Fig. 4. Neurogenesis in the ischemic brain. hUCB-MSCs may induce post-ischemic neuroprotection by increasing neurogenesis. (A) GFAP-delta-(red) or nestin-(green) positive cell distribution was dominant in all hUCB-MSC-treated groups (G19, G16, and G5) compared to the control group at day 28 after MCAO. Scale bar=20 µm. (B) Quantification of the neurogenic factor optical density. (C) Decreased apoptotic cell death as assessed by the TUNEL assay. Scale bar=50 µm.
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