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Fig. 2. Delayed neuromuscular synapse maturation in Gab1-MSKO mice. (A) Schematic drawing showing the postnatal maturation of the endplate morphology from ovoid to branched type. (B) Representative confocal micrographs showing the endplate morphology of Gab1f/f and Gab1-MSKO mice at P1 and P14. Single arrows indicate ovoid morphology, whereas double arrows indicate perforated or branched morphology. (C, D) Quantitative analysis of endplate maturation in Gab1f/f and Gab1-MSKO mice at P1 (C) and P14 (D) (n=3). Scale bar=20 µm. Data are mean±SEM. *p<0.05, **p<0.01. NS, non-significant.
Exp Neurobiol 2017;26:141~150
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