Fig. 1. Neurogenesis and gliogenesis in the adult brain. Potential neurogenic regions described in adult rodent (A1) and human (A2) brains. Solid pink lines indicate the rodent rostral migration stream and the known primary neurogenic regions in rodent and human brains. Pink dots in the rodent olfactory bulb and human striatum indicate the possible final destinations of SVZ-generated new neurons. Pink arrowheads mark some of the putative migration routes of the precursor cells before reaching their final destination (e.g. substantia nigra). Abbreviations: 3V, third ventricle; 4V, fourth ventricle; Aq, aqueduct; DG, dentate gyrus; Hip, hippocampus; LV, lateral ventricle; LVIH, inferior horn of the lateral ventricle; OB, olfactory bulb; RMS, rostral migration stream; SN, substantia nigra. (B) Potential factors reported to modulate the balance between neurogenesis and gliogenesis in rodents and cell cultures. Negative signs mark inhibitory effects. Production of different cell types is region-dependent (as indicated in the lower part of panel B), and this preference may be altered in response to certain diseases or other conditions. For details see the main text.
© Exp Neurobiol