Transgenic Alzheimer disease (AD) models were classified with respect to transgenic constructs and AD-related pathology
Aβ42 accumulation, plaque depositions, neurofibrillary tangles (NTFs), neuronal loss, and behavioral impairments for each line are summarized with references. APP, amyloid Precursor Protein; PS or PSEN, presenilins; CTF, carboxyl terminal fragment; PDGF-β, platelet-derived growth factor β-chain; PrP, prion Protein; Thy-1, Thymocyte differentiation antigen 1.