Fig. 2. Human brain expression of miR-1908-5p and its synaptic target genes. (a) Box plots showing the expression distribution of DLGAP4 in 16 human brain regions. The black line in each box indicates the median value. The lower and upper hinges of each box indicate the lower and upper quartile values, respectively. The whiskers of each box indicate the most extreme data values within 1.5 times the interquartile range. The open circles indicate the data values beyond the whisker limits. OFC, orbital prefrontal cortex; DFC, dorsolateral prefrontal cortex; VFC, ventrolateral prefrontal cortex; MFC, medial prefrontal cortex; M1C, primary motor cortex; S1C, primary somatosensory cortex; IPC, posterior inferior parietal cortex; A1C, primary auditory cortex; STC, superior temporal cortex; ITC, inferior temporal cortex; V1C, primary visual cortex; HIP, hippocampus; AMY, amygdala; STR, striatum; MD, mediodorsal nucleus of the thalamus; CBC, cerebellar cortex. (b) The expression distribution of GRIN1 in 16 human brain regions. (c) The expression distribution of GRM4 in 16 human brain regions. (d) The expression distribution of miR-1908-5p in 16 human brain regions. (e) Bar plots showing Spearman's correlations between the expression level of miR-1908-5p and those of DLGAP4, GRIN1, and GRM4 in 16 human brain regions. (f) The brain regions with relatively stronger inverse-correlation (<−0.4) between miR-1908-5p and GRM4 are shown (upper panel). Scatter plots showing the expression level for miR-1908-5p versus GRM4 in the striatum with linear regression line fit (Spearman's correlation coefficient, rho=−0.655) (lower panel).
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