| 6 weeks (n=6) | 3 months (n=6) | 6 months (n=6) | 8 months (n=6) | 10 months (n=5) | p-value | |
|---|---|---|---|---|---|---|
| TRP (μM) | 66.25 (59.36–77.07) | 71.85 (52.29–75.83) | 68.22 (57.97–78.57) | 48.66 (43.40–55.74) | 52.15 (47.02–63.17) | 0.039 |
| KYN (nM) | 1233.56 (1111.63–1294.89) | 702.18 (601.59–1039.49) | 717.33 (575.21–829.58) | 636.62 (493.41–934.99) | 902.22 (731.32–1007.00) | 0.013 |
| 3-HK (nM) | 210.28 (157.38–250.30) | 199.97 (136.19–328.48) | 139.03 (120.44–169.85) | 165.78 (130.57–231.37) | 142.31 (110.45–227.48) | 0.269 |
| KYNA (nM) | 125.81 (86.43–184.72) | 67.31 (53.70–96.64) | 30.32 (24.65–39.91) | 36.18 (20.13–50.27) | 37.49 (26.74–64.38) | 0.001 |
| KYN/TRP ratio | 0.017 (0.015–0.020) | 0.012 (0.009–0.014) | 0.012 (0.009–0.012) | 0.013 (0.010–0.019) | 0.015 (0.013–0.020) | 0.015 |
| 3-HK/KYN ratio | 0.18 (0.16–0.21) | 0.31 (0.21–0.33) | 0.19 (0.18–0.26) | 0.29 (0.24–0.33) | 0.16 (0.13–0.27) | 0.067 |
| KYNA/KYN ratio | 0.088 (0.079–0.135) | 0.087 (0.075–0.100) | 0.043 (0.027–0.057) | 0.040 (0.037–0.070) | 0.041 (0.033–0.061) | 0.001 |
Data presented as median and interquartile range. TRP indicates tryptophan; KYN, kynurenine; 3-HK, 3-hydroxylkynurenine; KYNA, kynurenic acid.
p-values were provided by Kruskal-Wallis test.