Fig. 3. Bicuculline and CGP55845 do not alter the amplitude of eEPSCs in WT mice but increases in APP/PS1 mice. (a) Representative eEPSCs before and after bath application of bicuculline in WT mice. (b) Summarizing results for effect of bicuculline on the amplitude of EPSCs in WT mice (9 cells). (c) Representative eEPSCs before and after bath application of CGP55845 in WT mice. (d) Summarizing results for effect of CGP55845 on the amplitude of EPSCs (4 cells). (e) Representative eEPSCs before and after bath application of bicuculline in APP/PS1 mice. (f) Summarizing results for effect of bicuculline on the amplitude of EPSCs in APP/PS1 mice (9 cells). Bicuculline was applied at a concentration of 10 µM. (g) The rise time of eEPSCs in control and selegiline-treated WT mice (9 cells) (h) The rise time of eEPSCs in control and selegiline-treated APP/PS1 (9 cells) mice. All data are represented as mean±S.E.M. (#non-significant, ***p<0.001, Student's paired t-test). In all experiments EPSCs were evoked by 100 µA stimulation of PP.
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