Fig. 1. Effect of i.c.v. pretreatment with KA on the blood glucose level in D-glucose-fed model. (A) After mice were pretreated i.c.v. with KA (from 0.01 to 0.1 µg) for 24 h, they were fed orally with D-glucose (2 g/kg). The blood glucose level was measured at 30, 60 and 120 min after D-glucose feeding. (B) After mice were pretreated i.c.v. with KA (0.1 µg) for 1, 2, 3, or 4 weeks, they were fed orally with D-glucose (2 g/kg). The blood glucose level was measured at 30 min after D-glucose feeding. The vertical bars indicate the standard error of mean (***p <0.001, **p <0.01, *p <0.05; compared to PBS+Saline, +++p <0.001, ++p <0.01, +p <0.05; compared to PBS+ D-glucose). The number of animals used for each group was 8~10.
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