Fig. 1. Rosmarinic acid extends the survival of G93A-SOD1 transgenic mice. (A) G93A-SOD1 transgenic mice treated with rosmarinic acid (30 or 400 mg/kg/day) from 7 weeks of age exhibited extended survival compared with untreated G93A-SOD1 mice. (B) Body weight changes of G93A-SOD1 mice during the administration of rosmarinic acid. Body weights were monitored weekly and are presented as percentages of mean body weight of each group at 7 weeks of age. Rosmarinic acid was administrated at 30 or 400 mg/kg/day to G93A-SOD1 mice from 7 weeks of age. Non-Tg, non-transgenic WT control; Tg-Con, G93A-SOD1 transgenic control; Tg+RA30 and Tg+RA400, G93A-SOD1 transgenic mice treated with rosmarinic acid of 30 mg/kg/day and 400 mg/kg/day, respectively; Tg+Rilu, G93A-SOD1 transgenic mice treated with 35 mg/kg/day of riluzole. Data are presented as means±SEM (n=6~13). **denotes differences from the Tg-control at 16 weeks at p<0.01. Two-way ANOVA and Bonferroni post hoc test were used.
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