The role of glial cells and leukocytes after ischemic stroke
Cell typeMajor function(s)Reference(s)
Microgliae- activity-dependent synaptic pruing and repair[15]
- morphologic transformation in acute brain injury[16,17]
- sweep foregin organism in brain injury[18,19,20], [21]
- role of M1 phenotype microglia in the brain[25], [28,29]
- role of M2 phenotype microglia in the brain[26], [27], [30,31]
- swith of M1 to M2 microglia[32,33,34], [35], [36]
- microglia functionin ischemic stroke[37], [38,39], [40,41,42], [45], [46], [47]
Astrocyte- regulation of immune reactions[48]
- reactive gliosis and glial scar formation[8], [18], [49]
- releasing various immune molecules[50], [51], [52,53]
Neutrophil- roles in acute ischemic brain injury[58]
- interaction with adhesive molecules[59,60]
- rolling and adhesion the pial vessels of brain[61]
- infiltration and immune response to ischemic brain[70], [71], [72,73]
Monocyte- phagocytic capacity[83,84]
- expression of chemokines[85], [86,87]
- expression of the pro- and anti-inflammatory cytokines[92]
T lymphocyte- improvement of inflammation in ischemic brain[68], [93,94], [95]
- increased astrocyte proliferation[102]
- oxidative tissue injury[105]
Exp Neurobiol 2016;25:241~251 https://doi.org/10.5607/en.2016.25.5.241
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