Fig. 3. PTP inhibitors suppress LPS-induced NO production in microglial cells. BV-2 microglial cells were treated with LPS (100 ng/ml) in the presence of the indicated concentration of a PTP inhibitors for PTP1B, TC-PTP, SHP2, MEG2, LYP, and RPTPβ for 24 h. The nitrite content was measured using the Griess reaction (left panel), and the cytotoxicity of the PTP inhibitors was assessed in a MTT assay (right panel). The data were expressed as the mean±SEM (n=3). *p<0.05 vs. LPS only; analyzed using one-way ANOVA with Tukey's multiple comparison test.
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