^*All studies were randomised, multi-centre, parallel-group and double-blind.

ADL: activities of daily living, CGI: clinical global impressions scale, LARGO: lasting effect in adjunct therapy with rasagiline given once daily, OFF: poor symptom response, ON: good symptom reponse, PD-QUALIF: parkinson's disease quality of life, PRESTO: Parkinson's rasagiline efficacy and safety in the treatment of OFF, TEMPO: trial of etanercept and methotrexate with radiographic patient outcomes, UPDRS-ADL: unified parkinson's disease rating scale-activities of daily living. From Rascol 2005.