en Experimental Neurobiology

Cited by CrossRef (107)

  1. Sara Pinto, Carolina Cunha, Marta Barbosa, Ana R. Vaz, Dora Brites. Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype. Front. Neurosci. 2017;11
    https://doi.org/10.3389/fnins.2017.00273
  2. Miles S. Lyon, Marlena Wosiski‐Kuhn, Rachel Gillespie, James Caress, Carol Milligan. Inflammation, Immunity, and amyotrophic lateral sclerosis: I. Etiology and pathology. Muscle and Nerve 2019;59:10
    https://doi.org/10.1002/mus.26289
  3. Noemi Gatto, Cleide Dos Santos Souza, Allan C. Shaw, Simon M. Bell, Monika A. Myszczynska, Samantha Powers, Kathrin Meyer, Lydia M. Castelli, Evangelia Karyka, Heather Mortiboys, Mimoun Azzouz, Guillaume M. Hautbergue, Nóra M. Márkus, Pamela J. Shaw, Laura Ferraiuolo. Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease. Aging Cell 2021;20
    https://doi.org/10.1111/acel.13281
  4. Carlos González-Fernández, Pau Gonzalez, Pol Andres-Benito, Isidro Ferrer, Francisco Javier Rodríguez. Wnt Signaling Alterations in the Human Spinal Cord of Amyotrophic Lateral Sclerosis Cases: Spotlight on Fz2 and Wnt5a. Mol Neurobiol 2019;56:6777
    https://doi.org/10.1007/s12035-019-1547-9
  5. Caterina Peggion, Tito Calì, Marisa Brini. Mitochondria Dysfunction and Neuroinflammation in Neurodegeneration: Who Comes First?. Antioxidants 2024;13:240
    https://doi.org/10.3390/antiox13020240
  6. Senthil T. Kumar, Sergey Nazarov, Sílvia Porta, Niran Maharjan, Urszula Cendrowska, Malek Kabani, Francesco Finamore, Yan Xu, Virginia M.-Y. Lee, Hilal A. Lashuel. Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage. Nat Neurosci 2023;26:983
    https://doi.org/10.1038/s41593-023-01341-4
  7. Sarah Logan, Thiago Arzua, Scott G. Canfield, Emily R. Seminary, Samantha L. Sison, Allison D. Ebert, Xiaowen Bai. Comprehensive Physiology. 2023.
    https://doi.org/10.1002/cphy.c180025
  8. Ting Zhou, Tina Khorshid Ahmad, Kiana Gozda, Jessica Truong, Jiming Kong, Michael Namaka. Implications of white matter damage in amyotrophic lateral sclerosis. 2017;16:4379
    https://doi.org/10.3892/mmr.2017.7186
  9. Asmita Gyawali, Shashi Gautam, Seung Jae Hyeon, Hoon Ryu, Young-Sook Kang. L-Citrulline Level and Transporter Activity Are Altered in Experimental Models of Amyotrophic Lateral Sclerosis. Mol Neurobiol 2021;58:647
    https://doi.org/10.1007/s12035-020-02143-6
  10. M. V. Ivanova, A. S. Voronkova, V. S. Sukhorukov, M. N. Zakharova. Variability of the Expression Patterns of Neuroinflammatory Genes in Mononuclear Cells of Peripheral Blood in Amyotrophic Lateral Sclerosis. Neurochem. J. 2021;15:203
    https://doi.org/10.1134/S1819712421020070
  11. Verena Surrey, Caren Zöller, Alicia Andrea Lork, Mehri Moradi, Stefanie Balk, Benjamin Dombert, Lena Saal-Bauernschubert, Michael Briese, Silke Appenzeller, Utz Fischer, Sibylle Jablonka. Impaired Local Translation of β-actin mRNA in Ighmbp2-Deficient Motoneurons: Implications for Spinal Muscular Atrophy with respiratory Distress (SMARD1). Neuroscience 2018;386:24
    https://doi.org/10.1016/j.neuroscience.2018.06.019
  12. David R Beers, Stanley H Appel. Immune dysregulation in amyotrophic lateral sclerosis: mechanisms and emerging therapies. The Lancet Neurology 2019;18:211
    https://doi.org/10.1016/S1474-4422(18)30394-6
  13. Saravana Babu Chidambaram, Nikhilesh Anand, Sudhir Rama Varma, Srinivasan Ramamurthy, Chandrasekaran Vichitra, Ambika Sharma, Arehally M. Mahalakshmi, Musthafa Mohamed Essa. Superoxide dismutase and neurological disorders. IBRO Neuroscience Reports 2024;16:373
    https://doi.org/10.1016/j.ibneur.2023.11.007
  14. Yaxing Chen, Chen Qin, Jianhan Huang, Xin Tang, Chang Liu, Keru Huang, Jianguo Xu, Gang Guo, Aiping Tong, Liangxue Zhou. The role of astrocytes in oxidative stress of central nervous system: A mixed blessing. Cell Proliferation 2020;53
    https://doi.org/10.1111/cpr.12781
  15. Michal Izrael, Shalom Guy Slutsky, Tamar Admoni, Louisa Cohen, Avital Granit, Arik Hasson, Joseph Itskovitz-Eldor, Lena Krush Paker, Graciela Kuperstein, Neta Lavon, Shiran Yehezkel Ionescu, Leonardo Javier Solmesky, Rachel Zaguri, Alina Zhuravlev, Ella Volman, Judith Chebath, Michel Revel. Safety and efficacy of human embryonic stem cell-derived astrocytes following intrathecal transplantation in SOD1G93A and NSG animal models. Stem Cell Res Ther 2018;9
    https://doi.org/10.1186/s13287-018-0890-5
  16. Arsh Haj Mohamad Ebrahim Ketabforoush, Rojin Chegini, Shirin Barati, Fatemeh Tahmasebi, Bardia Moghisseh, Mohammad Taghi Joghataei, Faezeh Faghihi, Fereshteh Azedi. Masitinib: The promising actor in the next season of the Amyotrophic Lateral Sclerosis treatment series. Biomedicine & Pharmacotherapy 2023;160:114378
    https://doi.org/10.1016/j.biopha.2023.114378
  17. Matthew Salter, Emily Corfield, Aroul Ramadass, Francis Grand, Jayne Green, Jurjen Westra, Chun Ren Lim, Lucy Farrimond, Emily Feneberg, Jakub Scaber, Alexander Thompson, Lynn Ossher, Martin Turner, Kevin Talbot, Merit Cudkowicz, James Berry, Ewan Hunter, Alexandre Akoulitchev. Initial Identification of a Blood-Based Chromosome Conformation Signature for Aiding in the Diagnosis of Amyotrophic Lateral Sclerosis. EBioMedicine 2018;33:169
    https://doi.org/10.1016/j.ebiom.2018.06.015
  18. Ella Zeldich, Ci-Di Chen, Emma Boden, Bryce Howat, Jason S. Nasse, Dean Zeldich, Anthony G. Lambert, Andrea Yuste, Jonathan D. Cherry, Rebecca M. Mathias, Qicheng Ma, Nelson C. Lau, Ann C. McKee, Theo Hatzipetros, Carmela R. Abraham. Klotho Is Neuroprotective in the Superoxide Dismutase (SOD1G93A) Mouse Model of ALS. J Mol Neurosci 2019;69:264
    https://doi.org/10.1007/s12031-019-01356-2
  19. Zewen Liu, Tingyang Zhou, Alexander C. Ziegler, Peter Dimitrion, Li Zuo. Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications. Oxidative Medicine and Cellular Longevity 2017;2017:1
    https://doi.org/10.1155/2017/2525967
  20. Paul G. Weightman Potter, Julia M. Vlachaki Walker, Josephine L. Robb, John K. Chilton, Ritchie Williamson, Andrew D Randall, Kate L. J. Ellacott, Craig Beall. Basal fatty acid oxidation increases after recurrent low glucose in human primary astrocytes. Diabetologia 2019;62:187
    https://doi.org/10.1007/s00125-018-4744-6
  21. Mohammadmahdi Sabahi, Asef Joshaghanian, Mahsa Dolatshahi, Parnian Jabbari, Farzaneh Rahmani, Nima Rezaei. Modification of Glial Cell Activation through Dendritic Cell Vaccination: Promises for Treatment of Neurodegenerative Diseases. J Mol Neurosci 2021;71:1410
    https://doi.org/10.1007/s12031-021-01818-6
  22. Andrew Tsui, Valentina L. Kouznetsova, Santosh Kesari, Milan Fiala, Igor F. Tsigelny. Role of Senataxin in Amyotrophic Lateral Sclerosis. J Mol Neurosci 2023;73:996
    https://doi.org/10.1007/s12031-023-02169-0
  23. Napissara Boonpraman, Sun Shin Yi. NADPH oxidase 4 (NOX4) as a biomarker and therapeutic target in neurodegenerative diseases. 2024;19:1961
    https://doi.org/10.4103/1673-5374.390973
  24. Carmen Rodríguez-Cueto, Irene Santos-García, Laura García-Toscano, Francisco Espejo-Porras, MLuz Bellido, Javier Fernández-Ruiz, Eduardo Muñoz, Eva de Lago. Neuroprotective effects of the cannabigerol quinone derivative VCE-003.2 in SOD1G93A transgenic mice, an experimental model of amyotrophic lateral sclerosis. Biochemical Pharmacology 2018;157:217
    https://doi.org/10.1016/j.bcp.2018.07.049
  25. Md. Ataur Rahman, Md Saidur Rahman, Md Jamal Uddin, A. N. M. Mamun-Or-Rashid, Md. Rezanur Rahman, Myung-Geol Pang, Hyewhon Rhim. Quality Control of Cellular Protein in Neurodegenerative Disorders. 2018.
    https://doi.org/10.4018/978-1-7998-1317-0.ch006
  26. Aimee N. Winter, Matthew C. Brenner, Noelle Punessen, Michael Snodgrass, Caleb Byars, Yingyot Arora, Daniel A. Linseman. Comparison of the Neuroprotective and Anti-Inflammatory Effects of the Anthocyanin Metabolites, Protocatechuic Acid and 4-Hydroxybenzoic Acid. Oxidative Medicine and Cellular Longevity 2017;2017:1
    https://doi.org/10.1155/2017/6297080
  27. David G. Ashbrook, Benjamin Hing, Lindsay T. Michalovicz, Kimberly A. Kelly, Julie V. Miller, Wilfred C. de Vega, Diane B. Miller, Gordon Broderick, James P. O’Callaghan, Patrick O. McGowan. Epigenetic impacts of stress priming of the neuroinflammatory response to sarin surrogate in mice: a model of Gulf War illness. J Neuroinflammation 2018;15
    https://doi.org/10.1186/s12974-018-1113-9
  28. Arnab Karmakar, Abhishek K. Das, Noyel Ghosh, Parames C. Sil. Antioxidants Effects in Health. 2018.
    https://doi.org/10.1016/B978-0-12-819096-8.00027-6
  29. Sylviane Muller, Susana Brun, Frédérique René, Jérôme de Sèze, Jean-Philippe Loeffler, Hélène Jeltsch-David. Autophagy in neuroinflammatory diseases. Autoimmunity Reviews 2017;16:856
    https://doi.org/10.1016/j.autrev.2017.05.015
  30. Simona Rossi, Mauro Cozzolino. Dysfunction of RNA/RNA-Binding Proteins in ALS Astrocytes and Microglia. Cells 2021;10:3005
    https://doi.org/10.3390/cells10113005
  31. Francisco Espejo‐Porras, Laura García‐Toscano, Carmen Rodríguez‐Cueto, Irene Santos‐García, Eva de Lago, Javier Fernandez‐Ruiz. Targeting glial cannabinoid CB2 receptors to delay the progression of the pathological phenotype in TDP‐43 (A315T) transgenic mice, a model of amyotrophic lateral sclerosis. British J Pharmacology 2019;176:1585
    https://doi.org/10.1111/bph.14216
  32. Natalia Nowicka, Kamila Zglejc-Waszak, Judyta Juranek, Agnieszka Korytko, Krzysztof Wąsowicz, Małgorzata Chmielewska-Krzesińska, Joanna Wojtkiewicz, Belgin Sever. Novel insights into RAGE signaling pathways during the progression of amyotrophic lateral sclerosis in RAGE-deficient SOD1 G93A mice. PLoS ONE 2024;19:e0299567
    https://doi.org/10.1371/journal.pone.0299567
  33. Mohammed Khamaysa, Pierre-François Pradat. Status of ALS Treatment, Insights into Therapeutic Challenges and Dilemmas. JPM 2022;12:1601
    https://doi.org/10.3390/jpm12101601
  34. Emily R. Seminary, Stephanie Santarriaga, Lynn Wheeler, Marie Mejaki, Jenica Abrudan, Wendy Demos, Michael T. Zimmermann, Raul A. Urrutia, Dominic Fee, Paul E. Barkhaus, Allison D. Ebert. Motor Neuron Generation from iPSCs from Identical Twins Discordant for Amyotrophic Lateral Sclerosis. Cells 2020;9:571
    https://doi.org/10.3390/cells9030571
  35. Débora Lanznaster, Denis Reis de Assis, Philippe Corcia, Pierre-François Pradat, Hélène Blasco. Metabolomics Biomarkers: A Strategy Toward Therapeutics Improvement in ALS. Front. Neurol. 2018;9
    https://doi.org/10.3389/fneur.2018.01126
  36. Yu Hashimoto, Ryo Yamasaki, Senri Ko, Eriko Matsuo, Yuko Kobayakawa, Katsuhisa Masaki, Dai Matsuse, Noriko Isobe. Connexin 30 Deficiency Ameliorates Disease Progression at the Early Phase in a Mouse Model of Amyotrophic Lateral Sclerosis by Suppressing Glial Inflammation. IJMS 2022;23:16046
    https://doi.org/10.3390/ijms232416046
  37. Kazuya Takahashi. Microglial heterogeneity in amyotrophic lateral sclerosis. 2023;82:140
    https://doi.org/10.1093/jnen/nlac110
  38. Evelien Van Schoor, Simona Ospitalieri, Sebastiaan Moonen, Sandra O. Tomé, Alicja Ronisz, Orkun Ok, Jochen Weishaupt, Albert C. Ludolph, Philip Van Damme, Ludo Van Den Bosch, Dietmar Rudolf Thal. Increased pyroptosis activation in white matter microglia is associated with neuronal loss in ALS motor cortex. Acta Neuropathol 2022;144:393
    https://doi.org/10.1007/s00401-022-02466-9
  39. Oihane Pikatza-Menoio, Amaia Elicegui, Xabier Bengoetxea, Neia Naldaiz-Gastesi, Adolfo López de Munain, Gorka Gerenu, Francisco Javier Gil-Bea, Sonia Alonso-Martín. The Skeletal Muscle Emerges as a New Disease Target in Amyotrophic Lateral Sclerosis. JPM 2021;11:671
    https://doi.org/10.3390/jpm11070671
  40. Yu Zhu, Yue Liu, Fang Yang, Wenzhi Chen, Jianxian Jiang, Pei He, Shishi Jiang, Menhua Li, Renshi Xu. All-Trans Retinoic Acid Exerts Neuroprotective Effects in Amyotrophic Lateral Sclerosis-Like Tg (SOD1*G93A)1Gur Mice. Mol Neurobiol 2020;57:3603
    https://doi.org/10.1007/s12035-020-01973-8
  41. JunHyuk Woo, Hyesun Cho, YunHee Seol, Soon Ho Kim, Chanhyeok Park, Ali Yousefian-Jazi, Seung Jae Hyeon, Junghee Lee, Hoon Ryu. Power Failure of Mitochondria and Oxidative Stress in Neurodegeneration and Its Computational Models. Antioxidants 2021;10:229
    https://doi.org/10.3390/antiox10020229
  42. Mengmeng Jin, Katja Akgün, Tjalf Ziemssen, Markus Kipp, Rene Günther, Andreas Hermann. Interleukin-17 and Th17 Lymphocytes Directly Impair Motoneuron Survival of Wildtype and FUS-ALS Mutant Human iPSCs. IJMS 2021;22:8042
    https://doi.org/10.3390/ijms22158042
  43. Komugi Tsuruta, Takato Shidara, Hiroko Miyagishi, Hiroshi Nango, Yoshihiko Nakatani, Naoto Suzuki, Taku Amano, Toyofumi Suzuki, Yasuhiro Kosuge. Anti-Inflammatory Effects of Miyako Bidens pilosa in a Mouse Model of Amyotrophic Lateral Sclerosis and Lipopolysaccharide-Stimulated BV-2 Microglia. IJMS 2023;24:13698
    https://doi.org/10.3390/ijms241813698
  44. Veronica Granatiero, Csaba Konrad, Kirsten Bredvik, Giovanni Manfredi, Hibiki Kawamata. Nrf2 signaling links ER oxidative protein folding and calcium homeostasis in health and disease. Life Sci. Alliance 2019;2:e201900563
    https://doi.org/10.26508/lsa.201900563
  45. Jia Liu, Fei Wang. Role of Neuroinflammation in Amyotrophic Lateral Sclerosis: Cellular Mechanisms and Therapeutic Implications. Front. Immunol. 2017;8
    https://doi.org/10.3389/fimmu.2017.01005
  46. Chetan Singh Rajpurohit, Vivek Kumar, Arquimedes Cheffer, Danyllo Oliveira, Henning Ulrich, Oswaldo Keith Okamoto, Mayana Zatz, Uzair Ahmad Ansari, Vinay Kumar Khanna, Aditya Bhushan Pant. Mechanistic Insights of Astrocyte-Mediated Hyperactive Autophagy and Loss of Motor Neuron Function in SOD1L39R Linked Amyotrophic Lateral Sclerosis. Mol Neurobiol 2020;57:4117
    https://doi.org/10.1007/s12035-020-02006-0
  47. Chaebin Kim, Ali Yousefian-Jazi, Seung-Hye Choi, Inyoung Chang, Junghee Lee, Hoon Ryu. Non-Cell Autonomous and Epigenetic Mechanisms of Huntington’s Disease. IJMS 2021;22:12499
    https://doi.org/10.3390/ijms222212499
  48. Jialing Peng, Jingrui Pan, Jingjing Mo, Ying Peng, Sachchida Nand Rai. MPO/HOCl Facilitates Apoptosis and Ferroptosis in the SOD1G93A Motor Neuron of Amyotrophic Lateral Sclerosis. Oxidative Medicine and Cellular Longevity 2022;2022:1
    https://doi.org/10.1155/2022/8217663
  49. Kangqin Yang, Yang Liu, Min Zhang. The Diverse Roles of Reactive Astrocytes in the Pathogenesis of Amyotrophic Lateral Sclerosis. Brain Sciences 2024;14:158
    https://doi.org/10.3390/brainsci14020158
  50. Aron S. Buchman, Sue E. Leurgans, Veronique G. J. M. VanderHorst, Sukriti Nag, Julie A. Schneider, David A. Bennett. Spinal motor neurons and motor function in older adults. J Neurol 2019;266:174
    https://doi.org/10.1007/s00415-018-9118-y
  51. Sana Latif, Young-Sook Kang. Change in Cationic Amino Acid Transport System and Effect of Lysine Pretreatment on Inflammatory State in Amyotrophic Lateral Sclerosis Cell Model. Biomolecules & Therapeutics 2021;29:498
    https://doi.org/10.4062/biomolther.2021.037
  52. Hélène E. Hirbec, Harun N. Noristani, Florence E. Perrin. Microglia Responses in Acute and Chronic Neurological Diseases: What Microglia-Specific Transcriptomic Studies Taught (and did Not Teach) Us. Front. Aging Neurosci. 2017;9
    https://doi.org/10.3389/fnagi.2017.00227
  53. Gino A. Kurian. Phospholipases in Physiology and Pathology. 2017.
    https://doi.org/10.1016/B978-0-443-15177-4.00003-0
  54. Natsuko Ohashi, Tomoya Terashima, Miwako Katagi, Yuki Nakae, Junko Okano, Yoshihisa Suzuki, Hideto Kojima. GLT1 gene delivery based on bone marrow-derived cells ameliorates motor function and survival in a mouse model of ALS. Sci Rep 2021;11
    https://doi.org/10.1038/s41598-021-92285-x
  55. Nuno Jorge Lamas, Laurent Roybon. Harnessing the Potential of Human Pluripotent Stem Cell-Derived Motor Neurons for Drug Discovery in Amyotrophic Lateral Sclerosis: From the Clinic to the Laboratory and Back to the Patient. Front. Drug. Discov. 2021;1
    https://doi.org/10.3389/fddsv.2021.773424
  56. Sana Latif, Young-Sook Kang. The effects of pro-inflammatory cytokines and glutamate on l-arginine transport in a human microglial cell line (HMC-3). J. Pharm. Investig. 2024;54:77
    https://doi.org/10.1007/s40005-023-00648-5
  57. Rebecca San Gil, Lezanne Ooi, Justin J. Yerbury, Heath Ecroyd. The heat shock response in neurons and astroglia and its role in neurodegenerative diseases. Mol Neurodegeneration 2017;12
    https://doi.org/10.1186/s13024-017-0208-6
  58. Yongzhi Xie, Ximei Luo, Haiqing He, Min Tang. Novel Insight Into the Role of Immune Dysregulation in Amyotrophic Lateral Sclerosis Based on Bioinformatic Analysis. Front. Neurosci. 2021;15
    https://doi.org/10.3389/fnins.2021.657465
  59. Murat Terzi, Gamze Altun, Sedat Şen, Adem Kocaman, Arife Ahsen Kaplan, Kıymet Kübra Yurt, Süleyman Kaplan. The use of non-steroidal anti-inflammatory drugs in neurological diseases. Journal of Chemical Neuroanatomy 2018;87:12
    https://doi.org/10.1016/j.jchemneu.2017.03.003
  60. Dylan V. Neel, Himanish Basu, Georgia Gunner, Isaac M. Chiu. Catching a killer: Mechanisms of programmed cell death and immune activation in Amyotrophic Lateral Sclerosis. Immunological Reviews 2022;311:130
    https://doi.org/10.1111/imr.13083
  61. Rachit Bakshi, Yuehang Xu, Kaly A. Mueller, Xiqun Chen, Eric Granucci, Sabrina Paganoni, Ghazaleh Sadri-Vakili, Michael A. Schwarzschild. Urate mitigates oxidative stress and motor neuron toxicity of astrocytes derived from ALS-linked SOD1 mutant mice. Molecular and Cellular Neuroscience 2018;92:12
    https://doi.org/10.1016/j.mcn.2018.06.002
  62. Caroline Barham, Daniel Fil, Stephanie D. Byrum, Yasir Rahmatallah, Galina Glazko, Mahmoud Kiaei. RNA-Seq Analysis of Spinal Cord Tissues from hPFN1G118V Transgenic Mouse Model of ALS at Pre-symptomatic and End-Stages of Disease. Sci Rep 2018;8
    https://doi.org/10.1038/s41598-018-31132-y
  63. Michele Longoni Calió, Elisandra Henriques, Amanda Siena, Clélia Rejane Antonio Bertoncini, Joana Gil-Mohapel, Tatiana Rosado Rosenstock. Mitochondrial Dysfunction, Neurogenesis, and Epigenetics: Putative Implications for Amyotrophic Lateral Sclerosis Neurodegeneration and Treatment. Front. Neurosci. 2020;14
    https://doi.org/10.3389/fnins.2020.00679
  64. Francesca Provenzano, Sophie Nyberg, Debora Giunti, Carola Torazza, Benedetta Parodi, Tiziana Bonifacino, Cesare Usai, Nicole Kerlero de Rosbo, Marco Milanese, Antonio Uccelli, Pamela J. Shaw, Laura Ferraiuolo, Giambattista Bonanno. Micro-RNAs Shuttled by Extracellular Vesicles Secreted from Mesenchymal Stem Cells Dampen Astrocyte Pathological Activation and Support Neuroprotection in In-Vitro Models of ALS. Cells 2022;11:3923
    https://doi.org/10.3390/cells11233923
  65. Mohit Kumar, Palkin Arora, Rajat Sandhir. The Biology of Glial Cells: Recent Advances. 2022.
    https://doi.org/10.1007/978-981-16-8313-8_18
  66. Jose-Luis González De Aguilar. Lipid Biomarkers for Amyotrophic Lateral Sclerosis. Front. Neurol. 2019;10
    https://doi.org/10.3389/fneur.2019.00284
  67. Carmen Rodríguez‐Cueto, Marta Gómez‐Almería, Laura García Toscano, Julián Romero, Cecilia J. Hillard, Eva de Lago, Javier Fernández‐Ruiz. Inactivation of the CB2 receptor accelerated the neuropathological deterioration in TDP‐43 transgenic mice, a model of amyotrophic lateral sclerosis. Brain Pathology 2021;31
    https://doi.org/10.1111/bpa.12972
  68. Roberto Stella, Raphael Severino Bonadio, Stefano Cagnin, Maria Lina Massimino, Alessandro Bertoli, Caterina Peggion. Perturbations of the Proteome and of Secreted Metabolites in Primary Astrocytes from the hSOD1(G93A) ALS Mouse Model. IJMS 2021;22:7028
    https://doi.org/10.3390/ijms22137028
  69. YunHee Seol, Soomin Ki, Hannah L. Ryu, Sooyoung Chung, Junghee Lee, Hoon Ryu. How Microglia Manages Non-cell Autonomous Vicious Cycling of Aβ Toxicity in the Pathogenesis of AD. Front. Mol. Neurosci. 2020;13
    https://doi.org/10.3389/fnmol.2020.593724
  70. Stephen D. Skaper, Laura Facci, Morena Zusso, Pietro Giusti. An Inflammation-Centric View of Neurological Disease: Beyond the Neuron. Front. Cell. Neurosci. 2018;12
    https://doi.org/10.3389/fncel.2018.00072
  71. Janani Manochkumar, C. George Priya Doss, Hesham R. El-Seedi, Thomas Efferth, Siva Ramamoorthy. The neuroprotective potential of carotenoids in vitro and in vivo. Phytomedicine 2021;91:153676
    https://doi.org/10.1016/j.phymed.2021.153676
  72. Alessia Serrano, Claudia Donno, Stefano Giannetti, Mina Perić, Pavle Andjus, Nadia D’Ambrosi, Fabrizio Michetti. The Astrocytic S100B Protein with Its Receptor RAGE Is Aberrantly Expressed in SOD1G93A Models, and Its Inhibition Decreases the Expression of Proinflammatory Genes. Mediators of Inflammation 2017;2017:1
    https://doi.org/10.1155/2017/1626204
  73. Chunting Zhang, Hongyong Wang, Weiwei Liang, Yueqing Yang, Chaohua Cong, Ying Wang, Shuyu Wang, Xudong Wang, Di Wang, Di Huo, Honglin Feng. Diphenyl diselenide protects motor neurons through inhibition of microglia-mediated inflammatory injury in amyotrophic lateral sclerosis. Pharmacological Research 2021;165:105457
    https://doi.org/10.1016/j.phrs.2021.105457
  74. Parul Katiyar, Souvik Ghosh, Saakshi Saini, Chandrachur Ghosh, Himanshu Agrawal, Debabrata Sircar, Partha Roy. Handbook of Nutraceuticals and Natural Products. 2021.
    https://doi.org/10.1002/9781119746843.ch8
  75. Marcelo Duarte Azevedo, Sibilla Sander, Liliane Tenenbaum. GDNF, A Neuron-Derived Factor Upregulated in Glial Cells during Disease. JCM 2020;9:456
    https://doi.org/10.3390/jcm9020456
  76. Rosario Gulino, Nunzio Vicario, Maria Giunta, Graziana Spoto, Giovanna Calabrese, Michele Vecchio, Massimo Gulisano, Giampiero Leanza, Rosalba Parenti. Neuromuscular Plasticity in a Mouse Neurotoxic Model of Spinal Motoneuronal Loss. IJMS 2019;20:1500
    https://doi.org/10.3390/ijms20061500
  77. Jelena Scekic-Zahirovic, Mathieu Fischer, Geoffrey Stuart-Lopez, Thibaut Burg, Johan Gilet, Sylvie Dirrig-Grosch, Christine Marques, Marie-Christine Birling, Pascal Kessler, Caroline Rouaux. Evidence that corticofugal propagation of ALS pathology is not mediated by prion-like mechanism. Progress in Neurobiology 2021;200:101972
    https://doi.org/10.1016/j.pneurobio.2020.101972
  78. Ilaria Bellezza, Silvia Grottelli, Egidia Costanzi, Paolo Scarpelli, Eva Pigna, Giulio Morozzi, Letizia Mezzasoma, Matthew J. Peirce, Viviana Moresi, Sergio Adamo, Alba Minelli. Peroxynitrite Activates the NLRP3 Inflammasome Cascade in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis. Mol Neurobiol 2018;55:2350
    https://doi.org/10.1007/s12035-017-0502-x
  79. Natalia Nowicka, Kamila Szymańska, Judyta Juranek, Kamila Zglejc-Waszak, Agnieszka Korytko, Michał Załęcki, Małgorzata Chmielewska-Krzesińska, Krzysztof Wąsowicz, Joanna Wojtkiewicz. The Involvement of RAGE and Its Ligands during Progression of ALS in SOD1 G93A Transgenic Mice. IJMS 2022;23:2184
    https://doi.org/10.3390/ijms23042184
  80. Sulieman Ibraheem Shelash Al‐Hawary, Anas Yahya Ali, Yasser Fakri Mustafa, Ria Margiana, Shamsutdinova Maksuda Ilyasovna, Montather F. Ramadan, Sami G. Almalki, Marim Alwave, Safa Alkhayyat, Ali Alsalamy. The microRNAs (miRs) overexpressing mesenchymal stem cells (MSCs) therapy in neurological disorders; hope or hype. Biotechnology Progress 2023;39
    https://doi.org/10.1002/btpr.3383
  81. Vincenzo Giuseppe Nicoletti, Krisztián Pajer, Damiano Calcagno, Gholam Pajenda, Antal Nógrádi. The Role of Metals in the Neuroregenerative Action of BDNF, GDNF, NGF and Other Neurotrophic Factors. Biomolecules 2022;12:1015
    https://doi.org/10.3390/biom12081015
  82. Fabiola De Marchi, Ivana Munitic, Amedeo Amedei, James D. Berry, Eva L. Feldman, Eleonora Aronica, Giovanni Nardo, Donatienne Van Weehaeghe, Elena Niccolai, Nikolina Prtenjaca, Stacey A. Sakowski, Caterina Bendotti, Letizia Mazzini. Interplay between immunity and amyotrophic lateral sclerosis: Clinical impact. Neuroscience & Biobehavioral Reviews 2021;127:958
    https://doi.org/10.1016/j.neubiorev.2021.06.027
  83. Laura E. Kuil, Anna López Martí, Ana Carreras Mascaro, Jeroen C. van den Bosch, Paul van den Berg, Herma C. van der Linde, Kees Schoonderwoerd, George J. G. Ruijter, Tjakko J. van Ham. Hexb enzyme deficiency leads to lysosomal abnormalities in radial glia and microglia in zebrafish brain development. Glia 2019;67:1705
    https://doi.org/10.1002/glia.23641
  84. Tiziana Bonifacino, Francesca Provenzano, Elena Gallia, Silvia Ravera, Carola Torazza, Simone Bossi, Sara Ferrando, Aldamaria Puliti, Ludo Van Den Bosch, Giambattista Bonanno, Marco Milanese. In-vivo genetic ablation of metabotropic glutamate receptor type 5 slows down disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis. Neurobiology of Disease 2019;129:79
    https://doi.org/10.1016/j.nbd.2019.05.007
  85. Gonçalo J. M. Afonso, Carla Cavaleiro, Jorge Valero, Sandra I. Mota, Elisabete Ferreiro. Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives. Cells 2023;12:1763
    https://doi.org/10.3390/cells12131763
  86. Yasuhiro Kosuge, Erina Kaneko, Hiroshi Nango, Hiroko Miyagishi, Kumiko Ishige, Yoshihisa Ito. Bidens pilosa Extract Administered after Symptom Onset Attenuates Glial Activation, Improves Motor Performance, and Prolongs Survival in a Mouse Model of Amyotrophic Lateral Sclerosis. Oxidative Medicine and Cellular Longevity 2020;2020:1
    https://doi.org/10.1155/2020/1020673
  87. Hannah Rostalski, Tomi Hietanen, Stina Leskelä, Andrea Behánová, Ali Abdollahzadeh, Rebekka Wittrahm, Petra Mäkinen, Nadine Huber, Dorit Hoffmann, Eino Solje, Anne M. Remes, Teemu Natunen, Mari Takalo, Jussi Tohka, Mikko Hiltunen, Annakaisa Haapasalo. BV-2 Microglial Cells Overexpressing C9orf72 Hexanucleotide Repeat Expansion Produce DPR Proteins and Show Normal Functionality but No RNA Foci. Front. Neurol. 2020;11
    https://doi.org/10.3389/fneur.2020.550140
  88. Davide Cossu, Kazumasa Yokoyama, Shigeto Sato, Sachiko Noda, Leonardo A. Sechi, Nobutaka Hattori. PARKIN modifies peripheral immune response and increases neuroinflammation in active experimental autoimmune encephalomyelitis (EAE). Journal of Neuroimmunology 2021;359:577694
    https://doi.org/10.1016/j.jneuroim.2021.577694
  89. Shashi Gautam, Sana Latif, Young-Sook Kang. Effect of Various Pathological Conditions on Nitric Oxide Level and L-Citrulline Uptake in Motor Neuron-Like (NSC-34) Cell Lines. Biomol Ther (Seoul) 2024;32:154
    https://doi.org/10.4062/biomolther.2023.110
  90. Izrael Michal, Slutsky Shalom Guy, Joseph Itskovitz-Eldor, Revel Michel. Astrocyte - Physiology and Pathology. 2024.
    https://doi.org/10.5772/intechopen.72862
  91. Gabriel Rodrigues Coutinho Pereira, Bárbara de Azevedo Abrahim Vieira, Joelma Freire De Mesquita, Maria Gasset. Comprehensive in silico analysis and molecular dynamics of the superoxide dismutase 1 (SOD1) variants related to amyotrophic lateral sclerosis. PLoS ONE 2021;16:e0247841
    https://doi.org/10.1371/journal.pone.0247841
  92. Cyril Jones Jagaraj, Sonam Parakh, Julie D. Atkin. Emerging Evidence Highlighting the Importance of Redox Dysregulation in the Pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Front. Cell. Neurosci. 2021;14
    https://doi.org/10.3389/fncel.2020.581950
  93. Sana Latif, Young-Sook Kang. Differences of Transport Activity of Arginine and Regulation on Neuronal Nitric Oxide Synthase and Oxidative Stress in Amyotrophic Lateral Sclerosis Model Cell Lines. Cells 2021;10:3554
    https://doi.org/10.3390/cells10123554
  94. Michael S. Bereman, Joshua Beri, Jeffrey R. Enders, Tara Nash. Machine Learning Reveals Protein Signatures in CSF and Plasma Fluids of Clinical Value for ALS. Sci Rep 2018;8
    https://doi.org/10.1038/s41598-018-34642-x
  95. Mandeep Kumar, Nhung Thi Phuong Nguyen, Marco Milanese, Giambattista Bonanno. Insights into Human-Induced Pluripotent Stem Cell-Derived Astrocytes in Neurodegenerative Disorders. Biomolecules 2022;12:344
    https://doi.org/10.3390/biom12030344
  96. Michael J. Strong, Michael Swash. Finding Common Ground on the Site of Onset of Amyotrophic Lateral Sclerosis. Neurology 2022;99:1042
    https://doi.org/10.1212/WNL.0000000000201387
  97. Sung Min Nam, Jong Hee Choi, Sun-Hye Choi, Hee-Jung Cho, Yeon-Jin Cho, Hyewhon Rhim, Hyoung-Chun Kim, Ik-Hyun Cho, Do-Geun Kim, Seung-Yeol Nah. Ginseng gintonin alleviates neurological symptoms in the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis through lysophosphatidic acid 1 receptor. Journal of Ginseng Research 2021;45:390
    https://doi.org/10.1016/j.jgr.2020.04.002
  98. Agnese Gugliandolo, Placido Bramanti, Emanuela Mazzon. Mesenchymal Stem Cells: A Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis?. Stem Cells International 2019;2019:1
    https://doi.org/10.1155/2019/3675627
  99. Francesca Provenzano, Carola Torazza, Tiziana Bonifacino, Giambattista Bonanno, Marco Milanese. The Key Role of Astrocytes in Amyotrophic Lateral Sclerosis and Their Commitment to Glutamate Excitotoxicity. IJMS 2023;24:15430
    https://doi.org/10.3390/ijms242015430
  100. Tereza Filipi, Zuzana Hermanova, Jana Tureckova, Ondrej Vanatko, Miroslava Anderova. Glial Cells—The Strategic Targets in Amyotrophic Lateral Sclerosis Treatment. JCM 2020;9:261
    https://doi.org/10.3390/jcm9010261
  101. Nilo Riva, Francesco Gentile, Federica Cerri, Francesca Gallia, Paola Podini, Giorgia Dina, Yuri Matteo Falzone, Raffaella Fazio, Christian Lunetta, Andrea Calvo, Giancarlo Logroscino, Giuseppe Lauria, Massimo Corbo, Sandro Iannaccone, Adriano Chiò, Alberto Lazzerini, Eduardo Nobile-Orazio, Massimo Filippi, Angelo Quattrini. Phosphorylated TDP-43 aggregates in peripheral motor nerves of patients with amyotrophic lateral sclerosis. 2022;145:276
    https://doi.org/10.1093/brain/awab285
  102. Edmundas Kaduševičius. Novel Applications of NSAIDs: Insight and Future Perspectives in Cardiovascular, Neurodegenerative, Diabetes and Cancer Disease Therapy. IJMS 2021;22:6637
    https://doi.org/10.3390/ijms22126637
  103. Irene Santos-García, Carmen Rodríguez-Cueto, Patricia Villegas, Fabiana Piscitelli, Anna Lauritano, Che-Kun J. Shen, Vincenzo Di Marzo, Javier Fernández-Ruiz, Eva de Lago. Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice. J Neuroinflammation 2023;20
    https://doi.org/10.1186/s12974-023-02792-z
  104. Hannah Rostalski, Stina Leskelä, Nadine Huber, Kasper Katisko, Antti Cajanus, Eino Solje, Mikael Marttinen, Teemu Natunen, Anne M. Remes, Mikko Hiltunen, Annakaisa Haapasalo. Astrocytes and Microglia as Potential Contributors to the Pathogenesis of C9orf72 Repeat Expansion-Associated FTLD and ALS. Front. Neurosci. 2019;13
    https://doi.org/10.3389/fnins.2019.00486
  105. Zi-ang Yao, Ling Xu, Li-ming Jin, Bai-xiang Wang, Cheng-zhu Fu, Ying Bai, Hai-ge Wu. κ-Carrageenan Oligosaccharides Inhibit the Inflammation of Lipopolysaccharide-Activated Microglia Via TLR4/NF-κB and p38/JNK MAPKs Pathways. Neurochem Res 2022;47:295
    https://doi.org/10.1007/s11064-021-03443-6
  106. Arwa Rekik, Saloua Mrabet, Imen Kacem, Amina Nasri, Mouna Ben Djebara, Amina Gargouri, Riadh Gouider. Eye Movement Abnormalities in Amyotrophic Lateral Sclerosis in a Tunisian Cohort. Neuro-Ophthalmology 2022;46:227
    https://doi.org/10.1080/01658107.2022.2038638
  107. Mina Peric, Ljiljana Nikolic, Pavle R. Andjus, Danijela Bataveljic. Dysfunction of oligodendrocyte inwardly rectifying potassium channel in a rat model of amyotrophic lateral sclerosis. Eur J of Neuroscience 2021;54:6339
    https://doi.org/10.1111/ejn.15451