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Fig. 1. Microcephaly-like brain size decrement and reduced dendritic spine density shown in the Git1 knockout brain. (A) Git1-/- mice show reduced brain size compared to wild-type littermates. n=3 (WT), 3 (KO). Scale bar, 1 cm. (B) Representative DiI images of the pyramidal neurons in the CA1 region of the hippocampus. Scale bar, 10 µm. (C) Quantification of the brain to body weight ratio. Git1-/- mice show decreased brain to body weight ratios compared to controls. (D-F) Quantification of the results from (B). Git1-/- mice show decreased dendritic spine density, while spine width and length are unaltered. n=8 (WT), 9 (KO). **p<0.01; Student's t test. Error bars indicate means±s.e.m.
Exp Neurobiol 2015;24:8~16
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