Fig. 1. Selegiline attenuates the amplitude of eEPSCs in DG granule neurons in WT mice but increases in APP/PS1 mice. (a) Schematic diagram of brain slice electrophysiology experiments. (b) The averaged amplitude values of eEPSCs plotted as a function of stimulus intensity (n=9 cells, 9 cells, 10 cells, and 10 cells for WT control, WT+selegiline, APP/PS1 control, and APP/PS1+selegiline, respectively). (c) Summarizing results for the amplitude of eEPSCs in WT and APP/PS1 mice. (d) Representative eEPSCs in control and selegiline-treated WT (upper panel) and APP/PS1 (lower panel) mice at 50 µA stimulation intensity of PP. (e) Summarizing results for absolute values of the amplitude of EPSCs evoked by 50 µA stimulation of PP in WT (9 cells) and APP/PS1 (10 cells) mice. (f) Summarizing results for normalized values of the amplitude of EPSCs in WT and APP/PS1 mice. (g) Representative eEPSCs in control and selegiline-treated WT (upper panel) and APP/PS1 (lower panel) mice at 100 µA stimulation intensity of PP. (h) Summarizing results for absolute values of the amplitude of EPSCs evoked by 100 µA stimulation of PP in WT (9 cells) and APP/PS1 (9 cells) mice. (i) Summarizing results for normalized values of the amplitude of EPSCs in WT and APP/PS1 mice. All data are represented as mean±S.E.M. (#non-significant, *p<0.05, **p<0.01, ***p<0.001, Student's unpaired t-test).
© Exp Neurobiol
