Fig. 1. Effects of 6-OHDA lesions on vehicle- and PA-5HT-treated mice. (A) Schematic of the 6-OHDA-lesion, drug injection and behavioral tests. (B) D-AMPH-induced rotations in vehicle- and PA-5HT- treated mice for 60 min (n=8-9). (C) Right forelimb use by vehicle- and PA-5HT-treated mice in the cylinder test before (pre-test) and after 6-OHDA injection (6-OHDA), and 30 min after the first treatment of L-DOPA (6-OHDA/L-DOPA) (n=8-9). Western blots (D) and immunostaining (E) of TH in the striatum and SNc of vehicle- and PA-5HT- treated mice. Scale bar 500 µm. **p<0.01, significant differences between indicated groups. One-way ANOVA followed by a Tukey-Kramer post hoc test. Data are presented as the mean±SEM. D-AMPH: D-amphetamine; PA-5HT: Palmitoyl serotonin; 6-OHDA: 6-hydroxydopamine; L-DOPA: L-3,4-dihydroxyphenylalanine; TH: tyrosine hydroxylase; SNc: substantia nigra pars compacta.
© Exp Neurobiol