Diagnostic sensitivity and specificity of various CSF biomarkers reported in previous clinical studies for early diagnosis of PD from controls, and their related pathogenesis
*The values with superscripts indicated the diagnostic performance of the alphabetically matched individual biomarker or combination. †Discovery and validation indicate the cohort to discover biomarkers and independently validate these, respectively. Two different pairs of sensitivity and specificity indicate the values when specificity (left) or sensitivity (right) is anchoring >80%, respectively.
Abbreviations: Sens., Sensitivity; Spec., Specificity; OND, other neurologic disease control; HC, healthy controls; MSA, multiple system atrophy; t-protein, total protein in CSF; o-syn; oligomeric α-syn; p-syn, phosphorylated α-syn; βGCase, β-glucocerebrosidase; βHAase, β-hexoaminidase; αFUCase, α-fucosidase; βGal, β-galactosidase.