Fig. 1. Microfluidic chip design, fabrication, computational simulation, and operation. (a) Top-view layout of the microfluidic chip with the 8 parallel channels (top) and the principles of the estimation of wall shear stress applied to RGCs (bottom). (b) Detailed wall shear stress profiles at the cross section (A–B) and at the cross section (X–Y). Uniform shear region of the channel, 3 mm-long and 2 mm-wide, shows a uniform wall shear stress (0.05 Pa when flow rate is 6.7 µL/min). (c) The inset of computational geometry with the generated mesh showing a close-up view of the features of the vertical mesh (left) and the table showing relationship between flow rates and corresponding shear stresses (right). (d) Fabrication methods for microfluidic chips. (e) Operational diagram of the microfluidic system for the study of shear stress.
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