Fig. 4. Hyperphosphorylation of ERK1/2 by chronic L-DOPA is reduced in the 6-OHDA-lesioned striatum of PA-5HT-treated mice. Protein levels of phospho-extracellular signal-regulated protein kinase (pERK) 1/2 and total ERK1/2 were evaluated by western blots (A). pERK1/ERK1 (B) and pERK2/ERK2 (C) levels in the 6-OHDA lesioned versus unlesioned striata (n=8-9). One-way ANOVA followed by a Tukey-Kramer post hoc test. *p<0.05 and **p<0.01. Data are presented as the mean±SEM. L-DOPA: L-3,4-dihydroxyphenylalanine; 6-OHDA: 6-hydroxydopamine; PA-5HT: Palmitoyl serotonin.
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