Fig. 1. Transplantation of hUCB-MSCs reduces lesion volume and improves the behavioral recovery of ICH rats. (A) Schematic timeline of the experimental procedures. MSCs indicates mesenchymal stem cells; Sacr, sacrifice; IF, immunofluorescence staining; WB, western blot; and BT, behavior test. (B) H&E staining of coronal sections for characterization of unilateral brain injury at 30 days after ICH. (C) The volume of lesion in the hUCB-MSCs-treated rats (n=8) was significantly smaller than in the controls (n=10) at 4 weeks after transplantation. **p<0.01. The lesion volume was determined by summation of the lesion area and analyzed by the Mann-Whitney U test. Data are shown as mean and SEM. (D) Results of the rotarod test. The hUCB-MSCs-treated rats (n=8) showed significantly better performance than the controls (n=10) at 4 weeks after transplantation. ****p<0.0001, repeated-measured analysis of variance (ANOVA). (E) Results of the limb placement test. The hUCB-MSCs-treated group (n=8) showed better performance than the controls (n=10) at 4 weeks after transplantation. **p<0.01, repeated-measured ANOVA. All data are shown as mean and SEM.
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