Fig. 4. Selective suppression of CaMKIIα in the dorsal striatum in AC5 KO mice and D2 KO mice blocked the behavioral preference for AC5 KO food pellets. (A) Western blots showing p-CaMKIIα levels in the dorsal striatum in the right (R) and left (L) hemispheres in WT mice, AC5 KO mice, and WT mice with whiskers trimmed unilaterally on the right side (whisker, right-cut) or the left side (whisker, left-cut) of the face. Quantification of p-CaMKIIα level in the dorsal striatum (bottom). (B, C) The siRNAmediated inhibition of p-CaMKIIα in AC5 KO mice in either the left (B) or the right (C) dorsal striatum suppressed a behavioral preference for AC5 KO pellets. (D, E) The siRNA-mediated inhibition of p-CaMKIIα in D2 KO mice in either the left (D) or the right (E) dorsal striatum suppressed a behavioral preference for AC5 KO pellets. Data are presented as the mean±SEM (n=7-8). * and **denote the difference between the indicated groups at p<0.05 and p<0.01, respectively (Student's t-test, or two-way repeated-measures ANOVA, and post-hoc test).
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