Fig. 2. (a) Immunostaining of mBest1 in the molecular layer of DG (both sexes at 9 months of age; scale bar, 10 mm) from wild type and APP/PS1 Alzheimer's disease model mouse. (b) Representative images of Best1 by immunogold electron microscopy labeling (black dots indicated by arrowheads) in DAB-stained astrocytes (outlined with dashed lines). Pre, presynaptic terminal; Post, postsynapse; scale bar, 300 nm. Bottom left, density of gold particles for Best1 in cell body, process and microdomain. ***p<0.001 (Student's t-test). (c) Model diagram of memory impairment in Alzheimer's disease.
© Exp Neurobiol