Fig. 1. FISH analysis for Alpha-Synuclein gene. Panel A presents an interphase of a lymphocyte showing the presence of three DNA regions hybridized with probes obtained from BAC (Bacterial Artificial Chromosomes) containing the Alpha-Synuclein gene. Panel B, on the right, shows a metaphase where the chromosomes carrying the Alpha-Synuclein gene can be observed. One of the chromosomes can be seen to be more intense and have a larger region than its homologous pair. Telomere markers (green) do not present noticeable differences. These results suggest that the duplication presents in the same chromosome, near the region where the gene is located.
© Exp Neurobiol
