Fig. 4. Bicuculline and CGP55845 do not alter the PPR in WT mice but bicuculline reduces the PPR in APP/PS1 mice. (a) Representative traces of two subsequent EPSCs before and after bath application of bicuculline in WT mice. Inter-pulse interval was 50 ms. (b) Summarizing results for effect of bicuculline on the PPR of EPSCs in WT (9 cells). (c) Representative traces of two subsequent EPSCs before and after bath application of CGP55845 in WT mice. (d) Summarizing results for effect of CGP55845 on the PPR of EPSCs in WT mice. Bicuculline was applied at a concentration of 10 µM. (e) Representative traces of two subsequent EPSCs before and after bath application of bicuculline in APP/PS1 mice. Inter-pulse interval was 50 ms. (f) Summarizing results for effect of bicuculline on the PPR of EPSCs in APP/PS1 mice (9 cells). Bicuculline was applied at a concentration of 10 µM. Data are represented as mean±S.E.M. (#non-significant, ***p<0.001, Student's paired t-test). In all experiments EPSCs were evoked by 100 µA stimulation of PP. Inter-pulse interval was 50 ms.
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