina F. Makhaeva, Nadezhda V. Kovaleva, Elena V. Rudakova, Natalia P. Boltneva, Maria V. Grishchenko, Sofya V. Lushchekina, Tatiana Y. Astakhova, Olga G. Serebryakova, Elena N. Timokhina, Ekaterina F. Zhilina, Evgeny V. Shchegolkov, Mariya V. Ulitko, Eugene V. Radchenko, Vladimir A. Palyulin, Yanina V. Burgart, Victor I. Saloutin, Sergey O. Bachurin, Rudy J. Richardson. Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer’s Disease. IJMS 2023;24:2285
    https://doi.org/10.3390/ijms24032285
  217. Qi Li, Siyu He, Yao Chen, Feng Feng, Wei Qu, Haopeng Sun. Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease. European Journal of Medicinal Chemistry 2018;158:463
    https://doi.org/10.1016/j.ejmech.2018.09.031
  218. Kristen Ellis, Carol J. Rollins, Daniel L. Krinsky. Vitamin E for Alzheimer disease: The answer is not so E-asy. Pharmacy Today 2017;23:14
    https://doi.org/10.1016/j.ptdy.2017.05.006
  219. Milena Duitama, Viviana Vargas-López, Zulma Casas, Sonia L. Albarracin, Jhon-Jairo Sutachan, Yolima P. Torres. TRP Channels Role in Pain Associated With Neurodegenerative Diseases. Front. Neurosci. 2020;14
    https://doi.org/10.3389/fnins.2020.00782
  220. Suene Vanessa da Silva Souza, Priscila Batista da Rosa, Vivian Binder Neis, Júlia Dubois Moreira, Ana Lúcia S. Rodrigues, Morgana Moretti. Effects of cholecalciferol on behavior and production of reactive oxygen species in female mice subjected to corticosterone-induced model of depression. Naunyn-Schmiedeberg's Arch Pharmacol 2020;393:111
    https://doi.org/10.1007/s00210-019-01714-2
  221. Kattamanchi Gnananath, Kalakonda Sri Nataraj, Battu Ganga Rao, Kolli Prabhanjan Kumar, Kommavari Chandrasekhar, Pooja Jain, Mohd. Aamir Mirza. Ternary System of Bacogenins with Fulvic Acid and Hydrogenated Soy Lecithin: Preparation, Characterization and, In vivo Studies. CTMC 2022;22:1966
    https://doi.org/10.2174/1568026621666211111155425
  222. Ana M. González-Paramás, Virginia Brighenti, Laura Bertoni, Laura Marcelloni, Begoña Ayuda-Durán, Susana González-Manzano, Federica Pellati, Celestino Santos-Buelga. Assessment of the In Vivo Antioxidant Activity of an Anthocyanin-Rich Bilberry Extract Using the Caenorhabditis elegans Model. Antioxidants 2020;9:509
    https://doi.org/10.3390/antiox9060509
  223. Okwakpam, Felicia Nmeazi, Otobo, Miebaka Beverly, Dokubo Awolayeofori, Nzor, Joyce Nornubari, Valentine Daddy Nkomadu, Tamuno-Boma Odinga . Evaluation of the Bioactive Composition and in vitro Neuroprotective Potential of the Combined Curcuma longa and Rosmarinus Officinalis Ethanol Extract. Trends Med. Res 2024;19:136
    https://doi.org/10.3923/tmr.2024.136.150
  224. Yasaman Esmaeili, Zahra Yarjanli, Fatemeh Pakniya, Elham Bidram, Marek J. Łos, Mehdi Eshraghi, Daniel J. Klionsky, Saeid Ghavami, Ali Zarrabi. Targeting autophagy, oxidative stress, and ER stress for neurodegenerative disease treatment. Journal of Controlled Release 2022;345:147
    https://doi.org/10.1016/j.jconrel.2022.03.001
  225. Azadeh Salehi, Zahra Rabiei, Mahbubeh Setorki. Effects of gallic acid and physical exercise on passive avoidance memory in male rat. Braz. J. Pharm. Sci. 2019;55
    https://doi.org/10.1590/s2175-97902019000218261
  226. Sandra Carrera-Juliá, Mari Luz Moreno, Carlos Barrios, Jose Enrique de la Rubia Ortí, Eraci Drehmer. Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review. Front. Physiol. 2020;11
    https://doi.org/10.3389/fphys.2020.00063
  227. Joshua M. Tublin, Jeremy M. Adelstein, Federica del Monte, Colin K. Combs, Loren E. Wold. Getting to the Heart of Alzheimer Disease. Circulation Research 2019;124:142
    https://doi.org/10.1161/CIRCRESAHA.118.313563
  228. Muneeb U. Rehman, Nouroz Sehar, Iyman Rasool, Rana M. Aldossari, Amir Bashir Wani, Shahzada Mudasir Rashid, Adil Farooq Wali, Aarif Ali, Azher Arafah, Andleeb Khan. Glymphatic pathway: An emerging perspective in the pathophysiology of neurodegenerative diseases. Int J Geriat Psychiatry 2024;39
    https://doi.org/10.1002/gps.6104
  229. Anna Mathew, Vignesh Balaji E, Sreedhara Ranganath K. Pai, Anoop Kishore, Vasudev Pai, Ramadevi Pemmireddy, Chandrashekar K.S. Current Drug Targets in Alzheimer’s Associated Memory Impairment: A Comprehensive Review. CNSNDDT 2023;22:255
    https://doi.org/10.2174/1871527321666220401124719
  230. Danira Toral-Rios, Karla Carvajal, Bryan Phillips-Farfán, Luz del Carmen Camacho-Castillo, Victoria Campos-Peña. Biochemistry of Oxidative Stress. 2023.
    https://doi.org/10.1007/978-3-319-45865-6_23
  231. Elisa Sassetti, Mads H. Clausen, Luca Laraia. Small-Molecule Inhibitors of Reactive Oxygen Species Production. J. Med. Chem. 2021;64:5252
    https://doi.org/10.1021/acs.jmedchem.0c01914
  232. Glenda Halliday, Nicolas Dzamko, Daniel R. Whiten, Dezerae Cox, Carolyn M. Sue. PINK1 signalling in neurodegenerative disease. 2021;65:913
    https://doi.org/10.1042/EBC20210036
  233. Emira Noumi, Iqrar Ahmad, Nouha Bouali, Harun Patel, Siwar Ghannay, Ayshah Aysh ALrashidi, Mohammad A. Abdulhakeem, Mitesh Patel, Ozgur Ceylan, Riadh Badraoui, Afnan Elayyan Mousa Elayyan, Mohd Adnan, Adel Kadri, Mejdi Snoussi. Thymus musilii Velen. Methanolic Extract: In Vitro and In Silico Screening of Its Antimicrobial, Antioxidant, Anti-Quorum Sensing, Antibiofilm, and Anticancer Activities. Life 2022;13:62
    https://doi.org/10.3390/life13010062
  234. Upasana Ganguly, Upinder Kaur, Sankha Shubhra Chakrabarti, Priyanka Sharma, Bimal Kumar Agrawal, Luciano Saso, Sasanka Chakrabarti, Jos L. Quiles. Oxidative Stress, Neuroinflammation, and NADPH Oxidase: Implications in the Pathogenesis and Treatment of Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity 2021;2021
    https://doi.org/10.1155/2021/7086512
  235. Zhong-Hao Zhang, Qiu-Yan Wu, Rui Zheng, Chen Chen, Yao Chen, Qiong Liu, Peter R. Hoffmann, Jia-Zuan Ni, Guo-Li Song. Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model. J. Neurosci. 2017;37:2449
    https://doi.org/10.1523/JNEUROSCI.3229-16.2017
  236. Namy George, Majed AbuKhader, Khalid Al Balushi, Bushra Al Sabahi, Shah Alam Khan. An insight into the neuroprotective effects and molecular targets of pomegranate (Punica granatum) against Alzheimer’s disease. Nutritional Neuroscience 2023;26:975
    https://doi.org/10.1080/1028415X.2022.2121092
  237. M. V. Shuvalov, S. Yu. Maklakova, E. V. Rudakova, N. V. Kovaleva, G. F. Makhaeva, T. A. Podrugina. New Possibilities of the Kabachnik–Fields and Pudovik Reactions in the Phthalocyanine-Catalyzed Syntheses of α-Aminophosphonic and α-Aminophosphinic Acid Derivatives. Russ J Gen Chem 2018;88:1761
    https://doi.org/10.1134/S1070363218090013
  238. Matthew Neal, Jason R. Richardson. Time to get personal: A framework for personalized targeting of oxidative stress in neurotoxicity and neurodegenerative disease. Current Opinion in Toxicology 2018;7:127
    https://doi.org/10.1016/j.cotox.2018.02.003
  239. In Soo Ryu, Dae Hoon Kim, Hyun-Jeong Cho, Jin-Hyeob Ryu. The role of microRNA-485 in neurodegenerative diseases. 2023;34:49
    https://doi.org/10.1515/revneuro-2022-0039
  240. Wenjun Tu, Hong Wang, Song Li, Qiang Liu, Hong Sha. The Anti-Inflammatory and Anti-Oxidant Mechanisms of the Keap1/Nrf2/ARE Signaling Pathway in Chronic Diseases. Aging and disease 2019;10:637
    https://doi.org/10.14336/AD.2018.0513
  241. Maria Quiles del Rey, Joseph D. Mancias. NCOA4-Mediated Ferritinophagy: A Potential Link to Neurodegeneration. Front. Neurosci. 2019;13
    https://doi.org/10.3389/fnins.2019.00238
  242. Alpana Singh, Ted M. Dawson, Subhash Kulkarni. Neurodegenerative disorders and gut-brain interactions. 2021;131
    https://doi.org/10.1172/JCI143775
  243. E. Martín-Montañez, J. Pavia, N. Valverde, F. Boraldi, E. Lara, B. Oliver, I. Hurtado-Guerrero, O. Fernandez, M. Garcia-Fernandez. The S1P mimetic fingolimod phosphate regulates mitochondrial oxidative stress in neuronal cells. Free Radical Biology and Medicine 2019;137:116
    https://doi.org/10.1016/j.freeradbiomed.2019.04.022
  244. Huimin Chi, Wa Cao, Ming Zhang, Donghong Su, Honglian Yang, Zhe Li, Chao Li, Xiaojun She, Kun Wang, Xiujie Gao, Kefeng Ma, Pengfang Zheng, Xiaofang Li, Bo Cui. Environmental noise stress disturbs commensal microbiota homeostasis and induces oxi-inflammmation and AD-like neuropathology through epithelial barrier disruption in the EOAD mouse model. J Neuroinflammation 2021;18
    https://doi.org/10.1186/s12974-020-02053-3
  245. Ibrahim Khan, Kamran Saeed, Min Gi Jo, Myeong Ok Kim. 17-β Estradiol Rescued Immature Rat Brain against Glutamate-Induced Oxidative Stress and Neurodegeneration via Regulating Nrf2/HO-1 and MAP-Kinase Signaling Pathway. Antioxidants 2021;10:892
    https://doi.org/10.3390/antiox10060892
  246. Francisco Arnaldo Viana Lima, Ivan Pinheiro Joventino, Francisca Pinheiro Joventino, Aline Cordeiro de Almeida, Kelly Rose Tavares Neves, Marta Regina do Carmo, Luzia Kalyne Almeida Moreira Leal, Geanne Matos de Andrade, Glauce Socorro de Barros Viana. Neuroprotective Activities of Spirulina platensis in the 6-OHDA Model of Parkinson’s Disease Are Related to Its Anti-Inflammatory Effects. Neurochem Res 2017;42:3390
    https://doi.org/10.1007/s11064-017-2379-5
  247. Dezhen Tu, Ravikanth Velagapudi, Yun Gao, Jau-Shyong Hong, Hui Zhou, Hui-Ming Gao. Activation of neuronal NADPH oxidase NOX2 promotes inflammatory neurodegeneration. Free Radical Biology and Medicine 2023;200:47
    https://doi.org/10.1016/j.freeradbiomed.2023.03.001
  248. Wan Jin, Yimei Dai, Funing Li, Lu Zhu, Zhibin Huang, Wei Liu, Jianchao Li, Mingjie Zhang, Jiulin Du, Wenqing Zhang, Zilong Wen. Dysregulation of Microglial Function Contributes to Neuronal Impairment in Mcoln1a-Deficient Zebrafish. iScience 2019;13:391
    https://doi.org/10.1016/j.isci.2019.02.031
  249. Matheus Scarpatto Rodrigues, Gabriela Cristina de Paula, Mariane Bernardo Duarte, Victoria Linden de Rezende, Jonathann Correa Possato, Hemelin Resende Farias, Eduarda Behenck Medeiros, Paulo Emilio Feuser, Emilio Luiz Streck, Ricardo Andrez Machado de Ávila, Rachel Krolow Santos Silva Bast, Josiane Budni, Andreza Fabro de Bem, Paulo César Lock Silveira, Jade de Oliveira. Nanotechnology as a therapeutic strategy to prevent neuropsychomotor alterations associated with hypercholesterolemia. Colloids and Surfaces B: Biointerfaces 2021;201:111608
    https://doi.org/10.1016/j.colsurfb.2021.111608
  250. Ke Yao, Jiamin Gan, Di Zhao, Mingding Li, Xiaoquan Shen, Yumin Yang, Peijian Feng, Qundong Shen. A core-satellite-like nanoassembly reverses a decisive tyrosine hydroxylase loss in degenerative dopaminergic neurons. Nano Res. 2023;16:9835
    https://doi.org/10.1007/s12274-023-5729-4
  251. Emine Karaca Sulukoğlu, Şükran Günaydın, Şeyda Nur Kalın, Ahmet Altay, Harun Budak. Diffractaic acid exerts anti-cancer effects on hepatocellular carcinoma HepG2 cells by inducing apoptosis and suppressing migration through targeting thioredoxin reductase 1. Naunyn-Schmiedeberg's Arch Pharmacol 2024;397:5745
    https://doi.org/10.1007/s00210-024-02980-5
  252. Hemmo A.F. Yska, Marc Engelen, Marianna Bugiani. The pathology of X-linked adrenoleukodystrophy: tissue specific changes as a clue to pathophysiology. Orphanet J Rare Dis 2024;19
    https://doi.org/10.1186/s13023-024-03105-0
  253. Jingsong Xiao, Qifu Zhang, Yaohui Shan, Feng Ye, Xi Zhang, Jin Cheng, Xiaogang Wang, Yuanpeng Zhao, Guorong Dan, Mingliang Chen, Yan Sai. The Mitochondrial-Derived Peptide (MOTS-c) Interacted with Nrf2 to Defend the Antioxidant System to Protect Dopaminergic Neurons Against Rotenone Exposure. Mol Neurobiol 2023;60:5915
    https://doi.org/10.1007/s12035-023-03443-3
  254. Daein Choi, Seulggie Choi, Sang Min Park. Effect of smoking cessation on the risk of dementia: a longitudinal study. Ann Clin Transl Neurol 2018;5:1192
    https://doi.org/10.1002/acn3.633
  255. K. Dec, A. Łukomska, D. Maciejewska, K. Jakubczyk, I. Baranowska-Bosiacka, D. Chlubek, A. Wąsik, I. Gutowska. The Influence of Fluorine on the Disturbances of Homeostasis in the Central Nervous System. Biol Trace Elem Res 2017;177:224
    https://doi.org/10.1007/s12011-016-0871-4
  256. Hui Yang, Qiting Zhang, Bin Zhang, Yufen Zhao, Ning Wang. Potential Active Marine Peptides as Anti-Aging Drugs or Drug Candidates. Marine Drugs 2023;21:144
    https://doi.org/10.3390/md21030144
  257. María-Aránzazu Martínez, José-Luis Rodríguez, Bernardo Lopez-Torres, Marta Martínez, María-Rosa Martínez-Larrañaga, Arturo Anadón, Irma Ares. Oxidative stress and related gene expression effects of cyfluthrin in human neuroblastoma SH-SY5Y cells: Protective effect of melatonin. Environmental Research 2019;177:108579
    https://doi.org/10.1016/j.envres.2019.108579
  258. Muhammed Khairujjaman Mazumder, Shuvasish Choudhury, Anupom Borah. An in silico investigation on the inhibitory potential of the constituents of Pomegranate juice on antioxidant defense mechanism: Relevance to neurodegenerative diseases. IBRO Reports 2019;6:153
    https://doi.org/10.1016/j.ibror.2019.05.003
  259. Ju Zhang, Ruona Shi, Haifeng Li, Yanxia Xiang, Lingyun Xiao, Minghua Hu, Fangli Ma, Chung Wah Ma, Zebo Huang. Antioxidant and neuroprotective effects of Dictyophora indusiata polysaccharide in Caenorhabditis elegans. Journal of Ethnopharmacology 2016;192:413
    https://doi.org/10.1016/j.jep.2016.09.031
  260. Anna-Sophie Rommel, Ginger L. Milne, Emily S. Barrett, Nicole R. Bush, Ruby Nguyen, Sheela Sathyanarayana, Shanna H. Swan, Kelly K. Ferguson. Associations between urinary biomarkers of oxidative stress in the third trimester of pregnancy and behavioral outcomes in the child at 4 years of age. Brain, Behavior, and Immunity 2020;90:272
    https://doi.org/10.1016/j.bbi.2020.08.029
  261. Richmond Arthur, Umashanker Navik, Puneet Kumar. Repurposing artemisinins as neuroprotective agents: a focus on the PI3k/Akt signalling pathway. Naunyn-Schmiedeberg's Arch Pharmacol 2023;396:593
    https://doi.org/10.1007/s00210-022-02350-z
  262. Habib Yaribeygi, Stephen L. Atkin, Alexandra E. Butler, Amirhossein Sahebkar. Sodium–glucose cotransporter inhibitors and oxidative stress: An update. Journal Cellular Physiology 2019;234:3231
    https://doi.org/10.1002/jcp.26760
  263. Sara Jarmakiewicz-Czaja, Katarzyna Ferenc, Rafał Filip. Antioxidants as Protection against Reactive Oxidative Stress in Inflammatory Bowel Disease. Metabolites 2023;13:573
    https://doi.org/10.3390/metabo13040573
  264. Vanessa Kappel da Silva, Betânia Souza de Freitas, Victória Campos Dornelles, Luiza Wilges Kist, Maurício Reis Bogo, Milena Carvalho Silva, Emílio Luiz Streck, Jaime Eduardo Hallak, Antônio Waldo Zuardi, José Alexandre S. Crippa, Nadja Schröder. Novel insights into mitochondrial molecular targets of iron-induced neurodegeneration: Reversal by cannabidiol. Brain Research Bulletin 2018;139:1
    https://doi.org/10.1016/j.brainresbull.2018.01.014
  265. Susana Cardoso, Paula I. Moreira. Diabesity and brain disturbances: A metabolic perspective. Molecular Aspects of Medicine 2019;66:71
    https://doi.org/10.1016/j.mam.2018.10.002
  266. Blanka Wolszczak-Biedrzycka, Justyna Dorf, Joanna Matowicka-Karna, Violetta Dymicka-Piekarska, Marzena Wojewódzka-Żeleźniakowicz, Piotr Żukowski, Anna Zalewska, Łukasz Dąbrowski, Mateusz Maciejczyk. Redox Biomarkers – An Effective Tool for Diagnosing COVID-19 Patients and Convalescents. JIR 2024;Volume 17:2589
    https://doi.org/10.2147/JIR.S456849
  267. Karthikeyan Murthykumar, Sheeja Varghese, Vijayashree Priyadharsini Jayaseelan. Association of SRXN1 Receptor Gene Polymorphism with Susceptibility to Periodontitis. 2022;13:363
    https://doi.org/10.4103/ccd.ccd_309_21
  268. P. Kurian, T.O. Obisesan, T.J.A. Craddock. Oxidative species-induced excitonic transport in tubulin aromatic networks: Potential implications for neurodegenerative disease. Journal of Photochemistry and Photobiology B: Biology 2017;175:109
    https://doi.org/10.1016/j.jphotobiol.2017.08.033
  269. Gemma Navarro, Eva Martínez-Pinilla, Alejandro Sánchez-Melgar, Raquel Ortiz, Véronique Noé, Mairena Martín, Carlos Ciudad, Rafael Franco, Barbara Bardoni. A genomics approach identifies selective effects of trans-resveratrol in cerebral cortex neuron and glia gene expression. PLoS ONE 2017;12:e0176067
    https://doi.org/10.1371/journal.pone.0176067
  270. Shou Jin Phang, Huey Xhin Teh, Mee Lee Looi, Bavani Arumugam, Mh Busra Fauzi, Umah Rani Kuppusamy. Phlorotannins from brown algae: a review on their antioxidant mechanisms and applications in oxidative stress-mediated diseases. J Appl Phycol 2023;35:867
    https://doi.org/10.1007/s10811-023-02913-4
  271. Wattanaporn Bhadhprasit, Chisato Kinoshita, Nobuko Matsumura, Koji Aoyama. Erythroid Differentiation Regulator 1 as a Regulator of Neuronal GSH Synthesis. Antioxidants 2024;13:771
    https://doi.org/10.3390/antiox13070771
  272. Bindu D. Paul, Solomon H. Snyder. Impaired Redox Signaling in Huntington’s Disease: Therapeutic Implications. Front. Mol. Neurosci. 2019;12
    https://doi.org/10.3389/fnmol.2019.00068
  273. Sergey O. Bachurin, Galina F. Makhaeva, Elena F. Shevtsova, Natalia P. Boltneva, Nadezhda V. Kovaleva, Sofya V. Lushchekina, Elena V. Rudakova, Ludmila G. Dubova, Daria V. Vinogradova, Vladimir B. Sokolov, Alexey Yu. Aksinenko, Vladimir P. Fisenko, Rudy J. Richardson, Gjumrakch Aliev. Conjugates of methylene blue with γ-carboline derivatives as new multifunctional agents for the treatment of neurodegenerative diseases. Sci Rep 2019;9
    https://doi.org/10.1038/s41598-019-41272-4
  274. Che-Wei Lin, Pei-Ying Lin, Ya-Wen Hsu, Tzu-Ming Pan, Chun-Lin Lee. Monascus-fermented metabolites repressed amyloid β-peptide-induced neurotoxicity and inflammatory response in in vitro and in vivo studies. Journal of Functional Foods 2023;104:105509
    https://doi.org/10.1016/j.jff.2023.105509
  275. Suet Lee Hor, Seong Lin Teoh, Wei Ling Lim. Plant Polyphenols as Neuroprotective Agents in Parkinson’s Disease Targeting Oxidative Stress. CDT 2020;21:458
    https://doi.org/10.2174/1389450120666191017120505
  276. Izabela Grabska-Kobyłecka, Piotr Szpakowski, Aleksandra Król, Dominika Książek-Winiarek, Andrzej Kobyłecki, Andrzej Głąbiński, Dariusz Nowak. Polyphenols and Their Impact on the Prevention of Neurodegenerative Diseases and Development. Nutrients 2023;15:3454
    https://doi.org/10.3390/nu15153454
  277. Josiel Mileno Mack, Marissa Giovanna Schamne, Tuane Bazanella Sampaio, Renata Aparecida Nedel Pértile, Pedro Augusto Carlos Magno Fernandes, Regina P. Markus, Rui Daniel Prediger, Serafina Perrone. Melatoninergic System in Parkinson’s Disease: From Neuroprotection to the Management of Motor and Nonmotor Symptoms. Oxidative Medicine and Cellular Longevity 2016;2016
    https://doi.org/10.1155/2016/3472032
  278. Iskander Madhi, Ji-Hee Kim, Ji Eun Shin, Younghee Kim. Ginsenoside Re exhibits neuroprotective effects by inhibiting neuroinflammation via CAMK/MAPK/NF‑κB signaling in microglia. Mol Med Rep 2021;24
    https://doi.org/10.3892/mmr.2021.12337
  279. AbelNosereme Agbon, HelenOchuko Kwanashie, WilsonOliver Hamman, AustinOseloka Ibegbu, Hamisu Sule, MurtalaHamza Yahaya, Rachael Henry, AndrewEkpenyong Ivang. Microscopic assessments of the effect of phoenix dactylifera L. in a rat model of mercury-triggered cerebral M1 changes. Ann Trop Pathol 2021;12:43
    https://doi.org/10.4103/atp.atp_3_21
  280. David Fisher, Olufemi A. Alamu. Oxidative Stress and Dietary Antioxidants in Neurological Diseases. 2021.
    https://doi.org/10.1016/B978-0-12-817780-8.00002-5
  281. Amjad Khan, Jun Sung Park, Min Hwa Kang, Hyeon Jin Lee, Jawad Ali, Muhammad Tahir, Kyonghwan Choe, Myeong Ok Kim. Caffeic Acid, a Polyphenolic Micronutrient Rescues Mice Brains against Aβ-Induced Neurodegeneration and Memory Impairment. Antioxidants 2023;12:1284
    https://doi.org/10.3390/antiox12061284
  282. Yingying Wang, Qianqian Wang, Xiao Han, Yingchao Ma, Zhenkun Zhang, Liang Zhao, Fangxia Guan, Shanshan Ma. Fucoidan: a promising agent for brain injury and neurodegenerative disease intervention. Food Funct. 2021;12:3820
    https://doi.org/10.1039/D0FO03153D
  283. Emrullah Kızıltunç, Murat Gök, Harun Kundi, Mustafa Çetin, Canan Topçuoğlu, Birsen Gülkan, Hülya Çiçekçioğlu, Ender Örnek. Plasma thiols and thiol-disulfide homeostasis in patients with isolated coronary artery ectasia. Atherosclerosis 2016;253:209
    https://doi.org/10.1016/j.atherosclerosis.2016.07.904
  284. Kristina Pilipović, Renata Jurišić Grubešić, Petra Dolenec, Natalia Kučić, Lea Juretić, Jasenka Mršić-Pelčić. Plant-Based Antioxidants for Prevention and Treatment of Neurodegenerative Diseases: Phytotherapeutic Potential of Laurus nobilis, Aronia melanocarpa, and Celastrol. Antioxidants 2023;12:746
    https://doi.org/10.3390/antiox12030746
  285. Sanjay Awasthi, Ashly Hindle, Neha A. Sawant, Mathew George, Murali Vijayan, Sudhir Kshirsagar, Hallie Morton, Lloyd E. Bunquin, Philip T. Palade, J. Josh Lawrence, Hafiz Khan, Chhanda Bose, P. Hemachandra Reddy, Sharda P. Singh. RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease. Cells 2021;10:3113
    https://doi.org/10.3390/cells10113113
  286. Wen-Xuan Yu, Chen-Qiang Lin, Qing Zhao, Xin-Jian Lin, Xiao-Li Dong. Neuroprotection against hydrogen peroxide-induced toxicity by Dictyophora echinovolvata polysaccharide via inhibiting the mitochondria-dependent apoptotic pathway. Biomedicine & Pharmacotherapy 2017;88:569
    https://doi.org/10.1016/j.biopha.2017.01.103
  287. Kay Rui Choy, Dianne J. Watters. Neurodegeneration in ataxia‐telangiectasia: Multiple roles of ATM kinase in cellular homeostasis. Developmental Dynamics 2018;247:33
    https://doi.org/10.1002/dvdy.24522
  288. Óscar M. Bautista‐Aguilera, Stefanie Hagenow, Alejandra Palomino‐Antolin, Víctor Farré‐Alins, Lhassane Ismaili, Pierre‐Louis Joffrin, María L. Jimeno, Ondřej Soukup, Jana Janočková, Lena Kalinowsky, Ewgenij Proschak, Isabel Iriepa, Ignacio Moraleda, Johannes S. Schwed, Alejandro Romero Martínez, Francisco López‐Muñoz, Mourad Chioua, Javier Egea, Rona R. Ramsay, José Marco‐Contelles, Holger Stark. Multitarget‐Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3R Antagonism for Neurodegenerative Diseases. Angew Chem Int Ed 2017;56:12765
    https://doi.org/10.1002/anie.201706072
  289. Adaze Bijou Enogieru, William Haylett, Donavon Charles Hiss, Soraya Bardien, Okobi Eko Ekpo, Renata Szymanska. Rutin as a Potent Antioxidant: Implications for Neurodegenerative Disorders. Oxidative Medicine and Cellular Longevity 2018;2018
    https://doi.org/10.1155/2018/6241017
  290. Jingyun Zheng, Baiyi Lu, Baojun Xu. An update on the health benefits promoted by edible flowers and involved mechanisms. Food Chemistry 2021;340:127940
    https://doi.org/10.1016/j.foodchem.2020.127940
  291. Zewen Liu, Tingyang Zhou, Alexander C. Ziegler, Peter Dimitrion, Li Zuo, James Duce. Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications. Oxidative Medicine and Cellular Longevity 2017;2017
    https://doi.org/10.1155/2017/2525967
  292. Md. Farhad Hossain, Ni Wang, Ruijun Chen, Siwen Li, Jaydeep Roy, Md. Giash Uddin, Zhong Li, Lee Wei Lim, You-Qiang Song. Exploring the multifunctional role of melatonin in regulating autophagy and sleep to mitigate Alzheimer’s disease neuropathology. Ageing Research Reviews 2021;67:101304
    https://doi.org/10.1016/j.arr.2021.101304
  293. Nazaneen Saleh, Caglar Cosarderelioglu, Ramya Vajapey, Jeremy Walston, Peter M Abadir, Rozalyn M Anderson. Losartan Mitigates Oxidative Stress in the Brains of Aged and Inflamed IL-10−/− Mice. 2022;77:1784
    https://doi.org/10.1093/gerona/glac101
  294. Gabriella Mendes Duarte, Francisco Emanoel Alves de Araújo, João Matheus Caé da Rocha, Francisca Idalina Neta, Amália Cinthia Meneses do Rego, Irami Araújo Filho, Francisco Irochima Pinheiro, Eduardo Pereira de Azevedo, Ricardo Ney Cobucci, Fausto Pierdoná Guzen. Neuroprotective Potential of Seed Extracts: Review of In Vitro and In Vivo Studies. Nutrients 2023;15:2502
    https://doi.org/10.3390/nu15112502
  295. Simon Valayer, David Kim, Anna Fogtman, Ulrich Straube, Andrew Winnard, Nick Caplan, David A. Green, Flora H. P. van Leeuwen, Tobias Weber. The Potential of Fasting and Caloric Restriction to Mitigate Radiation Damage—A Systematic Review. Front. Nutr. 2020;7
    https://doi.org/10.3389/fnut.2020.584543
  296. Maya A. Olshina, Galina Arkind, Fanindra Kumar Deshmukh, Irit Fainer, Mark Taranavsky, Daniel Hayat, Shifra Ben-Dor, Gili Ben-Nissan, Michal Sharon. Regulation of the 20S Proteasome by a Novel Family of Inhibitory Proteins. Antioxidants & Redox Signaling 2020;32:636
    https://doi.org/10.1089/ars.2019.7816
  297. Xin Zhang, Jingjing Liu, Hui Wang. The cGAS-STING-autophagy pathway: Novel perspectives in neurotoxicity induced by manganese exposure. Environmental Pollution 2022;315:120412
    https://doi.org/10.1016/j.envpol.2022.120412
  298. Grazia Maria Liuzzi, Tania Petraglia, Tiziana Latronico, Aniello Crescenzi, Rocco Rossano. Antioxidant Compounds from Edible Mushrooms as Potential Candidates for Treating Age-Related Neurodegenerative Diseases. Nutrients 2023;15:1913
    https://doi.org/10.3390/nu15081913
  299. Zahara Chaudhry, Donika Klenja, Najma Janjua, Gerta Cami-Kobeci, Bushra Ahmed. COVID-19 and Parkinson’s Disease: Shared Inflammatory Pathways Under Oxidative Stress. Brain Sciences 2020;10:807
    https://doi.org/10.3390/brainsci10110807
  300. Sonja E. Di Gregorio, Martin L. Duennwald. ALS Yeast Models—Past Success Stories and New Opportunities. Front. Mol. Neurosci. 2018;11
    https://doi.org/10.3389/fnmol.2018.00394
  301. Bibek Gyanwali, Zi Xiang Lim, Janjira Soh, Clarissa Lim, Shou Ping Guan, Jorming Goh, Andrea B. Maier, Brian K. Kennedy. Alpha-Ketoglutarate dietary supplementation to improve health in humans. Trends in Endocrinology & Metabolism 2022;33:136
    https://doi.org/10.1016/j.tem.2021.11.003
  302. Nan Qin, Anke Geng, Renhao Xue. Activated or Impaired: An Overview of DNA Repair in Neurodegenerative Diseases. Aging and disease 2022;13:987
    https://doi.org/10.14336/AD.2021.1212
  303. Hua Fan, Qing Shu, Xinlei Guan, Jiegang Zhao, Junqiang Yan, Xiangming Li, Jiangbo Liu, Zhaohui Jia, Jian Shi, Juan Li. Sinomenine Protects PC12 Neuronal Cells against H2O2-induced Cytotoxicity and Oxidative Stress via a ROS-dependent Up-regulation of Endogenous Antioxidant System. Cell Mol Neurobiol 2017;37:1387
    https://doi.org/10.1007/s10571-017-0469-1
  304. Andy Wai Kan Yeung, Nikolay T. Tzvetkov, Maya G. Georgieva, Iliyan V. Ognyanov, Karolina Kordos, Artur Jóźwik, Toni Kühl, George Perry, Maria Cristina Petralia, Emanuela Mazzon, Atanas G. Atanasov. Reactive Oxygen Species and Their Impact in Neurodegenerative Diseases: Literature Landscape Analysis. Antioxidants & Redox Signaling 2021;34:402
    https://doi.org/10.1089/ars.2019.7952
  305. Yao Xiao, Kailin Li, Ji Bian, Yao Zhang, Jia Li, Hang Liu, Yingzhi Ye, Lin Han, Lan Gong, Min Wang. Urolithin A Protects Neuronal Cells against Stress Damage and Apoptosis by Atp2a3 Inhibition. Molecular Nutrition Food Res 2023;67
    https://doi.org/10.1002/mnfr.202300146
  306. Piergiorgio La Rosa, Sara Petrillo, Enrico Silvio Bertini, Fiorella Piemonte. Oxidative Stress in DNA Repeat Expansion Disorders: A Focus on NRF2 Signaling Involvement. Biomolecules 2020;10:702
    https://doi.org/10.3390/biom10050702
  307. Marianna Lucio, Desiree Willkommen, Michael Schroeter, Ali Sigaroudi, Philippe Schmitt-Kopplin, Bernhard Michalke. Integrative Metabolomic and Metallomic Analysis in a Case–Control Cohort With Parkinson’s Disease. Front. Aging Neurosci. 2019;11
    https://doi.org/10.3389/fnagi.2019.00331
  308. Rita Crinelli, Carolina Zara, Michaël Smietana, Michele Retini, Mauro Magnani, Alessandra Fraternale. Boosting GSH Using the Co-Drug Approach: I-152, a Conjugate of N-acetyl-cysteine and β-mercaptoethylamine. Nutrients 2019;11:1291
    https://doi.org/10.3390/nu11061291
  309. Essia Hamdi, Slah Hidouri, Ana-Belén Muniz-Gonzalez, Alberto Marcos Bermejo, César Venero, Salem Amara, Ahmed Landoulsi. The role of glutamic acid-modified silica nanoparticles in promoting brain health. Advances in Redox Research 2024;10:100095
    https://doi.org/10.1016/j.arres.2024.100095
  310. Vasileios Siokas, Polyxeni Stamati, Georgia Pateraki, Ioannis Liampas, Athina-Maria Aloizou, Daniil Tsirelis, Anastasia Nousia, Markos Sgantzos, Grigorios Nasios, Dimitrios P. Bogdanos, Efthimios Dardiotis. Analysis of SOD2 rs4880 Genetic Variant in Patients with Alzheimer’s Disease. CIMB 2022;44:4406
    https://doi.org/10.3390/cimb44100302
  311. Valentina Oliveri, Graziella Vecchio. Metallocyclodextrins in Medicinal Chemistry. Future Med. Chem. 2018;10:663
    https://doi.org/10.4155/fmc-2017-0249
  312. Augustine Amalraj, Nimisha Pulikkal Sukumaran, Ajaikumar B. Kunnumakkara, Sreeraj Gopi. Curcumin for Neurological and Psychiatric Disorders. 2018.
    https://doi.org/10.1016/B978-0-12-815461-8.00006-2
  313. Youssef A. A. Hamin Neto, José César Rosa, Hamilton Cabral. Peptides with antioxidant properties identified from casein, whey, and egg albumin hydrolysates generated by two novel fungal proteases. Preparative Biochemistry and Biotechnology 2019;49:639
    https://doi.org/10.1080/10826068.2019.1566147
  314. Guoyuan Qi, Yashi Mi, Rong Fan, Beita Zhao, Bo Ren, Xuebo Liu. Tea polyphenols ameliorates neural redox imbalance and mitochondrial dysfunction via mechanisms linking the key circadian regular Bmal1. Food and Chemical Toxicology 2017;110:189
    https://doi.org/10.1016/j.fct.2017.10.031
  315. Mi Hye Kim, Da Yeon Kim, Hong Jun Lee, Young-Ho Park, Jae-Won Huh, Dong-Seok Lee. Comparison of the protective effect of cytosolic and mitochondrial Peroxiredoxin 5 against glutamate-induced neuronal cell death. Redox Report 2021;26:53
    https://doi.org/10.1080/13510002.2021.1901028
  316. Cécile Mathieu, Romain Duval, Angélique Cocaign, Emile Petit, Linh-Chi Bui, Iman Haddad, Joelle Vinh, Catherine Etchebest, Jean-Marie Dupret, Fernando Rodrigues-Lima. An Isozyme-specific Redox Switch in Human Brain Glycogen Phosphorylase Modulates Its Allosteric Activation by AMP. Journal of Biological Chemistry 2016;291:23842
    https://doi.org/10.1074/jbc.M116.757062
  317. Mahalingam Jeyakumar, Sethuraman Sathya, Soniya Gandhi, Prabhakararao Tharra, Murali Aarthy, Devasahayam Jaya Balan, Chandramohan Kiruthiga, Beeraiah Baire, Sanjeev Kumar Singh, Kasi Pandima Devi. α-bisabolol β-D-fucopyranoside inhibits β-amyloid (Aβ)25–35 induced oxidative stress in Neuro-2a cells via antioxidant approaches. Process Biochemistry 2022;121:493
    https://doi.org/10.1016/j.procbio.2022.07.026
  318. Hirotaka Iwaki, Rina Ando, Noriyuki Miyaue, Satoshi Tada, Tomoaki Tsujii, Hayato Yabe, Noriko Nishikawa, Masahiro Nagai, Masahiro Nomoto. One year safety and efficacy of inosine to increase the serum urate level for patients with Parkinson's disease in Japan. Journal of the Neurological Sciences 2017;383:75
    https://doi.org/10.1016/j.jns.2017.10.030
  319. Fernanda Silva Rodrigues, Angela Patrícia França, Núbia Broetto, Ana Flávia Furian, Mauro Schneider Oliveira, Adair Roberto Soares Santos, Luiz Fernando Freire Royes, Michele Rechia Fighera. Sustained glial reactivity induced by glutaric acid may be the trigger to learning delay in early and late phases of development: Involvement of p75NTR receptor and protection by N-acetylcysteine. Brain Research 2020;1749:147145
    https://doi.org/10.1016/j.brainres.2020.147145
  320. Cristina Minnelli, Paolo Moretti, Gianluca Fulgenzi, Paolo Mariani, Emiliano Laudadio, Tatiana Armeni, Roberta Galeazzi, Giovanna Mobbili. A Poloxamer-407 modified liposome encapsulating epigallocatechin-3-gallate in the presence of magnesium: Characterization and protective effect against oxidative damage. International Journal of Pharmaceutics 2018;552:225
    https://doi.org/10.1016/j.ijpharm.2018.10.004
  321. Gita A. Pathak, Talisa K. Silzer, Jie Sun, Zhengyang Zhou, Ann A. Daniel, Leigh Johnson, Sid O’Bryant, Nicole R. Phillips, Robert C. Barber. Genome-Wide Methylation of Mild Cognitive Impairment in Mexican Americans Highlights Genes Involved in Synaptic Transport, Alzheimer’s Disease-Precursor Phenotypes, and Metabolic Morbidities. JAD 2019;72:733
    https://doi.org/10.3233/JAD-190634
  322. Stanisław Szlufik, Kamila Kopeć, Stanisław Szleszkowski, Dariusz Koziorowski. Glymphatic System Pathology and Neuroinflammation as Two Risk Factors of Neurodegeneration. Cells 2024;13:286
    https://doi.org/10.3390/cells13030286
  323. In Young Kim, Jong Min Kim, Hyo Lim Lee, Min Ji Go, Han Su Lee, Ju Hui Kim, Hyun Ji Eo, Chul-Woo Kim, Ho Jin Heo. Neuroprotective effect of Aster yomena ethanolic extract in HT-22 and SK-N-MC cells based on antioxidant activity. Food Sci. Preserv. 2024;31:99
    https://doi.org/10.11002/fsp.2024.31.1.99
  324. Daniel H. Pfaff, Thomas Fleming, Peter Nawroth, Aurelio A. Teleman. Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal Detoxification. Journal of Biological Chemistry 2017;292:685
    https://doi.org/10.1074/jbc.M116.743823
  325. Carlos Fernandes, Miguel Pinto, Cláudia Martins, Maria João Gomes, Bruno Sarmento, Paulo J. Oliveira, Fernando Remião, Fernanda Borges. Development of a PEGylated-Based Platform for Efficient Delivery of Dietary Antioxidants Across the Blood–Brain Barrier. Bioconjugate Chem. 2018;29:1677
    https://doi.org/10.1021/acs.bioconjchem.8b00151
  326. Chouari Zhor, Lounis Wafaa, Imen Ghzaiel, Khadidja Kessas, Amira Zarrouk, Mohamed Ksila, Taoufik Ghrairi, Norbert Latruffe, Olfa Masmoudi-Kouki, Adil El Midaoui, Dominique Vervandier-Fasseur, Mohamed Hammami, Gérard Lizard, Anne Vejux, Omar Kharoubi. Effects of polyphenols and their metabolites on age-related diseases. Biochemical Pharmacology 2023;214:115674
    https://doi.org/10.1016/j.bcp.2023.115674
  327. Subajiny Sivakanthan, Sarathadevi Rajendran, Ashoka Gamage, Terrence Madhujith, Sudhagar Mani. Antioxidant and antimicrobial applications of biopolymers: A review. Food Research International 2020;136:109327
    https://doi.org/10.1016/j.foodres.2020.109327
  328. Arunadevi Mani, Anis Ahamed, Daoud Ali, Saud Alarifi, Idhayadhulla Akbar. Dopamine-Mediated Vanillin Multicomponent Derivative Synthesis via Grindstone Method: Application of Antioxidant, Anti-Tyrosinase, and Cytotoxic Activities. DDDT 2021;Volume 15:787
    https://doi.org/10.2147/DDDT.S288389
  329. Devyani Bhatnagar, Shreya Ladhe, Dileep Kumar. Discerning the Prospects of miRNAs as a Multi-Target Therapeutic and Diagnostic for Alzheimer’s Disease. Mol Neurobiol 2023;60:5954
    https://doi.org/10.1007/s12035-023-03446-0
  330. Carlos Benitez-Martin, Juan A. Guadix, John R. Pearson, Francisco Najera, Jose M. Perez-Pomares, Ezequiel Perez-Inestrosa. A turn-on two-photon fluorescent probe for detecting lysosomal hydroxyl radicals in living cells. Sensors and Actuators B: Chemical 2019;284:744
    https://doi.org/10.1016/j.snb.2018.12.163
  331. Maja Jazvinšćak Jembrek, Nada Oršolić, Lucija Mandić, Anja Sadžak, Suzana Šegota. Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-κB and p53 Pathways in Neurodegeneration. Antioxidants 2021;10:1628
    https://doi.org/10.3390/antiox10101628
  332. Patrycja Michalska, Rafael León. When It Comes to an End: Oxidative Stress Crosstalk with Protein Aggregation and Neuroinflammation Induce Neurodegeneration. Antioxidants 2020;9:740
    https://doi.org/10.3390/antiox9080740
  333. Shylesh Bhaskaran, Gaurav Kumar, Nidheesh Thadathil, Katarzyna M. Piekarz, Sabira Mohammed, Sergio Dominguez Lopez, Rizwan Qaisar, Dorothy Walton, Jacob L. Brown, Ashley Murphy, Nataliya Smith, Debra Saunders, Michael J. Beckstead, Scott Plafker, Tommy L. Lewis, Rheal Towner, Sathyaseelan S. Deepa, Arlan Richardson, Robert C. Axtell, Holly Van Remmen. Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis. Redox Biology 2023;59:102550
    https://doi.org/10.1016/j.redox.2022.102550
  334. Chunxiu Lin, Yizi Lin, Jie Xiao, Yaqi Lan, Yong Cao, Yunjiao Chen. Effect of Momordica saponin‑ and Cyclocarya paliurus polysaccharide‐enriched beverages on oxidative stress and fat accumulation in Caenorhabditis elegans. J Sci Food Agric 2021;101:3366
    https://doi.org/10.1002/jsfa.10966
  335. Venugopalan D. Nair, Yongchao Ge. Alterations of miRNAs reveal a dysregulated molecular regulatory network in Parkinson’s disease striatum. Neuroscience Letters 2016;629:99
    https://doi.org/10.1016/j.neulet.2016.06.061
  336. Md. Rashedunnabi Akanda, Myung-Jin Kim, In-Shik Kim, Dongchoon Ahn, Hyun-Jin Tae, Md. Mahfujur Rahman, Yang-Gyu Park, Jae-Won Seol, Hyeon-Hwa Nam, Byung-Kil Choo, Byung-Yong Park. Neuroprotective Effects of Sigesbeckia pubescens Extract on Glutamate-Induced Oxidative Stress in HT22 Cells via Downregulation of MAPK/caspase-3 Pathways. Cell Mol Neurobiol 2018;38:497
    https://doi.org/10.1007/s10571-017-0496-y
  337. Neil B. Panchal. Bridging Biochemistry and Aging: A Journey Towards Prolonged Health span. Biosci., Biotech. Res. Asia 2024;21:295
    https://doi.org/10.13005/bbra/3226
  338. Laura Bordoni, Cinzia Nasuti, Donatella Fedeli, Roberta Galeazzi, Emiliano Laudadio, Luca Massaccesi, Gerardo López-Rodas, Rosita Gabbianelli. Early impairment of epigenetic pattern in neurodegeneration: Additional mechanisms behind pyrethroid toxicity. Experimental Gerontology 2019;124:110629
    https://doi.org/10.1016/j.exger.2019.06.002
  339. Mengfan Zhang, Lingyan Liu, Peng Wei, Wei Feng, Tao Yi. A proximity tagging strategy utilizing an activated aldehyde group as the active site. Chinese Chemical Letters 2024:110127
    https://doi.org/10.1016/j.cclet.2024.110127
  340. Amina Amakran, Meriem Hamoudane, Fabrice Pagniez, Ahmed Lamarti, Carine Picot, Gilles Figueredo, Mohamed Nhiri, Patrice Le Pape. Chemical Composition, Antifungal, Antioxidant, and Hemolytic Activities of Moroccan Thymus capitatus Essential Oil. Chemistry & Biodiversity 2024
    https://doi.org/10.1002/cbdv.202300563
  341. Andrea Donoso, Javiera González-Durán, Andrés Agurto Muñoz, Pablo A. González, Cristian Agurto-Muñoz. “Therapeutic uses of natural astaxanthin: An evidence-based review focused on human clinical trials”. Pharmacological Research 2021;166:105479
    https://doi.org/10.1016/j.phrs.2021.105479
  342. Laura Dumitrescu, Iulia Popescu-Olaru, Liviu Cozma, Delia Tulbă, Mihail Eugen Hinescu, Laura Cristina Ceafalan, Mihaela Gherghiceanu, Bogdan Ovidiu Popescu, Maria Luca. Oxidative Stress and the Microbiota‐Gut‐Brain Axis. Oxidative Medicine and Cellular Longevity 2018;2018
    https://doi.org/10.1155/2018/2406594
  343. Chiara Giacomelli, Simona Daniele, Claudia Martini. Potential biomarkers and novel pharmacological targets in protein aggregation-related neurodegenerative diseases. Biochemical Pharmacology 2017;131:1
    https://doi.org/10.1016/j.bcp.2017.01.017
  344. Ochuko L. Erukainure, Omamuyovwi M. Ijomone, Olajumoke A. Oyebode, Chika I. Chukwuma, Michael Aschner, Md. Shahidul Islam. Hyperglycemia-induced oxidative brain injury: Therapeutic effects of Cola nitida infusion against redox imbalance, cerebellar neuronal insults, and upregulated Nrf2 expression in type 2 diabetic rats. Food and Chemical Toxicology 2019;127:206
    https://doi.org/10.1016/j.fct.2019.03.044
  345. Yameng Hao. The Role of Catechol in Caffeic Acid Phenethyl Ester Derivatives for Neuroprotective Effects. ChemistrySelect 2024;9
    https://doi.org/10.1002/slct.202400461
  346. Boglarka H. Varkuti, Miklos Kepiro, Ze Liu, Kyle Vick, Yosef Avchalumov, Rodrigo Pacifico, Courtney M. MacMullen, Theodore M. Kamenecka, Sathyanarayanan V. Puthanveettil, Ronald L. Davis. Neuron-based high-content assay and screen for CNS active mitotherapeutics. Sci. Adv. 2020;6
    https://doi.org/10.1126/sciadv.aaw8702
  347. Zhi-Tong Zhang, Guang-Xiao Huang, Wen-Jiao He, Wen-Ting Gu, Xue Wang, Zhi-Quan Chen, Fu-Jun Bi, Lu-Yong Zhang, Shu-Mei Wang, Dan Tang. Rapid screening of neuroprotective components from Huang-Lian-Jie-Du Decoction by living cell biospecific extraction coupled with HPLC-Q-Orbitrap-HRMS/MS analysis. Journal of Chromatography B 2021;1176:122764
    https://doi.org/10.1016/j.jchromb.2021.122764
  348. Parinee Kittimongkolsuk, Nattaporn Pattarachotanant, Siriporn Chuchawankul, Michael Wink, Tewin Tencomnao. Neuroprotective Effects of Extracts from Tiger Milk Mushroom Lignosus rhinocerus Against Glutamate-Induced Toxicity in HT22 Hippocampal Neuronal Cells and Neurodegenerative Diseases in Caenorhabditis elegans. Biology 2021;10:30
    https://doi.org/10.3390/biology10010030
  349. Ana Ortíz de Zárate, Marta Pérez-Torralba, Iñigo Bonet Isidro, Concepción López, Rosa M. Claramunt, Diana Martínez-Casanova, Isabel Sánchez-Vera, Jesús Jiménez-González, José Luis Lavandera. 1,5-Benzodiazepin-2(3H)-ones: In Vitro Evaluation as Antiparkinsonian Agents. Antioxidants 2021;10:1584
    https://doi.org/10.3390/antiox10101584
  350. Stephanie M. Lim, Henk-Jan van den Ham, Minoushka Oduber, Eurydice Martina, Fatiha Zaaraoui-Boutahar, Jeroen M. Roose, Wilfred F. J. van IJcken, Albert D. M. E. Osterhaus, Arno C. Andeweg, Penelope Koraka, Byron E. E. Martina. Transcriptomic Analyses Reveal Differential Gene Expression of Immune and Cell Death Pathways in the Brains of Mice Infected with West Nile Virus and Chikungunya Virus. Front. Microbiol. 2017;8
    https://doi.org/10.3389/fmicb.2017.01556
  351. Hongying Zhao, Jiaxin Song, Tian Wang, Xiaodan Fan. Selenium nanoparticles decorated with polysaccharides from Sargassum fusiforme protects against 6-OHDA-induced neurotoxicity in PC12 cells and rat model of Parkinson's disease. Nanomedicine: Nanotechnology, Biology and Medicine 2024;59:102755
    https://doi.org/10.1016/j.nano.2024.102755
  352. Arjun Thapa, Nick Carroll. Dietary Modulation of Oxidative Stress in Alzheimer’s Disease. IJMS 2017;18:1583
    https://doi.org/10.3390/ijms18071583
  353. Bindu D. Paul, Solomon H. Snyder. Therapeutic Applications of Cysteamine and Cystamine in Neurodegenerative and Neuropsychiatric Diseases. Front. Neurol. 2019;10
    https://doi.org/10.3389/fneur.2019.01315
  354. Cyril Quessada, Alexandra Bouscary, Frédérique René, Cristiana Valle, Alberto Ferri, Shyuan T. Ngo, Jean-Philippe Loeffler. Skeletal Muscle Metabolism: Origin or Prognostic Factor for Amyotrophic Lateral Sclerosis (ALS) Development?. Cells 2021;10:1449
    https://doi.org/10.3390/cells10061449
  355. Yosuke Tabei, Hiroko Abe, Shingo Suzuki, Nobuaki Takeda, Jun-ichiro Arai, Yoshihiro Nakajima. Sedanolide Activates KEAP1–NRF2 Pathway and Ameliorates Hydrogen Peroxide-Induced Apoptotic Cell Death. IJMS 2023;24:16532
    https://doi.org/10.3390/ijms242216532
  356. Mateusz Maciejczyk, Piotr Gerreth, Anna Zalewska, Katarzyna Hojan, Karolina Gerreth, Massimo Collino. Salivary Gland Dysfunction in Stroke Patients Is Associated with Increased Protein Glycoxidation and Nitrosative Stress. Oxidative Medicine and Cellular Longevity 2020;2020:1
    https://doi.org/10.1155/2020/6619439
  357. Charles Gnanaraj, Mahendran Sekar, Shivkanya Fuloria, Shasank S. Swain, Siew Hua Gan, Kumarappan Chidambaram, Nur Najihah Izzati Mat Rani, Tavamani Balan, Sarah Stephenie, Pei Teng Lum, Srikanth Jeyabalan, M. Yasmin Begum, Vivek Chandramohan, Lakshmi Thangavelu, Vetriselvan Subramaniyan, Neeraj Kumar Fuloria. In Silico Molecular Docking Analysis of Karanjin against Alzheimer’s and Parkinson’s Diseases as a Potential Natural Lead Molecule for New Drug Design, Development and Therapy. Molecules 2022;27:2834
    https://doi.org/10.3390/molecules27092834
  358. Nitish Rai, Rahul Kumar, Gaurav Rajesh Desai, G. Venugopalan, Shashank Shekhar, Prasun Chatterjee, Manjari Tripathi, Ashish Datt Upadhyay, Sadanand Dwivedi, Aparajit B. Dey, Sharmistha Dey. Relative Alterations in Blood-Based Levels of Sestrin in Alzheimer’s Disease and Mild Cognitive Impairment Patients. JAD 2016;54:1147
    https://doi.org/10.3233/JAD-160479
  359. Soren Impey, Carl Pelz, Lara-Kirstie Riparip, Amanuel Tafessu, Fatema Fareh, Damian G. Zuloaga, Tessa Marzulla, Blair Stewart, Susanna Rosi, Mitchell S. Turker, Jacob Raber. Postsynaptic density radiation signature following space irradiation. Front. Physiol. 2023;14
    https://doi.org/10.3389/fphys.2023.1215535
  360. Jie Yu, Jia-Jia Lin, Rui Yu, Shan He, Qin-Wen Wang, Wei Cui, Jin-Rong Zhang. Fucoxanthin prevents H2O2-induced neuronal apoptosis via concurrently activating the PI3-K/Akt cascade and inhibiting the ERK pathway. Food & Nutrition Research 2017;61:1304678
    https://doi.org/10.1080/16546628.2017.1304678
  361. Sisi Liu, Guangming Li, Haijie Tang, Rui Pan, Huili Wang, Fujun Jin, Xueqin Yan, Yanyan Xing, Guiling Chen, Yongmei Fu, Jun Dong. Madecassoside ameliorates lipopolysaccharide-induced neurotoxicity in rats by activating the Nrf2-HO-1 pathway. Neuroscience Letters 2019;709:134386
    https://doi.org/10.1016/j.neulet.2019.134386
  362. Iswariyaraja Sridevi Gurubaran, Johanna Viiri, Ali Koskela, Juha M.T. Hyttinen, Jussi J. Paterno, Gréta Kis, Miklós Antal, Arto Urtti, Anu Kauppinen, Szabolcs Felszeghy, Kai Kaarniranta. Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α-/- Mouse Model. IJMS 2020;21:1976
    https://doi.org/10.3390/ijms21061976
  363. Alexandre Vallée, Jean-Noël Vallée, Yves Lecarpentier. Potential role of cannabidiol in Parkinson’s disease by targeting the WNT/β-catenin pathway, oxidative stress and inflammation. Aging 2021;13:10796
    https://doi.org/10.18632/aging.202951
  364. Mansi Garg, Lei Li, Roseline Godbout. Role of DDX1 in the oxidative response of ataxia telangiectasia patient-derived fibroblasts. Redox Biology 2024;69:102988
    https://doi.org/10.1016/j.redox.2023.102988
  365. Laura Mahoney-Sánchez, Hind Bouchaoui, Scott Ayton, David Devos, James A. Duce, Jean-Christophe Devedjian. Ferroptosis and its potential role in the physiopathology of Parkinson’s Disease. Progress in Neurobiology 2021;196:101890
    https://doi.org/10.1016/j.pneurobio.2020.101890
  366. Jusong Kim, Jaewon Kim, Hee Jung Lim, Sanghyuk Lee, Yun Soo Bae, Jaesang Kim. Nox4-IGF2 Axis Promotes Differentiation of Embryoid Body Cells Into Derivatives of the Three Embryonic Germ Layers. Stem Cell Rev and Rep 2022;18:1181
    https://doi.org/10.1007/s12015-021-10303-x
  367. Hasya Nazli Ekin, Alper Gokbulut, Zubeyde Ugurlu Aydin, A. Ali Donmez, Ilkay Erdogan Orhan. Insight into anticholinesterase and antioxidant potential of thirty-four Rosaceae samples and phenolic characterization of the active extracts by HPLC. Industrial Crops and Products 2016;91:104
    https://doi.org/10.1016/j.indcrop.2016.06.029
  368. Bindu Diana Paul. Neuroprotective Roles of the Reverse Transsulfuration Pathway in Alzheimer’s Disease. Front. Aging Neurosci. 2021;13
    https://doi.org/10.3389/fnagi.2021.659402
  369. Obaid Afzal, Mahmood Hassan Dalhat, Abdulmalik S. A. Altamimi, Rabia Rasool, Sami I. Alzarea, Waleed Hassan Almalki, Bibi Nazia Murtaza, Saima Iftikhar, Shamaila Nadeem, Muhammad Shahid Nadeem, Imran Kazmi. Green Tea Catechins Attenuate Neurodegenerative Diseases and Cognitive Deficits. Molecules 2022;27:7604
    https://doi.org/10.3390/molecules27217604
  370. Sanaz Nasoohi, Saifudeen Ismael, Tauheed Ishrat. Thioredoxin-Interacting Protein (TXNIP) in Cerebrovascular and Neurodegenerative Diseases: Regulation and Implication. Mol Neurobiol 2018;55:7900
    https://doi.org/10.1007/s12035-018-0917-z
  371. E. Vrbanović, I. Lapić, D. Rogić, I. Z. Alajbeg. Changes in salivary oxidative status, salivary cortisol, and clinical symptoms in female patients with temporomandibular disorders during occlusal splint therapy: a 3-month follow up. BMC Oral Health 2019;19
    https://doi.org/10.1186/s12903-019-0791-8
  372. Alessandra da Silva, Ana Paula Silva Caldas, Sônia Lopes Pinto, Helen Hermana M. Hermsdorff, Aline Marcadenti, Ângela Cristine Bersch-Ferreira, Camila Ragne Torreglosa, Bernardete Weber, Josefina Bressan. Dietary total antioxidant capacity is inversely associated with cardiovascular events and cardiometabolic risk factors: A cross-sectional study. Nutrition 2021;89:111140
    https://doi.org/10.1016/j.nut.2021.111140
  373. Jung Bok Lee, Young Min Shin, Won Shik Kim, Seo Yeon Kim, Hak-Joon Sung. Biomimetic Medical Materials. 2021.
    https://doi.org/10.1007/978-981-13-0445-3_15
  374. . .
    https://doi.org/
  375. Chihiro Sakauchi, Hiroaki Wakatsuki, Hidenori Ichijo, Kazuki Hattori. Pleiotropic properties of ASK1. Biochimica et Biophysica Acta (BBA) - General Subjects 2017;1861:3030
    https://doi.org/10.1016/j.bbagen.2016.09.028
  376. Bahare Salehi, Cristina Quispe, Javad Sharifi‐Rad, Lalit Giri, Renu Suyal, Arun K. Jugran, Paolo Zucca, Antonio Rescigno, Stefania Peddio, Otilia Bobiş, Adela Ramona Moise, Gerardo Leyva‐Gómez, María L. Del Prado‐Audelo, Hernán Cortes, Marcello Iriti, Miquel Martorell, Natália Cruz‐Martins, Manoj Kumar, Wissam Zam. Antioxidant potential of family Cucurbitaceae with special emphasis on Cucurbita genus: A key to alleviate oxidative stress‐mediated disorders. Phytotherapy Research 2021;35:3533
    https://doi.org/10.1002/ptr.7045
  377. Kornrawee Suwannakot, Nataya Sritawan, Salinee Naewla, Anusara Aranarochana, Apiwat Sirichoat, Wanassanun Pannangrong, Peter Wigmore, Jariya Umka Welbat, Víctor M. Mendoza-Núñez. Melatonin Attenuates Methotrexate-Induced Reduction of Antioxidant Activity Related to Decreases of Neurogenesis in Adult Rat Hippocampus and Prefrontal Cortex. Oxidative Medicine and Cellular Longevity 2022;2022:1
    https://doi.org/10.1155/2022/1596362
  378. Cristian Gerónimo-Olvera, Lourdes Massieu. Autophagy as a Homeostatic Mechanism in Response to Stress Conditions in the Central Nervous System. Mol Neurobiol 2019;56:6594
    https://doi.org/10.1007/s12035-019-1546-x
  379. Alexandre Vallée, Yves Lecarpentier, Rémy Guillevin, Jean-Noël Vallée. Reprogramming energetic metabolism in Alzheimer's disease. Life Sciences 2018;193:141
    https://doi.org/10.1016/j.lfs.2017.10.033
  380. Md. Mamunul Haque, Dhiraj P. Murale, Yun Kyung Kim, Jun-Seok Lee. Crosstalk between Oxidative Stress and Tauopathy. IJMS 2019;20:1959
    https://doi.org/10.3390/ijms20081959
  381. Feiyi Sun, Yulin Deng, Xiaowei Han, Qingqing Liu, Peng Zhang, Robina Manzoor, Hong Ma. A secret that underlies Parkinson's disease: The damaging cycle. Neurochemistry International 2019;129:104484
    https://doi.org/10.1016/j.neuint.2019.104484
  382. Xia Zhang, Liangwei Zhang, Xiaoyan Wang, Xiaoyue Han, Yan Huang, Bowei Li, Lingxin Chen. Visualizing and evaluating mitochondrial cysteine via near-infrared fluorescence imaging in cells, tissues and in vivo under hypoxia/reperfusion stress. Journal of Hazardous Materials 2021;419:126476
    https://doi.org/10.1016/j.jhazmat.2021.126476
  383. Kwadwo Ofori, Anurupa Ghosh, Dinesh Kumar Verma, Darice Wheeler, Gabriela Cabrera, Jong-Bok Seo, Yong-Hwan Kim. A Novel NOX Inhibitor Alleviates Parkinson’s Disease Pathology in PFF-Injected Mice. IJMS 2023;24:14278
    https://doi.org/10.3390/ijms241814278
  384. Xiao Chen, Min Zhang, Mukhtar Ahmed, Krishna Mohan Surapaneni, Vishnu Priya Veeraraghavan, Palanisamy Arulselvan. Neuroprotective effects of ononin against the aluminium chloride-induced Alzheimer’s disease in rats. Saudi Journal of Biological Sciences 2021;28:4232
    https://doi.org/10.1016/j.sjbs.2021.06.031
  385. Abdel Fawaz Bagoudou, Yifeng Zheng, Masahiro Nakabayashi, Saroat Rawdkuen, Hyun-Young Park, Dhiraj A. Vattem, Kenji Sato, Soichiro Nakamura, Shigeru Katayama. Glochidion littorale Leaf Extract Exhibits Neuroprotective Effects in Caenorhabditis elegans via DAF-16 Activation. Molecules 2021;26:3958
    https://doi.org/10.3390/molecules26133958
  386. Heesun Choi, Haeng Jun Kim, Jisoo Kim, Soohyun Kim, Jinhee Yang, Wonik Lee, Yeonju Park, Seung Jae Hyeon, Dong-Sup Lee, Hoon Ryu, Junho Chung, Inhee Mook-Jung. Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of Aβ-induced impaired axonal transport. Mol Neurodegeneration 2017;12
    https://doi.org/10.1186/s13024-017-0164-1
  387. Saima Zameer, Abul Kalam Najmi, Divya Vohora, Mohd Akhtar. A review on therapeutic potentials of Trigonella foenum graecum (fenugreek) and its chemical constituents in neurological disorders: Complementary roles to its hypolipidemic, hypoglycemic, and antioxidant potential. Nutritional Neuroscience 2018;21:539
    https://doi.org/10.1080/1028415X.2017.1327200
  388. Nicholas J. Abuid, Kerim M. Gattás-Asfura, Daniel J. LaShoto, Alexia M. Poulos, Cherie L. Stabler. Nanoparticles for Biomedical Applications. 2018.
    https://doi.org/10.1016/B978-0-12-816662-8.00017-5
  389. Coram Guevara, Sinay C. Vicencio, Ignacio S. Pizarro, Francisca Villavicencio-Tejo, Rodrigo A. Quintanilla, Pablo Astudillo, Estibaliz Ampuero, Rodrigo Varas, Juan A. Orellana, Fernando C. Ortiz. Evidence for TGF-β1/Nrf2 Signaling Crosstalk in a Cuprizone Model of Multiple Sclerosis. Antioxidants 2024;13:914
    https://doi.org/10.3390/antiox13080914
  390. Glory Florence Meejuru, Anushri Somavarapu, Ravi Chandra Sekhara Reddy Danduga, Lakshmi Sudeepthi Nissankara Roa, Phani Kumar Kola. Protective effects of duloxetine against chronic immobilisation stress-induced anxiety, depression, cognitive impairment and neurodegeneration in mice. 2021;73:522
    https://doi.org/10.1093/jpp/rgaa003
  391. Iva Z. Alajbeg, Ivana Lapić, Dunja Rogić, Lea Vuletić, Ana Andabak Rogulj, Davor Illeš, Dubravka Knezović Zlatarić, Tomislav Badel, Ema Vrbanović, Ivan Alajbeg. Within-Subject Reliability and between-Subject Variability of Oxidative Stress Markers in Saliva of Healthy Subjects: A Longitudinal Pilot Study. Disease Markers 2017;2017:1
    https://doi.org/10.1155/2017/2697464
  392. Chinyere Aloke, Ihechi I. Ezeigbo, Ikenna C. Ohanenye, Chibuike C. Udenigwe, Claus Jacob, Chukwunonso E. C. C. Ejike. A Small Green Red-Ox Carries a Bright Medical Future for Sub-Saharan Africa. Curr Pharmacol Rep 2019;5:245
    https://doi.org/10.1007/s40495-019-00182-9
  393. Octavio Binvignat, Jordi Olloquequi. Excitotoxicity as a Target Against Neurodegenerative Processes. CPD 2020;26:1251
    https://doi.org/10.2174/1381612826666200113162641
  394. Mingeun Kim, Juhye Kang, Misun Lee, Jiyeon Han, Geewoo Nam, Eunyoung Tak, Min Sun Kim, Hyuck Jin Lee, Eunju Nam, Jiyong Park, Soo Jin Oh, Ji-Yoon Lee, Joo-Yong Lee, Mu-Hyun Baik, Mi Hee Lim. Minimalistic Principles for Designing Small Molecules with Multiple Reactivities against Pathological Factors in Dementia. J. Am. Chem. Soc. 2020;142:8183
    https://doi.org/10.1021/jacs.9b13100
  395. Qin-Mei Zhou, Hao-Yu Zhao, Chuan Ma, Lu Huang, Jie Liu, Li Guo, Cheng Peng, Liang Xiong. Pocahemiketone A, a Sesquiterpenoid Possessing a Spirocyclic Skeleton with a Hemiketal Endoperoxide Unit, Alleviates Aβ25–35-Induced Pyroptosis and Oxidative Stress in SH-SY5Y Cells. Org. Lett. 2022;24:4734
    https://doi.org/10.1021/acs.orglett.2c01587
  396. Paola Costanzo, Manuela Oliverio, Jessica Maiuolo, Sonia Bonacci, Giuseppina De Luca, Mariorosario Masullo, Rosaria Arcone, Antonio Procopio. Novel Hydroxytyrosol-Donepezil Hybrids as Potential Antioxidant and Neuroprotective Agents. Front. Chem. 2021;9
    https://doi.org/10.3389/fchem.2021.741444
  397. Wudtipong Vongthip, Chanin Sillapachaiyaporn, Kyu-Won Kim, Monruedee Sukprasansap, Tewin Tencomnao. Thunbergia laurifolia Leaf Extract Inhibits Glutamate-Induced Neurotoxicity and Cell Death through Mitophagy Signaling. Antioxidants 2021;10:1678
    https://doi.org/10.3390/antiox10111678
  398. Willian Orlando Castillo, Andres Felipe Aristizabal-Pachon, Elsa Sakamoto-Hojo, Cristian Aldemar Gasca, Fabio Antonio Cabezas-Fajardo, Catarina Takahashi. Caliphruria subedentata (Amaryllidaceae) decreases genotoxicity and cell death induced by β-amyloid peptide in SH-SY5Y cell line. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2018;836:54
    https://doi.org/10.1016/j.mrgentox.2018.06.010
  399. Rafat Ali, Hilal Ahmad Pal, Rohil Hameed, Aamir Nazir, Sandeep Verma. Controlled release of hydrogen sulfide significantly reduces ROS stress and increases dopamine levels in transgenic C. elegans. Chem. Commun. 2019;55:10142
    https://doi.org/10.1039/C9CC05153H
  400. Kapil D. Patel, Zalike Keskin-Erdogan, Prasad Sawadkar, Nik Syahirah Aliaa Nik Sharifulden, Mark Robert Shannon, Madhumita Patel, Lady Barrios Silva, Rajkumar Patel, David Y. S. Chau, Jonathan C. Knowles, Adam W. Perriman, Hae-Won Kim. Oxidative stress modulating nanomaterials and their biochemical roles in nanomedicine. Nanoscale Horiz. 2024
    https://doi.org/10.1039/D4NH00171K
  401. Sunil Kumar Sharma, Mohinder Pal Bansal, Rajat Sandhir. Altered dietary selenium influences brain iron content and behavioural outcomes. Behavioural Brain Research 2019;372:112011
    https://doi.org/10.1016/j.bbr.2019.112011
  402. Katarzyna Socha, Katarzyna Klimiuk, Sylwia K. Naliwajko, Jolanta Soroczyńska, Anna Puścion-Jakubik, Renata Markiewicz-Żukowska, Jan Kochanowicz. Dietary Habits, Selenium, Copper, Zinc and Total Antioxidant Status in Serum in Relation to Cognitive Functions of Patients with Alzheimer’s Disease. Nutrients 2021;13:287
    https://doi.org/10.3390/nu13020287
  403. Hye-Sun Lim, Joong-Sun Kim, Byeong Cheol Moon, Seung Mok Ryu, Jun Lee, Gunhyuk Park. Batryticatus Bombyx Protects Dopaminergic Neurons against MPTP-Induced Neurotoxicity by Inhibiting Oxidative Damage. Antioxidants 2019;8:574
    https://doi.org/10.3390/antiox8120574
  404. Ji Won Choi, Geum Jin Kim, Hyeon Jeong Kim, Joo-Won Nam, Jushin Kim, Jungwook Chin, Jong-Hyun Park, Hyukjae Choi, Ki Duk Park. Identification and evaluation of a napyradiomycin as a potent Nrf2 activator: Anti-oxidative and anti-inflammatory activities. Bioorganic Chemistry 2020;105:104434
    https://doi.org/10.1016/j.bioorg.2020.104434
  405. Fernanda Barbosa Lopes, Mariáurea Matias Sarandy, Rômulo Dias Novaes, Giuseppe Valacchi, Reggiani Vilela Gonçalves. OxInflammatory Responses in the Wound Healing Process: A Systematic Review. Antioxidants 2024;13:823
    https://doi.org/10.3390/antiox13070823
  406. Feng-mao An, Zheng Liu, Xin-ran Xuan, Qing-shan Liu, Cheng-xi Wei. Sanweidoukou decoction, a Chinese herbal formula, ameliorates β-amyloid protein-induced neuronal insult via modulating MAPK/NF-κB signaling pathways: Studies in vivo and in vitro. Journal of Ethnopharmacology 2021;273:114002
    https://doi.org/10.1016/j.jep.2021.114002
  407. Gabriela Debom, Marta Gazal, Mayara Sandrielly Pereira Soares, Carlus Augustu Tavares do Couto, Bruna Mattos, Claiton Lencina, Manuella Pinto Kaster, Gabriele Codenonzi Ghisleni, Rejane Tavares, Elizandra Braganhol, Vitor Clasen Chaves, Flávio Henrique Reginatto, Francieli Stefanello, Roselia Maria Spanevello. Preventive effects of blueberry extract on behavioral and biochemical dysfunctions in rats submitted to a model of manic behavior induced by ketamine. Brain Research Bulletin 2016;127:260
    https://doi.org/10.1016/j.brainresbull.2016.10.008
  408. Alireza Abdanipour, Fatemeh Deheshjo, Davood Sohrabi, Iraj Jafari Anarkooli, Reza Nejatbakhsh. Neuroprotective effect of lovastatin through down-regulation of pro-apoptoticMst1gene expression in rat model pilocarpine epilepsy. Neurological Research 2018;40:874
    https://doi.org/10.1080/01616412.2018.1497252
  409. Barry B. Muhoberac, Ruben Vidal. Iron, Ferritin, Hereditary Ferritinopathy, and Neurodegeneration. Front. Neurosci. 2019;13
    https://doi.org/10.3389/fnins.2019.01195
  410. Cristina Eugenia Gallegos, Mariana Bartos, Fernanda Gumilar, Alejandra Minetti, Carlos Javier Baier. Behavioral and neurochemical impairments after intranasal administration of chlorpyrifos formulation in mice. Pesticide Biochemistry and Physiology 2023;189:105315
    https://doi.org/10.1016/j.pestbp.2022.105315
  411. Amit U. Joshi, Lauren D. Van Wassenhove, Kelsey R. Logas, Paras S. Minhas, Katrin I. Andreasson, Kenneth I. Weinberg, Che-Hong Chen, Daria Mochly-Rosen. Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer’s disease related pathology. acta neuropathol commun 2019;7
    https://doi.org/10.1186/s40478-019-0839-7
  412. Dinesh Kumar Verma, Dhirendra Kumar Singh, Sonam Gupta, Parul Gupta, Abhishek Singh, Joyshree Biswas, Sarika Singh. Minocycline diminishes the rotenone induced neurotoxicity and glial activation via suppression of apoptosis, nitrite levels and oxidative stress. NeuroToxicology 2018;65:9
    https://doi.org/10.1016/j.neuro.2018.01.006
  413. Andrey G. Moiseenok, Nina P. Kanunnikova. Brain CoA and Acetyl CoA Metabolism in Mechanisms of Neurodegeneration. Biochemistry Moscow 2023;88:466
    https://doi.org/10.1134/S000629792304003X
  414. Qian Tan, Xiaoqiong Yan, Lizhu Chen, Kun Jiang, Zhenli Guo. Dietary flavonoids protect human brain microvascular endothelial cell from oxidative stress-induced dysfunction. Mol. Cell. Toxicol. 2024
    https://doi.org/10.1007/s13273-024-00461-7
  415. Bridget Martinez, PhilipV Peplow. MicroRNAs in Parkinson's disease and emerging therapeutic targets. Neural Regen Res 2017;12:1945
    https://doi.org/10.4103/1673-5374.221147
  416. Zahra Jahangiri, Zahra Gholamnezhad, Mahmoud Hosseini. The effects of exercise on hippocampal inflammatory cytokine levels, brain oxidative stress markers and memory impairments induced by lipopolysaccharide in rats. Metab Brain Dis 2019;34:1157
    https://doi.org/10.1007/s11011-019-00410-7
  417. M. A. Olude, S. T. Bello, O. A. Mustapha, F. E. Olopade, J. Plendl, A. O. Ihunwo, J. O. Olopade. Oligodendrocyte morphology in the developing brain of the African giant rat (Cricetomys gambianus, Waterhouse): Histology, immunohistochemistry and electron microscopy. Anat Histol Embryol 2018;47:231
    https://doi.org/10.1111/ahe.12348
  418. Maria Bandookwala, Disha Thakkar, Pinaki Sengupta. Advancements in the Analytical Quantification of Nitroxidative Stress Biomarker 3-Nitrotyrosine in Biological Matrices. Critical Reviews in Analytical Chemistry 2020;50:265
    https://doi.org/10.1080/10408347.2019.1623010
  419. Miriam Martínez-Huélamo, Jose Rodríguez-Morató, Anna Boronat, Rafael De la Torre. Modulation of Nrf2 by Olive Oil and Wine Polyphenols and Neuroprotection. Antioxidants 2017;6:73
    https://doi.org/10.3390/antiox6040073
  420. Kabirat Temitope Babalola, Oyetola Oyebanjo, Victor Adetayo Adekoya, Ismaheel Akinwale Adeniyi, Abayomi Mayowa Ajayi, Samuel Adetunji Onasanwo. Protective effect of methanol leaf extract of Cnidoscolus aconitifolius against lipopolysaccharides-induced cortico-hippocampal neuroinflammation, oxidative stress and memory impairment. ADV TRADIT MED (ADTM) 2023;23:145
    https://doi.org/10.1007/s13596-021-00578-3
  421. Jie Ren, Ling Yuan, Wenbin Wang, Meiju Zhang, Qun Wang, Simin Li, Ling Zhang, Kun Hu. Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway. Toxicology and Applied Pharmacology 2019;378:114617
    https://doi.org/10.1016/j.taap.2019.114617
  422. Bernardo Gindri dos Santos, Pauline Maciel August, Cristiane Matté. Treatments, Nutraceuticals, Supplements, and Herbal Medicine in Neurological Disorders. 2019.
    https://doi.org/10.1016/B978-0-323-90052-2.00025-1
  423. M. Zuluaga, V. Gueguen, D. Letourneur, G. Pavon-Djavid. Astaxanthin-antioxidant impact on excessive Reactive Oxygen Species generation induced by ischemia and reperfusion injury. Chemico-Biological Interactions 2018;279:145
    https://doi.org/10.1016/j.cbi.2017.11.012
  424. Regina G. Daré, Celso V. Nakamura, Valdecir F. Ximenes, Sueli O.S. Lautenschlager. Tannic acid, a promising anti-photoaging agent: Evidences of its antioxidant and anti-wrinkle potentials, and its ability to prevent photodamage and MMP-1 expression in L929 fibroblasts exposed to UVB. Free Radical Biology and Medicine 2020;160:342
    https://doi.org/10.1016/j.freeradbiomed.2020.08.019
  425. Bianca A. Trombetta, Chao‐Yi Wu, Evan Kuo, Matthijs B. de Geus, Hiroko H. Dodge, Becky C. Carlyle, Pia Kivisäkk, Steven E. Arnold. Cerebrospinal fluid biomarker profiling of diverse pathophysiological domains in Alzheimer's disease. A&D Transl Res & Clin Interv 2024;10
    https://doi.org/10.1002/trc2.12440
  426. Mohammad Hassan Baig, Abu Baker, Ghulam M Ashraf, Jae-June Dong. ASK1 and its role in cardiovascular and other disorders: available treatments and future prospects. Expert Review of Proteomics 2019;16:857
    https://doi.org/10.1080/14789450.2019.1676735
  427. Fiorella Colasuonno, Chiara Marioli, Marco Tartaglia, Enrico Bertini, Claudia Compagnucci, Sandra Moreno. New Insights into the Neurodegeneration Mechanisms Underlying Riboflavin Transporter Deficiency (RTD): Involvement of Energy Dysmetabolism and Cytoskeletal Derangement. Biomedicines 2022;10:1329
    https://doi.org/10.3390/biomedicines10061329
  428. Jinying Xu, Yangyang Zheng, Liangjia Wang, Yining Liu, Xishu Wang, Yulin Li, Guangfan Chi. miR-124: A Promising Therapeutic Target for Central Nervous System Injuries and Diseases. Cell Mol Neurobiol 2022;42:2031
    https://doi.org/10.1007/s10571-021-01091-6
  429. Ayomide Victor Atoki, Patrick Maduabuchi Aja, Erick Nyakundi Ondari, Tijjani Salihu Shinkafi. Advances in Alzheimer’s disease therapeutics: biochemistry, exploring bioactive compounds and novel approaches. International Journal of Food Properties 2023;26:2091
    https://doi.org/10.1080/10942912.2023.2243050
  430. Carolina A. Ferreira, Dalong Ni, Zachary T. Rosenkrans, Weibo Cai. Scavenging of reactive oxygen and nitrogen species with nanomaterials. Nano Res. 2018;11:4955
    https://doi.org/10.1007/s12274-018-2092-y
  431. Wei Wang, Jinyang Zheng, Hao Zhou, Qiang Liu, Li Jia, Xiuming Zhang, Dongtao Ge, Wei Shi, Yanan Sun. Polydopamine-Based Nanocomposite as a Biomimetic Antioxidant with a Variety of Enzymatic Activities for Parkinson’s Disease. ACS Appl. Mater. Interfaces 2022;14:32901
    https://doi.org/10.1021/acsami.2c06981
  432. Maria H. Ribeiro, Patricia Lage. Handbook of Dietary Flavonoids. 2022.
    https://doi.org/10.1007/978-3-030-94753-8_29-1
  433. Ehsan Dadgostar, Mahsa Moghanlou, Mehrnoosh Parvaresh, Salimeh Mohammadi, Mohammadali Khandan, Michael Aschner, Hamed Mirzaei, Omid Reza Tamtaji. Can Berberine Serve as a New Therapy for Parkinson’s Disease?. Neurotox Res 2022;40:1096
    https://doi.org/10.1007/s12640-022-00526-2
  434. Ana Thalita Gonçalves Soares, Luiz Brasil Lopes Rodrigues, Willian Goulart Salgueiro, Ana Helena de Castro Dal Forno, Cristiane Freitas Rodrigues, Manoela Sacramento, Jeferson Franco, Diego Alves, Riva de Paula Oliveira, Simone Pinton, Daiana S. Ávila. Organoselenotriazoles attenuate oxidative damage induced by mitochondrial dysfunction in mev-1 Caenorhabditis elegans mutants. Journal of Trace Elements in Medicine and Biology 2019;53:34
    https://doi.org/10.1016/j.jtemb.2019.01.017
  435. Alvaro Martinez Guimera, Ciaran M. Welsh, Carole J. Proctor, Anne McArdle, Daryl P. Shanley. ‘Molecular habituation’ as a potential mechanism of gradual homeostatic loss with age. Mechanisms of Ageing and Development 2018;169:53
    https://doi.org/10.1016/j.mad.2017.11.010
  436. Yan Yang, Xiufang Chen, Haiyan Min, Shiyu Song, Juan Zhang, Shanshan Fan, Long Yi, Hongwei Wang, Xiaoping Gu, Zhengliang Ma, Qian Gao. Persistent mitoKATP Activation Is Involved in the Isoflurane-induced Cytotoxicity. Mol Neurobiol 2017;54:1101
    https://doi.org/10.1007/s12035-016-9710-z
  437. Theng Choon Ooi, Munirah Ahmad Munawar, Nur Hasnieza Mohd Rosli, Siti Nur Aqilah Abdul Malek, Hanisah Rosli, Farah Wahida Ibrahim, Norazrina Azmi, Hasnah Haron, Razinah Sharif, Suzana Shahar, Nor Fadilah Rajab, Rocío De la Puerta. Neuroprotection of Tropical Fruit Juice Mixture via the Reduction of iNOS Expression and CRH Level in β‐Amyloid‐Induced Rats Model of Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine 2020;2020
    https://doi.org/10.1155/2020/5126457
  438. Olakunle J. Onaolapo, Ademola O. Odeniyi, Adejoke Y. Onaolapo. Parkinson’s Disease: Is there a Role for Dietary and Herbal Supplements?. CNSNDDT 2021;20:343
    https://doi.org/10.2174/1871527320666210218082954
  439. Weishun Tian, Suyoung Heo, Dae-Woon Kim, In-Shik Kim, Dongchoon Ahn, Hyun-Jin Tae, Myung-Kon Kim, Byung-Yong Park. Ethanol Extract of Maclura tricuspidata Fruit Protects SH-SY5Y Neuroblastoma Cells against H2O2-Induced Oxidative Damage via Inhibiting MAPK and NF-κB Signaling. IJMS 2021;22:6946
    https://doi.org/10.3390/ijms22136946
  440. Jiangning Yin, Jun Jiang, Huajun Wang, Guoyuan Lu. Protective effects of specneuzhenide on renal injury in rats with diabetic nephropathy. 2019;14:740
    https://doi.org/10.1515/med-2019-0085
  441. Lu Wang, Yingjuan Wei, Zhenzhou Sun, Wenya Tai, Hui Li, Yaling Yin, Lin‐Hua Jiang, Jian‐Zhi Wang. Effectiveness and mechanisms of combined use of antioxidant nutrients in protecting against oxidative stress‐induced neuronal loss and related neurological deficits. CNS Neurosci Ther 2024;30
    https://doi.org/10.1111/cns.14886
  442. Mohammed Hassi, Oumaima Ouaddi, Raja ElKheloui, Rachid Bouharroud, Fatima Hamadi, Mohamed Alouani. Haematococcus. 2024.
    https://doi.org/10.1007/978-981-99-2901-6_13
  443. Jingqi Yang, Li Fang, Hongyan Lu, Chunlei Liu, Ji Wang, Dan Wu, Weihong Min. Walnut-Derived Peptide Enhances Mitophagy via JNK-Mediated PINK1 Activation to Reduce Oxidative Stress in HT-22 Cells. J. Agric. Food Chem. 2022;70:2630
    https://doi.org/10.1021/acs.jafc.2c00005
  444. Giuseppe Caruso, Anna Privitera, Miriam Wissam Saab, Nicolò Musso, Salvatore Maugeri, Annamaria Fidilio, Anna Provvidenza Privitera, Alessandra Pittalà, Renaud Blaise Jolivet, Luca Lanzanò, Giuseppe Lazzarino, Filippo Caraci, Angela Maria Amorini. Characterization of Carnosine Effect on Human Microglial Cells under Basal Conditions. Biomedicines 2023;11:474
    https://doi.org/10.3390/biomedicines11020474
  445. César A. Zaa, Clara Espitia, Karen L. Reyes-Barrera, Zhiqiang An, Marco A. Velasco-Velázquez. Neuroprotective Agents with Therapeutic Potential for COVID-19. Biomolecules 2023;13:1585
    https://doi.org/10.3390/biom13111585
  446. Deborah Mudali, Jaison Jeevanandam, Michael K. Danquah. Probing the characteristics and biofunctional effects of disease-affected cells and drug response via machine learning applications. Critical Reviews in Biotechnology 2020;40:951
    https://doi.org/10.1080/07388551.2020.1789062
  447. Jaehyeok Roh, Subbaya Subramanian, Neal J. Weinreb, Reena V. Kartha. Gaucher disease – more than just a rare lipid storage disease. J Mol Med 2022;100:499
    https://doi.org/10.1007/s00109-021-02174-z
  448. Seung-Hwan Kwon, Seoung Rak Lee, Yong Joo Park, Moonjin Ra, Yongjun Lee, Changhyun Pang, Ki Hyun Kim. Suppression of 6-Hydroxydopamine-Induced Oxidative Stress by Hyperoside Via Activation of Nrf2/HO-1 Signaling in Dopaminergic Neurons. IJMS 2019;20:5832
    https://doi.org/10.3390/ijms20235832
  449. Iana Bantim Felicio Calou, Milena de Barros Viana, Daniel Araki Ribeiro, Débora Estadella, Glauce Socorro de Barros Viana. Vitamins and Minerals in Neurological Disorders. 2019.
    https://doi.org/10.1016/B978-0-323-89835-5.00024-7
  450. María Magallón, Sara Pastor, Ana Carrión, Lucía Bañuls, Daniel Pellicer, Silvia Castillo, Sergio Bondía, María Navarro-García, Cruz González, Francisco Dasí. Oxidative Stress and Endoplasmic Reticulum Stress in Rare Respiratory Diseases. JCM 2021;10:1268
    https://doi.org/10.3390/jcm10061268
  451. Shylesh Bhaskaran, Natalie Pollock, Peter C. Macpherson, Bumsoo Ahn, Katarzyna M. Piekarz, Caroline A. Staunton, Jacob L. Brown, Rizwan Qaisar, Aphrodite Vasilaki, Arlan Richardson, Anne McArdle, Malcolm J. Jackson, Susan V. Brooks, Holly Van Remmen. Neuron‐specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice. Aging Cell 2020;19
    https://doi.org/10.1111/acel.13225
  452. Brandon Emanuel León, Shinwoo Kang, Gabriela Franca-Solomon, Pei Shang, Doo-Sup Choi. Alcohol-Induced Neuroinflammatory Response and Mitochondrial Dysfunction on Aging and Alzheimer’s Disease. Front. Behav. Neurosci. 2022;15
    https://doi.org/10.3389/fnbeh.2021.778456
  453. Liyan Hou, Lin Zhang, Jau-Shyong Hong, Dan Zhang, Jie Zhao, Qingshan Wang. Nicotinamide Adenine Dinucleotide Phosphate Oxidase and Neurodegenerative Diseases: Mechanisms and Therapy. Antioxidants & Redox Signaling 2020;33:374
    https://doi.org/10.1089/ars.2019.8014
  454. B R Cardoso, D J Hare, A I Bush, B R Roberts. Glutathione peroxidase 4: a new player in neurodegeneration?. Mol Psychiatry 2017;22:328
    https://doi.org/10.1038/mp.2016.196
  455. Zeinab Abdulwanis Mohamed, Enas Mohamed Eliaser, Mohammed Sani Jaafaru, Norshariza Nordin, Costas Ioannides, Ahmad Faizal Abdull Razis. Neuroprotective Effects of 7-Geranyloxycinnamic Acid from Melicope lunu ankenda Leaves. Molecules 2020;25:3724
    https://doi.org/10.3390/molecules25163724
  456. Archana Arjunan, Ravindran Rajan. Noise and brain. Physiology & Behavior 2020;227:113136
    https://doi.org/10.1016/j.physbeh.2020.113136
  457. R.P. Parameswari., Thangavelu Lakshmi. Microalgae as a potential therapeutic drug candidate for neurodegenerative diseases. Journal of Biotechnology 2022;358:128
    https://doi.org/10.1016/j.jbiotec.2022.09.009
  458. Reny Rosalina, Natthida Weerapreeyakul. An Insight into Sesamolin: Physicochemical Properties, Pharmacological Activities, and Future Research Prospects. Molecules 2021;26:5849
    https://doi.org/10.3390/molecules26195849
  459. Khadga Raj, G. D. Gupta, Shamsher Singh. l -Theanine ameliorates motor deficit, mitochondrial dysfunction, and neurodegeneration against chronic tramadol induced rats model of Parkinson’s disease . Drug and Chemical Toxicology 2022;45:2097
    https://doi.org/10.1080/01480545.2021.1907909
  460. Claudia Salcedo, Jens V. Andersen, Kasper Tore Vinten, Lars H. Pinborg, Helle S. Waagepetersen, Kristine K. Freude, Blanca I. Aldana. Functional Metabolic Mapping Reveals Highly Active Branched-Chain Amino Acid Metabolism in Human Astrocytes, Which Is Impaired in iPSC-Derived Astrocytes in Alzheimer's Disease. Front. Aging Neurosci. 2021;13
    https://doi.org/10.3389/fnagi.2021.736580
  461. Rifat Jahan, Mohammad Yousaf, Hamayun Khan, Shahid Ali Shah, Abdul Aziz Khan, Nousheen Bibi, Fatima Javed, Musarrat Ijaz, Arif Ali, Dong-Qing Wei. Zinc Ortho Methyl Carbonodithioate Improved Pre and Post-Synapse Memory Impairment via SIRT1/p-JNK Pathway against Scopolamine in Adult Mice. J Neuroimmune Pharmacol 2023;18:183
    https://doi.org/10.1007/s11481-023-10067-w
  462. Chiara Musillo, Marta Borgi, Nadine Saul, Steffen Möller, Walter Luyten, Alessandra Berry, Francesca Cirulli. Natural products improve healthspan in aged mice and rats: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews 2021;121:89
    https://doi.org/10.1016/j.neubiorev.2020.12.001
  463. . Pharmaceutical Nanotechnology: Innovation and Production. 2021.
    https://doi.org/10.1002/9783527800681.ch27
  464. Rajat Goyal, Kashish Wilson, Anjali Saharan, Rupesh K. Gautam, Hitesh Chopra, Sumeet Gupta, Mohammad Amjad Kamal. Insights on aspects of apoptosis in neurodegenerative disorders: a comprehensive review. 2024:89
    https://doi.org/10.37349/emed.2024.00208
  465. Shu-Shong Hsu, Yung-Shang Lin, Wei-Zhe Liang. Inhibition of the pesticide rotenone-induced Ca2+ signaling, cytotoxicity and oxidative stress in HCN-2 neuronal cells by the phenolic compound hydroxytyrosol. Pesticide Biochemistry and Physiology 2021;179:104979
    https://doi.org/10.1016/j.pestbp.2021.104979
  466. Anthony Nina‐Diogo, Janek Hyzewicz, Marie‐Paule Hamon, Jeremy Forté, Serge Thorimbert, Bertrand Friguet, Candice Botuha. Synthesis of New Bodipy Hydrazide Fluorescent Probes for the Detection of Carbonylated Proteins Generated by Oxidative Stress. ChemBioChem 2024
    https://doi.org/10.1002/cbic.202400093
  467. Regina G. Daré, Elayaraja Kolanthai, Craig J. Neal, Yifei Fu, Sudipta Seal, Celso V. Nakamura, Sueli O. S. Lautenschlager. Cerium Oxide Nanoparticles Conjugated with Tannic Acid Prevent UVB-Induced Oxidative Stress in Fibroblasts: Evidence of a Promising Anti-Photodamage Agent. Antioxidants 2023;12:190
    https://doi.org/10.3390/antiox12010190
  468. Md. Abdul Hannan, Raju Dash, Abdullah Al Mamun Sohag, Md. Nazmul Haque, Il Soo Moon. Neuroprotection Against Oxidative Stress: Phytochemicals Targeting TrkB Signaling and the Nrf2-ARE Antioxidant System. Front. Mol. Neurosci. 2020;13
    https://doi.org/10.3389/fnmol.2020.00116
  469. Rammohan V. Rao. Encyclopedia of Gerontology and Population Aging. 2020.
    https://doi.org/10.1007/978-3-319-69892-2_922-1
  470. Shi-Liang Ji, Ke-Ke Cao, Xing-Xing Zhao, Nai-Xin Kang, Ying Zhang, Qiong-Ming Xu, Shi-Lin Yang, Yan-Li Liu, Cheng Wang. Antioxidant activity of phenylethanoid glycosides on glutamate-induced neurotoxicity. 2019;83:2016
    https://doi.org/10.1080/09168451.2019.1637243
  471. Anil Gupta. Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases. 2019.
    https://doi.org/10.1016/B978-0-12-820122-0.00002-9
  472. Hongxia Che, Xueyuan Fu, Lingyu Zhang, Xiang Gao, Min Wen, Lei Du, Changhu Xue, Jie Xu, Yuming Wang. Neuroprotective Effects of n-3 Polyunsaturated Fatty Acid-Enriched Phosphatidylserine Against Oxidative Damage in PC12 Cells. Cell Mol Neurobiol 2018;38:657
    https://doi.org/10.1007/s10571-017-0516-y
  473. Catherine Smit, Sholto De Wet, Tamryn Barron, Ben Loos. Rooibos tea—in the cross fire of ROS, mitochondrial dysfunction and loss of proteostasis—positioned for healthy aging. Biogerontology 2023;24:149
    https://doi.org/10.1007/s10522-022-10012-z
  474. Mahsah Nikbakht, iraj jafari anarkooli, Alireza Abdanipour. Neuroprotective effects of 1,8-cineole on inhibition of apoptosis and Bcl-2/Caspase-3 mRNA expression in the hippocampus of Pilocarpine model epileptic rats. J Adv Med Biomed Res 2022;30:1
    https://doi.org/10.30699/jambs.30.e415
  475. Haibo Wang, Muralidhar L. Hegde. Amyotrophic Lateral Sclerosis - Recent Advances and Therapeutic Challenges. 2022.
    https://doi.org/10.5772/intechopen.92637
  476. Saida Haider, Laraib Liaquat, Saara Ahmad, Zehra Batool, Rafat Ali Siddiqui, Saiqa Tabassum, Sidrah Shahzad, Sahar Rafiq, Narjis Naz, Israel Silman. Naringenin protects AlCl3/D-galactose induced neurotoxicity in rat model of AD via attenuation of acetylcholinesterase levels and inhibition of oxidative stress. PLoS ONE 2020;15:e0227631
    https://doi.org/10.1371/journal.pone.0227631
  477. Henrike Kristen, Isabel Sastre, Teresa Muñoz-Galdeano, Maria Recuero, Jesus Aldudo, Maria J. Bullido. The lysosome system is severely impaired in a cellular model of neurodegeneration induced by HSV-1 and oxidative stress. Neurobiology of Aging 2018;68:5
    https://doi.org/10.1016/j.neurobiolaging.2018.03.025
  478. Swati Dhasmana, Anupam Dhasmana, Sudhir Kotnala, Varsha Mangtani, Acharan S. Narula, Shafiul Haque, Meena Jaggi, Murali M. Yallapu, Subhash C. Chauhan. Boosting Mitochondrial Potential: An Imperative Therapeutic Intervention in Amyotrophic Lateral Sclerosis. CN 2023;21:1117
    https://doi.org/10.2174/1570159X20666220915092703
  479. Wanting Xie, Sopon Wiriyarattanakul, Thanyada Rungrotmongkol, Liyi Shi, Amphawan Wiriyarattanakul, Phornphimon Maitarad. Rational Design of a Low-Data Regime of Pyrrole Antioxidants for Radical Scavenging Activities Using Quantum Chemical Descriptors and QSAR with the GA-MLR and ANN Concepts. Molecules 2023;28:1596
    https://doi.org/10.3390/molecules28041596
  480. Yusuf Sıcak, Hüseyin Kekeçmuhammed, Ayşegül Karaküçük‐İyidoğan, Tuğba Taşkın‐Tok, Emine Elçin Oruç‐Emre, Mehmet Öztürk. Chalcones bearing nitrogen‐containing heterocyclics as multi‐targeted inhibitors: Design, synthesis, biological evaluation and molecular docking studies. J of Molecular Recognition 2023;36
    https://doi.org/10.1002/jmr.3020
  481. Amany M. Hegazy, Eman M. El-Sayed, Khadiga S. Ibrahim, Amal S. Abdel-Azeem. Dietary antioxidant for disease prevention corroborated by the Nrf2 pathway. 2019;16
    https://doi.org/10.1515/jcim-2018-0161
  482. Fahadul Islam, Md Mohaimenul Islam, Atkia Farzana Khan Meem, Mohamed H. Nafady, Md Rezaul Islam, Aklima Akter, Saikat Mitra, Fahad A. Alhumaydhi, Talha Bin Emran, Ameer Khusro, Jesus Simal-Gandara, Aziz Eftekhari, Fatemeh Karimi, Mehdi Baghayeri. Multifaceted role of polyphenols in the treatment and management of neurodegenerative diseases. Chemosphere 2022;307:136020
    https://doi.org/10.1016/j.chemosphere.2022.136020
  483. Vijakhana Pilaisangsuree, Kanitha Supdensong, Pimpimon Lumpa, Jintana Pankam, Apinun Limmongkon. DNA protective and DNA damage activity of induced peanut hairy root crude extract with antioxidant and pro-oxidant properties. Acta Physiol Plant 2021;43
    https://doi.org/10.1007/s11738-021-03326-x
  484. Simona Daniele, Deborah Pietrobono, Jonathan Fusi, Caterina Iofrida, Lucia Chico, Lucia Petrozzi, Annalisa Lo Gerfo, Filippo Baldacci, Fabio Galetta, Gabriele Siciliano, Ubaldo Bonuccelli, Gino Santoro, Maria Letizia Trincavelli, Ferdinando Franzoni, Claudia Martini. α-Synuclein Aggregates with β-Amyloid or Tau in Human Red Blood Cells: Correlation with Antioxidant Capability and Physical Exercise in Human Healthy Subjects. Mol Neurobiol 2018;55:2653
    https://doi.org/10.1007/s12035-017-0523-5
  485. Chun-Han Chang, Chia-Cheng Wei, Chi-Tang Ho, Vivian Hsiu-Chuan Liao. N-γ-(L-glutamyl)-L-selenomethionine shows neuroprotective effects against Parkinson's disease associated with SKN-1/Nrf2 and TRXR-1 in Caenorhabditis elegans. Phytomedicine 2021;92:153733
    https://doi.org/10.1016/j.phymed.2021.153733
  486. Priyanka Rathod, Raman P. Yadav. Nanopolyphenols. 2022;9:419
    https://doi.org/10.4103/mgmj.mgmj_100_22
  487. Mai M. Anwar. Oxidative stress‐A direct bridge to central nervous system homeostatic dysfunction and Alzheimer's disease. Cell Biochemistry & Function 2022;40:17
    https://doi.org/10.1002/cbf.3673
  488. Asmaa E. Kassab, Ehab M. Gedawy, Alaa S. Sayed. Fused thiophene as a privileged scaffold: A review on anti-Alzheimer's disease potentials via targeting cholinesterases, monoamine oxidases, glycogen synthase kinase-3, and Aβ aggregation. International Journal of Biological Macromolecules 2024;265:131018
    https://doi.org/10.1016/j.ijbiomac.2024.131018
  489. Aayushi Agnihotri, Okezie I. Aruoma. Alzheimer’s Disease and Parkinson’s Disease: A Nutritional Toxicology Perspective of the Impact of Oxidative Stress, Mitochondrial Dysfunction, Nutrigenomics and Environmental Chemicals. Journal of the American College of Nutrition 2020;39:16
    https://doi.org/10.1080/07315724.2019.1683379
  490. Agnieszka Ścibior, Juan Llopis, Paweł Piotr Dobrakowski, Tomasz Męcik-Kronenberg. CNS-Related Effects Caused by Vanadium at Realistic Exposure Levels in Humans: A Comprehensive Overview Supplemented with Selected Animal Studies. IJMS 2023;24:9004
    https://doi.org/10.3390/ijms24109004
  491. Guzel Ziyatdinova, Yulia Zelenova, Herman Budnikov. Novel modified electrode with immobilized galvinoxyl radical for the voltammetric determination of antioxidant activity. Journal of Electroanalytical Chemistry 2020;856:113677
    https://doi.org/10.1016/j.jelechem.2019.113677
  492. Daniele Moretti, Sara Tambone, Mauro Cerretani, Paola Fezzardi, Antonino Missineo, Leticia-Toledo Sherman, Ignacio Munoz-Sajuan, Steven Harper, Celia Dominquez, Robert Pacifici, Licia Tomei, Larry Park, Alberto Bresciani. NRF2 activation by reversible KEAP1 binding induces the antioxidant response in primary neurons and astrocytes of a Huntington's disease mouse model. Free Radical Biology and Medicine 2021;162:243
    https://doi.org/10.1016/j.freeradbiomed.2020.10.022
  493. Anna Santoro, Michela Campolo, Chen Liu, Hiromi Sesaki, Rosaria Meli, Zhong-Wu Liu, Jung Dae Kim, Sabrina Diano. DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons. Cell Metabolism 2017;25:647
    https://doi.org/10.1016/j.cmet.2017.01.003
  494. Hyoung Kyu Kim, Heetak Lee, Ji Ho So, Seung Hun Jeong, Dae Yun Seo, Jong-Yeol Kim, Sanguk Kim, Jin Han. Energy metabolism and whole-exome sequencing-based analysis of Sasang constitution: a pilot study. Integrative Medicine Research 2017;6:165
    https://doi.org/10.1016/j.imr.2017.03.002
  495. Qianqian Tan, Chenxi Zhang, Xiuqin Rao, Wei Wan, Wei Lin, Shupeng Huang, Jun Ying, Yue Lin, Fuzhou Hua. The interaction of lipocalin-2 and astrocytes in neuroinflammation: mechanisms and therapeutic application. Front. Immunol. 2024;15
    https://doi.org/10.3389/fimmu.2024.1358719
  496. Anurupa A. Ghosh, Dinesh Kumar Verma, Gabriela Cabrera, Kwadwo Ofori, Karina Hernandez-Quijada, Jae-Kwan Kim, Joo Hee Chung, Michael Moore, Sung Hwan Moon, Jong Bok Seo, Yong-Hwan Kim. A Novel NOX Inhibitor Treatment Attenuates Parkinson’s Disease-Related Pathology in Mouse Models. IJMS 2022;23:4262
    https://doi.org/10.3390/ijms23084262
  497. Yanahi Posadas, Víctor E. López-Guerrero, Trinidad Arcos-López, Richard I. Sayler, Carolina Sánchez-López, José Segovia, Claudia Perez-Cruz, Liliana Quintanar. Comprehensive Inorganic Chemistry III. 2022.
    https://doi.org/10.1016/B978-0-12-823144-9.00115-1
  498. Stephanie Spannl, Maria Tereshchenko, Giovanni J. Mastromarco, Sean J. Ihn, Hyun O. Lee. Biomolecular condensates in neurodegeneration and cancer. Traffic 2019;20:890
    https://doi.org/10.1111/tra.12704
  499. Ahmed Abdal Dayem, Soo Lee, Hye Choi, Ssang-Goo Cho. Silver Nanoparticles: Two-Faced Neuronal Differentiation-Inducing Material in Neuroblastoma (SH-SY5Y) Cells. IJMS 2018;19:1470
    https://doi.org/10.3390/ijms19051470
  500. Concetta Di Natale, Alessandra Monaco, Carlo Pedone, Alessandro Tessitore, Antonio De Mase, Gioacchino Tedeschi, Paolo Antonio Netti, Paolo Abrescia. The level of 24-hydroxycholesteryl esters decreases in plasma of patients with Parkinson’s disease. Neuroscience Letters 2018;672:108
    https://doi.org/10.1016/j.neulet.2018.02.041
  501. V.K.D. Krishnaswamy, Phaniendra Alugoju, Latha Periyasamy. Multifaceted targeting of neurodegeneration with bioactive molecules of saffron (Crocus sativus): An insilco evidence-based hypothesis. Medical Hypotheses 2020;143:109872
    https://doi.org/10.1016/j.mehy.2020.109872
  502. Fu-jia YANG, Xu CHEN, Mu-chen HUANG, Qian YANG, Xi-xi CAI, Xuan CHEN, Ming DU, Jian-lian HUANG, Shao-yun WANG. Molecular characteristics and structure–activity relationships of food-derived bioactive peptides. Journal of Integrative Agriculture 2021;20:2313
    https://doi.org/10.1016/S2095-3119(20)63463-3
  503. Aruna Raja, Soha Ahmadi, Fernanda de Costa, Nan Li, Kagan Kerman. Attenuation of Oxidative Stress by Cannabinoids and Cannabis Extracts in Differentiated Neuronal Cells. Pharmaceuticals 2020;13:328
    https://doi.org/10.3390/ph13110328
  504. Rammohan V. Rao. Encyclopedia of Gerontology and Population Aging. 2020.
    https://doi.org/10.1007/978-3-319-69892-2_922-2
  505. Arne Sahm, Martin Bens, Karol Szafranski, Susanne Holtze, Marco Groth, Matthias Görlach, Cornelis Calkhoven, Christine Müller, Matthias Schwab, Johann Kraus, Hans A. Kestler, Alessandro Cellerino, Hynek Burda, Thomas Hildebrandt, Philip Dammann, Matthias Platzer, Gregory S. Barsh. Long-lived rodents reveal signatures of positive selection in genes associated with lifespan. PLoS Genet 2018;14:e1007272
    https://doi.org/10.1371/journal.pgen.1007272
  506. Mohamed ali Smach, Jawhar Hafsa, Jihen Ben abdallah, Bassem Charfeddine, Khalifa Limem. Neuroprotective and anti-amnesic effects of Laurus Nobilis essential oil against scopolamine-induced memory deficits in mice brain. Journal of Ethnopharmacology 2024;319:117151
    https://doi.org/10.1016/j.jep.2023.117151
  507. Magisetty Obulesu. Parkinson's Disease Therapeutics. 2024.
    https://doi.org/10.1016/B978-0-12-819882-7.00002-7
  508. Kerry C. Ryan, Zahra Ashkavand, Kenneth R. Norman. The Role of Mitochondrial Calcium Homeostasis in Alzheimer’s and Related Diseases. IJMS 2020;21:9153
    https://doi.org/10.3390/ijms21239153
  509. Jéssica Rabelo Bezerra, Tyciane de Souza Nascimento, Juliete Tavares, Mayara Sandrielly Soares de Aguiar, Maiara Virgínia Viana Maia, Geanne Matos de Andrade. Neuroprotective Effect of Chlorogenic Acid in an Animal Model of Sporadic Alzheimer's Disease Induced by Streptozotocin. Mol Neurobiol 2024
    https://doi.org/10.1007/s12035-024-04299-x
  510. Francesco D’Egidio, Vanessa Castelli, Annamaria Cimini, Michele d’Angelo. Cell Rearrangement and Oxidant/Antioxidant Imbalance in Huntington’s Disease. Antioxidants 2023;12:571
    https://doi.org/10.3390/antiox12030571
  511. Nooshin Ghavidel, Fariba Khodagholi, Abolhassan Ahmadiani, Reza Khosrowabadi, Sareh Asadi, Jamal Shams.

    Frontocingulate Dysfunction Is Associated with Depression and Decreased Serum PON1 in Methamphetamine-Dependent Patients

    . NDT 2020;Volume 16:489
    https://doi.org/10.2147/NDT.S237528
  512. Joshua M. Marcus, Mohammed I. Hossain, Jean-Philippe Gagné, Guy G. Poirier, Lori L. McMahon, Rita M. Cowell, Shaida A. Andrabi. PARP-1 activation leads to cytosolic accumulation of TDP-43 in neurons. Neurochemistry International 2021;148:105077
    https://doi.org/10.1016/j.neuint.2021.105077
  513. Khaled G. Abdel-Wahhab, Rehab S. Sayed, Doaa G. EL-Sahra, Laila K. Hassan, Ghada M. Elqattan, Fathia A. Mannaa. Echinacea purpurea extract intervention for counteracting neurochemical and behavioral changes induced by bifenthrin. Metab Brain Dis 2023;39:101
    https://doi.org/10.1007/s11011-023-01303-6
  514. Yoonsu Kim, Minjung Cho, Jeong Soon Lee, Jisun Oh, Jinkyu Lim. Protocatechuic Acid from Euonymus alatus Mitigates Scopolamine-Induced Memory Impairment in Mice. Foods 2024;13:2664
    https://doi.org/10.3390/foods13172664
  515. Olivia J Rickman, Emma L Baple, Andrew H Crosby. Lipid metabolic pathways converge in motor neuron degenerative diseases. 2020;143:1073
    https://doi.org/10.1093/brain/awz382
  516. Hassan Kahal, Anna Halama, Ahmed Aburima, Aditya M. Bhagwat, Alexandra E. Butler, Johannes Graumann, Karsten Suhre, Thozhukat Sathyapalan, Stephen L. Atkin. Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects. Sci Rep 2020;10
    https://doi.org/10.1038/s41598-020-61531-z
  517. Priya Sharma, Manish Kumar, Nitin Bansal. Ellagic acid prevents 3-nitropropionic acid induced symptoms of Huntington’s disease. Naunyn-Schmiedeberg's Arch Pharmacol 2021;394:1917
    https://doi.org/10.1007/s00210-021-02106-1
  518. Benjamin Guy Trist, Dominic James Hare, Kay Lorraine Double. A Proposed Mechanism for Neurodegeneration in Movement Disorders Characterized by Metal Dyshomeostasis and Oxidative Stress. Cell Chemical Biology 2018;25:807
    https://doi.org/10.1016/j.chembiol.2018.05.004
  519. Ivana Cacciatore, Lisa Marinelli, Antonio Di Stefano, Valerio Di Marco, Giustino Orlando, Mirko Gabriele, Daniela Maria Pia Gatta, Alessio Ferrone, Sara Franceschelli, Lorenza Speranza, Antonia Patruno. Chelating and antioxidant properties of l-Dopa containing tetrapeptide for the treatment of neurodegenerative diseases. Neuropeptides 2018;71:11
    https://doi.org/10.1016/j.npep.2018.06.002
  520. Aurélien Bour, Sergei G. Kruglik, Morgan Chabanon, Padmini Rangamani, Nicolas Puff, Stephanie Bonneau. Lipid Unsaturation Properties Govern the Sensitivity of Membranes to Photoinduced Oxidative Stress. Biophysical Journal 2019;116:910
    https://doi.org/10.1016/j.bpj.2019.01.033
  521. Manpreet Kaur, Ty Shitanaka, K.C Surendra, Samir Kumar Khanal. Macroalgae-derived bioactive compounds for functional food and pharmaceutical applications—a critical review. Critical Reviews in Food Science and Nutrition 2024:1
    https://doi.org/10.1080/10408398.2024.2384643
  522. Hung-Lin Kan, Chia-Chi Wang, Ying-Chi Lin, Chun-Wei Tung. Computational identification of preservatives with potential neuronal cytotoxicity. Regulatory Toxicology and Pharmacology 2021;119:104815
    https://doi.org/10.1016/j.yrtph.2020.104815
  523. Mona Shahlaei, Maryam Saeidifar, Ali Zamanian. Sustained release of sulforaphane by bioactive extracellular vesicles for neuroprotective effect on chick model. J Biomed Mater Res 2022;110:2636
    https://doi.org/10.1002/jbm.b.35117
  524. Marijana Kosanić, Branislav Ranković. Lichen Secondary Metabolites. 2022.
    https://doi.org/10.1007/978-3-030-16814-8_8
  525. Shanmugam Manoharan, Gilles J. Guillemin, Rajagopal Selladurai Abiramasundari, Musthafa Mohamed Essa, Mohammed Akbar, Mohammed D. Akbar, Rodrigo Franco. The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review. Oxidative Medicine and Cellular Longevity 2016;2016
    https://doi.org/10.1155/2016/8590578
  526. Bruna R. B. Gomes, Marina Firmino, Jardeson S. Jorge, Maria L. O. Ferreira, Thays M. Rodovalho, Simone N. Weis, Gloria E. P. Souza, Paulo C. Morais, Marcelo V. Sousa, Paulo E. N. Souza, Fabiane H. Veiga-Souza. Increase of reactive oxygen species in different tissues during lipopolysaccharide-induced fever and antipyresis: an electron paramagnetic resonance study. Free Radical Research 2018;52:351
    https://doi.org/10.1080/10715762.2018.1425549
  527. Yanshree, Wing Shan Yu, Man Lung Fung, Chi Wai Lee, Lee Wei Lim, Kah Hui Wong. The Monkey Head Mushroom and Memory Enhancement in Alzheimer’s Disease. Cells 2022;11:2284
    https://doi.org/10.3390/cells11152284
  528. Fredrick Nwude Eze. Transthyretin Amyloidosis: Role of oxidative stress and the beneficial implications of antioxidants and nutraceutical supplementation. Neurochemistry International 2024;179:105837
    https://doi.org/10.1016/j.neuint.2024.105837
  529. Hang Lv, Chuan'an Zhu, Ruolin Wu, Hui Ni, Jiating Lian, Yunlong Xu, Yucen Xia, Guoqi Shi, Zhixing Li, Ruth B. Caldwell, Robert William Caldwell, Lin Yao, Yongjun Chen. Chronic mild stress induced anxiety-like behaviors can Be attenuated by inhibition of NOX2-derived oxidative stress. Journal of Psychiatric Research 2019;114:55
    https://doi.org/10.1016/j.jpsychires.2019.04.008
  530. Mohammad Sarraf, Monia Jemni, Ibrahim Kahramanoğlu, Francisco Artés, Shirin Shahkoomahally, Ahmad Namsi, Muhammad Ihtisham, Marian Brestic, Mostafa Mohammadi, Anshu Rastogi. Commercial techniques for preserving date palm (Phoenix dactylifera) fruit quality and safety: A review. Saudi Journal of Biological Sciences 2021;28:4408
    https://doi.org/10.1016/j.sjbs.2021.04.035
  531. A Masi, R Narducci, G Mannaioni. Harnessing ionic mechanisms to achieve disease modification in neurodegenerative disorders. Pharmacological Research 2019;147:104343
    https://doi.org/10.1016/j.phrs.2019.104343
  532. Dwarakanath P. Radhakrishnan, Abinaya Kanakaraja, Nagasathiya Krishnan, Meenakumari Sakthivelu, Subash C. B. Gopinath, Raman Pachaiappan. HPLC purification of antioxidant and antibacterial peptides from a lichen “Parmotrema perlatum (Huds.) M. Choisy”: Identification by LC‐MS/MS peptide mass fingerprinting. Biotech and App Biochem 2024;71:627
    https://doi.org/10.1002/bab.2563
  533. Wei-Ting Chen, Yu-Yi Kuo, Guan-Bo Lin, Chueh-Hsuan Lu, Hao-Ping Hsu, Yi-Kun Sun, Chih-Yu Chao, Michal Hetman. Thermal cycling protects SH-SY5Y cells against hydrogen peroxide and β-amyloid-induced cell injury through stress response mechanisms involving Akt pathway. PLoS ONE 2020;15:e0240022
    https://doi.org/10.1371/journal.pone.0240022
  534. Fleur L. Meulmeester, Jiao Luo, Leon G. Martens, Kevin Mills, Diana van Heemst, Raymond Noordam. Antioxidant Supplementation in Oxidative Stress-Related Diseases: What Have We Learned from Studies on Alpha-Tocopherol?. Antioxidants 2022;11:2322
    https://doi.org/10.3390/antiox11122322
  535. Eugene Yu-Chuan Kang, Pei-Kang Liu, Yao-Tseng Wen, Peter M. J. Quinn, Sarah R. Levi, Nan-Kai Wang, Rong-Kung Tsai. Role of Oxidative Stress in Ocular Diseases Associated with Retinal Ganglion Cells Degeneration. Antioxidants 2021;10:1948
    https://doi.org/10.3390/antiox10121948
  536. Manuela Leri, Marzia Vasarri, Luana Palazzi, Emanuela Barletta, Erik Nielsen, Monica Bucciantini, Donatella Degl’Innocenti. Maysin plays a protective role against α-Synuclein oligomers cytotoxicity by triggering autophagy activation. Food and Chemical Toxicology 2020;144:111626
    https://doi.org/10.1016/j.fct.2020.111626
  537. Yi Jiang, Jun-Jie Li, Ya-Wei Mu, Han-Yang Jiang, Zi-Xuan Wei, Zi-Yao Xiao, Jing-Jing Zhao, Xian-Hua Chen. Overexpression of Cpg15 Alleviates the Oxidative Stress in Neuronal Cells Via Regulating Redox Enzymes and Nrf2 Antioxidative Pathway. Neurotox Res 2022;40:365
    https://doi.org/10.1007/s12640-022-00473-y
  538. Giuseppe Caruso, Claudia Fresta, Nicolò Musso, Mariaconcetta Giambirtone, Margherita Grasso, Simona Spampinato, Sara Merlo, Filippo Drago, Giuseppe Lazzarino, Maria Sortino, Susan Lunte, Filippo Caraci. Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1. Cells 2019;8:64
    https://doi.org/10.3390/cells8010064
  539. Alaa Behairy, Ashraf Elkomy, Faten Elsayed, Mohamed M. S. Gaballa, Ahmed Soliman, Mohamed Aboubakr. Antioxidant and anti-inflammatory potential of spirulina and thymoquinone mitigate the methotrexate-induced neurotoxicity. Naunyn-Schmiedeberg's Arch Pharmacol 2023
    https://doi.org/10.1007/s00210-023-02739-4
  540. Mahbubeh Setorki, Zahra Hooshmandi, Zahra Zanganehnejad. The effects of Biarum carduchrum hydroalcoholic extract on oxidative stress and catalepsy in the 6-hydroxydopamine-induced rat model of Parkinson's disease. J Adv Med Biomed Res 2019;27:8
    https://doi.org/10.30699/jambs.27.120.8
  541. Weishun Tian, Jing Zhao, Jeong-Ho Lee, Md Rashedunnabi Akanda, Jeong-Hwi Cho, Sang-Ki Kim, Yu-Jin Choi, Byung-Yong Park. Neuroprotective Effects of Cornus officinalis on Stress-Induced Hippocampal Deficits in Rats and H2O2-Induced Neurotoxicity in SH-SY5Y Neuroblastoma Cells. Antioxidants 2019;9:27
    https://doi.org/10.3390/antiox9010027
  542. Philipp Agyeman, Denis Grandgirard, Stephen L. Leib. The Blood Brain Barrier and Inflammation. 2019.
    https://doi.org/10.1007/978-3-319-45514-3_10
  543. Ramandeep Kaur, Sidharth Mehan, Shamsher Singh. Understanding multifactorial architecture of Parkinson’s disease: pathophysiology to management. Neurol Sci 2019;40:13
    https://doi.org/10.1007/s10072-018-3585-x
  544. Nicholas S. Kron, Michael C. Schmale, Lynne A. Fieber. Changes in Metabolism and Proteostasis Drive Aging Phenotype in Aplysia californica Sensory Neurons. Front. Aging Neurosci. 2020;12
    https://doi.org/10.3389/fnagi.2020.573764
  545. Sydney M. Murray, Brandon M. Waddell, Cheng-Wei Wu. Neuron-specific toxicity of chronic acrylamide exposure in C. elegans. Neurotoxicology and Teratology 2020;77:106848
    https://doi.org/10.1016/j.ntt.2019.106848
  546. Muhammad Shajih Zafar, Alessandra Quarta, Marco Marradi, Andrea Ragusa. Recent Developments in the Reduction of Oxidative Stress through Antioxidant Polymeric Formulations. Pharmaceutics 2019;11:505
    https://doi.org/10.3390/pharmaceutics11100505
  547. Emily K. G. Moreno, Isaac Y. L. de Macêdo, Erica A. Batista, Fabio B. Machado, Gabrielle R. Santos, Daniela M. L. Andrade, Matheus L. Rocha, Nerilson M. Lima, Boniek G. Vaz, Eric S. Gil, Sumbal Saba. Evaluation of Antioxidant Potential of Commercial Cinnamon Samples and Its Vasculature Effects. Oxidative Medicine and Cellular Longevity 2022;2022:1
    https://doi.org/10.1155/2022/1992039
  548. Soren Impey, Jacob Raber. Irradiation and Alterations in Hippocampal DNA Methylation. Epigenomes 2024;8:27
    https://doi.org/10.3390/epigenomes8030027
  549. Xiao-dan Guo, Guang-long Sun, Ting-ting Zhou, Xin Xu, Zhi-yuan Zhu, Vatcharin Rukachaisirikul, Li-hong Hu, Xu Shen. Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance. Acta Pharmacol Sin 2016;37:1281
    https://doi.org/10.1038/aps.2016.80
  550. Thomas Whitehurst, Oliver Howes. The role of mitochondria in the pathophysiology of schizophrenia: A critical review of the evidence focusing on mitochondrial complex one. Neuroscience & Biobehavioral Reviews 2022;132:449
    https://doi.org/10.1016/j.neubiorev.2021.11.047
  551. Musbau Adewumi Akanji, Damilare Emmanuel Rotimi, Tobiloba Christiana Elebiyo, Oluwakemi Josephine Awakan, Oluyomi Stephen Adeyemi, Luciana Hannibal. Redox Homeostasis and Prospects for Therapeutic Targeting in Neurodegenerative Disorders. Oxidative Medicine and Cellular Longevity 2021;2021
    https://doi.org/10.1155/2021/9971885
  552. Bin Xu, Li-Min Lang, Shuai Lian, Jing-Ru Guo, Jian-Fa Wang, Huan-Min Yang, Shi-Ze Li. Oxidation Stress-Mediated MAPK Signaling Pathway Activation Induces Neuronal Loss in the CA1 and CA3 Regions of the Hippocampus of Mice Following Chronic Cold Exposure. Brain Sciences 2019;9:273
    https://doi.org/10.3390/brainsci9100273
  553. Wenzhi Chen, Ling Guo, Manna Li, Caihui Wei, Shu Li, Renshi Xu. The pathogenesis of amyotrophic lateral sclerosis: Mitochondrial dysfunction, protein misfolding and epigenetics. Brain Research 2022;1786:147904
    https://doi.org/10.1016/j.brainres.2022.147904
  554. Boon-Keat Khor, Nelson Jeng-Yeou Chear, Juzaili Azizi, Kooi-Yeong Khaw. Chemical Composition, Antioxidant and Cytoprotective Potentials of Carica papaya Leaf Extracts: A Comparison of Supercritical Fluid and Conventional Extraction Methods. Molecules 2021;26:1489
    https://doi.org/10.3390/molecules26051489
  555. Lihua Chen, Beidong Liu, Serafina Perrone. Relationships between Stress Granules, Oxidative Stress, and Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity 2017;2017
    https://doi.org/10.1155/2017/1809592
  556. Veronica F. Salau, Ochuko L. Erukainure, Collins U. Ibeji, Tosin A. Olasehinde, Neil A. Koorbanally, Md. Shahidul Islam. Vanillin and vanillic acid modulate antioxidant defense system via amelioration of metabolic complications linked to Fe2+-induced brain tissues damage. Metab Brain Dis 2020;35:727
    https://doi.org/10.1007/s11011-020-00545-y
  557. Kaori Ishikawa, Satoshi Yamamoto, Satoko Hattori, Naoya Nishimura, Hirokazu Matsumoto, Tsuyoshi Miyakawa, Kazuto Nakada. Neuronal degeneration and cognitive impairment can be prevented via the normalization of mitochondrial dynamics. Pharmacological Research 2021;163:105246
    https://doi.org/10.1016/j.phrs.2020.105246
  558. Barbara Shukitt-Hale, Nopporn Thangthaeng, Megan E. Kelly, Donald E. Smith, Marshall G. Miller. Raspberry differentially improves age-related declines in psychomotor function dependent on baseline motor ability. Food Funct. 2017;8:4752
    https://doi.org/10.1039/C7FO00894E
  559. Thais B. Fernandes, Micael R. Cunha, Renata P. Sakata, Thalita M. Candido, André R. Baby, Maurício T. Tavares, Euzébio G. Barbosa, Wanda P. Almeida, Roberto Parise‐Filho. Synthesis, Molecular Modeling, and Evaluation of Novel Sulfonylhydrazones as Acetylcholinesterase Inhibitors for Alzheimer's Disease. Archiv der Pharmazie 2017;350
    https://doi.org/10.1002/ardp.201700163
  560. Hehe Tian, Haichao Wen, Xinquan Yang, Siying Li, Jingming Li. Exploring the effects of anthocyanins on volatile organic metabolites of alzheimer’s disease model mice based on HS-GC-IMS and HS-SPME-GC–MS. Microchemical Journal 2021;162:105848
    https://doi.org/10.1016/j.microc.2020.105848
  561. Udit Kumar Dash, Debashree Mazumdar, Santosh Singh. High Mobility Group Box Protein (HMGB1): A Potential Therapeutic Target for Diabetic Encephalopathy. Mol Neurobiol 2024
    https://doi.org/10.1007/s12035-024-04081-z
  562. Meryam Debbabi, Thomas Nury, Amira Zarrouk, Nadia Mekahli, Maryem Bezine, Randa Sghaier, Stéphane Grégoire, Lucy Martine, Philippe Durand, Emmanuelle Camus, Anne Vejux, Aymen Jabrane, Lionel Bretillon, Michel Prost, Thibault Moreau, Sofien Ammou, Mohamed Hammami, Gérard Lizard. Protective Effects of α-Tocopherol, γ-Tocopherol and Oleic Acid, Three Compounds of Olive Oils, and No Effect of Trolox, on 7-Ketocholesterol-Induced Mitochondrial and Peroxisomal Dysfunction in Microglial BV-2 Cells. IJMS 2016;17:1973
    https://doi.org/10.3390/ijms17121973
  563. Yu Zhang, Yanan Li, Shen Bin, Xi Cheng, Qi Niu. A Neglected Gene: The Role of the ANG Gene in the Pathogenesis of Amyotrophic Lateral Sclerosis. Aging and disease 2024
    https://doi.org/10.14336/AD.2024.0107
  564. Jacob G. Kraus, Peter Koulen. Resveratrol Directly Controls the Activity of Neuronal Ryanodine Receptors at the Single-Channel Level. Mol Neurobiol 2020;57:422
    https://doi.org/10.1007/s12035-019-01705-7
  565. Camille A. Juźwik, Sienna S. Drake, Yang Zhang, Nicolas Paradis-Isler, Alexandra Sylvester, Alexandre Amar-Zifkin, Chelsea Douglas, Barbara Morquette, Craig S. Moore, Alyson E. Fournier. microRNA dysregulation in neurodegenerative diseases: A systematic review. Progress in Neurobiology 2019;182:101664
    https://doi.org/10.1016/j.pneurobio.2019.101664
  566. G. T. Rikhireva, M. G. Makletsova. Application of EPR Spectroscopy in the Study of Iron Metabolism in Parkinson’s Disease. BIOPHYSICS 2020;65:327
    https://doi.org/10.1134/S0006350920020190
  567. Fiorenza Provenzano, Jesús Lozano Sánchez, Estella Rao, Radha Santonocito, Lorena Anna Ditta, Isabel Borrás Linares, Rosa Passantino, Patrizia Campisi, Maria Giovanna Dia, Maria Assunta Costa, Antonio Segura-Carretero, Pier Luigi San Biagio, Daniela Giacomazza. Water Extract of Cryphaea heteromalla (Hedw.) D. Mohr Bryophyte as a Natural Powerful Source of Biologically Active Compounds. IJMS 2019;20:5560
    https://doi.org/10.3390/ijms20225560
  568. Ekramy Elmorsy, Ayat Al-Ghafari, Huda Al Doghaither, Mohamed Salama, Wayne G. Carter. An Investigation of the Neurotoxic Effects of Malathion, Chlorpyrifos, and Paraquat to Different Brain Regions. Brain Sciences 2022;12:975
    https://doi.org/10.3390/brainsci12080975
  569. Jing-si Zhou, Zhou Zhu, Feng Wu, Ying Zhou, Rui Sheng, Jun-chao Wu, Zheng-hong Qin. NADPH ameliorates MPTP-induced dopaminergic neurodegeneration through inhibiting p38MAPK activation. Acta Pharmacol Sin 2019;40:180
    https://doi.org/10.1038/s41401-018-0003-0
  570. Tauqeerunnisa Syeda, Jason R. Cannon. Potential Role of Heterocyclic Aromatic Amines in Neurodegeneration. Chem. Res. Toxicol. 2022;35:59
    https://doi.org/10.1021/acs.chemrestox.1c00274
  571. Adrian Soto-Mota, Nicholas G. Norwitz, Kieran Clarke. Why a d-β-hydroxybutyrate monoester?. 2020;48:51
    https://doi.org/10.1042/BST20190240
  572. Amira El-Helaly, Amoura M. Abou-El-Na, Khulud M. Alshehri, Mai Alaa El-Dein. Miracle Tree (Moringa oleifera) Attuned GFAP and Synaptophysin Levels, Oxidative Stress and Biomarkers in Cerebellar Fluorosis of Pregnant Rats. Pakistan J. of Biological Sciences 2023;26:628
    https://doi.org/10.3923/pjbs.2023.628.650
  573. Naoki Inoue, Taisei Hirouchi, Atsushi Kasai, Shintaro Higashi, Natsumi Hiraki, Shota Tanaka, Takanobu Nakazawa, Kazuto Nunomura, Bangzhong Lin, Akiko Omori, Atsuko Hayata-Takano, Yoon-Jeong Kim, Takefumi Doi, Akemichi Baba, Hitoshi Hashimoto, Norihito Shintani. Unbiased compound screening with a reporter gene assay highlights the role of p13 in the cardiac cellular stress response. Biochemical and Biophysical Research Communications 2018;495:1992
    https://doi.org/10.1016/j.bbrc.2017.11.116
  574. Zhen Li. Imaging of hydrogen peroxide (H2O2) during the ferroptosis process in living cancer cells with a practical fluorescence probe. Talanta 2020;212:120804
    https://doi.org/10.1016/j.talanta.2020.120804
  575. Raushan Kumar, Komal Saraswat, Syed Ibrahim Rizvi. Curcumin for Neurological and Psychiatric Disorders. 2020.
    https://doi.org/10.1016/B978-0-12-815461-8.00013-X
  576. Vardhan Satalkar, Theo A. Rusmore, Elizabeth Phillips, Xiaoliang Pan, Enrico Benassi, Qin Wu, Chongzhao Ran, Yihan Shao. Computational modeling of curcumin-based fluorescent probe molecules. Theor Chem Acc 2019;138
    https://doi.org/10.1007/s00214-019-2415-4
  577. Maria Tsamou, Francesca Pistollato, Erwin L. Roggen. A Tau-Driven Adverse Outcome Pathway Blueprint Toward Memory Loss in Sporadic (Late-Onset) Alzheimer’s Disease with Plausible Molecular Initiating Event Plug-Ins for Environmental Neurotoxicants. JAD 2021;81:459
    https://doi.org/10.3233/JAD-201418
  578. Carmen Peña-Bautista, Esther Casas-Fernández, Máximo Vento, Miguel Baquero, Consuelo Cháfer-Pericás. Stress and neurodegeneration. Clinica Chimica Acta 2020;503:163
    https://doi.org/10.1016/j.cca.2020.01.019
  579. Farah Syed, Kumud K. Awasthi, Lalit P. Chandravanshi, Rajbala Verma, Neelu K. Rajawat, Vinay K. Khanna, P. J. John, Inderpal Soni. Bifenthrin-induced neurotoxicity in rats: involvement of oxidative stress. Toxicol. Res. 2018;7:48
    https://doi.org/10.1039/C7TX00205J
  580. Paulo César Lock Silveira, Matheus Scarpatto Rodrigues, Daniel Pens Gelain, Jade de Oliveira. Gold nanoparticles application to the treatment of brain dysfunctions related to metabolic diseases: evidence from experimental studies. Metab Brain Dis 2023;38:123
    https://doi.org/10.1007/s11011-022-00929-2
  581. Raju Dash, Md. Chayan Ali, Israt Jahan, Yeasmin Akter Munni, Sarmistha Mitra, Md. Abdul Hannan, Binod Timalsina, Diyah Fatimah Oktaviani, Ho Jin Choi, Il Soo Moon. Emerging potential of cannabidiol in reversing proteinopathies. Ageing Research Reviews 2021;65:101209
    https://doi.org/10.1016/j.arr.2020.101209
  582. Aida V. Garcia Corrales, Mansour Haidar, Jeroen F. J. Bogie, Jerome J. A. Hendriks. Fatty Acid Synthesis in Glial Cells of the CNS. IJMS 2021;22:8159
    https://doi.org/10.3390/ijms22158159
  583. Mara-Luciana Floare, Scott P. Allen. Why TDP-43? Why Not? Mechanisms of Metabolic Dysfunction in Amyotrophic Lateral Sclerosis. J Exp Neurosci 2020;15:263310552095730
    https://doi.org/10.1177/2633105520957302
  584. Omowumi Oyeronke Adewale, Oluwaseun Abraham Adebisi, Taiwo A. Ojurongbe, Damilare Adedayo Adekomi, Isaac Olawale Babatunde, Emmanuel O. Adebayo. Xylopia aethiopica suppresses markers of oxidative stress, inflammation, and cell death in the brain of Wistar rats exposed to glyphosate. Environ Sci Pollut Res 2023;30:60946
    https://doi.org/10.1007/s11356-023-26470-y
  585. Eva Mezeiova, Katarina Spilovska, Eugenie Nepovimova, Lukas Gorecki, Ondrej Soukup, Rafael Dolezal, David Malinak, Jana Janockova, Daniel Jun, Kamil Kuca, Jan Korabecny. Profiling donepezil template into multipotent hybrids with antioxidant properties. Journal of Enzyme Inhibition and Medicinal Chemistry 2018;33:583
    https://doi.org/10.1080/14756366.2018.1443326
  586. Harquin Simplice Foyet, Eglantine Keugong Wado, Hervé Hervé Ngatanko Abaissou, Emmanuel Acha Assongalem, Oben Kenneth Eyong. Anticholinesterase and Antioxidant Potential of Hydromethanolic Extract ofZiziphus mucronata(Rhamnaceae) Leaves on Scopolamine-Induced Memory and Cognitive Dysfunctions in Mice. Evidence-Based Complementary and Alternative Medicine 2019;2019:1
    https://doi.org/10.1155/2019/4568401
  587. Ji‑Dong Guo, Xin Zhao, Yang Li, Guang‑Ren Li, Xiao‑Liang Liu. Damage to dopaminergic neurons by oxidative stress in Parkinson's disease (Review). Int J Mol Med 2018
    https://doi.org/10.3892/ijmm.2018.3406
  588. Hussain Al Dera, Mohammed Alassiri, Reem Al Kahtani, Samy M. Eleawa, Mohammad K. AlMulla, Abdulhakeem Alamri. Melatonin attenuates cerebral hypoperfusion-induced hippocampal damage and memory deficits in rats by suppressing TRPM7 channels. Saudi Journal of Biological Sciences 2022;29:2958
    https://doi.org/10.1016/j.sjbs.2022.01.018
  589. Onesimus Mahdi, Samaila Musa Chiroma, Mohamad Taufik Hidayat Baharuldin, Nurul Huda Mohd Nor, Che Norma Mat Taib, Saravanan Jagadeesan, Shamala Devi, Mohamad Aris Mohd Moklas. WIN55,212-2 Attenuates Cognitive Impairments in AlCl3 + d-Galactose-Induced Alzheimer’s Disease Rats by Enhancing Neurogenesis and Reversing Oxidative Stress. Biomedicines 2021;9:1270
    https://doi.org/10.3390/biomedicines9091270
  590. Neha, Iqra Mazahir, Sara Akhtar Khan, Pooja Kaushik, Suhel Parvez. The Interplay of Mitochondrial Bioenergetics and Dopamine Agonists as an Effective Disease-Modifying Therapy for Parkinson’s Disease. Mol Neurobiol 2024
    https://doi.org/10.1007/s12035-024-04078-8
  591. A.D. Surowka, A. Ziomber, M. Czyzycki, A. Migliori, L. Pieklo, K. Kasper, M. Szczerbowska-Boruchowska. Combined use of infrared and hard X-ray microprobes for spectroscopy-based neuroanatomy. J. Inst. 2018;13:C05008
    https://doi.org/10.1088/1748-0221/13/05/C05008
  592. Maria Bandookwala, Pinaki Sengupta. 3-Nitrotyrosine: a versatile oxidative stress biomarker for major neurodegenerative diseases. International Journal of Neuroscience 2020;130:1047
    https://doi.org/10.1080/00207454.2020.1713776
  593. Surinder Hundal, Julia Green. Experience of Western Herbal Medicine practitioners in supporting brain health in mid-life and older patients: A qualitative research study. Journal of Herbal Medicine 2022;32:100547
    https://doi.org/10.1016/j.hermed.2022.100547
  594. Aline de Araújo Brasil, Mariana Dias Castela de Carvalho, Ellen Gerhardt, Daniela Dias Queiroz, Marcos Dias Pereira, Tiago Fleming Outeiro, Elis Cristina Araujo Eleutherio. Characterization of the activity, aggregation, and toxicity of heterodimers of WT and ALS-associated mutant Sod1. Proc. Natl. Acad. Sci. U.S.A. 2019;116:25991
    https://doi.org/10.1073/pnas.1902483116
  595. Shane Sakamaki-Ching, Monique Williams, My Hua, Jun Li, Steve M Bates, Andrew N Robinson, Timothy W Lyons, Maciej Lukasz Goniewicz, Prue Talbot. Correlation between biomarkers of exposure, effect and potential harm in the urine of electronic cigarette users. BMJ Open Resp Res 2020;7:e000452
    https://doi.org/10.1136/bmjresp-2019-000452
  596. Marta Rui, Giacomo Rossino, Daniela Rossi, Simona Collina. Emerging Drugs and Targets for Multiple Sclerosis. 2020.
    https://doi.org/10.1039/9781788016070-00264
  597. Negar Hajimohammadi Oushani, Masoumeh Valipour, Parvaneh Maghami. Protective role of selenium on structural change of human hemoglobin in the presence of vinyl chloride. Toxicol Res. 2022;38:557
    https://doi.org/10.1007/s43188-022-00137-1
  598. Nicolas Toro-Urrego, Liliana F. Turner, Marco F. Avila-Rodriguez. New Insights into Oxidative Damage and Iron Associated Impairment in Traumatic Brain Injury. CPD 2020;25:4737
    https://doi.org/10.2174/1381612825666191111153802
  599. Sheeja Varghese, Mohmed Isaqali Karobari, Selvaraj Jayaraman, Dhanraj Ganapathy, Karthikeyan Murthy Kumar. Comparative Evaluation of Gingival Crevicular Fluid Sulfiredoxin Levels in Patients with Periodontitis Prior and after Periodontal Therapy: A Prospective Clinical Trial. 2024;15:394
    https://doi.org/10.5005/jp-journals-10015-2400
  600. Rita Langasco, Silvia Fancello, Giovanna Rassu, Massimo Cossu, Roberta Cavalli, Grazia Galleri, Paolo Giunchedi, Rossana Migheli, Elisabetta Gavini. Increasing protective activity of genistein by loading into transfersomes: A new potential adjuvant in the oxidative stress-related neurodegenerative diseases?. Phytomedicine 2019;52:23
    https://doi.org/10.1016/j.phymed.2018.09.207
  601. Sehwan Jang, Nataliya Chorna, Keishla M. Rodríguez-Graciani, Mikhail Inyushin, Silvia Fossati, Sabzali Javadov. The Effects of Amyloid-β on Metabolomic Profiles of Cardiomyocytes and Coronary Endothelial Cells. JAD 2023;93:307
    https://doi.org/10.3233/JAD-221199
  602. Amjad Khan, Muhammad Ikram, Jong Ryeal Hahm, Myeong Ok Kim. Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders. Antioxidants 2020;9:609
    https://doi.org/10.3390/antiox9070609
  603. Alberto Bresciani, Antonino Missineo, Mariana Gallo, Mauro Cerretani, Paola Fezzardi, Licia Tomei, Daniel Oscar Cicero, Sergio Altamura, Alessia Santoprete, Raffaele Ingenito, Elisabetta Bianchi, Robert Pacifici, Celia Dominguez, Ignacio Munoz-Sanjuan, Steven Harper, Leticia Toledo-Sherman, Larry C. Park. Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1). Archives of Biochemistry and Biophysics 2017;631:31
    https://doi.org/10.1016/j.abb.2017.08.003
  604. Doortje W. Dekens, Ulrich L.M. Eisel, Leonie Gouweleeuw, Regien G. Schoemaker, Peter P. De Deyn, Petrus J.W. Naudé. Lipocalin 2 as a link between ageing, risk factor conditions and age-related brain diseases. Ageing Research Reviews 2021;70:101414
    https://doi.org/10.1016/j.arr.2021.101414
  605. Sweta Bawari, Devesh Tewari, Sandro Argüelles, Archana N. Sah, Seyed Fazel Nabavi, Suowen Xu, Rosa Anna Vacca, Seyed Mohammad Nabavi, Samira Shirooie. Targeting BDNF signaling by natural products: Novel synaptic repair therapeutics for neurodegeneration and behavior disorders. Pharmacological Research 2019;148:104458
    https://doi.org/10.1016/j.phrs.2019.104458
  606. Chang Liu, Bingquan Leng, Yi Li, Hong Jiang, Weisong Duan, Yansu Guo, Chunyan Li, Kun Hong. Diallyl Trisulfide Protects Motor Neurons from the Neurotoxic Protein TDP-43 via Activating Lysosomal Degradation and the Antioxidant Response. Neurochem Res 2018;43:2304
    https://doi.org/10.1007/s11064-018-2651-3
  607. Arduino A. Mangoni, Angelo Zinellu. Ischemia‐modified albumin in rheumatic diseases: A systematic review and meta‐analysis. Immunity Inflam & Disease 2024;12
    https://doi.org/10.1002/iid3.1324
  608. Lun Wang, Xiaoying Cai, Mingsong Shi, Linlin Xue, Shuang Kuang, Ruiling Xu, Wenyan Qi, Yan Li, Xu Ma, Ruijia Zhang, Feng Hong, Haoyu Ye, Lijuan Chen. Identification and optimization of piperine analogues as neuroprotective agents for the treatment of Parkinson’s disease via the activation of Nrf2/keap1 pathway. European Journal of Medicinal Chemistry 2020;199:112385
    https://doi.org/10.1016/j.ejmech.2020.112385
  609. Margrethe A. Olesen, Francisca Villavicencio-Tejo, Rodrigo A. Quintanilla. The use of fibroblasts as a valuable strategy for studying mitochondrial impairment in neurological disorders. Transl Neurodegener 2022;11
    https://doi.org/10.1186/s40035-022-00308-y
  610. Kuldeep Dhama, Shyma K. Latheef, Maryam Dadar, Hari Abdul Samad, Ashok Munjal, Rekha Khandia, Kumaragurubaran Karthik, Ruchi Tiwari, Mohd. Iqbal Yatoo, Prakash Bhatt, Sandip Chakraborty, Karam Pal Singh, Hafiz M. N. Iqbal, Wanpen Chaicumpa, Sunil Kumar Joshi. Biomarkers in Stress Related Diseases/Disorders: Diagnostic, Prognostic, and Therapeutic Values. Front. Mol. Biosci. 2019;6
    https://doi.org/10.3389/fmolb.2019.00091
  611. Yanan Hou, Shoujiao Peng, Xinming Li, Juan Yao, Jianqiang Xu, Jianguo Fang. Honokiol Alleviates Oxidative Stress-Induced Neurotoxicity via Activation of Nrf2. ACS Chem. Neurosci. 2018;9:3108
    https://doi.org/10.1021/acschemneuro.8b00290
  612. Michael F. Almeida, Carolliny M. Silva, Rodrigo S. Chaves, Nathan C. R. Lima, Renato S. Almeida, Karla P. Melo, Marilene Demasi, Tiago Fernandes, Edilamar M. Oliveira, Luis E. S. Netto, Sandra M. Cardoso, Merari F. R. Ferrari. Effects of mild running on substantia nigra during early neurodegeneration. Journal of Sports Sciences 2018;36:1363
    https://doi.org/10.1080/02640414.2017.1378494
  613. S.D. Voulgaropoulou, T.A.M.J. van Amelsvoort, J. Prickaerts, C. Vingerhoets. The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies. Brain Research 2019;1725:146476
    https://doi.org/10.1016/j.brainres.2019.146476
  614. Angelica Varesi, Lucrezia Irene Maria Campagnoli, Adelaide Carrara, Ilaria Pola, Elena Floris, Giovanni Ricevuti, Salvatore Chirumbolo, Alessia Pascale. Non-Enzymatic Antioxidants against Alzheimer’s Disease: Prevention, Diagnosis and Therapy. Antioxidants 2023;12:180
    https://doi.org/10.3390/antiox12010180
  615. Jisu Kim, Kang Pa Lee, Suji Beak, Hye Ra Kang, Yong Kyun Kim, Kiwon Lim. Effect of black chokeberry on skeletal muscle damage and neuronal cell death. JENB 2019;23:26
    https://doi.org/10.20463/jenb.2019.0028
  616. Camille Taccola, Pascal Barneoud, Sylvaine Cartot-Cotton, Delphine Valente, Nathalie Schussler, Bruno Saubaméa, Stéphanie Chasseigneaux, Véronique Cochois, Virginie Mignon, Emmanuel Curis, Murielle Lochus, Sophie Nicolic, Agnès Dodacki, Salvatore Cisternino, Xavier Declèves, Fanchon Bourasset. Modifications of physical and functional integrity of the blood-brain barrier in an inducible mouse model of neurodegeneration. Neuropharmacology 2021;191:108588
    https://doi.org/10.1016/j.neuropharm.2021.108588
  617. A. Ahnaou, W.H.I.M Drinkenburg. Sleep, neuronal hyperexcitability, inflammation and neurodegeneration: Does early chronic short sleep trigger and is it the key to overcoming Alzheimer’s disease?. Neuroscience & Biobehavioral Reviews 2021;129:157
    https://doi.org/10.1016/j.neubiorev.2021.06.039
  618. Yasmina Martí, Friederike Matthaeus, Thorsten Lau, Patrick Schloss. Methyl-4-phenylpyridinium (MPP +) differentially affects monoamine release and re-uptake in murine embryonic stem cell-derived dopaminergic and serotonergic neurons. Molecular and Cellular Neuroscience 2017;83:37
    https://doi.org/10.1016/j.mcn.2017.06.009
  619. Juan Zhang, Zhu Chen, Hui Chen, Yan Deng, Song Li, Lian Jin. Recent Advances in the Roles of MicroRNA and MicroRNA-Based Diagnosis in Neurodegenerative Diseases. Biosensors 2022;12:1074
    https://doi.org/10.3390/bios12121074
  620. Tao Peng, Yifan Yang, Jingying Ma, Peili Xu, Xinchun Xie, Nan Hu, Yongmei Yan. Dementia and metabolic syndrome: a bibliometric analysis. Front. Aging Neurosci. 2024;16
    https://doi.org/10.3389/fnagi.2024.1400589
  621. Sarah Danehower. Targeting gut dysbiosis as a means to enhance recovery from surgical brain injury. 2021;12:210
    https://doi.org/10.25259/SNI_72_2021
  622. Tatjana Lazarevic, Zoran Kovacevic. Neuropathy - Exponent of Accelerated Involution in Uremia: The Role of Carbamylation. 2021
    https://doi.org/10.2478/sjecr-2021-0013
  623. Kennadiid A Abdulla, Caroline Y Um, Myron D Gross, Roberd M Bostick. Circulating γ-Tocopherol Concentrations Are Inversely Associated with Antioxidant Exposures and Directly Associated with Systemic Oxidative Stress and Inflammation in Adults. The Journal of Nutrition 2018;148:1453
    https://doi.org/10.1093/jn/nxy132
  624. Ebtesam Alsulami, Majed Alokail, Amani Alghamedi, Abir Alamro, Samina Haq. Effect of vitamin D treatment on VDR expression in primary cerebral cortical cells in induced oxidative stress. JCB 2021;6:81
    https://doi.org/10.3233/JCB-200020
  625. Lei Zhu, Zhengwei Li, Liping Sheng, Fengfei Zhang, Wei Ji. Ginkgolide A attenuated apoptosis via inhibition of oxidative stress in mice with traumatic brain injury. Heliyon 2024;10:e24759
    https://doi.org/10.1016/j.heliyon.2024.e24759
  626. Aimie Syahirah Ibrahim, Rashidah Sukor, Farooq Anwar, Suganya Murugesu, Jinap Selamat, Siva Raseetha. Nutritional, nutraceutical attributes, microbiological and chemical safety of different varieties of dates—A review. Future Foods 2024;10:100421
    https://doi.org/10.1016/j.fufo.2024.100421
  627. Xinlei Chen, Baojun Xu. Insights into chemical components, health-promoting effects, and processing impact of golden chanterelle mushroom Cantharellus cibarius. Food Funct. 2024;15:7696
    https://doi.org/10.1039/D4FO00891J
  628. Guzel Ziyatdinova, Yulia Snegureva, Herman Budnikov. Novel approach for the voltammetric evaluation of antioxidant activity using DPPH -modified electrode. Electrochimica Acta 2017;247:97
    https://doi.org/10.1016/j.electacta.2017.06.155
  629. Guiliana Soraya Victoria, Chiara Zurzolo. The spread of prion-like proteins by lysosomes and tunneling nanotubes: Implications for neurodegenerative diseases. 2017;216:2633
    https://doi.org/10.1083/jcb.201701047
  630. Eveljn Scarian, Camilla Viola, Francesca Dragoni, Rosalinda Di Gerlando, Bartolo Rizzo, Luca Diamanti, Stella Gagliardi, Matteo Bordoni, Orietta Pansarasa. New Insights into Oxidative Stress and Inflammatory Response in Neurodegenerative Diseases. IJMS 2024;25:2698
    https://doi.org/10.3390/ijms25052698
  631. Marie-Christine Tonon, Hubert Vaudry, Julien Chuquet, Florent Guillebaud, Jinjiang Fan, Olfa Masmoudi-Kouki, David Vaudry, Damien Lanfray, Fabrice Morin, Vincent Prevot, Vassilios Papadopoulos, Jean-Denis Troadec, Jérôme Leprince. Endozepines and their receptors: Structure, functions and pathophysiological significance. Pharmacology & Therapeutics 2020;208:107386
    https://doi.org/10.1016/j.pharmthera.2019.06.008
  632. Maria Garofalo, Cecilia Pandini, Matteo Bordoni, Orietta Pansarasa, Federica Rey, Alfredo Costa, Brigida Minafra, Luca Diamanti, Susanna Zucca, Stephana Carelli, Cristina Cereda, Stella Gagliardi. Alzheimer’s, Parkinson’s Disease and Amyotrophic Lateral Sclerosis Gene Expression Patterns Divergence Reveals Different Grade of RNA Metabolism Involvement. IJMS 2020;21:9500
    https://doi.org/10.3390/ijms21249500
  633. Klara Zubčić, Vedrana Radovanović, Josipa Vlainić, Patrick R. Hof, Nada Oršolić, Goran Šimić, Maja Jazvinšćak Jembrek. PI3K/Akt and ERK1/2 Signalling Are Involved in Quercetin-Mediated Neuroprotection against Copper-Induced Injury. Oxidative Medicine and Cellular Longevity 2020;2020:1
    https://doi.org/10.1155/2020/9834742
  634. Alan Zanardi, Massimo Alessio. Ceruloplasmin Deamidation in Neurodegeneration: From Loss to Gain of Function. IJMS 2021;22:663
    https://doi.org/10.3390/ijms22020663
  635. Theresa M. Curtis, Joseph M. Hannett, Rebecca M. Harman, Nicholas A. Puoplo, Gerlinde R. Van de Walle. The secretome of adipose-derived mesenchymal stem cells protects SH-SY5Y cells from arsenic-induced toxicity, independent of a neuron-like differentiation mechanism. NeuroToxicology 2018;67:54
    https://doi.org/10.1016/j.neuro.2018.04.009
  636. Muhammad Ikram, Rahat Ullah, Amjad Khan, Myeong Ok Kim. Ongoing Research on the Role of Gintonin in the Management of Neurodegenerative Disorders. Cells 2020;9:1464
    https://doi.org/10.3390/cells9061464
  637. Chyn Boon Wong, Yodai Kobayashi, Jin-zhong Xiao. Gut Microbiota - Brain Axis. 2020.
    https://doi.org/10.5772/intechopen.79088
  638. Mei-Yan Jiang, Chuan Han, Chen Zhang, Qian Zhou, Bei Zhang, Mei-Ling Le, Meng-Xing Huang, Yinuo Wu, Hai-Bin Luo. Discovery of effective phosphodiesterase 2 inhibitors with antioxidant activities for the treatment of Alzheimer’s disease. Bioorganic & Medicinal Chemistry Letters 2021;41:128016
    https://doi.org/10.1016/j.bmcl.2021.128016
  639. Dalia Khammash, Shreya K. Rajagopal, Thad A. Polk. Neurobiology of Brain Disorders. 2021.
    https://doi.org/10.1016/B978-0-323-85654-6.00057-5
  640. Sean-Patrick Riechers, Jelena Mojsilovic-Petrovic, Tayler B. Belton, Ram P. Chakrabarty, Mehraveh Garjani, Valentina Medvedeva, Casey Dalton, Yvette C. Wong, Navdeep S. Chandel, Gerald Dienel, Robert G. Kalb. Neurons undergo pathogenic metabolic reprogramming in models of familial ALS. Molecular Metabolism 2022;60:101468
    https://doi.org/10.1016/j.molmet.2022.101468
  641. Sharmistha Chatterjee, Parames C. Sil. ROS-Influenced Regulatory Cross-Talk With Wnt Signaling Pathway During Perinatal Development. Front. Mol. Biosci. 2022;9
    https://doi.org/10.3389/fmolb.2022.889719
  642. Irena Majkutewicz. Dimethyl fumarate: A review of preclinical efficacy in models of neurodegenerative diseases. European Journal of Pharmacology 2022;926:175025
    https://doi.org/10.1016/j.ejphar.2022.175025
  643. Stephan van Vliet, Frederick D. Provenza, Scott L. Kronberg. Health-Promoting Phytonutrients Are Higher in Grass-Fed Meat and Milk. Front. Sustain. Food Syst. 2021;4
    https://doi.org/10.3389/fsufs.2020.555426
  644. Che Wang, Zhengxu Cai, Wei Wang, Min Wei, Xinhong Si, Yuting Shang, Zhaofei Yang, Tianbai Li, Huishu Guo, Song Li. Piperine regulates glycogen synthase kinase-3β-related signaling and attenuates cognitive decline in D-galactose-induced aging mouse model. The Journal of Nutritional Biochemistry 2020;75:108261
    https://doi.org/10.1016/j.jnutbio.2019.108261
  645. Kyle J. Trageser, Chad Smith, Francis J. Herman, Kenjiro Ono, Giulio Maria Pasinetti. Mechanisms of Immune Activation by c9orf72-Expansions in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Front. Neurosci. 2019;13
    https://doi.org/10.3389/fnins.2019.01298
  646. Eshak I. Bahbah, Sherief Ghozy, Mohamed S. Attia, Ahmed Negida, Talha Bin Emran, Saikat Mitra, Ghadeer M. Albadrani, Mohamed M. Abdel-Daim, Md. Sahab Uddin, Jesus Simal-Gandara. Molecular Mechanisms of Astaxanthin as a Potential Neurotherapeutic Agent. Marine Drugs 2021;19:201
    https://doi.org/10.3390/md19040201
  647. Minji Woo, Jeong Sook Noh, Eun Ju Cho, Yeong Ok Song. Bioactive Compounds of Kimchi Inhibit Apoptosis by Attenuating Endoplasmic Reticulum Stress in the Brain of Amyloid β-Injected Mice. J. Agric. Food Chem. 2018;66:4883
    https://doi.org/10.1021/acs.jafc.8b01686
  648. Francisca Villavicencio Tejo, Rodrigo A Quintanilla. Contribution of the Nrf2 Pathway on Oxidative Damage and Mitochondrial Failure in Parkinson and Alzheimer’s Disease. Antioxidants 2021;10:1069
    https://doi.org/10.3390/antiox10071069
  649. Laura Bonfili, Valentina Cecarini, Massimiliano Cuccioloni, Mauro Angeletti, Sara Berardi, Silvia Scarpona, Giacomo Rossi, Anna Maria Eleuteri. SLAB51 Probiotic Formulation Activates SIRT1 Pathway Promoting Antioxidant and Neuroprotective Effects in an AD Mouse Model. Mol Neurobiol 2018;55:7987
    https://doi.org/10.1007/s12035-018-0973-4
  650. Arif Tasleem Jan, Mudsser Azam, Safikur Rahman, Angham M. S. Almigeiti, Duk Hwan Choi, Eun Ju Lee, Qazi Mohd Rizwanul Haq, Inho Choi. Perspective Insights into Disease Progression, Diagnostics, and Therapeutic Approaches in Alzheimer's Disease: A Judicious Update. Front. Aging Neurosci. 2017;9
    https://doi.org/10.3389/fnagi.2017.00356
  651. Karolina Dec, Agnieszka Łukomska, Karolina Skonieczna-Żydecka, Karolina Jakubczyk, Maciej Tarnowski, Anna Lubkowska, Irena Baranowska-Bosiacka, Daniel Styburski, Marta Skórka-Majewicz, Dominika Maciejewska, Izabela Gutowska. Chronic Exposure to Fluoride Affects GSH Level and NOX4 Expression in Rat Model of This Element of Neurotoxicity. Biomolecules 2020;10:422
    https://doi.org/10.3390/biom10030422
  652. Cinzia Sanna, Andrea Maxia, Giuseppe Fenu, Maria Cecilia Loi. So Uncommon and so Singular, but Underexplored: An Updated Overview on Ethnobotanical Uses, Biological Properties and Phytoconstituents of Sardinian Endemic Plants. Plants 2020;9:958
    https://doi.org/10.3390/plants9080958
  653. Debashis Mohapatra, Srikant Kanungo, Sweta Priyadarshini Pradhan, Susmita Jena, Shakti Ketan Prusty, Pratap Sahu. Captopril Is More Effective than Perindopril Against Aluminium Chloride Induced Amyloidogenesis and Cognitive Dysfunction. SSRN Journal 2021
    https://doi.org/10.2139/ssrn.3950129
  654. Patrícia Molz, Nadja Schröder. Potential Therapeutic Effects of Lipoic Acid on Memory Deficits Related to Aging and Neurodegeneration. Front. Pharmacol. 2017;8
    https://doi.org/10.3389/fphar.2017.00849
  655. Jia Xu, Kai Wang, Ye Yuan, Hui Li, Ruining Zhang, Shuwen Guan, Liping Wang. A Novel Peroxidase Mimics and Ameliorates Alzheimer’s Disease-Related Pathology and Cognitive Decline in Mice. IJMS 2018;19:3304
    https://doi.org/10.3390/ijms19113304
  656. Gulshan R. Walke, Dnyanesh S. Ranade, Archika M. Bapat, Rapole Srikanth, Prasad P. Kulkarni. Mn(III)‐Salen Protect Against Different ROS Species Generated by the Aβ16‐Cu Complex. ChemistrySelect 2016;1:3497
    https://doi.org/10.1002/slct.201600808
  657. Anninda Faiz Fauzya, Rika Indri Astuti, Nisa Rachmania Mubarik. Effect of Ethanol-Derived Clove Leaf Extract on the Oxidative Stress Response in Yeast Schizosaccharomyces pombe. International Journal of Microbiology 2019;2019:1
    https://doi.org/10.1155/2019/2145378
  658. Divya Soni, Puneet Kumar. GSK-3β-mediated regulation of Nrf2/HO-1 signaling as a new therapeutic approach in the treatment of movement disorders. Pharmacol. Rep 2022;74:557
    https://doi.org/10.1007/s43440-022-00390-z
  659. Zihan Yin, Zuoqin Yang, Yiwei Liu, Ling Zhao, Fanrong Liang. Oxidative stress and neurodegenerative diseases: a bidirectional Mendelian randomization study. Nutritional Neuroscience 2024:1
    https://doi.org/10.1080/1028415X.2024.2352195
  660. Isabel Ureña-Vacas, Elena González-Burgos, Pradeep Kumar Divakar, María Pilar Gómez-Serranillos. Lichen Extracts from Cetrarioid Clade Provide Neuroprotection against Hydrogen Peroxide-Induced Oxidative Stress. Molecules 2022;27:6520
    https://doi.org/10.3390/molecules27196520
  661. Himadri Sharma, Niti Sharma, Seong Soo A. An. Black Pepper (Piper nigrum) Alleviates Oxidative Stress, Exerts Potential Anti-Glycation and Anti-AChE Activity: A Multitargeting Neuroprotective Agent against Neurodegenerative Diseases. Antioxidants 2023;12:1089
    https://doi.org/10.3390/antiox12051089
  662. Natan Feter, Roselia Maria Spanevello, Mayara Sandrielly Pereira Soares, Luiza Spohr, Nathalia Stark Pedra, Natália Pontes Bona, Matheus Pintanel Freitas, Nicole Gomes Gonzales, Luiz Guilherme Martinho Sampaio Ito, Francieli Moro Stefanello, Airton José Rombaldi. How does physical activity and different models of exercise training affect oxidative parameters and memory?. Physiology & Behavior 2019;201:42
    https://doi.org/10.1016/j.physbeh.2018.12.002
  663. Hongwei Shi, Yue Yan, Hong Yang, Peng Pu, Heng Tang, Agata Stanek. Schisandrin B Diet Inhibits Oxidative Stress to Reduce Ferroptosis and Lipid Peroxidation to Prevent Pirarubicin-Induced Hepatotoxicity. BioMed Research International 2022;2022:1
    https://doi.org/10.1155/2022/5623555
  664. Ravirajsinh N. Jadeja, Folami L. Powell, Pamela M. Martin. Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications. 2022.
    https://doi.org/10.5772/intechopen.91915
  665. Archana Kumari, Rajesh Kumar Singh. Synthesis, Drug-Likeness Evaluation of Some Heterocyclic Moieties Fused Indole Derivatives as Potential Antioxidants. CCHTS 2023;26:2077
    https://doi.org/10.2174/1386207326666230102111810
  666. Yuhua Yin, Thuỳ Linh Phạm, Juhee Shin, Nara Shin, Dong-Wook Kang, Sun Yeul Lee, Wonhyung Lee, Cuk-Seong Kim, Sang Ryong Kim, Jinpyo Hong, Dong-Woon Kim. Arginase 2 Deficiency Promotes Neuroinflammation and Pain Behaviors Following Nerve Injury in Mice. JCM 2020;9:305
    https://doi.org/10.3390/jcm9020305
  667. T. N. Fedorova, A. A. Logvinenko, V. V. Poleshchuk, O. A. Muzychuk, A. A. Shabalina, S. N. Illarioshkin. Significance of Oxidative Damage to Proteins and DNA in the Blood of Patients with Parkinson’s Disease in Assessing the Severity of the Disease. Neurochem. J. 2021;15:211
    https://doi.org/10.1134/S1819712421020057
  668. Angie Bustos-Rangel, Jonathan Muñoz-Cabrera, Luis Cuca, Gonzalo Arboleda, Mónica Ávila Murillo, Adrián G. Sandoval-Hernández. Neuroprotective and antioxidant activities of Colombian plants against paraquat and C2-ceramide exposure in SH-SY5Y cells. Front. Nat. Prod. 2023;2
    https://doi.org/10.3389/fntpr.2023.1169182
  669. Francisco J. Carvajal, Waldo Cerpa. Regulation of Phosphorylated State of NMDA Receptor by STEP61 Phosphatase after Mild-Traumatic Brain Injury: Role of Oxidative Stress. Antioxidants 2021;10:1575
    https://doi.org/10.3390/antiox10101575
  670. Tobore Onojighofia Tobore. On the Neurobiological Role of Oxidative Stress in Alcohol-Induced Impulsive, Aggressive and Suicidal Behavior. Substance Use & Misuse 2019;54:2290
    https://doi.org/10.1080/10826084.2019.1645179
  671. Valery Danilenko, Andrey Devyatkin, Mariya Marsova, Madina Shibilova, Rustem Ilyasov, Vladimir Shmyrev. Common Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention. JIR 2021;Volume 14:6349
    https://doi.org/10.2147/JIR.S333887
  672. Elif Alan, Zeliha Kerry, Gulnur Sevin. Molecular mechanisms of Alzheimer's disease: From therapeutic targets to promising drugs. Fundamemntal Clinical Pharma 2023;37:397
    https://doi.org/10.1111/fcp.12861
  673. Hafsa Suhail Najim Al-Anbari, Dawser K. Ismail, Mohammed Khudair Hasan, Qutaiba Ahmed Al Khames Aga, Pottathil Shinu, Anroop B. Nair. High Blood Lead Levels: An Increased Risk for Development of Brain Hyperintensities among Type 2 Diabetes Mellitus Patients. Biol Trace Elem Res 2021;199:2149
    https://doi.org/10.1007/s12011-020-02359-6
  674. Anna Ainslie, Wouter Huiting, Lara Barazzuol, Steven Bergink. Genome instability and loss of protein homeostasis: converging paths to neurodegeneration?. Open Biol. 2021;11
    https://doi.org/10.1098/rsob.200296
  675. Christian Griñán-Ferré, Aina Bellver-Sanchis, Vanessa Izquierdo, Rubén Corpas, Joan Roig-Soriano, Miguel Chillón, Cristina Andres-Lacueva, Milán Somogyvári, Csaba Sőti, Coral Sanfeliu, Mercè Pallàs. The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: From antioxidant to epigenetic therapy. Ageing Research Reviews 2021;67:101271
    https://doi.org/10.1016/j.arr.2021.101271
  676. Mateus Grings, Bianca Seminotti, Anuradha Karunanidhi, Lina Ghaloul-Gonzalez, Al-Walid Mohsen, Peter Wipf, Johan Palmfeldt, Jerry Vockley, Guilhian Leipnitz. ETHE1 and MOCS1 deficiencies: Disruption of mitochondrial bioenergetics, dynamics, redox homeostasis and endoplasmic reticulum-mitochondria crosstalk in patient fibroblasts. Sci Rep 2019;9
    https://doi.org/10.1038/s41598-019-49014-2
  677. Samskruthi Madireddy, Sahithi Madireddy. Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia. Brain Sciences 2020;10:742
    https://doi.org/10.3390/brainsci10100742
  678. Оlga G. Kmet, Nаtaliia D. Filipets, Taras I. Kmet, Yurii M. Vepriuk, Kateryna V. Vlasova. BIOCHEMICAL AND MORPHOLOGICAL MARKERS OF EXPERIMENTAL SCOPOLAMINE-INDUCED NEURODEGENERATION AND THE EFFECT OF ENALAPRIL ON THEM. Wiad Lek 2020;73:2114
    https://doi.org/10.36740/WLek202010102
  679. Imran Kazmi, Muhammad Afzal, Faisal Imam, Sami I. Alzarea, Shaktipal Patil, Amrapali Mhaiskar, Ujashkumar Shah, Waleed Hassan Almalki. Barbaloin’s Chemical Intervention in Aluminum Chloride Induced Cognitive Deficits and Changes in Rats through Modulation of Oxidative Stress, Cytokines, and BDNF Expression. ACS Omega 2024;9:6976
    https://doi.org/10.1021/acsomega.3c08791
  680. Zhi Tang, Chen‐Cen Lai, Jun Luo, Yuan‐Ting Ding, Qian Chen, Zhi‐Zhong Guan. Mangiferin prevents the impairment of mitochondrial dynamics and an increase in oxidative stress caused by excessive fluoride in SH‐SY5Y cells. J Biochem & Molecular Tox 2021;35
    https://doi.org/10.1002/jbt.22705
  681. Sehwan Jang, Xavier R. Chapa-Dubocq, Rebecca M. Parodi-Rullán, Silvia Fossati, Sabzali Javadov. Beta-Amyloid Instigates Dysfunction of Mitochondria in Cardiac Cells. Cells 2022;11:373
    https://doi.org/10.3390/cells11030373
  682. Francesca Gorini, Giovanni Scala, Marcus S. Cooke, Barbara Majello, Stefano Amente. Towards a comprehensive view of 8-oxo-7,8-dihydro-2’-deoxyguanosine: Highlighting the intertwined roles of DNA damage and epigenetics in genomic instability. DNA Repair 2021;97:103027
    https://doi.org/10.1016/j.dnarep.2020.103027
  683. Gulsah Beyza ERTOSUN, Mehmet ERGEN, Hilal BARDAKCI, Timur Hakan BARAK, Guldal SUYEN. Cholinergic cognitive enhancer effect of Salvia triloba L. essential oil inhalation in rats. 2023;36:361
    https://doi.org/10.5472/marumj.1368345
  684. Sonu Singh, Akanksha Mishra, Sandeep Kumar Mishra, Shubha Shukla. ALCAR promote adult hippocampal neurogenesis by regulating cell-survival and cell death-related signals in rat model of Parkinson's disease like-phenotypes. Neurochemistry International 2017;108:388
    https://doi.org/10.1016/j.neuint.2017.05.017
  685. Merry W. Ma, Jing Wang, Krishnan M. Dhandapani, Darrell W. Brann. Deletion of NADPH oxidase 4 reduces severity of traumatic brain injury. Free Radical Biology and Medicine 2018;117:66
    https://doi.org/10.1016/j.freeradbiomed.2018.01.031
  686. Giulia Tarricone, Valentina Castagnola, Valentina Mastronardi, Lorenzo Cursi, Doriana Debellis, Dinu Zinovie Ciobanu, Andrea Armirotti, Fabio Benfenati, Luca Boselli, Pier Paolo Pompa. Catalytic Bioswitch of Platinum Nanozymes: Mechanistic Insights of Reactive Oxygen Species Scavenging in the Neurovascular Unit. Nano Lett. 2023;23:4660
    https://doi.org/10.1021/acs.nanolett.3c01479
  687. Izabela Sadowska-Bartosz, Grzegorz Bartosz. Redox nanoparticles: synthesis, properties and perspectives of use for treatment of neurodegenerative diseases. J Nanobiotechnol 2018;16
    https://doi.org/10.1186/s12951-018-0412-8
  688. Deepak Basyal, Sooyeun Lee, Hye Jin Kim. Antioxidants and Mechanistic Insights for Managing Dry Age-Related Macular Degeneration. Antioxidants 2024;13:568
    https://doi.org/10.3390/antiox13050568
  689. Slađana Krivokapić, Milorad Vlaović, Biljana Damjanović Vratnica, Andrej Perović, Svetlana Perović. Biowaste as a Potential Source of Bioactive Compounds—A Case Study of Raspberry Fruit Pomace. Foods 2021;10:706
    https://doi.org/10.3390/foods10040706
  690. Noriko Shinjyo, Julia Green. Are sage, rosemary and lemon balm effective interventions in dementia? A narrative review of the clinical evidence. European Journal of Integrative Medicine 2017;15:83
    https://doi.org/10.1016/j.eujim.2017.08.013
  691. Mostafa Y. Morad, Heba El-Sayed, Ahmed A. Elhenawy, Shereen M. Korany, Abeer S. Aloufi, Amina M. Ibrahim. Myco-Synthesized Molluscicidal and Larvicidal Selenium Nanoparticles: A New Strategy to Control Biomphalaria alexandrina Snails and Larvae of Schistosoma mansoni with an In Silico Study on Induced Oxidative Stress. JoF 2022;8:262
    https://doi.org/10.3390/jof8030262
  692. Ida Boček, Kristina Starčević, Ivana Novak Jovanović, Robert Vianello, Marijana Hranjec. Novel imidazo[4,5-b]pyridine derived acrylonitriles: A combined experimental and computational study of their antioxidative potential. Journal of Molecular Liquids 2021;342:117527
    https://doi.org/10.1016/j.molliq.2021.117527
  693. Munmun Chakraborty, Aparna Rao, Kuldeep Mohanty. Role of Mitochondrial Mutations in Ocular Aggregopathy. 2022
    https://doi.org/10.7759/cureus.27129
  694. Hyoung Kyu Kim, Jin Han. Mitochondrial Dynamics in Cardiovascular Medicine. 2022.
    https://doi.org/10.1007/978-3-319-55330-6_32
  695. Beihui Liu, A. G. Teschemacher, Sergey Kasparov. Neuroprotective potential of astroglia. J of Neuroscience Research 2017;95:2126
    https://doi.org/10.1002/jnr.24140
  696. Thais A. Sales, Ingrid G. Prandi, Alexandre A. de Castro, Daniel H. S. Leal, Elaine F. F. da Cunha, Kamil Kuca, Teodorico C. Ramalho. Recent Developments in Metal-Based Drugs and Chelating Agents for Neurodegenerative Diseases Treatments. IJMS 2019;20:1829
    https://doi.org/10.3390/ijms20081829
  697. Devendra Singh, K.H. Reeta, Uma Sharma, N.R. Jagannathan, A.K. Dinda, Y.K. Gupta. Neuro-protective effect of monomethyl fumarate on ischemia reperfusion injury in rats: Role of Nrf2/HO1 pathway in peri-infarct region. Neurochemistry International 2019;126:96
    https://doi.org/10.1016/j.neuint.2019.03.010
  698. Masamichi Ikawa, Hidehiko Okazawa, Makoto Yoneda. Molecular imaging for mitochondrial metabolism and oxidative stress in mitochondrial diseases and neurodegenerative disorders. Biochimica et Biophysica Acta (BBA) - General Subjects 2021;1865:129832
    https://doi.org/10.1016/j.bbagen.2020.129832
  699. Alka Ashok Singh, Dhananjay Yadav, Fazlurrahman Khan, Minseok Song. Indole-3-Carbinol and Its Derivatives as Neuroprotective Modulators. Brain Sciences 2024;14:674
    https://doi.org/10.3390/brainsci14070674
  700. Amit Kumar, Rajiv R. Ratan. Oxidative Stress and Huntington’s Disease: The Good, The Bad, and The Ugly. JHD 2016;5:217
    https://doi.org/10.3233/JHD-160205
  701. Justyna Kowalska, Klaudia Banach, Zuzanna Rzepka, Jakub Rok, Marta Karkoszka, Dorota Wrześniok. Changes in the Oxidation-Reduction State of Human Dermal Fibroblasts as an Effect of Lomefloxacin Phototoxic Action. Cells 2022;11:1971
    https://doi.org/10.3390/cells11121971
  702. Behnaz Khavari, Ebrahim Mahmoudi, Michael P. Geaghan, Murray J. Cairns. Oxidative Stress Impact on the Transcriptome of Differentiating Neuroblastoma Cells: Implication for Psychiatric Disorders. IJMS 2020;21:9182
    https://doi.org/10.3390/ijms21239182
  703. Eva Rahman Kabir, Namara Mariam Chowdhury, Hasina Yasmin, Md. Tanvir Kabir, Rokeya Akter, Asma Perveen, Ghulam Md. Ashraf, Shamima Akter, Md. Habibur Rahman, Sherouk Hussein Sweilam. Unveiling the Potential of Polyphenols as Anti-Amyloid Molecules in Alzheimer’s Disease. CN 2023;21:787
    https://doi.org/10.2174/1570159X20666221010113812
  704. Luodan Yang, Hannah Youngblood, Chongyun Wu, Quanguang Zhang. Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation. Transl Neurodegener 2020;9
    https://doi.org/10.1186/s40035-020-00197-z
  705. Tae Yeon Kim, Eunju Leem, Jae Man Lee, Sang Ryong Kim. Control of Reactive Oxygen Species for the Prevention of Parkinson’s Disease: The Possible Application of Flavonoids. Antioxidants 2020;9:583
    https://doi.org/10.3390/antiox9070583
  706. Tapan Behl, Rashita Makkar, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Gokhan Zengin, Simona Bungau, Felicia Liana Andronie-Cioara, Mihai Alexandru Munteanu, Mihaela Cristina Brisc, Diana Uivarosan, Ciprian Brisc. Current Trends in Neurodegeneration: Cross Talks between Oxidative Stress, Cell Death, and Inflammation. IJMS 2021;22:7432
    https://doi.org/10.3390/ijms22147432
  707. Aikaterina L. Stefi, Lukas H. Margaritis, Aikaterini S. Skouroliakou, Dido Vassilacopoulou. Mobile phone electromagnetic radiation affects Amyloid Precursor Protein and α-synuclein metabolism in SH-SY5Y cells. Pathophysiology 2019;26:203
    https://doi.org/10.1016/j.pathophys.2019.02.004
  708. Azizul Haque, Kelsey P. Drasites, April Cox, Mollie Capone, Ali I. Myatich, Ramsha Shams, Denise Matzelle, Dena P. Garner, Mikhail Bredikhin, Donald C. Shields, Alexey Vertegel, Naren L. Banik. Protective Effects of Estrogen via Nanoparticle Delivery to Attenuate Myelin Loss and Neuronal Death after Spinal Cord Injury. Neurochem Res 2021;46:2979
    https://doi.org/10.1007/s11064-021-03401-2
  709. Sima Gul Ghasemi, Alireza Khoshrou, Samaneh Kakhki, Atefeh Shirinzadeh Feizabadi, Maha Masoudi, Faezeh Bagherifar, Farimah Beheshti. Ascorbic Acid Supplementation Improves Adolescent Stress-induced Cognitive Impairment Through Restoration of Behavioral, Biochemical and Electrophysiological Alterations in Male Rats. Neuroscience 2024;549:55
    https://doi.org/10.1016/j.neuroscience.2024.04.012
  710. Wei-Ning Lin, Kishan Kapupara, Yao-Tseng Wen, Yi-Hsun Chen, I-Hong Pan, Rong-Kung Tsai. Haematococcus pluvialis-Derived Astaxanthin Is a Potential Neuroprotective Agent against Optic Nerve Ischemia. Marine Drugs 2020;18:85
    https://doi.org/10.3390/md18020085
  711. Afshin Montazeri, Milad Akhlaghi, Ahmad Reza Barahimi, Ali Jahanbazi Jahan Abad, Reza Jabbari. The Role of Metals in Neurodegenerative Diseases of the Central Nervous System. Shefaye Khatam 2020;8:130
    https://doi.org/10.29252/shefa.8.2.130
  712. Ziyan Hu, Yifan Luo, Jinxi Zhu, Danling Jiang, Zhenzhong Luo, Lidong Wu, Jin Li, Shengliang Peng, Jialing Hu. Role of the P2 × 7 receptor in neurodegenerative diseases and its pharmacological properties. Cell Biosci 2023;13
    https://doi.org/10.1186/s13578-023-01161-w
  713. Jianguo He, Haitao Wu, YanYan Zhou, Chao Zheng. Tomentosin inhibit cerebral ischemia/reperfusion induced inflammatory response via TLR4/ NLRP3 signalling pathway – in vivo and in vitro studies. Biomedicine & Pharmacotherapy 2020;131:110697
    https://doi.org/10.1016/j.biopha.2020.110697
  714. Piteesha Ramlagan, Darshini Narrain, Shameem Fawdar, Theeshan Bahorun. Non-Alcoholic Beverages. 2020.
    https://doi.org/10.1016/B978-0-12-815270-6.00001-3
  715. Sumit Barua, Jong Youl Kim, Midori A. Yenari, Jong Eun Lee. The role of NOX inhibitors in neurodegenerative diseases. IBRO Reports 2019;7:59
    https://doi.org/10.1016/j.ibror.2019.07.1721
  716. Qian Liu, Yaya Hu, Youfang Cao, Ge Song, Zhigang Liu, Xuebo Liu. Chicoric Acid Ameliorates Lipopolysaccharide-Induced Oxidative Stress via Promoting the Keap1/Nrf2 Transcriptional Signaling Pathway in BV-2 Microglial Cells and Mouse Brain. J. Agric. Food Chem. 2017;65:338
    https://doi.org/10.1021/acs.jafc.6b04873
  717. Saba Naqvi, Archna Panghal, S. J. S. Flora. Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs. Front. Neurosci. 2020;14
    https://doi.org/10.3389/fnins.2020.00494
  718. Claudia Cannas, Giada Lostia, Pier Andrea Serra, Alessandra Tiziana Peana, Rossana Migheli. Food and Food Waste Antioxidants: Could They Be a Potent Defence against Parkinson’s Disease?. Antioxidants 2024;13:645
    https://doi.org/10.3390/antiox13060645
  719. Kushal Kumar, Ashwani Kumar, Richard M. Keegan, Rahul Deshmukh. Recent advances in the neurobiology and neuropharmacology of Alzheimer’s disease. Biomedicine & Pharmacotherapy 2018;98:297
    https://doi.org/10.1016/j.biopha.2017.12.053
  720. Thanyaphorn Vachirarojpisan, Bhumrapee Srivichit, Savitri Vaseenon, Warit Powcharoen, Napatsorn Imerb. Therapeutic roles of coenzyme Q10 in peripheral nerve injury-induced neurosensory disturbances: Mechanistic insights from injury to recovery. Nutrition Research 2024;129:55
    https://doi.org/10.1016/j.nutres.2024.07.011
  721. Kuo-Hsuan Chang, Chiung-Mei Chen. The Role of NRF2 in Trinucleotide Repeat Expansion Disorders. Antioxidants 2024;13:649
    https://doi.org/10.3390/antiox13060649
  722. Limya Yagoup Osman, Talal Ahmed Awad, Sahar Abdalla, Mohamed Osman El-Faki, Amna Ali, Eltayeb Fadul Fadul Alla. In silico and in vitro profiling of coumarins and flavonoids for anti-Alzheimer and antioxidant activity. 2024;96:327
    https://doi.org/10.1515/pac-2023-1110
  723. S* Madireddy, S Madireddy. Protection from the Pathogenesis of Neurodegenerative Disorders, including Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Huntington’s Disease, and Parkinson’s Diseases, through the Mitigation of Reactive Oxygen Species. J Neurosci Neurol Disord 2019;3:148
    https://doi.org/10.29328/journal.jnnd.1001026
  724. Anat Elmann, Alona Telerman, Hilla Erlank, Rivka Ofir, Yoel Kashman, Elie Beit-Yannai. Achillolide A Protects Astrocytes against Oxidative Stress by Reducing Intracellular Reactive Oxygen Species and Interfering with Cell Signaling. Molecules 2016;21:301
    https://doi.org/10.3390/molecules21030301
  725. Emily Mohn, Matthew Kuchan, John Erdman, Martha Neuringer, Nirupa Matthan, Chung-Yen Chen, Elizabeth Johnson. The Subcellular Distribution of Alpha-Tocopherol in the Adult Primate Brain and Its Relationship with Membrane Arachidonic Acid and Its Oxidation Products. Antioxidants 2017;6:97
    https://doi.org/10.3390/antiox6040097
  726. Yumiko Oshima, Etienne Cartier, Liron Boyman, Nicolas Verhoeven, Brian M. Polster, Weiliang Huang, Maureen Kane, W. Jonathan Lederer, Mariusz Karbowski. Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination. 2021;220
    https://doi.org/10.1083/jcb.202006043
  727. Ye-Lim You, Ha-Jun Byun, Jeong Soon Lee, Hyeon-Son Choi, Jin-Soo Youk. Euonymus alatus and its compounds suppress hydrogen peroxide-induced oxidative stress in HT22 cells. Food Sci Biotechnol 2024
    https://doi.org/10.1007/s10068-024-01601-4
  728. Krystian Miazek, Karolina Beton, Agnieszka Śliwińska, Beata Brożek-Płuska. The Effect of β-Carotene, Tocopherols and Ascorbic Acid as Anti-Oxidant Molecules on Human and Animal In Vitro/In Vivo Studies: A Review of Research Design and Analytical Techniques Used. Biomolecules 2022;12:1087
    https://doi.org/10.3390/biom12081087
  729. Gabrieli L. Parrilha, Raquel G. dos Santos, Heloisa Beraldo. Applications of radiocomplexes with thiosemicarbazones and bis(thiosemicarbazones) in diagnostic and therapeutic nuclear medicine. Coordination Chemistry Reviews 2022;458:214418
    https://doi.org/10.1016/j.ccr.2022.214418
  730. ASLI Özbek Bilgin, Renad Mammadov, Bahadır Suleyman. Taksifolinin Sıçanlarda Etanolle İndüklenen Oksidatif Beyin Hasarına Etkisi. 2018
    https://doi.org/10.31832/smj.457718
  731. I. Ayelen Ramallo, Mario O. Salazar, Ricardo L. E. Furlan. Targeting Enzymes for Pharmaceutical Development. 2018.
    https://doi.org/10.1007/978-1-0716-0163-1_12
  732. Mariano Catanesi, Giulia Caioni, Vanessa Castelli, Elisabetta Benedetti, Michele d’Angelo, Annamaria Cimini. Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders. Marine Drugs 2021;19:24
    https://doi.org/10.3390/md19010024
  733. Hyejin Park, Jun Chen, Ivan E. Dimitrov, Jae Mo Park, Qiu Wang. Design and Characterization of Hyperpolarized 15N-BBCP as a H2O2-Sensing Probe. ACS Sens. 2022;7:2928
    https://doi.org/10.1021/acssensors.2c01720
  734. Hyunseong Kim, Wanjin Jeon, Jinyoung Hong, Junseon Lee, Changhwan Yeo, Yoonjae Lee, Seungho Baek, Inhyuk Ha. Gongjin-Dan Enhances Neurite Outgrowth of Cortical Neuron by Ameliorating H2O2-Induced Oxidative Damage via Sirtuin1 Signaling Pathway. Nutrients 2021;13:4290
    https://doi.org/10.3390/nu13124290
  735. Jan Homolak, Konstantinos Varvaras, Vittorio Sciacca, Ana Babic Perhoc, Davor Virag, Ana Knezovic, Jelena Osmanovic Barilar, Melita Salkovic-Petrisic. Insights into Gastrointestinal Redox Dysregulation in a Rat Model of Alzheimer’s Disease and the Assessment of the Protective Potential of D-Galactose. ACS Omega 2024;9:11288
    https://doi.org/10.1021/acsomega.3c07152
  736. Tobore Onojighofia Tobore. Towards a Comprehensive Theory of Non-Cancer Acute and Chronic Pain Management: The Critical Role of Reactive Oxygen and Nitrogen Species in Pain, and Opioid Dependence, Addiction, Hyperalgesia, and Tolerance. Advances in Redox Research 2021;2:100003
    https://doi.org/10.1016/j.arres.2021.100003
  737. Daniel Rand, Orly Ravid, Dana Atrakchi, Hila Israelov, Yael Bresler, Chen Shemesh, Liora Omesi, Sigal Liraz-Zaltsman, Fabien Gosselet, Taber S. Maskrey, Michal Schnaider Beeri, Peter Wipf, Itzik Cooper. Endothelial Iron Homeostasis Regulates Blood-Brain Barrier Integrity via the HIF2α—Ve-Cadherin Pathway. Pharmaceutics 2021;13:311
    https://doi.org/10.3390/pharmaceutics13030311
  738. Ricardo A. Santana-Martínez, Juan Carlos León-Contreras, Diana Barrera-Oviedo, José Pedraza-Chaverri, Rogelio Hernández-Pando, Perla D. Maldonado. Sustained Activation of JNK Induced by Quinolinic Acid Alters the BDNF/TrkB Axis in the Rat Striatum. Neuroscience 2018;383:22
    https://doi.org/10.1016/j.neuroscience.2018.04.034
  739. Sorayya Kheirouri, Mohammad Alizadeh. Dietary Inflammatory Potential and the Risk of Neurodegenerative Diseases in Adults. 2019;41:109
    https://doi.org/10.1093/epirev/mxz005
  740. Maddie Perdoncin, Alec Konrad, Joshua R. Wyner, Samir Lohana, Sneha S. Pillai, Duane G. Pereira, Hari Vishal Lakhani, Komal Sodhi. A Review of miRNAs as Biomarkers and Effect of Dietary Modulation in Obesity Associated Cognitive Decline and Neurodegenerative Disorders. Front. Mol. Neurosci. 2021;14
    https://doi.org/10.3389/fnmol.2021.756499
  741. Lucie Orliaguet, Vinood B. Patel, Victor R. Preedy, Fawaz Alzaid. Aging. 2021.
    https://doi.org/10.1016/B978-0-12-818698-5.00003-1
  742. Priya Tyagi, Mohd Tasleem, Shweta Prakash, Garima Chouhan. Intermingling of gut microbiota with brain: Exploring the role of probiotics in battle against depressive disorders. Food Research International 2020;137:109489
    https://doi.org/10.1016/j.foodres.2020.109489
  743. Banseok Lee, Myeongcheol Shin, Youngjae Park, So-Yoon Won, Kyoung Sang Cho. Physical Exercise-Induced Myokines in Neurodegenerative Diseases. IJMS 2021;22:5795
    https://doi.org/10.3390/ijms22115795
  744. Virginia Protto, Antonella Tramutola, Marco Fabiani, Maria Elena Marcocci, Giorgia Napoletani, Federica Iavarone, Federica Vincenzoni, Massimo Castagnola, Marzia Perluigi, Fabio Di Domenico, Giovanna De Chiara, Anna Teresa Palamara. Multiple Herpes Simplex Virus-1 (HSV-1) Reactivations Induce Protein Oxidative Damage in Mouse Brain: Novel Mechanisms for Alzheimer’s Disease Progression. Microorganisms 2020;8:972
    https://doi.org/10.3390/microorganisms8070972
  745. Jaewon Ju, Sung Dong Kim, Mikyung Shin. Pomegranate Polyphenol-Derived Injectable Therapeutic Hydrogels to Enhance Neuronal Regeneration. Mol. Pharmaceutics 2023;20:4786
    https://doi.org/10.1021/acs.molpharmaceut.3c00623
  746. Stephen K. Godin, Jinsoo Seo, Li-Huei Tsai. The Molecular and Cellular Basis of Neurodegenerative Diseases. 2023.
    https://doi.org/10.1016/B978-0-12-811304-2.00017-1
  747. Gabriele Deidda, Manuele Biazzo. Gut and Brain: Investigating Physiological and Pathological Interactions Between Microbiota and Brain to Gain New Therapeutic Avenues for Brain Diseases. Front. Neurosci. 2021;15
    https://doi.org/10.3389/fnins.2021.753915
  748. Sotiris Kyriakou, William Cheung, Theodora Mantso, Melina Mitsiogianni, Ioannis Anestopoulos, Stephany Veuger, Dimitris T. Trafalis, Rodrigo Franco, Aglaia Pappa, David Tetard, Mihalis I. Panayiotidis. A novel methylated analogue of L-Mimosine exerts its therapeutic potency through ROS production and ceramide-induced apoptosis in malignant melanoma. Invest New Drugs 2021;39:971
    https://doi.org/10.1007/s10637-021-01087-5
  749. Jin Young Hong, Hyunseong Kim, Junseon Lee, Wan-Jin Jeon, Seung Ho Baek, In-Hyuk Ha. Neurotherapeutic Effect of Inula britannica var. Chinensis against H2O2-Induced Oxidative Stress and Mitochondrial Dysfunction in Cortical Neurons. Antioxidants 2021;10:375
    https://doi.org/10.3390/antiox10030375
  750. Sheikh Azimullah, Mohamed Fizur Nagoor Meeran, Khatija Ayoob, Seenipandi Arunachalam, Shreesh Ojha, Rami Beiram. Tannic Acid Mitigates Rotenone-Induced Dopaminergic Neurodegeneration by Inhibiting Inflammation, Oxidative Stress, Apoptosis, and Glutamate Toxicity in Rats. IJMS 2023;24:9876
    https://doi.org/10.3390/ijms24129876
  751. Ricardo Pardillo-Díaz, Patricia Pérez-García, Carmen Castro, Pedro Nunez-Abades, Livia Carrascal. Oxidative Stress as a Potential Mechanism Underlying Membrane Hyperexcitability in Neurodegenerative Diseases. Antioxidants 2022;11:1511
    https://doi.org/10.3390/antiox11081511
  752. I.E. Dueñas-García, M.E. Heres-Pulido, M.R. Arellano-Llamas, J. De la Cruz-Núñez, V. Cisneros-Carrillo, C.S. Palacios-López, L. Acosta-Anaya, L.F. Santos-Cruz, L. Castañeda-Partida, A. Durán-Díaz. Lycopene, resveratrol, vitamin C and FeSO 4 increase damage produced by pro-oxidant carcinogen 4-nitroquinoline-1-oxide in Drosophila melanogaster : Xenobiotic metabolism implications. Food and Chemical Toxicology 2017;103:233
    https://doi.org/10.1016/j.fct.2017.02.007
  753. Tulendy Nurkenov, Andrey Tsoy, Farkhad Olzhayev, Elvira Abzhanova, Anel Turgambayeva, Aizhan Zhussupova, Bharathi Avula, Samir Ross, Aigerim Aituarova, Dariya Kassymova, Galiya Zhusupova, Tamara Shalakhmetova, Tursonjan Tokay, James C. Lee, Sholpan Askarova. Plant Extract of Limonium gmelinii Attenuates Oxidative Responses in Neurons, Astrocytes, and Cerebral Endothelial Cells In Vitro and Improves Motor Functions of Rats after Middle Cerebral Artery Occlusion. Antioxidants 2021;10:1814
    https://doi.org/10.3390/antiox10111814
  754. Antonio Monaco, Ida Ferrandino, Floriana Boscaino, Ennio Cocca, Luisa Cigliano, Francesco Maurano, Diomira Luongo, Maria Stefania Spagnuolo, Mauro Rossi, Paolo Bergamo. Conjugated linoleic acid prevents age-dependent neurodegeneration in a mouse model of neuropsychiatric lupus via the activation of an adaptive response. Journal of Lipid Research 2018;59:48
    https://doi.org/10.1194/jlr.M079400
  755. Abid Bhat, Ananda Staats Pires, Vanessa Tan, Saravana Babu Chidambaram, Gilles J Guillemin. Effects of Sleep Deprivation on the Tryptophan Metabolism. Int J�Tryptophan�Res 2020;13:117864692097090
    https://doi.org/10.1177/1178646920970902
  756. Natalia Cichon, Angela Dziedzic, Leslaw Gorniak, Elzbieta Miller, Michal Bijak, Michal Starosta, Joanna Saluk-Bijak. Unusual Bioactive Compounds with Antioxidant Properties in Adjuvant Therapy Supporting Cognition Impairment in Age-Related Neurodegenerative Disorders. IJMS 2021;22:10707
    https://doi.org/10.3390/ijms221910707
  757. Santanu Kaity, Anoop Kumar. Natural Product-based Synthetic Drug Molecules in Alzheimer's Disease. 2021.
    https://doi.org/10.1007/978-981-99-6038-5_3
  758. Justyna Pyrzanowska. Pharmacological activity ofAspalathus linearisextracts: pre-clinical research in view of prospective neuroprotection. Nutritional Neuroscience 2023;26:384
    https://doi.org/10.1080/1028415X.2022.2051955
  759. Elizabeth T. Akinluyi, Edem E. Edem, Kelvin M. Dakoru, Chinaza J. Nnodim, Michael A. Oladipupo, Olusegun A. Adeoluwa, Abiola O. Obisesan, Benneth Ben-Azu, Olusegun G. Adebayo. Psychobiotic interventions attenuate chronic alcohol use-mediated exacerbation of posttraumatic stress disorder in rats: the role of gut-liver axis response. 2023;20:92
    https://doi.org/10.1515/jcim-2022-0353
  760. Tahir Ali, Shafiq Ur Rehman, Fawad Ali Shah, Myeong Ok Kim. Acute dose of melatonin via Nrf2 dependently prevents acute ethanol-induced neurotoxicity in the developing rodent brain. J Neuroinflammation 2018;15
    https://doi.org/10.1186/s12974-018-1157-x
  761. Daphne Alcalá-Zúniga, Erika Espinoza-Torres, Ranjit Kumar Das, Magaly Vargas, Oscar Maldonado, Omar Benavides, Arvind Manojkumar, Roberto de la Garza, Natalia Davila, Isaac Perez, Alejandro Hernandez Martinez, Deepa Roy, Alejandro López-Juárez, Masoud M. Zarei, Kelsey A. Baker, Mario Gil, Hansapani Rodrigo, Gabriel A. de Erausquin, Upal Roy. Enriched Environment Contributes to the Recovery from Neurotoxin-Induced Parkinson’s Disease Pathology. Mol Neurobiol 2024;61:6734
    https://doi.org/10.1007/s12035-024-03951-w
  762. Fangyi Cheng, Sumasri Kotha, Miao Fu, Qi Yang, Heng Wang, Weiwei He, Xiaobo Mao. Nanozyme enabled protective therapy for neurological diseases. Nano Today 2024;54:102142
    https://doi.org/10.1016/j.nantod.2023.102142
  763. Iswariyaraja Sridevi Gurubaran. Mitochondrial damage and clearance in retinal pigment epithelial cells. Acta Ophthalmologica 2024;102:3
    https://doi.org/10.1111/aos.16661
  764. Thi Kim Quy Ha, Thi Phuong Doan, Ha Thanh Tung Pham, Ngoc Hieu Nguyen, Trong Tuan Nguyen, Thi Buu Hue Bui. Molecular networking-based chemical profiling and anti-influenza viral and neuroprotective effects of Elaeocarpus hygrophilus Kurz.. Chem. Pap. 2021;75:5323
    https://doi.org/10.1007/s11696-021-01723-7
  765. Setthawut Apiraksattayakul, Ratchanok Pingaew, Ronnakorn Leechaisit, Veda Prachayasittikul, Waralee Ruankham, Napat Songtawee, Tanawut Tantimongcolwat, Somsak Ruchirawat, Virapong Prachayasittikul, Supaluk Prachayasittikul, Kamonrat Phopin. Aminochalcones Attenuate Neuronal Cell Death under Oxidative Damage via Sirtuin 1 Activity. ACS Omega 2023;8:33367
    https://doi.org/10.1021/acsomega.3c03047
  766. Hamdy A.M. Soliman, Alaa El-Din H. Sayed. Poikilocytosis and tissue damage as negative impacts of tramadol on juvenile of Tilapia (Oreochromis niloticus). Environmental Toxicology and Pharmacology 2020;78:103383
    https://doi.org/10.1016/j.etap.2020.103383
  767. Ana Filošević Vujnović, Marko Rubinić, Ivona Starčević, Rozi Andretić Waldowski. Influence of Redox and Dopamine Regulation in Cocaine-Induced Phenotypes Using Drosophila. Antioxidants 2023;12:933
    https://doi.org/10.3390/antiox12040933
  768. Vaibhav Oli, Rohan Gupta, Pravir Kumar. FOXO and related transcription factors binding elements in the regulation of neurodegenerative disorders. Journal of Chemical Neuroanatomy 2021;116:102012
    https://doi.org/10.1016/j.jchemneu.2021.102012
  769. Uzma Saleem, Zohaib Raza, Fareeha Anwar, Zunera Chaudary, Bashir Ahmad. Systems pharmacology based approach to investigate the in-vivo therapeutic efficacy of Albizia lebbeck (L.) in experimental model of Parkinson’s disease. BMC Complement Altern Med 2019;19
    https://doi.org/10.1186/s12906-019-2772-5
  770. Andrea Vergallo, Linda Giampietri, Filippo Baldacci, Leda Volpi, Lucia Chico, Cristina Pagni, Filippo Sean Giorgi, Roberto Ceravolo, Gloria Tognoni, Gabriele Siciliano, Ubaldo Bonuccelli. Oxidative Stress Assessment in Alzheimer’s Disease: A Clinic Setting Study. Am J Alzheimers Dis Other Demen 2018;33:35
    https://doi.org/10.1177/1533317517728352
  771. Md Mominur Rahman, Md Rezaul Islam, Mst Afroza Alam Tumpa, Sheikh Shohag, Shakil khan shuvo, Jannatul Ferdous, Saima Akter Kajol, Abdullah S.M. Aljohani, Waleed Al Abdulmonem, Abdur Rauf, Muthu Thiruvengadam. Insights into the promising prospect of medicinal chemistry studies against neurodegenerative disorders. Chemico-Biological Interactions 2023;373:110375
    https://doi.org/10.1016/j.cbi.2023.110375
  772. Silvia Sorce, Roland Stocker, Tamara Seredenina, Rikard Holmdahl, Adriano Aguzzi, Adriano Chio, Antoine Depaulis, Freddy Heitz, Peter Olofsson, Tomas Olsson, Venceslas Duveau, Despina Sanoudou, Sara Skosgater, Antonia Vlahou, Dominique Wasquel, Karl-Heinz Krause, Vincent Jaquet. NADPH oxidases as drug targets and biomarkers in neurodegenerative diseases: What is the evidence?. Free Radical Biology and Medicine 2017;112:387
    https://doi.org/10.1016/j.freeradbiomed.2017.08.006
  773. Jung Hwan Park, Dae Won Kim, Min Jea Shin, Jinseu Park, Kyu Hyung Han, Keun Wook Lee, Jong Kook Park, Yeon Joo Choi, Hyeon Ji Yeo, Eun Ji Yeo, Eun Jeong Sohn, Hyoung-Chun Kim, Eun-Joo Shin, Sung-Woo Cho, Duk-Soo Kim, Yong-Jun Cho, Won Sik Eum, Soo Young Choi. Tat-indoleamine 2,3-dioxygenase 1 elicits neuroprotective effects on ischemic injury. BMB Rep. 2020;53:582
    https://doi.org/10.5483/BMBRep.2020.53.11.114
  774. E. D. Khilazheva, E. V. Lychkovskaya, V. A. Kutyakov, A. V. Morgun, V. V. Salmin. In vitro Effects of Plasma Acid on Proliferation of Rat Brain Endothelial Cells. J Evol Biochem Phys 2022;58:1163
    https://doi.org/10.1134/S0022093022040196
  775. Jie Yu, Jiacheng Zheng, Jiajia Lin, Linlu Jin, Rui Yu, Shinghung Mak, Shengquan Hu, Hongya Sun, Xiang Wu, Zaijun Zhang, Mingyuen Lee, Wahkeung Tsim, Wei Su, Wenhua Zhou, Wei Cui, Yifan Han, Qinwen Wang. Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3β and the ERK Pathway. Cell Mol Neurobiol 2017;37:655
    https://doi.org/10.1007/s10571-016-0402-z
  776. Simona Collina, Marta Rui, Silvia Stotani, Emanuele Bignardi, Daniela Rossi, Daniela Curti, Fabrizio Giordanetto, Alessio Malacrida, Arianna Scuteri, Guido Cavaletti. Are Sigma Receptor Modulators a Weapon Against Multiple Sclerosis Disease?. Future Med. Chem. 2017;9:2029
    https://doi.org/10.4155/fmc-2017-0122
  777. Tiantian Meng, Chunming Liu, Yulian Chen, Manrong Yu, Jianfu He, Bihui Tan, Xiaoqin Fu, Jianhua He, Dingfu Xiao. Dietary Chito-oligosaccharide attenuates LPS-challenged intestinal inflammation via regulating mitochondrial apoptotic and MAPK signaling pathway. International Immunopharmacology 2024;126:111153
    https://doi.org/10.1016/j.intimp.2023.111153
  778. Preeti Singh, Peter S. Hanson, Christopher M. Morris. SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson’s disease. BMC Neurosci 2017;18
    https://doi.org/10.1186/s12868-017-0364-1
  779. Ochuko L. Erukainure, Motlalepula G. Matsabisa, Veronica F. Salau, Md. Shahidul Islam. Tetrahydrocannabinol-Rich Extracts From Cannabis Sativa L. Improve Glucose Consumption and Modulate Metabolic Complications Linked to Neurodegenerative Diseases in Isolated Rat Brains. Front. Pharmacol. 2020;11
    https://doi.org/10.3389/fphar.2020.592981
  780. Vedrana Radovanović, Josipa Vlainić, Nikolina Hanžić, Petra Ukić, Nada Oršolić, Goran Baranović, Maja Jazvinšćak Jembrek. Neurotoxic Effect of Ethanolic Extract of Propolis in the Presence of Copper Ions is Mediated through Enhanced Production of ROS and Stimulation of Caspase-3/7 Activity. Toxins 2019;11:273
    https://doi.org/10.3390/toxins11050273
  781. Jan Spaas, Lieve van Veggel, Melissa Schepers, Assia Tiane, Jack van Horssen, David M. Wilson, Pablo R. Moya, Elisabeth Piccart, Niels Hellings, Bert O. Eijnde, Wim Derave, Rudy Schreiber, Tim Vanmierlo. Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders. Cell. Mol. Life Sci. 2021;78:4615
    https://doi.org/10.1007/s00018-021-03802-0
  782. Laraib Liaquat, Zehra Batool, Sadia Sadir, Sahar Rafiq, Sidrah Shahzad, Tahira Perveen, Saida Haider. Naringenin-induced enhanced antioxidant defence system meliorates cholinergic neurotransmission and consolidates memory in male rats. Life Sciences 2018;194:213
    https://doi.org/10.1016/j.lfs.2017.12.034
  783. Zeyu Song, Ying Zhou, Xiao Han, Jieling Qin, Xiaoying Tang. Recent advances in enzymeless-based electrochemical sensors to diagnose neurodegenerative diseases. J. Mater. Chem. B 2021;9:1175
    https://doi.org/10.1039/D0TB02745F
  784. Tobore Onojighofia Tobore. Towards a comprehensive theory of obesity and a healthy diet: The causal role of oxidative stress in food addiction and obesity. Behavioural Brain Research 2020;384:112560
    https://doi.org/10.1016/j.bbr.2020.112560
  785. Liwen Zhang, Yijing He, Kecheng Lei, Zhuo Fang, Qian Li, Jun Su, Zhiyu Nie, Yichun Xu, Lingjing Jin. Gene expression profiling of early Parkinson’s disease patient reveals redox homeostasis. Neuroscience Letters 2021;753:135893
    https://doi.org/10.1016/j.neulet.2021.135893
  786. Cindy Gunawan, Megan S. Lord, Emma Lovell, Roong Jien Wong, Moon Sun Jung, Diana Oscar, Riti Mann, Rose Amal. Oxygen-Vacancy Engineering of Cerium-Oxide Nanoparticles for Antioxidant Activity. ACS Omega 2019;4:9473
    https://doi.org/10.1021/acsomega.9b00521
  787. M. G. Makletsova, T. N. Fedorova, V. V. Poleschuk, G. T. Rikhireva. The effect of dopamine on in vitro methemoglobin formation in erythrocytes of patients with Parkinson’s disease under oxidative stress. BIOPHYSICS 2017;62:247
    https://doi.org/10.1134/S0006350917020154
  788. Wataru Kadowaki, Yuki Sugahara, Tomoyasu Toyoizumi, Teruko Nakajima, Shigenori Kumazawa. Isolation and identification of antioxidant phenylpropanoids from the fruit peel of Akebia trifoliata koidz. FSTR 2023;29:27
    https://doi.org/10.3136/fstr.FSTR-D-22-00127
  789. Maria do Carmo Carreiras, Lhassane Ismaili, José Marco-Contelles. Propargylamine-derived multi-target directed ligands for Alzheimer’s disease therapy. Bioorganic & Medicinal Chemistry Letters 2020;30:126880
    https://doi.org/10.1016/j.bmcl.2019.126880
  790. Vignesh Narasimman, Saravanan Ramachandran. Purification, structural characterization, and neuroprotective effect of 3,6‐diisobutyl‐2,5‐piperazinedione from Halomonas pacifica CARE‐V15 against okadaic acid‐induced neurotoxicity in zebrafish model. J Biochem & Molecular Tox 2024;38
    https://doi.org/10.1002/jbt.23708
  791. Snjezana Petrovic, Aleksandra Arsic, Danijela Ristic-Medic, Zorica Cvetkovic, Vesna Vucic. Lipid Peroxidation and Antioxidant Supplementation in Neurodegenerative Diseases: A Review of Human Studies. Antioxidants 2020;9:1128
    https://doi.org/10.3390/antiox9111128
  792. Isabelle Matthiesen, Dimitrios Voulgaris, Polyxeni Nikolakopoulou, Thomas E. Winkler, Anna Herland. Continuous Monitoring Reveals Protective Effects of N‐Acetylcysteine Amide on an Isogenic Microphysiological Model of the Neurovascular Unit. Small 2021;17
    https://doi.org/10.1002/smll.202101785
  793. Wanyu Wang, Jiao Li, Huizhen Zhang, Xiaokai Wang, Xiaofeng Zhang. Effects of vitamin E supplementation on the risk and progression of AD: a systematic review and meta-analysis. Nutritional Neuroscience 2021;24:13
    https://doi.org/10.1080/1028415X.2019.1585506
  794. Nayanne Hardy Lima Pontes, Thomas Dominik de Sousa dos Reis, Carlos Franciney Moreira Vasconcelos, Paulo de Tarso Teles Dourado de Aragão, Ricardo Basto Souza, Francisco Eduardo Aragão Catunda Junior, Lissiana Magna Vasconcelos Aguiar, Rodrigo Maranguape Silva da Cunha. Impact of eugenol onin vivomodel of 6-hydroxydopamine-induced oxidative stress. Free Radical Research 2021;55:556
    https://doi.org/10.1080/10715762.2021.1971662
  795. Shruti Shandilya, Sandeep Kumar, Niraj Kumar Jha, Kavindra Kumar Kesari, Janne Ruokolainen. Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection. Journal of Advanced Research 2022;38:223
    https://doi.org/10.1016/j.jare.2021.09.005
  796. Hamed Mirzaei, Saman Sedighi, Ebrahim Kouchaki, Erfaneh Barati, Ehsan Dadgostar, Michael Aschner, Omid Reza Tamtaji. Probiotics and the Treatment of Parkinson's Disease: An Update. Cell Mol Neurobiol 2022;42:2449
    https://doi.org/10.1007/s10571-021-01128-w
  797. Kaitlyn Thompson, Stella Tsirka. The Diverse Roles of Microglia in the Neurodegenerative Aspects of Central Nervous System (CNS) Autoimmunity. IJMS 2017;18:504
    https://doi.org/10.3390/ijms18030504
  798. Xiang Gao, Jieling Qin, Zhenqi Jiang, Juan Li, Aiguo Wu. TiO2 Nanoparticles. 2017.
    https://doi.org/10.1002/9783527825431.ch7
  799. Shirel Argueti-Ostrovsky, Leenor Alfahel, Joy Kahn, Adrian Israelson. All Roads Lead to Rome: Different Molecular Players Converge to Common Toxic Pathways in Neurodegeneration. Cells 2021;10:2438
    https://doi.org/10.3390/cells10092438
  800. Charley C. Gruber, Graham C. Walker. Incomplete base excision repair contributes to cell death from antibiotics and other stresses. DNA Repair 2018;71:108
    https://doi.org/10.1016/j.dnarep.2018.08.014
  801. Takuya Ohba, Shinsuke Nakamura, Masamitsu Shimazawa, Yoshihiro Hayashi, Hiroyuki Kono, Hideaki Hara. Protective effects of Huperzia serrata and its components against oxidative damage and cognitive dysfunction. PharmaNutrition 2020;13:100203
    https://doi.org/10.1016/j.phanu.2020.100203
  802. Sandeep Kumar, Sachin Kumar, Richmond Arthur, Puneet Kumar. Trans-cinnamaldehyde mitigates rotenone-induced neurotoxicity via inhibiting oxidative stress in rats. Pharmacological Research - Modern Chinese Medicine 2023;6:100209
    https://doi.org/10.1016/j.prmcm.2022.100209
  803. Marc Morissette, Nadhir Litim, Thérèse Di Paolo. Discovery and Development of Neuroprotective Agents from Natural Products. 2023.
    https://doi.org/10.1016/B978-0-12-809593-5.00002-1
  804. Houman Kahroba, Bahman Ramezani, Hamid Maadi, Mohammad Reza Sadeghi, Hajar Jaberie, Fatemeh Ramezani. The role of Nrf2 in neural stem/progenitors cells: From maintaining stemness and self-renewal to promoting differentiation capability and facilitating therapeutic application in neurodegenerative disease. Ageing Research Reviews 2021;65:101211
    https://doi.org/10.1016/j.arr.2020.101211
  805. Yukiya Ohnishi, Daisuke Tsuji, Kohji Itoh. Oxidative Stress Impairs Autophagy via Inhibition of Lysosomal Transport of VAMP8. Biological & Pharmaceutical Bulletin 2022;45:1609
    https://doi.org/10.1248/bpb.b22-00131
  806. Mariusz G. Fleszar, Jerzy Wiśniewski, Izabela Berdowska, Bogdan Zieliński, Marzena Zboch, Dorota Diakowska, Andrzej Gamian, Małgorzata Krzystek-Korpacka. Systemic hepcidin quantified with LC–MS/MS in dementia in association with disease pathology and severity and with structural changes in the brain. Peptides 2019;122:170169
    https://doi.org/10.1016/j.peptides.2019.170169
  807. Xiuyun Liu, Haodong Li, Meijun Pang, Jinzhen Liu, Xizi Song, Runnan He, Mengqi He, Xiqi Jian, Cheng Ma, Handi Deng, Yixuan Wu, Dong Ming. Photoacoustic imaging in brain disorders: Current progress and clinical applications. VIEW 2024;5
    https://doi.org/10.1002/VIW.20240023
  808. Aleksandra Duda-Chodak, Tomasz Tarko. Possible Side Effects of Polyphenols and Their Interactions with Medicines. Molecules 2023;28:2536
    https://doi.org/10.3390/molecules28062536
  809. Laura Scott, Valina L. Dawson, Ted M. Dawson. Trumping neurodegeneration: Targeting common pathways regulated by autosomal recessive Parkinson's disease genes. Experimental Neurology 2017;298:191
    https://doi.org/10.1016/j.expneurol.2017.04.008
  810. Woo Sik Kim, Yi-Eun Kim, Eun-Ji Cho, Eui-Baek Byun, Woo Yong Park, Ha-Yeon Song, Kwangwook Kim, Sang-Hyun Park, Eui-Hong Byun. Neuroprotective effect of Annona muricata-derived polysaccharides in neuronal HT22 cell damage induced by hydrogen peroxide. 2020;84:1001
    https://doi.org/10.1080/09168451.2020.1715201
  811. Bingyan Yang, Yixin Dong, Fei Wang, Yu Zhang. Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols. Molecules 2020;25:4613
    https://doi.org/10.3390/molecules25204613
  812. Stuart P. Moon, Aaron T. Balana, Matthew R. Pratt. Consequences of post-translational modifications on amyloid proteins as revealed by protein semisynthesis. Current Opinion in Chemical Biology 2021;64:76
    https://doi.org/10.1016/j.cbpa.2021.05.007
  813. Shuo Wang, Gleniece Irving, Lulu Jiang, Hui Wang, Ming Li, Xujing Wang, Wenting Han, Yongpeng Xu, Yilin Yang, Tao Zeng, Fuyong Song, Xiulan Zhao, Keqin Xie. Oxidative Stress Mediated Hippocampal Neuron Apoptosis Participated in Carbon Disulfide-Induced Rats Cognitive Dysfunction. Neurochem Res 2017;42:583
    https://doi.org/10.1007/s11064-016-2113-8
  814. Chirle de O. Raphaelli, Jéssica G. Azevedo, Gabriel O. Dalmazo, Juliana R. Vinholes, Elizandra Braganhol, Márcia Vizzotto , Leonardo Nora. Effect of Fruit Secondary Metabolites on Melanoma: A Systematic Review of In vitro Studies. CBC 2020;16:1009
    https://doi.org/10.2174/1573407215666190808113341
  815. Omamuyovwi M. Ijomone, Oritoke M. Aluko, Comfort O.A. Okoh, Airton Cunha Martins, Michael Aschner. Role for calcium signaling in manganese neurotoxicity. Journal of Trace Elements in Medicine and Biology 2019;56:146
    https://doi.org/10.1016/j.jtemb.2019.08.006
  816. Ju Zheng, Joris Winderickx, Vanessa Franssens, Beidong Liu. A Mitochondria-Associated Oxidative Stress Perspective on Huntington’s Disease. Front. Mol. Neurosci. 2018;11
    https://doi.org/10.3389/fnmol.2018.00329
  817. Nikolay Solovyev, Evgenii Drobyshev, Bastian Blume, Bernhard Michalke. Selenium at the Neural Barriers: AReview. Front. Neurosci. 2021;15
    https://doi.org/10.3389/fnins.2021.630016
  818. Bryan Tungland. Human Microbiota in Health and Disease. 2021.
    https://doi.org/10.1016/B978-0-12-814649-1.00012-0
  819. Chih-Hsiung Hsieh, Chueh-Hsuan Lu, Yu-Yi Kuo, Guan-Bo Lin, Chih-Yu Chao, Ferenc Gallyas. The protective effect of non-invasive low intensity pulsed electric field and fucoidan in preventing oxidative stress-induced motor neuron death via ROCK/Akt pathway. PLoS ONE 2019;14:e0214100
    https://doi.org/10.1371/journal.pone.0214100
  820. Dong Yue, Chaorong Zeng, Samuel Kumi Okyere, Zhengli Chen, Yanchun Hu. Glycine nano-selenium prevents brain oxidative stress and neurobehavioral abnormalities caused by MPTP in rats. Journal of Trace Elements in Medicine and Biology 2021;64:126680
    https://doi.org/10.1016/j.jtemb.2020.126680
  821. Alexandre Vallée, Yves Lecarpentier, Rémy Guillevin, Jean-Noël Vallée. Circadian rhythms, Neuroinflammation and Oxidative Stress in the Story of Parkinson’s Disease. Cells 2020;9:314
    https://doi.org/10.3390/cells9020314
  822. Yukyung Lee, Gaeun Choi, Hyongjun Jeon, Dongsoo Kim, Sun Ryu, Sungtae Koo, Ki-Tae Ha, Seungtae Kim. Acupuncture stimulation at GB34 suppresses 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced oxidative stress in the striatum of mice. J Physiol Sci 2018;68:455
    https://doi.org/10.1007/s12576-017-0547-7
  823. Rammohan V. Rao. Encyclopedia of Gerontology and Population Aging. 2018.
    https://doi.org/10.1007/978-3-030-22009-9_922
  824. Meng-Chang Tsai, Tiao-Lai Huang. Decreased S100B serum levels after treatment in bipolar patients in a manic phase. Comprehensive Psychiatry 2017;74:27
    https://doi.org/10.1016/j.comppsych.2016.12.008
  825. Erika Kropf, Margaret Fahnestock. Effects of Reactive Oxygen and Nitrogen Species on TrkA Expression and Signalling: Implications for proNGF in Aging and Alzheimer’s Disease. Cells 2021;10:1983
    https://doi.org/10.3390/cells10081983
  826. Jordan J. Comfort, Samantha C. Chomyshen, Brandon M. Waddell, Hadi Tabarraei, Cheng-Wei Wu. Molecular characterization of ethyl carbamate toxicity in Caenorhabditis elegans. Toxicology Reports 2022;9:619
    https://doi.org/10.1016/j.toxrep.2022.03.029
  827. Robert L. Bertrand. Iron accumulation, glutathione depletion, and lipid peroxidation must occur simultaneously during ferroptosis and are mutually amplifying events. Medical Hypotheses 2017;101:69
    https://doi.org/10.1016/j.mehy.2017.02.017
  828. Marek Piotrowski, Danuta Jantas, Monika Leśkiewicz, Krzysztof Szczepanowicz, Piotr Warszyński, Władysław Lasoń. Polyelectrolyte-coated nanocapsules containing cyclosporine A protect neuronal-like cells against oxidative stress-induced cell damage. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2018;555:264
    https://doi.org/10.1016/j.colsurfa.2018.07.005
  829. Sukanya Saha, Pritam Sadhukhan, Parames C. Sil. Neuroprotective Natural Products. 2018.
    https://doi.org/10.1002/9783527803781.ch3
  830. Yinyan Yin, Nuo Xu, Tao Qin, Bangyue Zhou, Yi Shi, Xinyi Zhao, Bixia Ma, Zhengzhong Xu, Chunmei Li. Astaxanthin Provides Antioxidant Protection in LPS-Induced Dendritic Cells for Inflammatory Control. Marine Drugs 2021;19:534
    https://doi.org/10.3390/md19100534
  831. Mariacristina Failla, Angelo Ferlazzo, Vincenzo Abbate, Giovanni Neri, Erika Saccullo, Antonino Gulino, Antonio Rescifina, Vincenzo Patamia, Giuseppe Floresta. THP as a sensor for the electrochemical detection of H2O2. Bioorganic Chemistry 2024;152:107721
    https://doi.org/10.1016/j.bioorg.2024.107721
  832. Fengwu Wang, Feng Wang, Tiejun Chen. Secondary metabolites of Galactomyces geotrichum from Laminaria japonica ameliorate cognitive deficits and brain oxidative stress in D-galactose induced Alzheimer’s disease mouse model. Natural Product Research 2021;35:5323
    https://doi.org/10.1080/14786419.2020.1753738
  833. Lilin Yi, Man Luo, Maoju Wang, Zhifang Dong, Yehong Du. Fangchinoline alleviates cognitive impairments through enhancing autophagy and mitigating oxidative stress in Alzheimer’s disease models. Front. Cell Dev. Biol. 2023;11
    https://doi.org/10.3389/fcell.2023.1288506
  834. Rosamaria Militello, Simone Luti, Tania Gamberi, Alessio Pellegrino, Alessandra Modesti, Pietro Amedeo Modesti. Physical Activity and Oxidative Stress in Aging. Antioxidants 2024;13:557
    https://doi.org/10.3390/antiox13050557
  835. Yujeong Lee, Min-Sun Kim, Jaewon Lee. Neuroprotective strategies to prevent and treat Parkinson’s disease based on its pathophysiological mechanism. Arch. Pharm. Res. 2017;40:1117
    https://doi.org/10.1007/s12272-017-0960-8
  836. Antea Krsek, Ana Jagodic, Lara Baticic. Nanomedicine in Neuroprotection, Neuroregeneration, and Blood–Brain Barrier Modulation: A Narrative Review. Medicina 2024;60:1384
    https://doi.org/10.3390/medicina60091384
  837. Alexander D. Landgraf, Amsha Saud Alsegiani, Saleh Alaqel, Sandeep Thanna, Zahoor A. Shah, Steven J. Sucheck. Neuroprotective and Anti-neuroinflammatory Properties of Ebselen Derivatives and Their Potential to Inhibit Neurodegeneration. ACS Chem. Neurosci. 2020;11:3008
    https://doi.org/10.1021/acschemneuro.0c00328
  838. Norwin Kubick, Marta Pajares, Ioana Enache, Gina Manda, Michel-Edwar Mickael. Repurposing Zileuton as a Depression Drug Using an AI and In Vitro Approach. Molecules 2020;25:2155
    https://doi.org/10.3390/molecules25092155
  839. Miguel Reina, Christian A. Celaya, Jesús Muñiz. C36and C35E (E=N and B) Fullerenes as Potential Nanovehicles for Neuroprotective Drugs: A Comparative DFT Study. ChemistrySelect 2021;6:4844
    https://doi.org/10.1002/slct.202101227
  840. Gaetano Terrone, Federica Frigerio, Silvia Balosso, Teresa Ravizza, Annamaria Vezzani. Inflammation and reactive oxygen species in status epilepticus: Biomarkers and implications for therapy. Epilepsy & Behavior 2019;101:106275
    https://doi.org/10.1016/j.yebeh.2019.04.028
  841. Simone Muniz Pacheco, Mayara Sandrielly Pereira Soares, Jessié Martins Gutierres, Mariana Freire Barbieri Gerzson, Fabiano Barbosa Carvalho, Juliana Hofstatter Azambuja, Maria Rosa Chitolina Schetinger, Francieli Moro Stefanello, Roselia Maria Spanevello. Anthocyanins as a potential pharmacological agent to manage memory deficit, oxidative stress and alterations in ion pump activity induced by experimental sporadic dementia of Alzheimer's type. The Journal of Nutritional Biochemistry 2018;56:193
    https://doi.org/10.1016/j.jnutbio.2018.02.014
  842. D. MICHALIČKOVÁ, M. ŠÍMA, O. SLANAŘ. New Insights in the Mechanisms of Impaired Redox Signaling and its Interplay With Inflammation and Immunity in Multiple Sclerosis. Physiol Res 2020:1
    https://doi.org/10.33549/physiolres.934276
  843. Xin Lu, Yueqing Li, Qianwen Guan, Huajing Yang, Yijun Liu, Chenxi Du, Lei Wang, Qinghua Wang, Yuqiong Pei, Liang Wu, Haopeng Sun, Yao Chen. Discovery, Structure-Based Modification, In Vitro, In Vivo, and In Silico Exploration of m-Sulfamoyl Benzoamide Derivatives as Selective Butyrylcholinesterase Inhibitors for Treating Alzheimer’s Disease. ACS Chem. Neurosci. 2024;15:1135
    https://doi.org/10.1021/acschemneuro.3c00737
  844. Merry W. Ma, Jing Wang, Quanguang Zhang, Ruimin Wang, Krishnan M. Dhandapani, Ratna K. Vadlamudi, Darrell W. Brann. NADPH oxidase in brain injury and neurodegenerative disorders. Mol Neurodegeneration 2017;12
    https://doi.org/10.1186/s13024-017-0150-7
  845. Haziq Kamal, Geok Chin Tan, Siti Fatimah Ibrahim, Mohd. Farooq Shaikh, Isa Naina Mohamed, Rashidi M. Pakri Mohamed, Adila A. Hamid, Azizah Ugusman, Jaya Kumar. Alcohol Use Disorder, Neurodegeneration, Alzheimer’s and Parkinson’s Disease: Interplay Between Oxidative Stress, Neuroimmune Response and Excitotoxicity. Front. Cell. Neurosci. 2020;14
    https://doi.org/10.3389/fncel.2020.00282
  846. Roberta Oliveira da Costa, Carlos Vinicius Jataí Gadelha-Filho, Pedro Everson Alexandre de Aquino, Ludmila Araújo Rodrigues Lima, Jalles Dantas de Lucena, Wesley Lyeverton Correia Ribeiro, Francisco Arnaldo Viana Lima, Kelly Rose Tavares Neves, Glauce Socorro de Barros Viana. Vitamin D (VD3) Intensifies the Effects of Exercise and Prevents Alterations of Behavior, Brain Oxidative Stress, and Neuroinflammation, in Hemiparkinsonian Rats. Neurochem Res 2023;48:142
    https://doi.org/10.1007/s11064-022-03728-4
  847. Jordi Olloquequi, Roberto Díaz-Peña, Ester Verdaguer, Miren Ettcheto, Carme Auladell, Antoni Camins. From Inhalation to Neurodegeneration: Air Pollution as a Modifiable Risk Factor for Alzheimer’s Disease. IJMS 2024;25:6928
    https://doi.org/10.3390/ijms25136928
  848. Cui Huo, Lei Wu, Zhiqiang Jiang, Jiacheng Yang, Zhouyu Wang, Yuzhi Li, Shan Qian. Current Research on Pro-drug Therapies for Parkinson's and Alzheimer's Disease. MC 2022;18:655
    https://doi.org/10.2174/1573406418666211130150821
  849. Zhiwen Zeng, Jinying Xu, Wenhua Zheng. Artemisinin protects PC12 cells against β-amyloid-induced apoptosis through activation of the ERK1/2 signaling pathway. Redox Biology 2017;12:625
    https://doi.org/10.1016/j.redox.2017.04.003
  850. Zainab Riaz, Adhithiya Charli, Hannah Wickham, Huajun Jin, Gary Zenitsky, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy. Parkinsonism and the Environment. 2017.
    https://doi.org/10.1007/978-3-030-87451-3_5
  851. Franziska Pohl, Paul Kong Thoo Lin. The Potential Use of Plant Natural Products and Plant Extracts with Antioxidant Properties for the Prevention/Treatment of Neurodegenerative Diseases: In Vitro, In Vivo and Clinical Trials. Molecules 2018;23:3283
    https://doi.org/10.3390/molecules23123283
  852. Marjan Erfani, Zohreh Ghazi Tabatabaei, Saeed Sadigh‐Eteghad, Fatemeh Farokhi‐Sisakht, Fereshteh Farajdokht, Javad Mahmoudi, Pouran Karimi, Ava Nasrolahi. Rosa caninaL. methanolic extract prevents heat stress‐induced memory dysfunction in rats. Experimental Physiology 2019;104:1544
    https://doi.org/10.1113/EP087535
  853. Min Pan, Fengping Zhang, Kai Qu, Chang Liu, Jingyao Zhang, Ziwei Zhang. TXNIP: A Double-Edged Sword in Disease and Therapeutic Outlook. Oxidative Medicine and Cellular Longevity 2022;2022:1
    https://doi.org/10.1155/2022/7805115
  854. Scarlett E. Delgado, Arles Urrutia, Florence Gutzwiller, Chiayu Q. Chiu, Andrea Calixto. Microbiota and Diapause-Induced Neuroprotection Share a Dependency on Calcium But Differ in Their Effects on Mitochondrial Morphology. eNeuro 2023;10:ENEURO.0424-22.2023
    https://doi.org/10.1523/ENEURO.0424-22.2023
  855. Evon S. Ereifej, Griffin M. Rial, John K. Hermann, Cara S. Smith, Seth M. Meade, Jacob M. Rayyan, Keying Chen, He Feng, Jeffrey R. Capadona. Implantation of Neural Probes in the Brain Elicits Oxidative Stress. Front. Bioeng. Biotechnol. 2018;6
    https://doi.org/10.3389/fbioe.2018.00009
  856. Lianne R. de Haan, Megan J. Reiniers, Laurens F. Reeskamp, Ali Belkouz, Lei Ao, Shuqun Cheng, Baoyue Ding, Rowan F. van Golen, Michal Heger. Experimental Conditions That Influence the Utility of 2′7′-Dichlorodihydrofluorescein Diacetate (DCFH2-DA) as a Fluorogenic Biosensor for Mitochondrial Redox Status. Antioxidants 2022;11:1424
    https://doi.org/10.3390/antiox11081424
  857. Mark A.A. Harrison, Sara L. Morris, Grace A. Rudman, Daniel J. Rittenhouse, Chandler H. Monk, Siva S.V.P. Sakamuri, Md Mehedi Hasan, Mst Shamima Khatun, Hanyun Wang, Lucas P. Garfinkel, Elizabeth B. Norton, Sangku Kim, Jay K. Kolls, S. Michal Jazwinski, Ricardo Mostany, Prasad V,G. Katakam, Elizabeth B. Engler-Chiurazzi, Kevin J. Zwezdaryk. Intermittent cytomegalovirus infection alters neurobiological metabolism and induces cognitive deficits in mice. Brain, Behavior, and Immunity 2024;117:36
    https://doi.org/10.1016/j.bbi.2023.12.033
  858. Hakan Öğütlü, Cuma Mertoğlu, Gamze Gök, Salim Neşelioğlu. Thiols and ceruloplasmin levels in serum of children with attention deficit hyperactivity disorder: A cross-sectional study. Psychiatry Research 2020;294:113546
    https://doi.org/10.1016/j.psychres.2020.113546
  859. Chiara Cervetto, Monica Averna, Laura Vergani, Marco Pedrazzi, Sarah Amato, Simone Pelassa, Stefano Giuliani, Francesca Baldini, Guido Maura, Paolo Mariottini, Manuela Marcoli, Manuela Cervelli. Reactive Astrocytosis in a Mouse Model of Chronic Polyamine Catabolism Activation. Biomolecules 2021;11:1274
    https://doi.org/10.3390/biom11091274
  860. Dahua Fan, Liping Liu, Zhengzhi Wu, Meiqun Cao. Combating Neurodegenerative Diseases with the Plant Alkaloid Berberine: Molecular Mechanisms and Therapeutic Potential. CN 2019;17:563
    https://doi.org/10.2174/1570159X16666180419141613
  861. Shailaja Kesaraju Allani, Ramanjaneyulu Rayala, Oscar Rivera, Howard M. Prentice, Xi Chen, Verónica Ramírez-Alcántara, Joshua Canzoneri, Janet Menzie-Suderam, Xupei Huang, Constantin Georgescu, Jonathan D. Wren, Gary A. Piazza, Herbert Weissbach. A Novel Sulindac Derivative Protects against Oxidative Damage by a Cyclooxygenase-Independent Mechanism. J Pharmacol Exp Ther 2022;382:79
    https://doi.org/10.1124/jpet.122.001086
  862. André L.F. Nascimento, Pamela O.S. Medeiros, Luiz F.A.T. Pedrão, Vitoria C. Queiroz, Luiz M. Oliveira, Leonardo S. Novaes, Ariadiny L. Caetano, Carolina D. Munhoz, Ana C. Takakura, Barbara Falquetto. Oxidative Stress Inhibition Via Apocynin Prevents Medullary Respiratory Neurodegeneration and Respiratory Pattern Dysfunction in a 6-Hydroxydopamine Animal Model of Parkinson’s Disease. Neuroscience 2022;502:91
    https://doi.org/10.1016/j.neuroscience.2022.07.034
  863. Umar Amjid, Ubair Aziz, Uzma Habib, Ishrat Jabeen. Biological regulatory network analysis for targeting the mitochondrial calcium uniporter (MCU) mediated calcium (Ca2+) transport in neurodegenerative disorders. Cell Biochemistry & Function 2024;42
    https://doi.org/10.1002/cbf.4082
  864. Eun-Ok Choi, Da Hee Son, Min Young Kim, Hyun Hwang-Bo, Hong Jae Kim, Jin-Woo Jeong, Su Hyun Hong, Cheol Park, Yung Hyun Choi. Anti-oxidant and Anti-microbial Activities of Herb-combined Remedies used in Traditional Korean Medicine for Treating Breast Cancer. Journal of Life Science 2016;26:680
    https://doi.org/10.5352/JLS.2016.26.6.680
  865. Hyunseong Kim, Jin Young Hong, Wan-Jin Jeon, Junseon Lee, Yoon Jae Lee, In-Hyuk Ha. Melittin regulates iron homeostasis and mediates macrophage polarization in rats with lumbar spinal stenosis. Biomedicine & Pharmacotherapy 2022;156:113776
    https://doi.org/10.1016/j.biopha.2022.113776
  866. Fang Fang, Jiaying Zhao, Lijian Ding, Chunhui Huang, C. Benjamin Naman, Shan He, Bin Wu, Peng Zhu, Qijun Luo, William H. Gerwick, Xiaojun Yan, Qinwen Wang, Zaijun Zhang, Wei Cui. 5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34. Marine Drugs 2017;15:260
    https://doi.org/10.3390/md15080260
  867. Shruti Shandilya, Kavindra Kumar Kesari, Janne Ruokolainen. Vitamin K2 Modulates Organelle Damage and Tauopathy Induced by Streptozotocin and Menadione in SH-SY5Y Cells. Antioxidants 2021;10:983
    https://doi.org/10.3390/antiox10060983
  868. Sheena E.B. Tyler, Luke D.K. Tyler. Pathways to healing: Plants with therapeutic potential for neurodegenerative diseases. IBRO Neuroscience Reports 2023;14:210
    https://doi.org/10.1016/j.ibneur.2023.01.006
  869. Paula Sienes Bailo, Elena Llorente Martín, Pilar Calmarza, Silvia Montolio Breva, Adrián Bravo Gómez, Adela Pozo Giráldez, Joan José Sánchez-Pascuala Callau, Juana Maria Vaquer Santamaría, Anita Dayaldasani Khialani, Concepción Cerdá Micó, Jordi Camps Andreu, Guillermo Sáez Tormo, Isabel Fort Gallifa. Implicación del estrés oxidativo en las enfermedades neurodegenerativas y posibles terapias antioxidantes. 2022;3:351
    https://doi.org/10.1515/almed-2022-0022
  870. Yulia Sidorova, Andrii Domanskyi. Detecting Oxidative Stress Biomarkers in Neurodegenerative Disease Models and Patients. MPs 2020;3:66
    https://doi.org/10.3390/mps3040066
  871. André Kühl, Angela Dixon, Mirabela Hali, Aaron K. Apawu, Antonela Muca, Moaz Sinan, James Warila, Rod D. Braun, Bruce A. Berkowitz, Avril Genene Holt. Novel QUEST MRI In Vivo Measurement of Noise-induced Oxidative Stress in the Cochlea. Sci Rep 2019;9
    https://doi.org/10.1038/s41598-019-52439-4
  872. Luiza Flavia Veiga Francisco, Debora da Silva Baldivia, Bruno do Amaral Crispim, Adrivanio Baranoski, Syla Maria Farias Ferraz Klafke, Edson Lucas dos Santos, Rodrigo Juliano Oliveira, Alexeia Barufatti. In vitro evaluation of the cytotoxic and genotoxic effects of Al and Mn in ambient concentrations detected in groundwater intended for human consumption. Ecotoxicology and Environmental Safety 2023;264:115415
    https://doi.org/10.1016/j.ecoenv.2023.115415
  873. Mohammad Althubiti, Mohamed Elzubier, Ghazzi Sallih Alotaibi, Mohammed Abdullah Althubaiti, Hazim Hamed Alsadi, Ziyad Abdulaziz Alhazmi, Fares Alghamdi, Mahmoud Zaki El-Readi, Riyad Almaimani, Abdullatif Babakr. Beta 2 microglobulin correlates with oxidative stress in elderly. Experimental Gerontology 2021;150:111359
    https://doi.org/10.1016/j.exger.2021.111359
  874. Junseon Lee, Hyunseong Kim, Wan-Jin Jeon, Changhwan Yeo, Hyun Kim, Jin Young Hong, Seung Ho Baek, Yoon Jae Lee, In-Hyuk Ha. Neuroprotective Effect of Fructus Ligustri Lucidi in Spinal Cord Neuron Injury during H2O2-Mediated Oxidative Stress. Journal of Food Biochemistry 2024;2024:1
    https://doi.org/10.1155/2024/6679695
  875. E. M. Molochkina, Yu. A. Treshchenkova. The Effect of Alpha-Tocopherol on the Activity of Acetylcholinesterases from Different Sources. Neurochem. J. 2019;13:36
    https://doi.org/10.1134/S1819712419010161
  876. Alycia N. Galindo, David A. Frey Rubio, Marian H. Hettiaratchi. Biomaterial strategies for regulating the neuroinflammatory response. Mater. Adv. 2024;5:4025
    https://doi.org/10.1039/D3MA00736G
  877. Patrycja Michalska, Giammarco Tenti, Michelle Satriani, Angel Cores, María Teresa Ramos, Antonio G. García, José Carlos Menéndez, Rafael León. Aza‐CGP37157‐lipoic hybrids designed as novel Nrf2‐inducers and antioxidants exert neuroprotection against oxidative stress and show neuroinflammation inhibitory properties. Drug Development Research 2020;81:283
    https://doi.org/10.1002/ddr.21618
  878. Patrycja Mulica, Anne Grünewald, Sandro L. Pereira. Astrocyte-Neuron Metabolic Crosstalk in Neurodegeneration: A Mitochondrial Perspective. Front. Endocrinol. 2021;12
    https://doi.org/10.3389/fendo.2021.668517
  879. Andrea Valeri, Emanuela Mazzon. State of the Art and Future of Stem Cell Therapy in Ischemic Stroke: Why Don’t We Focus on Their Administration?. Bioengineering 2023;10:118
    https://doi.org/10.3390/bioengineering10010118
  880. Marjan Nassiri-Asl, Hossein Hosseinzadeh. Oxidative Stress and Dietary Antioxidants in Neurological Diseases. 2023.
    https://doi.org/10.1016/B978-0-12-817780-8.00023-2
  881. Elise Lévy, Nadine El Banna, Dorothée Baïlle, Amélie Heneman-Masurel, Sandrine Truchet, Human Rezaei, Meng-Er Huang, Vincent Béringue, Davy Martin, Laurence Vernis. Causative Links between Protein Aggregation and Oxidative Stress: A Review. IJMS 2019;20:3896
    https://doi.org/10.3390/ijms20163896
  882. A. S. Piatoikina, T. V. Zhilyaeva, G. E. Mazo. Cognitive impairments in schizophrenia and their impact on oxidative stress. V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY 2022;56:66
    https://doi.org/10.31363/2313-7053-2022-56-3-66-79
  883. Saba Parvez, Marcus J. C. Long, Jesse R. Poganik, Yimon Aye. Redox Signaling by Reactive Electrophiles and Oxidants. Chem. Rev. 2018;118:8798
    https://doi.org/10.1021/acs.chemrev.7b00698
  884. Klaus W. Lange. Bailey's Industrial Oil and Fat Products. 2018.
    https://doi.org/10.1002/047167849X.bio118
  885. G. Bodega, M. Alique, L. Puebla, J. Carracedo, R. M. Ramírez. Microvesicles: ROS scavengers and ROS producers. J of Extracellular Vesicle 2019;8
    https://doi.org/10.1080/20013078.2019.1626654
  886. Franziska Pohl, Andreia Teixeira-Castro, Marta Daniela Costa, Victoria Lindsay, Juliana Fiúza-Fernandes, Marie Goua, Giovanna Bermano, Wendy Russell, Patrícia Maciel, Paul Kong Thoo Lin. GST-4-Dependent Suppression of Neurodegeneration in C. elegans Models of Parkinson’s and Machado-Joseph Disease by Rapeseed Pomace Extract Supplementation. Front. Neurosci. 2019;13
    https://doi.org/10.3389/fnins.2019.01091
  887. Luiz Eduardo Baggio Savio, Raíssa Leite-Aguiar, Vinícius Santos Alves, Robson Coutinho-Silva, Angela T.S. Wyse. Purinergic signaling in the modulation of redox biology. Redox Biology 2021;47:102137
    https://doi.org/10.1016/j.redox.2021.102137
  888. Simone Brogi, Anna Ramunno, Lida Savi, Giulia Chemi, Gloria Alfano, Alessandra Pecorelli, Erika Pambianchi, Paola Galatello, Giulia Compagnoni, Federico Focher, Giuseppe Biamonti, Giuseppe Valacchi, Stefania Butini, Sandra Gemma, Giuseppe Campiani, Margherita Brindisi. First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents. European Journal of Medicinal Chemistry 2017;138:438
    https://doi.org/10.1016/j.ejmech.2017.06.017
  889. Lukasz Gwozdzinski, Joanna Bernasinska-Slomczewska, Anna Wiktorowska-Owczarek, Edward Kowalczyk, Anna Pieniazek. Diosmin and Bromelain Stimulate Glutathione and Total Thiols Production in Red Blood Cells. Molecules 2023;28:2291
    https://doi.org/10.3390/molecules28052291
  890. Ángel Cores, Noelia Carmona-Zafra, José Clerigué, Mercedes Villacampa, J. Carlos Menéndez. Quinones as Neuroprotective Agents. Antioxidants 2023;12:1464
    https://doi.org/10.3390/antiox12071464
  891. Scott D. Heinemann, Jessica M. Posimo, Daniel M. Mason, Daniel F. Hutchison, Rehana K. Leak. Synergistic stress exacerbation in hippocampal neurons: Evidence favoring the dual‐hit hypothesis of neurodegeneration. Hippocampus 2016;26:980
    https://doi.org/10.1002/hipo.22580
  892. Gaurav Bhatia, Jatinder Singh, Bimla Nehru. Neuroprotective effects of hydro-alcoholic extract of Eclipta alba against 1-methyl-4-phenylpyridinium-induced in vitro and in vivo models of Parkinson’s disease. Environ Sci Pollut Res 2021;28:9390
    https://doi.org/10.1007/s11356-020-11452-1
  893. Caglar Cosarderelioglu, Lolita S. Nidadavolu, Claudene J. George, Esther S. Oh, David A. Bennett, Jeremy D. Walston, Peter M. Abadir. Brain Renin–Angiotensin System at the Intersect of Physical and Cognitive Frailty. Front. Neurosci. 2020;14
    https://doi.org/10.3389/fnins.2020.586314
  894. Sukanya Tripathy, Sanjay Singh, Monisha Banerjee, Anand Prakash. Neurodegenerative Diseases: Multifactorial Degenerative Processes, Biomarkers and Therapeutic Approaches (First Edition). 2020.
    https://doi.org/10.2174/9789815040913122010006
  895. Konrad A. Szychowski, Bartosz Skóra, Anna K. Wójtowicz. Elastin-Derived Peptides in the Central Nervous System: Friend or Foe. Cell Mol Neurobiol 2022;42:2473
    https://doi.org/10.1007/s10571-021-01140-0
  896. Zhigang Liang, Zhuli Liu, Xuwen Sun, Manli Tao, Xiao Xiao, Guoping Yu, Xiaomin Wang. The Effect of Fucoidan on Cellular Oxidative Stress and the CatD-Bax Signaling Axis in MN9D Cells Damaged by 1-Methyl-4-Phenypyridinium. Front. Aging Neurosci. 2019;10
    https://doi.org/10.3389/fnagi.2018.00429
  897. Max Vidal-Gutiérrez, Ramón Enrique Robles-Zepeda, Wagner Vilegas, Gustavo Adolfo Gonzalez-Aguilar, Heriberto Torres-Moreno, Julio César López-Romero. Phenolic composition and antioxidant activity of Bursera microphylla A. Gray. Industrial Crops and Products 2020;152:112412
    https://doi.org/10.1016/j.indcrop.2020.112412
  898. Binnur Eroglu, Xiongjie Jin, Sadiki Deane, Bahadır Öztürk, Owen A. Ross, Demetrius Moskophidis, Nahid F. Mivechi. Dusp26 phosphatase regulates mitochondrial respiration and oxidative stress and protects neuronal cell death. Cell. Mol. Life Sci. 2022;79
    https://doi.org/10.1007/s00018-022-04162-z
  899. Kholoud I. Eissa, Mona M. Kamel, Lamia W. Mohamed, Asmaa E. Kassab. Development of new Alzheimer's disease drug candidates using donepezil as a key model. Archiv der Pharmazie 2023;356
    https://doi.org/10.1002/ardp.202200398
  900. Benjamin B. Tournier, Silvia Sorce, Antoine Marteyn, Roberta Ghidoni, Luisa Benussi, Giuliano Binetti, François R Herrmann, Karl‐Heinz Krause, Dina Zekry. CCR5 deficiency: Decreased neuronal resilience to oxidative stress and increased risk of vascular dementia. Alzheimer's & Dementia 2024;20:124
    https://doi.org/10.1002/alz.13392
  901. Seyedeh Parisa Moosavian, Arman Arab, Zamzam Paknahad, Sajjad Moradi. The effects of garlic supplementation on oxidative stress markers: A systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Medicine 2020;50:102385
    https://doi.org/10.1016/j.ctim.2020.102385
  902. Daria Khaltourina, Yuri Matveyev, Aleksey Alekseev, Franco Cortese, Anca Ioviţă. Aging Fits the Disease Criteria of the International Classification of Diseases. Mechanisms of Ageing and Development 2020;189:111230
    https://doi.org/10.1016/j.mad.2020.111230
  903. Yasen Maimaitiyiming, Hong-Hu Zhu, Chang Yang, Hua Naranmandura. Biotransformation of arsenic trioxide by AS3MT favors eradication of acute promyelocytic leukemia: revealing the hidden facts. Drug Metabolism Reviews 2020;52:425
    https://doi.org/10.1080/03602532.2020.1791173
  904. Solomon Idowu, Ademola Ezekiel Adekoya, Oluwakemi Osarumwense Igiehon, Anthony Temitope Idowu. Clove (Syzygium aromaticum) spices: a review on their bioactivities, current use, and potential application in dairy products. Food Measure 2021;15:3419
    https://doi.org/10.1007/s11694-021-00915-9
  905. Qian Jiao, Xixun Du, Jie Wei, Yong Li, Hong Jiang. Oxidative Stress Regulated Iron Regulatory Protein IRP2 Through FBXL5-Mediated Ubiquitination-Proteasome Way in SH-SY5Y Cells. Front. Neurosci. 2019;13
    https://doi.org/10.3389/fnins.2019.00020
  906. G. F. Makhaeva, E. V. Rudakova, N. V. Kovaleva, S. V. Lushchekina, N. P. Boltneva, A. N. Proshin, E. V. Shchegolkov, Ya. V. Burgart, V. I. Saloutin. Cholinesterase and carboxylesterase inhibitors as pharmacological agents. Russ Chem Bull 2019;68:967
    https://doi.org/10.1007/s11172-019-2507-2
  907. Camellia Akhgarjand, Zahra Vahabi, Sakineh Shab-Bidar, Aliarash Anoushirvani, Kurosh Djafarian. The effects of probiotic supplements on oxidative stress and inflammation in subjects with mild and moderate Alzheimer’s disease: a randomized, double-blind, placebo-controlled study. Inflammopharmacol 2024;32:1413
    https://doi.org/10.1007/s10787-023-01427-2
  908. Debashish Mohapatra, Srikant Kanungo, Sweta Priyadarshini Pradhan, Susmita Jena, Shakti Ketan Prusty, Pratap Kumar Sahu. Captopril is more effective than Perindopril against aluminium chloride induced amyloidogenesis and AD like pathology. Heliyon 2022;8:e08935
    https://doi.org/10.1016/j.heliyon.2022.e08935
  909. Meghan E. Carey, Juliette Rando, Stepan Melnyk, S Jill James, Nathaniel Snyder, Carolyn Salafia, Lisa A. Croen, M Daniele Fallin, Irva Hertz-Picciotto, Heather Volk, Craig Newschaffer, Kristen Lyall. Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression. J Autism Dev Disord 2023;53:2975
    https://doi.org/10.1007/s10803-022-05625-9
  910. Eman N. Hosny, Hussein G. Sawie, Mohamed E. Elhadidy, Yasser A. Khadrawy. Evaluation of antioxidant and anti-inflammatory efficacy of caffeine in rat model of neurotoxicity. Nutritional Neuroscience 2019;22:789
    https://doi.org/10.1080/1028415X.2018.1446812
  911. Chandra Prakash, Monika Mishra, Pavan Kumar, Vikas Kumar, Deepak Sharma. Dehydroepiandrosterone alleviates oxidative stress and apoptosis in iron-induced epilepsy via activation of Nrf2/ARE signal pathway. Brain Research Bulletin 2019;153:181
    https://doi.org/10.1016/j.brainresbull.2019.08.019
  912. Christina A. Castellani, Ryan J. Longchamps, Jing Sun, Eliseo Guallar, Dan E. Arking. Thinking outside the nucleus: Mitochondrial DNA copy number in health and disease. Mitochondrion 2020;53:214
    https://doi.org/10.1016/j.mito.2020.06.004
  913. Yinyan Yin, Bangyue Zhou, Lirong Bai, Danni Feng, Tao Qin, Chunmei Li. Holarrhena pubescens Wall. ex G. Don Extracts Inhibit LPS-Irritated Oxidative Stress in Dendritic Cells. Applied Sciences 2022;12:11343
    https://doi.org/10.3390/app122211343
  914. Matteo Scipioni, Graeme Kay, Ian L. Megson, Paul Kong Thoo Lin. Synthesis of novel vanillin derivatives: novel multi-targeted scaffold ligands against Alzheimer's disease. Med. Chem. Commun. 2019;10:764
    https://doi.org/10.1039/C9MD00048H
  915. Mehmed Abtulov, Silvia Gancheva, Milena Todorova, Miroslav Eftimov, Maria Zhelyazkova-Savova, Stefka Valcheva-Kuzmanova. Effect of Aronia melanocarpa fruit juice on the antioxidant defense system in rats with diet-induced metabolic syndrome. SSM 2021;53:47
    https://doi.org/10.14748/ssm.v0i0.7858
  916. Eva Filipovská, Zuzana Čočková, Barbora Černá, Aneta Kubištová, Veronika Spišská, Petr Telenský, Zdeňka Bendová. The role of N6‐methyladenosine RNA methylation in the crosstalk of circadian clock and neuroinflammation in rodent suprachiasmatic nuclei. Eur J of Neuroscience 2024;60:4586
    https://doi.org/10.1111/ejn.16471
  917. Fabiana Galland, Juliana Santos de Espindola, Daniel Saraiva Lopes, Milena Ferreira Taccola, Maria Teresa Bertoldo Pacheco. Food-derived bioactive peptides: Mechanisms of action underlying inflammation and oxidative stress in the central nervous system. Food Chemistry Advances 2022;1:100087
    https://doi.org/10.1016/j.focha.2022.100087
  918. Tyler B. Johnson, Jacob T. Cain, Katherine A. White, Denia Ramirez-Montealegre, David A. Pearce, Jill M. Weimer. Therapeutic landscape for Batten disease: current treatments and future prospects. Nat Rev Neurol 2019;15:161
    https://doi.org/10.1038/s41582-019-0138-8
  919. Shelli R. Kesler, Rebecca A. Harrison, Melissa L. Petersen, Vikram Rao, Hannah Dyson, Kristin Alfaro-Munoz, Shiao-Pei Weathers, John de Groot. Pre-surgical connectome features predict IDH status in diffuse gliomas. Oncotarget 2019;10:6484
    https://doi.org/10.18632/oncotarget.27301
  920. Elizabeth S. Childress, Stephanie J. Alexopoulos, Kyle L. Hoehn, Webster L. Santos. Small Molecule Mitochondrial Uncouplers and Their Therapeutic Potential. J. Med. Chem. 2018;61:4641
    https://doi.org/10.1021/acs.jmedchem.7b01182
  921. Michal Pokusa, Alžbeta Kráľová Trančíková, Rhian Touyz. The Central Role of Biometals Maintains Oxidative Balance in the Context of Metabolic and Neurodegenerative Disorders. Oxidative Medicine and Cellular Longevity 2017;2017
    https://doi.org/10.1155/2017/8210734
  922. Antonina Kurowska, Wojciech Ziemichód, Mariola Herbet, Iwona Piątkowska-Chmiel. The Role of Diet as a Modulator of the Inflammatory Process in the Neurological Diseases. Nutrients 2023;15:1436
    https://doi.org/10.3390/nu15061436
  923. Vanessa Castelli, Elisabetta Benedetti, Andrea Antonosante, Mariano Catanesi, Giuseppina Pitari, Rodolfo Ippoliti, Annamaria Cimini, Michele d’Angelo. Neuronal Cells Rearrangement During Aging and Neurodegenerative Disease: Metabolism, Oxidative Stress and Organelles Dynamic. Front. Mol. Neurosci. 2019;12
    https://doi.org/10.3389/fnmol.2019.00132
  924. Vusala Asadova, Zulfiye Gul, Rifat Levent Buyukuysal, Ozgur Yalcinbayir. Assessment of neuron-specific enolase, S100B and malondialdehyde levels in serum and vitreous of patients with proliferative diabetic retinopathy. Int Ophthalmol 2020;40:227
    https://doi.org/10.1007/s10792-019-01175-9
  925. Chang Feng, Sisi Liu, Fankun Zhou, Yanyan Gao, Yanshu Li, Guihua Du, Ying Chen, Huan Jiao, Jiangao Feng, Yuanyuan Zhang, Dandan Bo, Zongguang Li, Guangqin Fan. Oxidative stress in the neurodegenerative brain following lifetime exposure to lead in rats: Changes in lifespan profiles. Toxicology 2019;411:101
    https://doi.org/10.1016/j.tox.2018.11.003
  926. Ahad Banagozar Mohammadi, Saeed Sadigh-Eteghad, Mohammadali Torbati, Seyyed Mohammad Bagher Fazljou, Seyed Mehdi Vatandoust, Samad EJ Golzari, Fereshteh Farajdokht, Javad Mahmoudi. Identification and applications of neuroactive silk proteins: a narrative review. J Appl Biomed 2019;17:147
    https://doi.org/10.32725/jab.2019.012
  927. Recep Küçükdoğru, Hasan Türkez, Mehmet Enes Arslan, Özlem Özdemir Tozlu, Erdal Sönmez, Adil Mardinoğlu, Ivana Cacciatore, Antonio Di Stefano. Neuroprotective effects of boron nitride nanoparticles in the experimental Parkinson’s disease model against MPP+ induced apoptosis. Metab Brain Dis 2020;35:947
    https://doi.org/10.1007/s11011-020-00559-6
  928. Bastien Vallée Marcotte, Marie Verheyde, Sonia Pomerleau, Alain Doyen, Charles Couillard. Health Benefits of Apple Juice Consumption: A Review of Interventional Trials on Humans. Nutrients 2022;14:821
    https://doi.org/10.3390/nu14040821
  929. Seung Mi Sin, Ji Hyun Kim, Eun Ju Cho, Hyun Young Kim. Cognitive improvement effects of Momordica charantia in amyloid beta-induced Alzheimer's disease mouse model. JABC 2021;64:299
    https://doi.org/10.3839/jabc.2021.041
  930. Reem A. Al-Alawi, Jawhara H. Al-Mashiqri, Jawaher S. M. Al-Nadabi, Badria I. Al-Shihi, Younis Baqi. Date Palm Tree (Phoenix dactylifera L.): Natural Products and Therapeutic Options. Front. Plant Sci. 2017;8
    https://doi.org/10.3389/fpls.2017.00845
  931. Yixuan Wu, Zhigang Jiao, Zhiting Wan, Shaogang Qu. Role of autophagy and oxidative stress to astrocytes in fenpropathrin-induced Parkinson-like damage. Neurochemistry International 2021;145:105000
    https://doi.org/10.1016/j.neuint.2021.105000
  932. Masamichi Ikawa, Hidehiko Okazawa, Yasunari Nakamoto, Makoto Yoneda. PET Imaging for Oxidative Stress in Neurodegenerative Disorders Associated with Mitochondrial Dysfunction. Antioxidants 2020;9:861
    https://doi.org/10.3390/antiox9090861
  933. Hakan Kandemir, Samet İzgi, Irfan Cınar, Fatma Cebeci, Ebubekir Dirican, Mehmet F. Saglam, Ibrahim F. Sengul. Methoxy‐activated indole‐7‐carbohydrazides; synthesis, antioxidant, and anticancer properties. Journal of Heterocyclic Chem 2023;60:74
    https://doi.org/10.1002/jhet.4562
  934. Helena Berlamont, Arnout Bruggeman, Eva Bauwens, Charysse Vandendriessche, Elien Clarebout, Junhua Xie, Sofie De Bruyckere, Griet Van Imschoot, Elien Van Wonterghem, Richard Ducatelle, Patrick Santens, Annemieke Smet, Freddy Haesebrouck, Roosmarijn E. Vandenbroucke. Gastric Helicobacter suis Infection Partially Protects against Neurotoxicity in A 6-OHDA Parkinson’s Disease Mouse Model. IJMS 2021;22:11328
    https://doi.org/10.3390/ijms222111328
  935. Yu-Te Lin, Yi-Chung Wu, Gwo-Ching Sun, Chiu-Yi Ho, Tzyy-Yue Wong, Ching-Huang Lin, Hsin-Hung Chen, Tung-Chen Yeh, Chia-Jung Li, Ching-Jiunn Tseng, Pei-Wen Cheng. Effect of Resveratrol on Reactive Oxygen Species-Induced Cognitive Impairment in Rats with Angiotensin II-Induced Early Alzheimer’s Disease †. JCM 2018;7:329
    https://doi.org/10.3390/jcm7100329
  936. Laure-Estelle Cassagnes, Monivan Chhour, Pierre Pério, Jan Sudor, Régis Gayon, Gilles Ferry, Jean A. Boutin, Françoise Nepveu, Karine Reybier. Oxidative stress and neurodegeneration: The possible contribution of quinone reductase 2. Free Radical Biology and Medicine 2018;120:56
    https://doi.org/10.1016/j.freeradbiomed.2018.03.002
  937. Rehab F. Abdelhamid, Seiichi Nagano. Crosstalk between Oxidative Stress and Aging in Neurodegeneration Disorders. Cells 2023;12:753
    https://doi.org/10.3390/cells12050753
  938. Yuxin Bai, Zhaojie Wang, Liqun Yu, Kun Dong, Liming Cheng, Rongrong Zhu. The enhanced generation of motor neurons from mESCs by MgAl layered double hydroxide nanoparticles. Biomed. Mater. 2023;18:034101
    https://doi.org/10.1088/1748-605X/acc375
  939. Sara Aviles-Gaxiola, Marilyn S. Criollo-Mendoza, Melissa García-Carrasco, Erick P. Gutiérrez-Grijalva, Israel García-Aguiar, J. Basilio Heredia. Phytochemical Nanodelivery Systems as Potential Biopharmaceuticals. 2023.
    https://doi.org/10.1016/B978-0-323-90390-5.00001-3
  940. Yuri Zilberter, Dennis R. Tabuena, Misha Zilberter. NOX-induced oxidative stress is a primary trigger of major neurodegenerative disorders. Progress in Neurobiology 2023;231:102539
    https://doi.org/10.1016/j.pneurobio.2023.102539
  941. Daniela Mendes, Maria Manuel Oliveira, Paula I. Moreira, João Coutinho, Fernando M. Nunes, David M. Pereira, Patrícia Valentão, Paula B. Andrade, Romeu A. Videira. Beneficial effects of white wine polyphenols-enriched diet on Alzheimer’s disease-like pathology. The Journal of Nutritional Biochemistry 2018;55:165
    https://doi.org/10.1016/j.jnutbio.2018.02.001
  942. Ruo-Lan Li, Qing Zhang, Jia Liu, Jia-yi Sun, Li-Ying He, Hu-Xinyue Duan, Wei Peng, Chun-Jie Wu. Hydroxy-α-sanshool Possesses Protective Potentials on H2O2-Stimulated PC12 Cells by Suppression of Oxidative Stress-Induced Apoptosis through Regulation of PI3K/Akt Signal Pathway. Oxidative Medicine and Cellular Longevity 2020;2020:1
    https://doi.org/10.1155/2020/3481758
  943. Laura Bonfili, Valentina Cecarini, Olee Gogoi, Chunmei Gong, Massimiliano Cuccioloni, Mauro Angeletti, Giacomo Rossi, Anna Maria Eleuteri. Microbiota modulation as preventative and therapeutic approach in Alzheimer’s disease. The FEBS Journal 2021;288:2836
    https://doi.org/10.1111/febs.15571
  944. Xiao-yan Chen, Ting Zhang, Xin Wang, Mark T. Hamann, Jie Kang, De-quan Yu, Ruo-yun Chen. A Chemical Investigation of the Leaves of Morus alba L.. Molecules 2018;23:1018
    https://doi.org/10.3390/molecules23051018
  945. Jéssika P. Teixeira, Alexandre A. de Castro, Flávia V. Soares, Elaine F. F. da Cunha, Teodorico C. Ramalho. Future Therapeutic Perspectives into the Alzheimer’s Disease Targeting the Oxidative Stress Hypothesis. Molecules 2019;24:4410
    https://doi.org/10.3390/molecules24234410
  946. Yueqiang Hu, Wei Chen, Lin Wu, Lingfei Jiang, Lianmei Chen, Nong Tang. Clinical observation of the efficacy and mechanism of the Wenfei Jiangzhuo formula in lung and kidney deficiency-type vascular dementia. All Life 2020;13:144
    https://doi.org/10.1080/26895293.2020.1729869
  947. Cécile Mingard, Junzhou Wu, Maureen McKeague, Shana J. Sturla. Next-generation DNA damage sequencing. Chem. Soc. Rev. 2020;49:7354
    https://doi.org/10.1039/D0CS00647E
  948. Lihua Wang-Eckhardt, Asisa Bastian, Tobias Bruegmann, Philipp Sasse, Matthias Eckhardt. Carnosine synthase deficiency is compatible with normal skeletal muscle and olfactory function but causes reduced olfactory sensitivity in aging mice. Journal of Biological Chemistry 2020;295:17100
    https://doi.org/10.1074/jbc.RA120.014188
  949. Trish T. Hoang, Delinda A. Johnson, Ronald T. Raines, Jeffrey A. Johnson. Angiogenin activates the astrocytic Nrf2/antioxidant-response element pathway and thereby protects murine neurons from oxidative stress. Journal of Biological Chemistry 2019;294:15095
    https://doi.org/10.1074/jbc.RA119.008491
  950. Sandra Gonçalves, Inês Mansinhos, Anabela Romano. Plant-derived Bioactives. 2019.
    https://doi.org/10.1007/978-981-15-2361-8_19
  951. Meet Sheth, Hansika Sanjay Raina, Abhishek Kumar Singh. A Review on Diverse Neurological Disorders. 2019.
    https://doi.org/10.1016/B978-0-323-95735-9.00009-7
  952. Julia Konovalova, Dmytro Gerasymchuk, Ilmari Parkkinen, Piotr Chmielarz, Andrii Domanskyi. Interplay between MicroRNAs and Oxidative Stress in Neurodegenerative Diseases. IJMS 2019;20:6055
    https://doi.org/10.3390/ijms20236055
  953. Bartholomew P. Roland, Alison M. Zeccola, Samantha B. Larsen, Christopher G. Amrich, Aaron D. Talsma, Kimberly A. Stuchul, Annie Heroux, Edwin S. Levitan, Andrew P. VanDemark, Michael J. Palladino, Leo J Pallanck. Structural and Genetic Studies Demonstrate Neurologic Dysfunction in Triosephosphate Isomerase Deficiency Is Associated with Impaired Synaptic Vesicle Dynamics. PLoS Genet 2016;12:e1005941
    https://doi.org/10.1371/journal.pgen.1005941
  954. . .
    https://doi.org/
  955. Jiang-Ling Xiao, Heng-Yuan Liu, Chen-Chen Sun, Chang-Fa Tang. Regulation of Keap1-Nrf2 signaling in health and diseases. Mol Biol Rep 2024;51
    https://doi.org/10.1007/s11033-024-09771-4
  956. Yuri Zilberter, Tanya Zilberter. Metabolic correction of neurodegenerative pathologies: the role of macronutrients and timing. Explor Neurosci 2023:67
    https://doi.org/10.37349/en.2023.00013
  957. Nora Hanke, Abdelhaq Rami. Inhibition of autophagy rescues HT22 hippocampal neurons from erastin-induced ferroptosis. Neural Regen Res 2023;18:1548
    https://doi.org/10.4103/1673-5374.360246
  958. Ajay Kumar Sharma, Harshit Singh, Harinath Chakrapani. Photocontrolled endogenous reactive oxygen species (ROS) generation. Chem. Commun. 2019;55:5259
    https://doi.org/10.1039/C9CC01747J
  959. Mega O. Oyovwi, Benneth Ben-Azu, Faith Y. Falajiki, Oghenetega B. Onome, Rume A. Rotu, Rotu A. Rotu, Abioye A. Oyeleke, Godwin P. Okwute, Emuesiri G. Moke. D-ribose-L-cysteine exhibits restorative neurobehavioral functions through modulation of neurochemical activities and inhibition oxido-inflammatory perturbations in rats exposed to polychlorinated biphenyl. Naunyn-Schmiedeberg's Arch Pharmacol 2024;397:931
    https://doi.org/10.1007/s00210-023-02637-9
  960. Jia-Wen Shou, Chun-Kai Cheung, Jian Gao, Wei-Wei Shi, Pang-Chui Shaw. Berberine Protects C17.2 Neural Stem Cells From Oxidative Damage Followed by Inducing Neuronal Differentiation. Front. Cell. Neurosci. 2019;13
    https://doi.org/10.3389/fncel.2019.00395
  961. Yasmina Martí, Elina Nürnberg, Sandra Horschitz, Mathias Hafner, Patrick Schloss, Andreas Meyer-Lindenberg, Thorsten Lau. Refinement of a neuronal differentiation protocol predominantly yields human iPS cell-derived dopaminergic neurons for the investigation of neurodegenerative pathomechanisms in vitro. JCB 2017;3:61
    https://doi.org/10.3233/JCB-179007
  962. Francisco J. Carvajal, Rodrigo G. Mira, Maximiliano Rovegno, Alicia N. Minniti, Waldo Cerpa. Age-related NMDA signaling alterations in SOD2 deficient mice. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2018;1864:2010
    https://doi.org/10.1016/j.bbadis.2018.03.019
  963. Taruna Pandey, Shachi Shuchi Smita, Anjali Mishra, Shreesh Raj Sammi, Rakesh Pandey. Swertiamarin, a secoiridoid glycoside modulates nAChR and AChE activity. Experimental Gerontology 2020;138:111010
    https://doi.org/10.1016/j.exger.2020.111010
  964. Mohamad Khalil, Ali Bazzi, Dana Zeineddine, Wissam Jomaa, Ahmad Daher, Rana Awada. Repressive effect of Rhus coriaria L. fruit extracts on microglial cells-mediated inflammatory and oxidative stress responses. Journal of Ethnopharmacology 2021;269:113748
    https://doi.org/10.1016/j.jep.2020.113748
  965. Sajjad Makhdoomi, Mohammad Mehdi Mahboobian, Rasool Haddadi, Alireza Komaki, Mojdeh Mohammadi. Silibinin-loaded nanostructured lipid carriers (NLCs) ameliorated cognitive deficits and oxidative damages in aluminum chloride-induced neurotoxicity in male mice. Toxicology 2022;477:153260
    https://doi.org/10.1016/j.tox.2022.153260
  966. Maria Elena Ferrero. Rationale for the Successful Management of EDTA Chelation Therapy in Human Burden by Toxic Metals. BioMed Research International 2016;2016:1
    https://doi.org/10.1155/2016/8274504
  967. Kinga Krzysztoforska, Dagmara Mirowska-Guzel, Ewa Widy-Tyszkiewicz. Pharmacological effects of protocatechuic acid and its therapeutic potential in neurodegenerative diseases: Review on the basis of in vitro and in vivo studies in rodents and humans. Nutritional Neuroscience 2019;22:72
    https://doi.org/10.1080/1028415X.2017.1354543
  968. Ángel Cores, Sheila Abril, Patrycja Michalska, Pablo Duarte, Ana I. Olives, M. Antonia Martín, Mercedes Villacampa, Rafael León, J. Carlos Menéndez. Bisavenathramide Analogues as Nrf2 Inductors and Neuroprotectors in In Vitro Models of Oxidative Stress and Hyperphosphorylation. Antioxidants 2021;10:941
    https://doi.org/10.3390/antiox10060941
  969. Joana Torres, Inês Costa, Andreia F. Peixoto, Renata Silva, José Manuel Sousa Lobo, Ana Catarina Silva. Intranasal Lipid Nanoparticles Containing Bioactive Compounds Obtained from Marine Sources to Manage Neurodegenerative Diseases. Pharmaceuticals 2023;16:311
    https://doi.org/10.3390/ph16020311
  970. Olubukola H. Oyeniran, Famusiwa D. Courage, Adedayo O. Ademiluyi, Ganiyu Oboh. Sweet basil ( Ocimum basilicum ) leaf and seed extracts alleviate neuronal dysfunction in aluminum chloride-induced neurotoxicity in Drosophila melanogaster Meigen model . Drug and Chemical Toxicology 2024:1
    https://doi.org/10.1080/01480545.2024.2317828
  971. Tony E. R. Werner, David Bernson, Elin K. Esbjörner, Sandra Rocha, Pernilla Wittung-Stafshede. Amyloid formation of fish β-parvalbumin involves primary nucleation triggered by disulfide-bridged protein dimers. Proc. Natl. Acad. Sci. U.S.A. 2020;117:27997
    https://doi.org/10.1073/pnas.2015503117
  972. Chang-Hwan Jun, Choon-Ho Song. Inhibitory Effect of Lonicera japonica Thunb. Flower Buds against Glutamate-Induced Cytotoxicity in HT22 Hippocampal Neurons. Korean J Acupunct 2021;38:32
    https://doi.org/10.14406/acu.2021.002
  973. Gaetano Terrone, Silvia Balosso, Alberto Pauletti, Teresa Ravizza, Annamaria Vezzani. Inflammation and reactive oxygen species as disease modifiers in epilepsy. Neuropharmacology 2020;167:107742
    https://doi.org/10.1016/j.neuropharm.2019.107742
  974. Shannon Y. Lee, Emily W. Paolillo, Rowan Saloner, Yann Cobigo, Valentina E. Diaz, Eva Q. Gontrum, Anna VandeBunte, Ankita Chatterjee, Miwa Tucker, Joel H. Kramer, Kaitlin B. Casaletto. Moderating role of physical activity on hippocampal iron deposition and memory outcomes in typically aging older adults. Neurobiology of Aging 2023;131:124
    https://doi.org/10.1016/j.neurobiolaging.2023.07.026
  975. Silvia Lomartire, Ana M. M. Gonçalves. Marine Macroalgae Polyphenols as Potential Neuroprotective Antioxidants in Neurodegenerative Diseases. Marine Drugs 2023;21:261
    https://doi.org/10.3390/md21050261
  976. A. L. Manukyan, L. S. Hunanyan, L. M. Sukiasyan, W. H. Frey II, K. B. Yenkoyan, L. G. Danielyan, M. M. Melkonyan. The Role of the Adrenergic System in Neurodegeneration and Oxidative Stress-Induced Damage to the Brain. Neurochem. J. 2023;17:639
    https://doi.org/10.1134/S1819712423040165
  977. Magisetty Obulesu. Alzheimer's Disease Theranostics. 2023.
    https://doi.org/10.1016/B978-0-12-816412-9.00005-7
  978. Liya Qin, Ryan P. Vetreno, Fulton T. Crews. NADPH oxidase and endoplasmic reticulum stress is associated with neuronal degeneration in orbitofrontal cortex of individuals with alcohol use disorder. Addiction Biology 2023;28
    https://doi.org/10.1111/adb.13262
  979. Jia Hui Wang, Song Hui Hu, Ji Yan Su, Jun Ping Pan, Xiang Nan Mi, Hai Ju Geng, Wei Zhang, Liang Cai, Chao Fen Su, Ai Hua Hong, Huan Min Luo. Determination of the Pharmacokinetics and Tissue Distribution of Methyl 3,4-Dihydroxybenzoate (MDHB) in Mice Using Liquid Chromatography-Tandem Mass Spectrometry. Eur J Drug Metab Pharmacokinet 2019;44:237
    https://doi.org/10.1007/s13318-018-0512-8
  980. Fernández-Demeneghi Rafael, Vargas-Moreno Isidro, Acosta-Mesa Héctor-Gabriel, Puga-Olguín Abraham, Campos-Uscanga Yolanda, Romo-González Tania, Guzmán-Gerónimo Rosa-Isela, Patraca-Camacho Lorena, Herrera-Meza Socorro. Behavioral Pharmacology - From Basic to Clinical Research. 2019.
    https://doi.org/10.5772/intechopen.90428
  981. Xiaoxiao Liao, Shunkai Lai, Shuming Zhong, Ying Wang, Yiliang Zhang, Shiyi Shen, Hui Huang, Guanmao Chen, Feng Chen, Yanbin Jia. Interaction of Serum Copper and Neurometabolites on Executive Dysfunction in Unmedicated Patients With Major Depressive Disorder. Front. Psychiatry 2021;12
    https://doi.org/10.3389/fpsyt.2021.564375
  982. Jessica Audrey Feijó Corrêa, Tiago de Melo Nazareth, Giovanna Fernandes da Rocha, Fernando Bittencourt Luciano. Bioactive Antimicrobial Peptides from Food Proteins: Perspectives and Challenges for Controlling Foodborne Pathogens. Pathogens 2023;12:477
    https://doi.org/10.3390/pathogens12030477
  983. Gianluca Antonio Franco, Livia Interdonato, Marika Cordaro, Salvatore Cuzzocrea, Rosanna Di Paola. Bioactive Compounds of the Mediterranean Diet as Nutritional Support to Fight Neurodegenerative Disease. IJMS 2023;24:7318
    https://doi.org/10.3390/ijms24087318
  984. Pinky, Neha, Mubashshir Ali, Prachi Tiwari, Mohammad Mumtaz Alam, Haroonrashid M. Hattiwale, Azfar Jamal, Suhel Parvez. Unravelling of molecular biomarkers in synaptic plasticity of Alzheimer’s disease: Critical role of the restoration of neuronal circuits. Ageing Research Reviews 2023;91:102069
    https://doi.org/10.1016/j.arr.2023.102069
  985. Elmira Akbari, Zatollah Asemi, Reza Daneshvar Kakhaki, Fereshteh Bahmani, Ebrahim Kouchaki, Omid Reza Tamtaji, Gholam Ali Hamidi, Mahmoud Salami. Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial. Front. Aging Neurosci. 2016;8
    https://doi.org/10.3389/fnagi.2016.00256
  986. Jiao Luo, Kevin Mills, Saskia le Cessie, Raymond Noordam, Diana van Heemst. Ageing, age-related diseases and oxidative stress: What to do next?. Ageing Research Reviews 2020;57:100982
    https://doi.org/10.1016/j.arr.2019.100982
  987. Alfredo Sanabria-Castro, Alberto Alape-Girón, Marietta Flores-Díaz, Ann Echeverri-McCandless, Alexander Parajeles-Vindas. Oxidative stress involvement in the molecular pathogenesis and progression of multiple sclerosis: a literature review. 2024;35:355
    https://doi.org/10.1515/revneuro-2023-0091
  988. Anthony Temitope Idowu, Oluwakemi Osarumwense Igiehon, Ademola Ezekiel Adekoya, Solomon Idowu. Dates palm fruits: A review of their nutritional components, bioactivities and functional food applications. 2020;5:734
    https://doi.org/10.3934/agrfood.2020.4.734
  989. Camila B. Nobre, Erlânio O. Sousa, Cícera J. Camilo, Jean F. Machado, João M.F.L. Silva, Jaime R. Filho, Henrique D.M. Coutinho, José G.M. Costa. Antioxidative effect and phytochemical profile of natural products from the fruits of “babaçu” (Orbignia speciose) and “buriti” (Mauritia flexuosa). Food and Chemical Toxicology 2018;121:423
    https://doi.org/10.1016/j.fct.2018.08.068
  990. Zinan Zhao, Wenyan Guo, Chunwei Xu, Qian Wang, Chun Mao, Mimi Wan. Physiological functions and donor design of hydrogen sulfide and its application in central nervous system diseases. Chemical Engineering Journal 2023;452:139089
    https://doi.org/10.1016/j.cej.2022.139089
  991. K. Botsakis, S. Theodoritsi, K. Grintzalis, F. Angelatou, I. Antonopoulos, C.D. Georgiou, M. Margarity, N.A. Matsokis, N.T. Panagopoulos. 17β-Estradiol/N-acetylcysteine interaction enhances the neuroprotective effect on dopaminergic neurons in the weaver model of dopamine deficiency. Neuroscience 2016;320:221
    https://doi.org/10.1016/j.neuroscience.2016.01.068
  992. Benson OA Botchway, Favour C Okoye, Yili Chen, William E Arthur, Marong Fang. Alzheimer Disease: Recent Updates on Apolipoprotein E and Gut Microbiome Mediation of Oxidative Stress, and Prospective Interventional Agents. Aging and disease 2022;13:87
    https://doi.org/10.14336/AD.2021.0616
  993. Sarah R. Aldhaheri, Roohi Jeelani, Hamid-Reza Kohan-Ghadr, Sana N. Khan, Sasha Mikhael, Christina Washington, Robert T. Morris, Husam M. Abu-Soud. Dimercapto-1-propanesulfonic acid (DMPS) induces metaphase II mouse oocyte deterioration. Free Radical Biology and Medicine 2017;112:445
    https://doi.org/10.1016/j.freeradbiomed.2017.08.015
  994. Rasha S. Mohamed, Safaa S. Abozed, S. El-Damhougy, Manal F. Salama, Mona M. Hussein. Efficiency of newly formulated functional instant soup mixtures as dietary supplements for elderly. Heliyon 2020;6:e03197
    https://doi.org/10.1016/j.heliyon.2020.e03197
  995. Yuheng Liu, Bo Huang, Ziyun Zhu, Tao Zheng. Curcumae Ameliorates Diabetic Neuropathy in Streptozotocin Induced Diabetic Rats via Alteration of Gut Microbiota. International J. of Pharmacology 2022;18:374
    https://doi.org/10.3923/ijp.2022.374.387