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Fig. 1. HFD-induced obesity in C58BL/6 mice and decrease of general and motor behavior in HFD-fed mice. (A) HFD-fed, 5-week-old C57BL/6 mice (n=6/group) showed a significant increase in body weight gain compared with NCD-fed mice. (B) Plasma leptin levels in NCD- or HFD-fed mice was measured by ELISA. (C) Traces of mouse movements during open-field tests are presented. (D) The total moved distance of HFD-fed mice decreased compared with that of NCD-fed mice. (E) Movement was analyzed as distance per time. (F~J) A mouse was placed 3 cm from the bottom of the apparatus and allowed to climb upward, turn around, and climb down during recordings. (F) Total time is the sum of time to climb, make turn and climb down. (G) Time taken for the mouse to turn. (H) Time taken for the mouse to climb before it turned. (I) During the climb down, the number of failed hindlimb steps was measured and converted to a percentage of total steps. (J) Time taken for the mouse to climb down after is turned. In HFD-fed mice, the time to climb and percentage of missteps increased. There were no differences in the total time, time to turn, or time to climb down. *p<0.05, **p<0.01, ***p<0.001.
Exp Neurobiol 2017;26:104~112
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